Vacation rentals in Seneca

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Top-rated vacation rentals in Seneca

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A serene lake view is captured at sunset, featuring a dock and pavilion extending into the water. Lush grasses and landscaped stones frame the scene, as warm sunlight bathes the area in golden tones, enhancing the tranquil atmosphere of the shoreline.
Cottage in Six Mile
4.99 out of 5 average rating, 203 reviews

Lake Keowee Waterfront Cottage - Private Retreat

Lake-front retreat w/ unbelievable sunsets, swimming & kayaking, tucked in between the Cliffs & the Reserve, 30 miles west of Greenville. Private park-like setting for a couples getaway. Updated one-bedroom small cottage w/ living room, kitchen, bath, laundry, AC/heat. The entire property is included w/ your cottage rental; 1.1 acres, 800 ft of lake shoreline, a dock, a pier, a sunset deck, a social pavilion, waterfront hot-tub. It is a private lake experience; nothing really compares - unique!

Guest favorite
A spacious living area features two sofas, one in a deep blue hue, and a black armchair, arranged around a light area rug. A television is mounted above a classic fireplace, and a dining table accommodates several chairs. Large windows provide natural light.
Home in Seneca
4.95 out of 5 average rating, 129 reviews

Hanover Haven 3 BR/2 Bath

Hanover Haven is located close to all you need! Clemson University is only 3 miles away. There are 3 full grocery stores within 5 minutes. Lake Keowee access and marina all within 5 miles. The Gathering space is such a great place to have family fun! There are card games and large TVs with multiple streaming platforms. We are also working on a great outdoor space that will include a grill and sail shade ready for the summer. There is also an RV on the property that is an AirBNB with privacy.

Top guest favorite
A spacious outdoor dining area is visible through a large hinge window. The wooden table is surrounded by four folding chairs, with a scenic view of the lake and trees in the background. Sunlight filters through, enhancing the seamless indoor-outdoor connection.
Cottage in Seneca
4.99 out of 5 average rating, 116 reviews

Destination Keowee

A rustic industrial style Lake Keowee lakefront escape that places you right on a panoramic point in a private cove. Welcome the outdoors in with the 6ft kitchen hinge bar window to the upper deck or enjoy the 6-seat hot tub on lower deck. Deep water dock tie off space is available. Guests enjoy the use of 2 standup paddle boards, and lakeside fire pit (guest provide firewood). Great cove sunsets! 15 minutes to Clemson and 1 min Lighthouse Restaurant. Please read all details prior to booking!

Top guest favorite
The cottage exterior displays warm wood siding with large windows allowing natural light. A welcoming front porch features two chairs and a small plant, while a grill stands nearby. Surrounding landscaping creates a serene atmosphere in a private setting.
Cottage in Central
5 out of 5 average rating, 206 reviews

The Wildflower

Enjoy a relaxing experience at this centrally-located spot, away from the hustle and bustle but only 6 min from Clemson (10 min from Clemson University), nestled in the country in a peaceful, safe neighborhood with lots of privacy surrounding. The cottage has a front porch with 2 chairs, a 2 person hammock, grill, and a fire pit (wood is provided) with three lawn chairs. There’s a queen bed and also a CordaRoy beanbag (*bed #2) that opens up to a soft bed that sleeps 1 adult or two children.

Top guest favorite
A treehouse surrounded by trees glows gently with warm lights in the evening. Two Adirondack chairs are positioned around a fire pit, with a small table nearby. The forest setting offers a calm and inviting atmosphere for outdoor relaxation.
Treehouse in Mountain Rest
5 out of 5 average rating, 461 reviews

THE BELLA LUNA Romantic Treehouse - Outdoor Shower

This is the perfect ROMANTIC ESCAPE! Located in the Sumter National Forest the Bella Luna is just 5 minutes from Stumphouse Tunnel, Issaqueena Falls, Yellow Branch Falls hiking trail, and Stumphouse Mountain Bike Park and within an hour of Clemson, Lake Jocassee and Clayton, GA. Our romantic retreat features carefully curated vintage furnishings, an outdoor shower, napping net, relaxing seating areas and an outdoor fire pit stocked with firewood and a S’mores kit! We can't wait to host you!

Top guest favorite
A cozy bedroom is highlighted by a spacious bed with a patterned blanket. Two bedside lamps provide soft illumination on either side. A wooden dresser is positioned against the wall, and a window allows natural light to fill the space, complemented by cream-colored walls.
Apartment in Seneca
4.94 out of 5 average rating, 178 reviews

Clemson Mom Apartment

Roomy 1 bedroom, 1 bath apartment in Seneca, SC. Approximately 2.5 miles from Wal-Mart and 2 miles from Waffle House. 9 miles from Clemson football stadium. Excellent location with a short drive to restaurants, shopping, 3 24-hour gyms, and grocery stores. Located in a quiet subdivision with minimal traffic. This is the perfect spot, close to Seneca, but away from highly trafficked areas. Great for a working adult and quiet enough during the day for someone working third shift to sleep.

