Lake house vacation rentals in Santee

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Top-rated lake house rentals in Santee

Guests agree: these lake houses are highly rated for location, cleanliness, and more.

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Top guest favorite

An aerial view captures the lake house, surrounded by lush trees and situated on a point lot. The serene lake extends beyond the property, reflecting the clear sky. A spacious driveway leads to the house, emphasizing its inviting and open landscape.

Home in Chapin

5 out of 5 average rating, 17 reviews

Family Ties Lakeside Retreat

This luxurious lake house is a dream destination for large groups, comfortably sleeping up to 16 guests. Nestled on a point lot, this home offers breathtaking 180-degree views of the serene lake and its surrounding natural beauty.The interior of the lake house is both spacious and inviting, featuring five elegantly designed bedrooms. There's the large living room, open kitchen, huge patio, lakeside gazebo, private dock and more for your family to enjoy! Please no requests for Weddings or events

Guest favorite

An outdoor deck features several metal tables and chairs, providing ample seating for gatherings. Surrounding trees and a serene lake view create a natural backdrop, while string lights are hung overhead for an inviting ambiance. The private dock is visible in the distance.

Home in Ridgeway

4.95 out of 5 average rating, 38 reviews

Cove Cottage

Beautifully renovated 3 bedroom, 3 full bathroom lakefront home on Lake Wateree. Located near ski alley, this home offers upscale, modern finishes to guarantee your relaxing stay. The open concept floorplan is great for entertaining and high ceilings throughout the main living area and master bedroom offer an inviting space. Spa like master bathroom with soaking tub & separate shower. Indoor and outdoor dining spaces as well as outdoor fire pit and private dock. Fenced yard and dog friendly!

Top guest favorite

Home in Ridgeway

4.97 out of 5 average rating, 138 reviews

3000 sq ft lake house with views from every window

Lake Wateree 4 bedroom + bunk room with private dock and sleeps 12 comfortably. Our home has been completely renovated and is ready to enjoy! It is located in Ridgeway, SC and 20 minutes from Camden and Lugoff. Colonel Creek Landing is 4 miles away and the perfect location to launch your boat. You can dock your boat in 12 feet of water at our dock. Perfect location for fishing, kayaking and swimming. Two living spaces with smart tv's. Now you can enjoy the fire pit and outdoor shower.

Guest favorite

A light-filled living area showcases a large, circular wooden coffee table resting on a decorative area rug. A spacious sectional sofa is arranged nearby, complemented by various decorative pillows. Large windows invite natural light, and a TV is mounted on the wall opposite.

Home in Irmo

5 out of 5 average rating, 9 reviews

The Herons Nest

Escape to tranquility at our charming lakefront getaway, where breathtaking views and serene surroundings await you. This home offers a blend of comfort, style, and nature. Whether you're looking to unwind with a cup of coffee on the deck or enjoy water activities just steps away, our home has something for everyone. While you’ll feel worlds away in this serene retreat, you’re just a short drive from local shopping, dining, and entertainment options. Recently upgraded w/ Starlink Internet.

Top guest favorite

A spacious lakefront home is visible from the water, surrounded by lush green trees. The two-story structure features porches on each level. A sandy beach area and grassy yard lead up to the house, with white lounge chairs placed nearby, inviting relaxation by the water.

Home in Summerton

5 out of 5 average rating, 37 reviews

Large Lakefront Home w/360 view, beaches, & dock

This family-friendly spacious lakefront home with dock is located on a peninsula and boasts water access on three sides of the property. Park your boat at your own personal dock using the boat ramp located directly across from the property. This property has room for 13 people, but there is also access to an air mattress. Enjoy the 3 huge porches, fire pit, paddle boat, hammocks and swings, fishing, drop in your kayak or paddle board straight off the property and head out to Lake Marion.

Guest favorite

The image captures a beautiful lakefront view, showcasing the serene waters of Lake Murray surrounded by trees. A private dock extends into the water, complemented by additional docks along the shoreline. The residential area and distant landscape add to the tranquil atmosphere.

Home in Lexington

4.97 out of 5 average rating, 154 reviews

Lakefront home on Lake Murray with private dock

Lakefront home on Lake Murray in Lexington, SC on over 1/2 an acre, 166 feet of waterfront with deep water, private dock, and entertainment space- perfect for an unforgettable vacation or weekend. Entire home for rent-4BR, 3 Bath +2 half baths, 2 sofa sleepers, sleeps 12. Breathtaking kitchen & large living space, perfect for the entire family. 2 single person kayaks, outdoor grill, 65 inch and 55 inch TV, washer/dryer, and fast wifi. Master suite with a lavish bathroom and soaking tub.

