Guesthouse vacation rentals in Upstate South Carolina

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Top-rated guesthouse rentals in Upstate South Carolina

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Top guest favorite
A gravel path meanders through a grassy area, flanked by low shrubs and tall trees, creating a serene and natural environment. Soft sunlight casts a gentle glow over the scene, highlighting the rich green foliage and the open field stretching out in the distance.
Guesthouse in Abbeville
4.97 out of 5 average rating, 350 reviews

Scenic Loft in the Woods

Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Top guest favorite
A charming log cabin is nestled among lush greenery, featuring wooden walls and a sloping roof. The front door is framed by two windows adorned with flower boxes. Two white chairs sit on a stone pathway, inviting relaxation in the serene outdoor setting.
Guesthouse in Greenville
4.93 out of 5 average rating, 693 reviews

Historic 19th Century Cabin/Guest House

This 19th century cabin is your perfect cozy getaway. This guest house is located on a 3.5 acre property, secluded from the historic neighborhood, though it's just 3 miles from downtown Greenville and the Bon Secours Wellness Arena. Less than a mile to the Swamp Rabbit Trail, this cottage is perfect for jaunts to downtown Greenville, Furman University, Paris Mountain, Travelers Rest and Unity Park! Micro weddings and events are available upon request and approval with applicable fees applied.

Guest favorite
A charming cabin is nestled among towering trees, with a sloped metal roof and rustic log walls. Lush greenery surrounds the property, while vibrant blue hydrangeas bloom in the foreground. A fire pit with seating is positioned to the right, creating an inviting outdoor space.
Guesthouse in Sunset
4.92 out of 5 average rating, 411 reviews

Mountain Cabin on Creek at Jocassee Gorge.

Welcome to Laurel Valley. A tiny, sleepy neighborhood at the top of a mountain, hidden from the hustle of civilization. This adorable cabin is nestled in beautiful Jocassee Gorge. Minutes away from multiple attractions including Sassafras Mountain and Twin Falls. Property borders thousands of acres of protected land with 5 star trails . This mountain cabin is in a unique setting that time forgot. The rushing creek outside helps you to peel off the world and get a great night's sleep.

Top guest favorite
A modern cabin is nestled among tall trees, featuring a wooden exterior and a sloped metal roof. A small porch with wooden railing is visible, providing an inviting entryway. Surrounding foliage includes lush ferns and greenery, enhancing the natural setting.
Guesthouse in Ashville
4.95 out of 5 average rating, 405 reviews

Modern Cabin Retreat w/ Sauna

This space was designed with love and care and the hope that all who stay here feel relaxed and connected to nature. We recently added a cedar barrel sauna that heats up quickly and is user friendly. Often we don’t see guests but I’m always available for questions and recommendations. We live "next door" on the same property with our two young sons. The cabin is located in a neighborhood, so while it hopefully feels removed from any hustle and bustle, there is access to many conveniences.

Top guest favorite
The serene cottage is surrounded by lush greenery and colorful flowers, with pink azaleas and white dogwoods blooming prominently in the foreground. A charming red barn is nestled among the trees, enhancing the peaceful rural setting.
Guesthouse in Greenville
5 out of 5 average rating, 434 reviews

The Cottage at Old Oaks Farm

Built in the early 1900's, this serene cottage is located approximately one mile from Furman University at the base of Paris Mt. It has been lovingly improved, but the floors are a bit slanted and no corner is exactly square. Located in a neighborhood on a five acre farm, it consists of three large rooms, comfortably furnished and lots of natural light. The cottage is convenient to downtown Greenville(5 miles),Travelers Rest, Furman, and the Swamp Rabbit Trail. No pet fee or cleaning fee.

