House vacation rentals in South Carolina

Find and book unique houses on Airbnb

Top-rated house rentals in South Carolina

Guests agree: these houses are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Home in Iva

4.98 out of 5 average rating, 346 reviews

Country Cottage ~ Farm Animals!

Step away from your hustle as you enjoy this cozy, quiet setting in the country. We offer a small kitchen, microwave, toaster, a Keurig, refrigerator, and two-burner stove. You will find a comfy dining/sitting room area. Meander around outside, relax on the porch, or visit our farm animal pets. 20 minutes from Historic Abbeville. Greenwood or Anderson in 30 min. Greenville approx 1 hr. 5 miles from Erskine College 15 min to the famous Diamond Hill Mine! Heyward Manor wedding venue: 18 miles

Sep 19 – 26

€ 90 per night

Guest favorite

Home in Myrtle Beach

4.96 out of 5 average rating, 164 reviews

Entire New Home! Vacation Villa/Beach/Golf/wi-Fi

Recently constructed & beautifully decorated, this house is located in the heart of Myrtle Beach on 48th Avenue N. Within walking distance of the rolling green hills of the Myrtlewood golf course, it is also a 1 minute drive from the famous Broadway at the Beach (shopping, fun for the kids, rides, & nightlife), & only 5 minutes from the beach! Due to COVID-19, this house now employs *extra* cleaning and sanitation services before each stay in order to ensure your trip is as clean as possible!

Feb 18 – 25

€ 135 per night

Guest favorite

Home in Rock Hill

4.93 out of 5 average rating, 191 reviews

1800s Cabin on Holland Acres - Getaway or gather

Step back in time in a 1800s roadside cabin on four acres. Grill on the back deck, relax in the hot tub, soak in the claw foot tub and simply enjoy the serenity. Cabin has a full kitchen, two baths, and main floor & loft sleeping areas. You'll be minutes from downtown Rock Hill and the Event Center, restaurants, parks, & Winthrop Univ. Rural setting makes a perfect families & pets getaway; unique features make it great for gathering! Come enjoy this quaint piece of history & prepare to unwind!

May 20 – 27

€ 157 per night

Guest favorite

Home in Westminster

4.94 out of 5 average rating, 255 reviews

Waterfall Views, Lake Hartwell, Highland Architect

Come and enjoy nature with 100+ acres to roam. Paths for long walks. Architect James Fox designed this cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

Jan 20 – 27

€ 497 per night

Guest favorite

Home in Newberry

4.97 out of 5 average rating, 154 reviews

Nice CLEAN close to I26 downtown Newberry quiet

NO CATS! We manage and clean our home personally. It is a newer , super clean home that sits on an acre and a half of land. Close to downtown newberry, 7 mile. And 30 mile from Columbia/Irmo. About 4 mile to get on I-26 . easy to get to, off 176 on a nicely paved dead end road ,right near Sumter National Forest. There are beautiful country roads to ride bikes!! We are not fancy but we are super clean, and super comfortable, with everything you need. NO CATS , ALL DOGS MUST BE APPROVED !!

Oct 22 – 29

€ 83 per night

Guest favorite

Home in Charleston

4.89 out of 5 average rating, 273 reviews

The Island Hideaway

This little gem is an edition we built as a duplex. The Hideaway is very basic, totally private, and super clean. It's perfect for a quick getaway and you can't beat the price and location! We're right in between historic downtown Charleston and the eclectic Folly Beach. We designed the Hideaway to be the a rustic little haven that anyone can call their own. The little Hideaway is not the Hilton, but we have all the basics to give you a safe, quiet and cozy resting place for your vacation.

Jan 23 – 30

€ 130 per night

Guest favorite

Home in Beaufort

4.99 out of 5 average rating, 118 reviews

Deepwater Peaceful Reflections

Hello to all! Welcome to this lovely completely open concept second floor 650 sq ft condo with a full unobstructed view of Deepwater Battery Creek. We have all the needed amenities for a quick getaway or long term stay. 10 minutes from downtown Beautiful Beaufort SC,shopping,dining,walking paths and tours.5 minutes to Paris Island Marine Base,within an hours drive to Hunting Island State Park,Ace Basin Tours,Hilton Head Island,Savannah and Charleston. Watch for the dolphins in Battery Creek!

Oct 6 – 13

€ 134 per night

Guest favorite

Home in Easley

4.9 out of 5 average rating, 276 reviews

“Lake House Paradise” Waterfront Oasis

“Lake Paradise” is exquisitely furnished with 2 bedrooms and 1 and a half baths. Your Master Suite has its own screened in porch with private lake access. Wake up from your master suite to views from your bed of the water. Your en suite Master Bathroom has a large luxury marble shower. You will spend many hours of relaxation and peace in the most desirable location in the southeast. Visit Greenville SC's downtown just 15 minutes away. Clemson football Stadium is 20 miles away.

Sep 27 – Oct 4

€ 169 per night

Guest favorite

Home in Greenville

4.99 out of 5 average rating, 128 reviews

Cozy Treehouse

Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.

Jan 4 – 11

€ 326 per night

Guest favorite

Home in Prosperity

4.99 out of 5 average rating, 135 reviews

Anchors Aweigh

You'll enjoy this small cabin located less than 2 miles from Dreher Island State Recreation Area. The views from the living area and kitchen are breath-taking. You can sit on the dock & watch the sun set or take your boat out just a few hundred yards to watch the sun rise. This location is great for swimming & a dock is available so you can bring your boat. There is also great fishing from the dock and on a boat. This will provide an unforgettable vacation!

Aug 4 – 11

€ 163 per night

Guest favorite

Home in Dalzell

4.92 out of 5 average rating, 145 reviews

Near SHAW, Pet Friendly, Big Fenced Yard, King Bed

This home is ideal for ALL short and long term tenants. It is conveniently located near SHAW AFB. It has a KING size bed in the master bedroom with a walk in closet. A LARGE fenced in back yard. A new 55'' inch flat screen TV with Disney+, Amazon Prime, HBO MAX and HULU. Wifi is available for all guests as well as a built-in desk/office space. Appliances include: Washer, Dryer, Refrigerator, Oven, Stove, Microwave, and Coffee Maker.

Jul 30 – Aug 6

€ 126 per night

Guest favorite

Home in Folly Beach

4.83 out of 5 average rating, 133 reviews

Luxury Beach Front Pet Friendly

Located minutes from the Morris Island Light House, indulge in the epitome of seaside luxury at our beachfront vacation home, where every detail has been thoughtfully curated to ensure a perfect retreat. Located directly on Folly Beach's pristine shores, this 2023 to the studs renovated cottage seamlessly blends opulence with comfort, offering a harmonious escape for you, your loved ones, and even your four-legged friends.

Oct 11 – 18

€ 942 per night