Guest favorite

A fire pit surrounded by several dark chairs is set on a grassy area by the water's edge. The calm lake reflects the trees and distant docks, creating a serene lakeside environment. A few boats can be seen anchored along the shore.

Home in Ridgeway

4.97 out of 5 average rating, 107 reviews

Hillside Haven on Lake Wateree- Entire House

Lake Wateree rental with 3 bedrooms, 2 bathrooms that will comfortably sleep 10 guests. It is located in Ridgeway, SC and less than 5 minutes to Buck Hill Landing. Upstairs, you will find a fully stocked kitchen, living\dining room and master bedroom. Downstairs, there is a second living area with second kitchen, bathroom and 2 bedrooms. Home includes private deep water dock. Perfect location for swimming, kayaking and fishing. Fire pit is perfect for cool fall nights. Book it today!

Guest favorite

An aerial view reveals a serene point lot surrounded by water, with multiple docks extending into the lake. Lush greenery and trees frame the area, creating a tranquil atmosphere. Several nearby structures and boats are visible along the shoreline, enhancing the natural setting.

Home in Chapin

4.89 out of 5 average rating, 28 reviews

"Serenity Now"-Sunsets/ Beach/ Water On 3 Sides

"SERENITY NOW" -Sunset views / Point lot / Deep water / Mid-lake / Peaceful cove / Close to marinas & big water / Private beach / Private dock & boat ramp / Fire pit / Multi-generational & pet friendly / High speed internet / Spacious screen porch with TV & dining for 8 / Lots of parking / Loft / On site laundry / Great kids' bedroom / Indoor & outdoor games / fully remodeled with lake vibe. High end features like stone fireplace, bidet toilet seat, Bosch Dishwasher and Grohe faucets

Guest favorite

The spacious screened-in porch features comfortable seating, a circular table, and ceiling fans. Soft lighting enhances the area, with panoramic views of Lake Marion visible through large screens. Vibrant sunset colors are seen in the sky, reflecting off the water in the background.

Home in Summerton

4.97 out of 5 average rating, 149 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite

A spacious house is positioned near the edge of a calm lake. A wooden dock extends into the water, with a walking path leading to the home. The outdoor area features a deck with seating and landscaping including trees and shrubs.

Home in Irmo

4.87 out of 5 average rating, 107 reviews

Lakefront w pool, dock and pool table, sleeps12

Location, location, location! 10 minutes to Lexington, 15 minutes to Chapin, 15 minutes to downtown Columbia, 8 minutes to Harbison shopping. Boat parking at the dock. No need to pay high docking fees. Gorgeous sunsets, calm cove. Swim in the lake or relax by the pool. The massive deck is great for family fun or unforgettable events with your friends. Close to Liberty’s /Lake Murray marina on the lake, and Cat Fish Johnnys/rusty anchor marina. Not your typical Lake Murray Airbnb!

Top guest favorite

A private sandy beach area is highlighted, featuring a wooden dock with a blue umbrella providing shade. Two black chairs are positioned on the sand, overlooking a calm lake with clear blue waters and a bright sky.

Home in Summerton

5 out of 5 average rating, 17 reviews

Almost Heaven on Lake Marion, SC

Enjoy a serene getaway at our lake front spacious 3-bedroom, 2-bathroom lake house. Features include a king-size master bedroom with en-suite bathroom, queen and two full-size beds in other rooms, fully equipped kitchen, winter-only fireplace, screened porch with ample seating, smart TVs in all rooms, high-speed Wi-Fi, gas BBQ, private sandy beach, covered dock with power and seating, boat ramp, and ample parking. Dog-friendly (no cats). location provided after booking.

Guest favorite

A covered porch extends from the house, featuring a dining table surrounded by several chairs. Potted plants adorn the area, and a swing is positioned for relaxation. The spacious grassy yard is visible, providing ample space for outdoor activities.

Home in Bonneau

5 out of 5 average rating, 39 reviews

Lake Moultrie retreat

Relax with the whole family at this peaceful oasis on the water. This home offers a private boat ramp, with 40' dock to tie off multiple boats, kayaks,canoe, paddle board, log & gas fire pits, corn hole boards, hot tub, beautiful 12x28 covered porch to enjoy the water and listen to the birds, swimming for the kiddoes, and plenty of yard space for entertainment and barbecue's for the entire family and friends to enjoy. Inside is beautiful & very accommodating.