Vacation rentals in Seneca

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Top-rated vacation rentals in Seneca

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Camper/RV in West Union
4.94 out of 5 average rating, 196 reviews

Hot Tub, Firepit, Projector, No Extra Fees/Chores

WARNING⚠️This place is dangerous! Guests have loved their stays so much that they have threatened to move in! Book a stay at this cozy, tiny, bear themed camper where the covered deck, hot tub, and outdoor projector steal the show, before they do! Your own hideaway sits on a wooded acre just minutes from lakes, waterfalls, and three nearby towns for food, shopping and exploring. End the night by the firepit roasting marshmallows and wondering why you didn't book a longer stay in the first place!

Top guest favorite
A charming cottage with a distinctive A-frame structure is set amidst lush greenery. The front yard features well-maintained flower beds, and two benches flank the entrance. An American flag is displayed beside the front door, which is framed by two inviting windows.
Cottage in Anderson
4.96 out of 5 average rating, 113 reviews

A-Frame Lake Hartwell Cottage w/ Hot Tub

No lake water till it substantially rains Lake Hartwell cottage w/ Hot Tub ! Clemson 9 mi. away! 2 bdrm, 2 full bath, hot-tub, canoe, 2kayaks, 🎣 poles, life-vests, dining & patio table, grill+charcoal, 3tv, Netflix/2DVDplayers/DVDs, kitchen, pots/pans, 2crockpot, microwave, dishwasher+pods, keurig+coffee, washer+detergent, dryer, spices, shampoo/cond, hair dryer, curler, straightener, linens, towels, 3bikes, helmet, Karaoke, firepit+wood, wall of fun! (Boat-landing 1 mi. away! Cateechee Shores

Top guest favorite
The cottage exterior displays warm wood siding with large windows allowing natural light. A welcoming front porch features two chairs and a small plant, while a grill stands nearby. Surrounding landscaping creates a serene atmosphere in a private setting.
Cottage in Central
4.99 out of 5 average rating, 195 reviews

The Wildflower

Enjoy a relaxing experience at this centrally-located spot, away from the hustle and bustle but only 6 min from Clemson (10 min from Clemson University), nestled in the country in a peaceful, safe neighborhood with lots of privacy surrounding. The cottage has a front porch with 2 chairs, a 2 person hammock, grill, and a fire pit (wood is provided) with three lawn chairs. There’s a queen bed and also a CordaRoy beanbag (*bed #2) that opens up to a soft bed that sleeps 1 adult or two children.

Guest favorite
A cozy bedroom is highlighted by a spacious bed with a patterned blanket. Two bedside lamps provide soft illumination on either side. A wooden dresser is positioned against the wall, and a window allows natural light to fill the space, complemented by cream-colored walls.
Apartment in Seneca
4.94 out of 5 average rating, 176 reviews

Clemson Mom Apartment

Roomy 1 bedroom, 1 bath apartment in Seneca, SC. Approximately 2.5 miles from Wal-Mart and 2 miles from Waffle House. 9 miles from Clemson football stadium. Excellent location with a short drive to restaurants, shopping, 3 24-hour gyms, and grocery stores. Located in a quiet subdivision with minimal traffic. This is the perfect spot, close to Seneca, but away from highly trafficked areas. Great for a working adult and quiet enough during the day for someone working third shift to sleep.

Top guest favorite
A charming cabin is nestled among tall trees, accessed by a stone path. Warm string lights adorn the porch area, creating a welcoming glow. Fallen leaves blanket the ground, complementing the natural surroundings and inviting a sense of tranquility.
Cabin in Pickens
4.98 out of 5 average rating, 236 reviews

The Romantic Greystone Cottage

Follow the enchanting stone path to a private getaway where romance and connection await. Enjoy the ambiance of the starlit sky while cuddled up on the hammock or around the fire. Cozy up on the king-size bed and relish every moment of your stay. Indulge in a bottle of wine and relax by soaking in the luxurious claw-foot tub. Wake up to the tranquil sounds of the forest, savoring the morning with coffee on the porch. Escape the everyday and embrace what matters most at The Greystone Cottage.

Guest favorite
The exterior of a modern camper is displayed, featuring a sleek white exterior with black accents. A set of steps leads to the entrance, and ample surrounding greenery provides a natural backdrop. The driveway is paved, offering easy access.
Camper/RV in Anderson
4.87 out of 5 average rating, 115 reviews

33 Ft Camper perfect for a layover/getaway

Close to Clemson, I- 85, Lake Hartwell, and Anderson. My 2023 Wildwood 28vbxl CAMPER sits in my driveway which is also home to Freedom Fences, a non profit animal rescue. This is a working farm so people are always milling around. Well behaved, housetrained animals allowed but must be crated if left alone. Great spot for Clemson football. 25 minutes to Greenville. 10 minutes from downtown Anderson. Less than 7 miles to Garrison arena. NO Smoking! If you are high maintenance, don't book!

Guest favorite
A serene view of the Chauga River at sunrise, where gentle fog hovers above the water. The sun casts a warm reflection on the surface, flanked by lush green trees on both banks. A private dock is visible in the distance, contributing to the tranquil scene.
Cabin in Westminster
4.92 out of 5 average rating, 233 reviews

Tranquil Chauga River Getaway

Tranquil Chauga River Getaway offers a clean, safe, quiet retreat on beautiful Chauga River. There is a private dock that offers fishing and access by boat to Lake Hartwell. Multiple private decks provide river views, as well as, wildlife like ducks, blue herring, birds, and the occasional beaver. Private, dead end road access means minimal traffic. Area provides activities like waterfalls, hiking, kayaking, cycling, mountain biking, fishing pier, rafting, sightseeing, etc.