Top guest favorite
A charming cabin is nestled among tall trees, accessed by a stone path. Warm string lights adorn the porch area, creating a welcoming glow. Fallen leaves blanket the ground, complementing the natural surroundings and inviting a sense of tranquility.
Cabin in Pickens
4.98 out of 5 average rating, 256 reviews

The Romantic Greystone Cottage

Follow the enchanting stone path to a private getaway where romance and connection await. Enjoy the ambiance of the starlit sky while cuddled up on the hammock or around the fire. Cozy up on the king-size bed and relish every moment of your stay. Indulge in a bottle of wine and relax by soaking in the luxurious claw-foot tub. Wake up to the tranquil sounds of the forest, savoring the morning with coffee on the porch. Escape the everyday and embrace what matters most at The Greystone Cottage.

Guest favorite
A wooden dock extends across the calm water, leading toward a lush green shoreline. The surface of the lake reflects the blue sky, while gentle ripples are visible. Surrounding trees contribute to a serene natural setting.
Home in Seneca
4.85 out of 5 average rating, 247 reviews

Cozy Lake House 5 miles from Clemson w Dock

Only 5 miles from Clemson's campus, this retreat is perfectly situated on almost a full acre. You’ll love the cozy feel, with lots of amenities, including a well stocked kitchen, three-season screened-in porch, & open floor plan. Though the house isn’t directly on the water, our private dock on Hartwell is only a 1-2 min walk away! Nestled between Greenville and the mountains, this home is great for Clemson trips, lake adventures, close night life, restaurants, family entertainment, & more!

Guest favorite
Home in Westminster
4.94 out of 5 average rating, 294 reviews

Waterfall Views, Lake Hartwell, Highland Architect

Come and enjoy nature with 100+ acres to roam. Architect James Fox designed this cantilevered cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

Top guest favorite
A charming home is presented in a serene neighborhood setting, featuring a well-maintained lawn and flowering shrubs. The exterior showcases a light-colored façade with a welcoming front porch and a spacious driveway leading to a two-car garage.
Home in Seneca
4.99 out of 5 average rating, 226 reviews

The Cozy Cottage

Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. The backyard overlooks a peaceful wooded area, providing a serene and private escape. Our home offers the perfect blend of tranquility and convenience. Perfect for getaways, football weekends, graduation, and other Clemson University events!

Guest favorite
A bright living room is featured, showcasing a gray sofa facing a light rug and a pair of armchairs. A side table rests next to one chair, and a floor lamp stands beside the sofa. Natural light enters through the windows, enhancing the welcoming ambiance.
Home in Seneca
4.98 out of 5 average rating, 100 reviews

Modern & Cozy Cottage-12 min. from Clemson Uni.

Experience South Carolina from this new cottage in Seneca. It's 5 minutes from the Historic Ram Cat Alley with Live Outdoor music every Thursday Night (Apr.-Oct.) Shopping, Boutiques, Restaurants, Breweries, and Coffee Shops. It's only 12 minutes from Clemson University, and a short drive to Lake Keowee, Lake Jocassee, and Lake Hartwell. This area is home to numerous Waterfalls, Hiking Trails, and southern barbecue. If you want a quiet southern getaway, it's the place for you!

Top guest favorite
A charming cottage is surrounded by lush greenery and tall trees, featuring a welcoming front porch with seating. The exterior is clad in grey siding and highlights stylish architectural design elements. A gravel driveway leads up to the house, emphasizing its peaceful and private setting.
Home in Seneca
5 out of 5 average rating, 116 reviews

The Cottage

Relax, recharge, and enjoy the quiet. Unwind on the front porch as the sun sets and nature comes alive with the peaceful sounds of evening. Spend time by the pond and cast a line for a simple, relaxing escape (fishing poles not provided). Private and serene, yet just 5 minutes to Walmart and Oconee Memorial Hospital—and only 13 miles to Clemson. The perfect blend of tranquility and convenience. Minimum age to book is 25 years of age.

Popular amenities for Seneca vacation rentals

When is the best time to visit Seneca?

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Avg. price€ 124€ 119€ 123€ 133€ 173€ 144€ 161€ 203€ 195€ 168€ 195€ 155
Avg. temp6°C8°C12°C16°C21°C25°C27°C26°C23°C17°C11°C7°C

Frequently Asked Questions

  • What are the best places to stay in Seneca?

    Travelers often stay near Lake Keowee for access to water activities, Historic Downtown for local shops and restaurants, or in the countryside for a quieter experience. Many homes and apartments in these areas welcome visitors looking for both relaxation and recreation.