Top guest favorite
A private patio extends alongside the studio apartment, featuring a smooth concrete surface with various potted plants. The lake is visible beyond the trees, providing a peaceful backdrop with water reflecting the clear blue sky.
Guesthouse in Tuckasegee
4.99 out of 5 average rating, 241 reviews

Wolf Lake Escape - lake & mountain retreat

Beautiful secluded setting on Wolf Lake. Private studio apartment with full kitchen and bath. Stunning lake view and full lake access with use of kayaks, canoe and dock in the adjacent cove. Private patio with fire pit and grill. Paradise Falls trailhead 1 mile away. Close to Panthertown Valley Backcountry Area with multiple trails and waterfalls. 45 minutes from Brevard, Sylva and Cashiers, NC. Easy drive to Asheville and Biltmore House. Onsite parking. Well behaved pets welcome

Guest favorite
The open loft features a spacious bed and a striped couch adorned with decorative pillows. Natural light floods through large windows that frame views of the surrounding woods. Natural wood floors and a small side table complete the cozy atmosphere.
Guesthouse in Salem
4.89 out of 5 average rating, 318 reviews

Mountain Edge Loft

Private loft apartment on 25 wooded acres, sits separate from main farm house. Private deck overlooking the woods. Everything you need for a cozy stay. Located on the edge of the Blue Ridge Escarpment with lakes Jocassee and Keowee just a few miles away. Numerous state parks, hiking, biking , waterfalls and kayaking or just peace and quiet. We are a sustainable homestead with an organic garden, chickens ,quail, dogs and cats. Our water comes from a natural spring.

Top guest favorite
A charming cottage is positioned next to a swimming pool, featuring a sloped roof and large windows. Lush greenery surrounds the area, providing a natural feel. The pool deck is paved, with a diving board extending into the clear water, creating an inviting outdoor space.
Guesthouse in Greenville
4.98 out of 5 average rating, 258 reviews

Greenville With A View!

ONLY 10-15 MINUTE DRIVE TO THE HEART OF BEAUTIFUL DOWNTOWN GREENVILLE! We are only 11 miles to GSP Airport; 6 miles to Greenville Downtown Airport; and 10 minutes to the Swamp Rabbit Trail. We are minutes to Furman University, Bob Jones University, North Greenville University and Clemson University is only 45 minutes away. We are tucked away open top of Paris Mountain. If you want to bike, hike, paddle, swim, boat or just soak it all in, start here!

Top guest favorite
A charming cottage is set on a well-maintained lawn, with a pathway leading to its entry. Flanking greenery enhances the inviting ambiance, while the exterior features a sleek black finish complemented by light-colored door and window trim.
Guesthouse in Taylors
4.99 out of 5 average rating, 101 reviews

Entire Cottage w/Hot Tub - Easy Checkout!

The Cozy Cottage is a stunning 600-square-foot space containing 1br and 1ba, walk-in closet, full kitchen, washer and dryer, dishwasher, and living space. We have several premium features including an adjustable climate control system for the queen bed (BedJet) and access to our hot tub in the nearby outdoor living space! There is a dedicated 2 car parking pad for our guests and excellent lighting from the parking area all the way to the cottage.

Top guest favorite
The interior features a cozy living area with a dark gray sectional sofa, complemented by decorative pillows. A circular coffee table sits in front, holding a tray with books and a remote. The kitchen appears in the background, showcasing a modern design with white cabinetry.
Guesthouse in Inman
4.99 out of 5 average rating, 137 reviews

Foothills Favorite

Custom designed 1 bedroom suite in the Lake Bowen/Landrum/Inman area. Comfortable yet sleek space tucked above a semi-detached garage; private entry & stairway to suite. Private deck overlooks green spaces, wooded area & Lake Bowen (best views late fall and winter). Enjoy mountain views at nearby Lake Bowen park, local wineries, and scenic highways. Minutes from Landrum & Tryon & Equestrian Center.

Guest favorite
The exterior view of the Shou-Sugi-Ban Guest House features a dark wooden facade with a sloped roof. A spacious deck is present, furnished with two orange chairs and a potted plant. Lush greenery surrounds the area, providing a natural feel.
Guesthouse in Piedmont
4.98 out of 5 average rating, 116 reviews

Shou-Sugi-Ban Retreat on the Saluda River

The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.

Top guest favorite
A charming cottage is set among lush greenery, featuring a spacious deck that extends from the front. Large windows provide natural light, while surrounding trees and plants create a serene atmosphere.
Guesthouse in Greenville
5 out of 5 average rating, 153 reviews

Sally's Cottage

Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

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