Vacation rentals with lake access in Seneca

A single-story home is showcased, featuring a smooth driveway that leads to a covered front porch. Brightly colored chairs are placed on the porch, surrounded by landscaped shrubs. Tall trees provide a lush backdrop, creating a serene and inviting setting.

4.96 out of 5 average rating, 167 reviews

Lake Hartwell house w/ dock 2 miles from Clemson.

This is a simple, comfortable, recently renovated (2019) home for Clemson fans and lake vacationers. Decor is vintage/antique. It is 3 1/2 miles to stadium entrance. We have a deep water cove with fire ring, decks, dock, and stairs to gangway, parking for 6 cars, woods and lake on 3 sides, a variety of restaurants nearby. Clemson Marina is 1 cove away. Clemson golf course is across the lake. We are PET FRIENDLY with a max of 2 dogs. There is a $75 pet fee. Read the house rules concerning pets.

Superhost

A serene view of the cove showcases calm blue waters bordered by lush greenery and trees. Several boats are docked at a wooden pier, with homes visible along the shoreline. Fluffy clouds drift in a clear blue sky above this tranquil scene.

4.86 out of 5 average rating, 90 reviews

Peaceful Lake Keowee Waterfront Home ~Near Clemson

Live out your lake dreams at this 3/3 conveniently located 5 minutes to downtown Seneca!! Swim in the beautiful Keowee water right off private dock with direct access from backyard. Bring your boat or explore Lake Keowee in 2 available kayaks. Enjoy outdoor dining on the deck overlooking the lake, cooking in the open kitchen, grilling out in the backyard, or enjoying the fire pit. Separate downstairs suite with private access. Only 7 miles from Clemson and down the street from the Keowee Marina

4.95 out of 5 average rating, 73 reviews

A sign reading 'South Cove Cottage' stands at the foreground, with a well-maintained grassy area surrounding it. In the background, the exterior of the cottage is visible, showcasing a brick facade and large windows framed by trees.

Cottage in Seneca

South Cove Cottage ~ Lake Keowee

Enjoy easy access to Lake Keowee from this fully renovated cottage. Located just under 1 mi. from South Cove County Park which offers boat ramps, fishing, swimming, and more on Lake Keowee! Play all day at the lake, then relax on the private back patio ~ surrounded by nature. • Guest Pass for FREE County Park entry! • Ample parking for vehicles & boats. • Close to shops, restaurants, & Clemson U. • Lots of options for hiking, biking, & exploring. • Wifi, Washer/Dryer, fully-stocked kitchen.

4.93 out of 5 average rating, 166 reviews

A landscaped outdoor area features a winding pathway surrounded by mulch and greenery. Comfortable seating is arranged under the shade of trees, providing views of the lake. The water is visible beyond the trees, with structures in the background suggesting recreational activities.

Home in West Union

Dujardins Keowee Waterfront Home

2 night min. Deep water lot on Lake Keowee with double dock, and tons of entertaining space. On the main level, the great room/dining room is open to the kitchen. 4 bedrooms total, 3 king bedrooms (2 on first floor), 1 king and a bunk room with 2 doubles and 2 singles. A canoe, 2 paddle boards and 2 double kayaks included. Shuffleboard, foosball, outdoor Ping-Pong, board games and two person pac-man game, with additional 60 games! towels and linens included! Pickleball/tennis 10 min away!

4.96 out of 5 average rating, 165 reviews

A cozy living area features a stone fireplace flanked by windows, allowing natural light to illuminate the space. A comfortable sofa is arranged around a small table, accompanied by a chair. A TV is mounted above the fireplace for entertainment.

Condo in Salem

Beautiful Lake Keowee Condo with great Amenities

"Boasting lake views, a fully equipped kitchen, and resort-style amenities, this 2-bedroom, 2-bath Salem vacation rental condo in Keowee Key will have you experiencing the true meaning of life on the lake. Cool off with a dip in the community's outdoor pool which sits right next to the marina where you can rent a boat for a day out on the water. Tee up a round of golf on the renovated 18-hole course, walk along the trails of Oconee State Park, or catch a football game at Clemson University!"

A comfortable living room is presented with two sofas, a wooden coffee table, and a rustic stone fireplace. A television rests on a wooden media console, while natural light enters through nearby windows. The flooring is finished in a warm tone, creating an inviting space.

4.95 out of 5 average rating, 208 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

4.84 out of 5 average rating, 283 reviews

Home in Six Mile

House on Lake Keowee swim beach in cove w/ Dock

This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.

5.0 out of 5 average rating, 18 reviews

Clemson Games + Lake Keowee

Come stay at this new construction home in a Lake Keowee neighborhood, only 8 miles from Clemson and to Death Valley. Whether you're seeking convenient access to Clemson for college activities, such as move-in move out for students, game weekends, or to enjoy Lake Keowee this house is the perfect fit! This house offers plenty of amenities during your stay such as blackout curtains in all the bedrooms, a privacy fence in the backyard for barbecuing, and a ping-pong table in the garage!

A spacious sunken living area features a large brick fireplace as a central focal point, flanked by two inviting seating arrangements. Natural wood beams extend across the ceiling, and light fills the space through multiple large windows, creating a warm and welcoming environment.

4.94 out of 5 average rating, 78 reviews

Lakefront Mid-Century Dream Home / 3 mi to Clemson

We excitedly invite you to come enjoy a one of a kind experience at our personal lakefront home. Originally designed and built in the 60s, this home now has all the modern necessities, yet still brims with endless midcentury charm. Located only 3 miles from Clemson, our large outdoor entertainment space and direct access to our private dock invite you to enjoy the many sights and sounds that the lake has to offer. Use our 2 kayaks and canoe, or use the dock to tie up your own boat!

4.97 out of 5 average rating, 153 reviews

The charming cabin exterior is surrounded by lush greenery and mature trees. A welcoming front porch adorned with decorative plants leads to the entrance. An American flag hangs gracefully by the front door, and a paved driveway extends towards the cabin.

Cabin in Seneca

Lake Keowee Cabin: Peaceful and Bright

Welcome to Lizard Lodge. Relax in this quaint lake cabin with a mountain home vibe nestled in Northern Seneca on Lake Keowee. Enjoy the serenity of a beautifully modern 3-bedroom, 2.5 bath vacation cabin in a quiet gated cul-de-sac with scenic surroundings. On early mornings you can spot wildlife including deer and wild turkeys. Excellent location on the lake a few hundred feet away from a boat ramp. Come to relax, have fun on the lake or even enjoy a romantic escape.

4.89 out of 5 average rating, 178 reviews

The bedroom features a spacious bed with plush pillows and a textured bedspread. A stylish chandelier illuminates the room, complemented by natural light from two large windows. Decorative wall accents and a soft area rug enhance the inviting atmosphere.

Cabin in Seneca

Clemson- 5 Min | Hot Tub | Game Room | 5 King Beds

5 minutes to Clemson University & Lake Keowee with a private saltwater hot tub, full arcade-style game room and stocked bar—perfect for families or game-day groups! 4 spacious bedrooms, 7 total beds High-speed Wi-Fi & smart TVs in every room Outdoor deck with grill, fire-pit & cornhole Fully equipped kitchen + coffee bar Rated 4.9★ by 171 guests and hosted by a local husband/wife team who lives nearby for quick help. Book your Clemson retreat today—dates fill fast!