  • What are the best things to do in Seneca with kids?

    Families can explore local parks, visit playgrounds, or enjoy time by Lake Keowee for swimming and picnics. Educational centers, walking trails, and family-friendly events around town are also frequently suggested.

  • What are some of the best things to do in Seneca?

    Explore Historic Downtown’s boutiques and cafes, relax at Lake Keowee, or visit nearby state parks for hiking and outdoor recreation. Community festivals and farmers markets also add a local touch throughout the year.

  • How is the weather in Seneca?

    Seneca has mild winters around 33–53°F (1–12°C) and warm, humid summers that reach 90°F (32°C). Rain is spread throughout the year, so it is helpful to bring layers and a rain jacket for outdoor plans.

  • When is the best time to visit Seneca?

    Late spring and early autumn are often recommended for comfortable temperatures and colorful scenery. Summer is popular for lake activities, while spring brings local events and blooming landscapes.

  • What are the best places to visit in Seneca?

    Explore Lake Keowee’s shores, browse Historic Downtown’s local shops, or head to South Cove County Park for picnic spots and waterfront access. Cultural centers and museums around town are also frequently suggested.

  • What are some hiking trails in Seneca?

    You will find walking and hiking paths in South Cove County Park and around Lake Keowee. For more variety, nearby state parks are known for scenic trails suitable for most experience levels.

  • What are some family activities we can do in Seneca?

    Families can picnic at local parks, swim or paddle on Lake Keowee, and explore interactive exhibits in community centers. Seasonal festivals and farmers markets often host games, music, and family-friendly vendors.

  • What are some of the best day trip ideas from Seneca?

    Visitors frequently explore nearby state parks for hiking and waterfalls, check out upstate art towns, or tour local vineyards and orchards. Lakes, historic sites, and mountain views are also within easy reach for a full day’s adventure.

  • Are there any pet friendly accommodations available in Seneca?

    Many places in and around Seneca welcome pets, especially those near Lake Keowee or set in rural surroundings. It is helpful to check individual listings for rules on pets and any special amenities, such as fenced yards or easy trail access.

  • What are some local tips for visiting Seneca?

    Try the weekly farmers market for local produce and crafts, and enjoy the lake early or late in the day for quieter moments. Locals appreciate layered clothing due to changing weather and recommend checking for community events during your stay.

  • What is Seneca known for?

    Seneca has a lively lakeside community centered around Lake Keowee, a revitalized Historic Downtown, and access to outdoor recreation in the foothills of the Blue Ridge Mountains. Community events and historic sites reflect the area’s local traditions.

  • What are the best hidden gems to explore in Seneca?

    Many visitors enjoy lesser-known parks, local art galleries, and specialty shops tucked away in Historic Downtown. Quiet coves along Lake Keowee and nearby heritage museums also draw those seeking unique local experiences.

  • What are the best foods to try in Seneca?

    Seneca has locally rooted Southern cuisine, with dishes like barbecue, fried catfish, and homemade pies often recommended. Seasonal farmers markets around the area feature regional produce and handmade treats during parts of the year.

  • What should I bring for a trip to Seneca?

    Pack layers for changing temperatures, a rain jacket for unexpected showers, and comfortable shoes for outdoor activities. A swimsuit, sun protection, and reusable water bottle are helpful for time by the lakeshore or on trails.

  • What is the nightlife in Seneca like?

    Seneca’s nightlife features casual bars, local pubs, and live music venues around Historic Downtown. Events and open-air concerts bring residents and visitors together during warmer months.

  • What are the most popular events or festivals in Seneca?

    Seneca hosts seasonal festivals, including downtown music events, local fairs, and outdoor concerts, especially in the warmer months. Community celebrations around Memorial Day and late spring are frequently highlighted by locals.

  • Are there family friendly vacation rentals in Seneca?

    Seneca has a range of family-friendly rentals, including lakefront homes and properties in quiet residential neighborhoods. Many include amenities such as full kitchens, multiple bedrooms, and outdoor spaces for children to play.

Quick stats about vacation rentals in Seneca

  • Total vacation rentals

    Explore 60 vacation rentals in Seneca

  • Nightly prices starting at

    Seneca vacation rentals start at € 43 per night before taxes and fees

  • Verified guest reviews

    Over 2,400 verified reviews to help you choose

  • Family-friendly vacation rentals

    50 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    60 of Seneca vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Gym, BBQ grill, and Laptop-friendly workspace across Seneca rentals

  • 4.9 Average rating

    Seneca stays are highly rated by guests—averaging 4.9 out of 5!

  1. Airbnb
  2. United States
  3. South Carolina
  4. Oconee County
  5. Seneca