House vacation rentals in Upstate South Carolina

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Top-rated house rentals in Upstate South Carolina

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Top guest favorite

Home in Taylors

4.97 out of 5 average rating, 199 reviews

Vintage home near downtown Greenville.

Cozy home with vintage look. Be in downtown Greenville or Paris Mt. State Park in under ten minutes. Close to shopping and the state Farmer's Market is a mile away. Acre yard gives spacious feeling. A complimentary Power Point of South Carolina and local history, culture, events, and business is available to help introduce you to one of the country's best kept secrets. Cut flowers and help yourself to our organic garden for use during your stay (seasonally). Small RV parking but no hook ups.

Top guest favorite

Home in Greenville

4.97 out of 5 average rating, 107 reviews

The Greenville Nest - Retreat & Relaxation Home

This beautifully one-level home offers 3 queen beds and 2 baths, accommodating up to 6 guests. Centrally located in a peaceful neighborhood. 8-minute drive to GSP airport, 15-minute drive to downtown Greenville, minutes from I-85/385, and minutes from Woodruff and Pelham Rd. You'll appreciate the easy access to food delivery and restaurants. Enjoy a stylish Experience for entertaining, working, and relaxing with high-speed Wi-Fi. Quiet and safe with an enjoyable private screened porch and Grill.

Top guest favorite

Home in Fletcher

4.99 out of 5 average rating, 156 reviews

Atrium House - Spa Retreat

Come unwind and breathe at our couples mountain spa retreat. Atrium House has been designed to feel open to the lovely mountain surroundings yet let you relax in privacy. Our outdoor therapy hot tub, indoor/outdoor gas fireplace, and spacious two-person, walk-in shower make for a getaway so tranquil, you may never make it in to nearby Asheville! We're out in the country but just over a 15-minute drive from downtown Asheville, Biltmore, Hendersonville, Asheville Airport, and dozens of breweries.

Top guest favorite

Home in Greenville

4.99 out of 5 average rating, 169 reviews

Modern Designer Getaway Near Downtown Greenville

Welcome to your Greenville getaway! Minutes to downtown, GetawayGVL is a designer 1950s midcentury modern ranch that offers the conveniences of a hotel with the comforts of home. This bright and airy 3BR, 1.5BA tropical oasis boasts a stunning outdoor space with yard games for entertaining, a dedicated desk for working, and a designer den for relaxing. You're only minutes away from a walk on the Swamp Rabbit Trail, dinner by the Reedy River, or a concert at The Well! Book your getaway today!

Superhost

Home in Westminster

4.94 out of 5 average rating, 279 reviews

Waterfall Views, Lake Hartwell, Highland Architect

Come and enjoy nature with 100+ acres to roam. Paths for long walks. Architect James Fox designed this cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

Top guest favorite

Home in Greenville

4.97 out of 5 average rating, 215 reviews

Spectacular home 1 mile from Main St Greenville!

Enjoy your stay in this charming up to date house 1 mile from Main St Greenville! Take a walk through the Historic Pinckney district on your way to Greenville’s museums, restaurants, theaters, and stunning Reedy River Falls Park. Easy access to the Swamp Rabbit biking and walking trail, and just 4 blocks from the upcoming Unity Park. House is located on quiet residential street with private driveway. Relax on rocking chairs on front porch or around a portable fire pit in large backyard.

Top guest favorite

Home in Lake Toxaway

4.99 out of 5 average rating, 321 reviews

Cabin I Private hiking trails | Hot Tub I Sauna

Welcome to your private mountain escape in Lake Toxaway, NC! This 1-bedroom, 2-bathroom cabin is a one-of-a-kind retreat, offering breathtaking sunset views, a peaceful wooded setting, and unique architectural details. Unwind in the hot tub under the stars, relax in the sauna, challenge your partner to air hockey, or cozy up by the fire pit—all while enjoying the beauty of nature. Plus, enjoy exclusive access to 3 miles of private hiking trails, perfect for exploring the great outdoors!

Top guest favorite

Home in Greenwood

5 out of 5 average rating, 151 reviews

The Little White House

Kick back and relax in our newly built guest house. We have put a lot of thought and effort into our space for you to have a comfortable stay. Enjoy a country living feel while being just minutes from shopping, restaurants, and the hospital. The host also live behind the property should you need anything. No pets. No smoking. This space is for paying guest only. No parties! We also have a 2nd listing in Greenwood- The Cottage @ Hill & Dale. *OWNER IS A LICENSED REAL ESTATE AGENT.

Top guest favorite

Home in Candler

4.99 out of 5 average rating, 262 reviews

Million dollar View’s | Chef Kitchen | Luxury bath

Cloud 9 isn’t just a place to stay — it’s a place to feel. Elegant. Refined. Rooted in nature. Thoughtfully designed and tucked into the mountains, this soulful retreat offers stillness, beauty, and intention in every detail. It doesn’t compete with the land — it whispers into it. Here, quiet becomes the ultimate amenity. A place that feels like home — and a dream — all at once. Come experience the kind of calm that stays with you. Book your stay in the clouds!

Top guest favorite

Home in Greenville

4.99 out of 5 average rating, 205 reviews

Cozy Treehouse

Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.

Top guest favorite

Home in Abbeville

4.99 out of 5 average rating, 117 reviews

Lana’s Cottage

Welcome to our cozy cottage in historic Abbeville. We are in a quiet and family friendly neighborhood. This home comfortably sleeps six adults. The kitchen is fully stocked and is perfect for making a cup of coffee to cooking a full meal! There’s a smart TV with fast internet to be able to access your favorite streaming service. We are 1 mile from groceries and your choice of local restaurants. We are delighted to host you in our home.

Top guest favorite

Home in Chimney Rock

4.97 out of 5 average rating, 235 reviews

Spectacular Waterfall Views! ChimneyRock CottageEV

We look forward to welcoming guests back to our home in September! Enjoy the amazing views in this custom cottage half a mile to Chimney Rock village. We are 30 minutes to Asheville. Visit one of the many breweries or a local vineyard. Chimney Rock State Park is just down the road. There is nothing better than the view of the Hickory Nut Falls waterfall from the hot tub in the backyard! Level 2 EV Charger-Full charge in less than 3 hour