
House vacation rentals in Upstate South Carolina
Find and book unique houses on Airbnb
Top-rated house rentals in Upstate South Carolina
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Upstate South Carolina house rentals
House rentals with a pool

Lakeside Family & Dog Retreat Awaits! DWC

Aframe Amazing Views Hot Tub Dog & Family Friendly

POOL open til Oct 12 HOT TUB Sleeps 11 Gameroom

Wonderful mountain cottage with amazing view!

Shalom House with Pool near DT Greer SC

A quiet place in the country

Greenville Bungalow w/ Stock Tank Pool + Fire pit

Saluda Splash Home
Weekly house rentals

The Mountain House

Grace Mountain Cottage-Mtn views /Peaceful+Private

The Wright Place! 25/min DT G-Ville. Pool/Hottub.

Palmetto Trailside Retreat

Welcome to River House

Bohemian Bungalow

Cozy home in downtown TR

Pool, Pickleball, Poker, Ping-Pong! King beds!
Private house rentals

3 Min to Downtown, Game Room, King bed

Clemson Cottage: Secluded on 1.3 acres & quaint AF

Lakefront Getaway: Fire Pit ~ Dock ~ Games!

Kargohaus ~ Unique Shipping Container - Dog Park!

Modern Mountain Stream Overlook

Bear Ridge Retreat | Pets | New Build with VIEWS!

Beautiful Cashiers cabin nestled in the woods

Fountain Inn on Main St
Destinations to explore
- Western North Carolina Vacation rentals
- Nashville Vacation rentals
- Atlanta Vacation rentals
- Myrtle Beach Vacation rentals
- Charleston Vacation rentals
- Gatlinburg Vacation rentals
- Charlotte Vacation rentals
- Hilton Head Island Vacation rentals
- Pigeon Forge Vacation rentals
- Savannah Vacation rentals
- Asheville Vacation rentals
- North Myrtle Beach Vacation rentals
- Townhouse rentals Upstate South Carolina
- Rentals with a sauna Upstate South Carolina
- Villa rentals Upstate South Carolina
- Rentals with a home theater Upstate South Carolina
- Resort rentals Upstate South Carolina
- Rentals with an EV charger Upstate South Carolina
- Tiny house rentals Upstate South Carolina
- Chalet rentals Upstate South Carolina
- Guesthouse rentals Upstate South Carolina
- Treehouse rentals Upstate South Carolina
- Fitness-friendly rentals Upstate South Carolina
- Hotel rentals Upstate South Carolina
- Farmstay rentals Upstate South Carolina
- Rentals with breakfast Upstate South Carolina
- Pet-friendly rentals Upstate South Carolina
- Rentals with an accessible height toilet Upstate South Carolina
- Bed and breakfasts Upstate South Carolina
- Rentals with a kayak Upstate South Carolina
- Rentals with a hot tub Upstate South Carolina
- Rentals with outdoor seating Upstate South Carolina
- Barn rentals Upstate South Carolina
- Apartment rentals Upstate South Carolina
- Cabin rentals Upstate South Carolina
- Loft rentals Upstate South Carolina
- Vacation home rentals Upstate South Carolina
- Condo rentals Upstate South Carolina
- Serviced apartment rentals Upstate South Carolina
- Ski-in/ski-out rentals Upstate South Carolina
- Private suite rentals Upstate South Carolina
- Waterfront rentals Upstate South Carolina
- Rentals with a fire pit Upstate South Carolina
- Tent rentals Upstate South Carolina
- Boutique hotel rentals Upstate South Carolina
- Rentals with a patio Upstate South Carolina
- Rentals with pools Upstate South Carolina
- Rentals with a fireplace Upstate South Carolina
- Rentals with beach access Upstate South Carolina
- Cottage rentals Upstate South Carolina
- Rentals with a washer and dryer Upstate South Carolina
- Rentals with lake access Upstate South Carolina
- Beachfront rentals Upstate South Carolina
- Smoking-friendly rentals Upstate South Carolina
- Nature eco lodge rentals Upstate South Carolina
- Family-friendly rentals Upstate South Carolina
- House rentals South Carolina
- House rentals United States
- Blue Ridge Parkway
- Gorges State Park
- Table Rock State Park
- The North Carolina Arboretum
- Chimney Rock State Park
- Tryon International Equestrian Center
- Lake Lure Beach and Water Park
- Ski Sapphire Valley
- Wade Hampton Golf Club
- Jump Off Rock
- Victoria Valley Vineyards
- Discovery Island
- Haas Family Golf
- Carl Sandburg Home National Historic Site
- Saint Paul Mountain Vineyards
- City Scape Winery
- Burntshirt Vineyards
- Overmountain Vineyards
- Wellborn Winery
- Russian Chapel Hills Winery