
Guesthouse vacation rentals in South Carolina
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Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals

Red Roof Loft @ FireFly Farm

Bungalow on a 3 acre mini farm

Private w/kitchen - quiet walkable neighborhood.

New Loft in Historic Summerville

Summerville’s Tiny Oak Hideaway

Home on the farm

Lizzi & Scott’sTiny Guest House secluded USC-Vista

Finished Room over Garage (FROG) on Reedy River
Guest house rentals with a patio

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse

Coastal Charm: Village Hideaway

Foothills Favorite

1 BR Cottage/ Pool / Golf Cart/Near Beach

Driftwood Cottage

My Happy Place

The Violet Villa w/no cleaning fee

Cozy Cottage! 5 mins from Kiawah!
Guest house rentals with a washer and dryer

Low-country Carriage House

Camden Coach House Long term stay southern balance

James Island "La Casita" Nestled btw Beach & City

Cozy Park Circle, Charleston Guest House

Spacious Daniel Island Apartment

Old Mt. Pleasant/Shem Creek close to Sullivans/DT

The Cottage @JustA'MereLodge

Detached Guest Suite
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