Top guest favorite
A charming exterior view of the Tiny Treehouse features a bright red roof and wooden siding with a sunflower design. A picnic table sits on the lawn, surrounded by green grass and trees. A lounging area with rocking chairs is nearby, providing a welcoming outdoor space.
Tiny home in West Union
4.95 out of 5 average rating, 277 reviews

Holliday's Inn Tiny Tree-house

Tiny Treehouse is a ‘container’ house set in a private wooded locale at the foothills of the mountains. Find yourself hiking at Oconee State park or Caesar's Head mountain along with a multitude of waterfalls within our county. 5 minutes from downtown historic Walhalla, 10 minutes to city of Seneca, and 20 minutes from Clemson University where tailgaters unite before the big football game! Explore the artistic venues and cultural scenes of Greenville just an hour away!

Guest favorite
The open loft features a spacious bed and a striped couch adorned with decorative pillows. Natural light floods through large windows that frame views of the surrounding woods. Natural wood floors and a small side table complete the cozy atmosphere.
Guesthouse in Salem
4.88 out of 5 average rating, 322 reviews

Mountain Edge Loft

Private loft apartment on 25 wooded acres, sits separate from main farm house. Private deck overlooking the woods. Everything you need for a cozy stay. Located on the edge of the Blue Ridge Escarpment with lakes Jocassee and Keowee just a few miles away. Numerous state parks, hiking, biking , waterfalls and kayaking or just peace and quiet. We are a sustainable homestead with an organic garden, chickens ,quail, dogs and cats. Our water comes from a natural spring.

Top guest favorite
The exterior of a modern tiny house is depicted, featuring a dark blue façade and large windows allowing natural light to fill the interior. The covered porch is accessible from the gravel pathway, and greenery surrounds the property, enhancing the wooded setting.
Cottage in Westminster
4.97 out of 5 average rating, 610 reviews

Tiny house

BRAND NEW 490 sq ft tiny house/cottage nestled in the woods in a country setting. Complete with a queen bedroom, a twin/day bed and then a queen bed in loft ( comfortably sleeps 4 adults and one child). We are conveniently located 10 miles from I-85 exit 1 on S Hwy 11. 20 minutes from Clemson, 8 minutes from Seneca, and just a short drive to many hiking trails, lakes and parks in the beautiful foothills of the Blue Ridge mountains.

Guest favorite
The charming house, surrounded by lush greenery, features a screened-in front porch that invites relaxation. A flag gently flutters on the porch, while well-maintained landscaping frames the entrance. Large trees provide ample shade, enhancing the tranquil outdoor environment.
Home in Westminster
4.93 out of 5 average rating, 124 reviews

Shady Rest

As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.

Top guest favorite
A charming tiny house is set amidst wooded surroundings, featuring a welcoming entrance with a white door and a light-colored roof. Two white chairs and a small table are positioned on a wooden porch, complemented by a grill nearby. Lush greenery enhances the tranquil setting.
Tiny home in Seneca
4.96 out of 5 average rating, 239 reviews

Windmill Cottage

You’ll treasure your time at this cute little cottage. It is 295 sq feet and was built in 2023 at the edge of the woods on our property. It has a full kitchen, bedroom with a queen bed, bathroom and living room. It is perfect for one or two people, for either a quiet get-away in the country or for someone who is in town for work and is looking for a more extended stay. We offer discounts for weekly/monthly stays!

Popular amenities for Seneca vacation rentals

When is the best time to visit Seneca?

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Avg. price€ 121€ 116€ 121€ 131€ 170€ 141€ 158€ 199€ 191€ 191€ 212€ 127
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Frequently Asked Questions

  • Where should I stay in Seneca?

    Make yourself at home in Seneca by choosing from our most frequently booked neighborhoods. We have over 110 vacation rentals in Utica, and over 180 vacation rentals in Seneca.

  • Are there vacation rentals with a dedicated workspace in Seneca?

    Yes! Work meets play with ease at over 20 vacation rentals in Seneca featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Are there pet-friendly vacation rentals in Seneca?

    Four-legged friends are welcome in Seneca. Choose from more than 20 vacation rentals for guests traveling with pets.

  • How much does it cost to stay in house rentals in Seneca?

    Experience the best of Seneca with our house rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Do house rentals in Seneca have wifi?

    Absolutely! We offer over 40 house rentals with wifi in Seneca. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Seneca have air conditioning?

    Absolutely! We offer over 40 house rentals with air conditioning in Seneca. Enjoy a tailored experience with all the comforts you desire.

  • Are there family-friendly house rentals in Seneca?

    Seneca has more than 30 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.

  • What are the most popular amenities for House Rentals in Seneca?

    Enhance your stay in our House Rentals with the most popular amenities: over 40 homes with air conditioning, over 40 homes with wifi, and more. Indulge in the ultimate retreat, tailored to your preferences.

Quick stats about vacation rentals in Seneca

  • Total vacation rentals

    Explore 60 vacation rentals in Seneca

  • Nightly prices starting at

    Seneca vacation rentals start at € 34 per night before taxes and fees

  • Verified guest reviews

    Over 2,320 verified reviews to help you choose

  • Family-friendly vacation rentals

    50 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    60 of Seneca vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Gym, BBQ grill, and Laptop-friendly workspace across Seneca rentals

  • 4.9 Average rating

    Seneca stays are highly rated by guests—averaging 4.9 out of 5!

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  2. United States
  3. South Carolina
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