Lake house vacation rentals in Santee

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Top-rated lake house rentals in Santee

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Guest favorite

Aerial view of a lakefront property situated on a point, surrounded by water and greenery. The cottage features a deck, outdoor space, and a private dock, with trees lining the shore providing natural shade.

Home in Chapin

4.95 out of 5 average rating, 100 reviews

Lake Murray: Panoramic Views, Kayaks & Hot Tub

Welcome to 'Sunshine and Naptime' - This newly renovated home is located on the Chapin side of Lake Murray. The entire house is newly furnished and full of amenities. This 3 bedroom lakefront cottage sits on a point with 180 degree panoramic views. Vaulted rustic pine ceilings showcase the wall to wall windows for a view that will take your breath away. You can watch the sunrise AND sunset from the living room or 600 sq ft deck. There is a hot tub, 2 kayaks, shuffle board & private dock.

Guest favorite

A charming waterfront home is surrounded by trees, featuring a screened porch that provides a view of the yard. Green grass on a gentle slope leads up to the house, with bushes adding a touch of greenery. A dog stands near the porch, complementing the serene setting.

Home in Cameron

4.9 out of 5 average rating, 10 reviews

Fisherman's Dream at Low Falls Landing-Lake Marion

Don't Overlook this Waterfront Property! Fisherman's Dream on Lake Marion and Duck Hunter's Delight! Throw back from the 70's! Put in at Low Falls Landing & then tie on to the property's private dock. This is a 2 bdrm, 2 bth home. Screened porch w/swing & rocking chairs over looks waterfront. Open family rm & kitch. Gather w/friends & family. Large private dock w/ seating and rod holders. Lake Marion, largest lake in SC, catfish, crappy and brim fishing. Dogs welcome, No cats please.

Superhost

Home in Lexington

4.87 out of 5 average rating, 170 reviews

Lake Murray Paradise~2 BR, 1 Bth, Kit/Living area.

Enjoy the full lake adventure with 4 kayaks included. Our property is a lake front paradise w/ about 1 acre on Lake Murray near the dam on the Lexington side of the lake. Close to Columbia, USC and Ft. Jackson. 3 Decks, 1 dock, hot tub & fire pit w/ wood. Private upper deck to the 2 Bedroom, 1 Bath suite with Open Kitchen, Living & Game Area w/ large flat screen TVs, Pool, Ping Pong & Foosball table. The entire upstairs is your private area w/ views of the lake. We offer boat tours. Fees apply.

Top guest favorite

A wooden dock extends into calm waters, reflecting the vibrant colors of the sunset. Silhouetted trees frame the scene, which features a serene lake bordered by grassy areas, creating a tranquil lakeside atmosphere.

Home in Cross

5 out of 5 average rating, 14 reviews

Lakefront Fishing + Grilling | Home Sweet Home!

Escape to our serene Lakehouse Hideaway on Lake Moultrie, the perfect retreat for family vacations, fishing trips, or peaceful getaways. This charming 3-bedroom, 2-bath home features a spacious family room, fully equipped kitchen, kids’ room, queen bedrooms, and a lakefront porch on nearly an acre of private property. Enjoy fishing, relaxing, and exploring Lowcountry dining nearby. Just over an hour from Charleston, this tranquil oasis offers the ideal blend of relaxation and adventure.

Guest favorite

A spacious backyard features a well-maintained lawn bordered by trees, providing a sense of privacy. A wooden deck is accompanied by a gazebo, creating a relaxing outdoor space. The brick house showcases large windows that invite natural light into the living areas.

Home in Columbia

4.95 out of 5 average rating, 178 reviews

Downtown Columbia 3/2 - Entire House

* Entire House on a large lot with no neighbors behind for added privacy * 3 Bedrooms 2 Full Baths * 1.4 miles from PRISMA Hospital (4-minute drive) * NEWLY RENOVATED * BLACKOUT CURTAINS in all the bedrooms * 15 minutes to Fort Jackson * 7 minutes to Riverbanks Zoo * 5 minutes to the Columbia Museum of Art and Soda City Market * Split floor plan with the main bedroom on the right side of the home with on-suite * Open kitchen adjacent to the dining room overlooking the living and sunroom

Guest favorite

The exterior of a modern log home is visible by the water, surrounded by tall trees. A wooden fishing pier extends toward the water, leading to a sandy area with seating. The sky exhibits shades of purple and pink during sunset, creating a serene atmosphere.

Home in Summerton

4.97 out of 5 average rating, 157 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite

A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.

Home in Santee

4.97 out of 5 average rating, 157 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Guest favorite

A spacious kitchen area features a dark countertop and a large sink, overlooking expansive lake views through large windows. Seating for four is provided at a nearby high-top table, while additional seating is arranged at the kitchen island. Natural light floods the room, enhancing the welcoming environment.

Home in Gilbert

4.95 out of 5 average rating, 179 reviews

10 Mile View on Lake Murray w/ Dock and Ramp

Enjoy our Waterfront getaway on Lake Murray. It includes a private boat ramp, private dock, and over 600 sq ft deck across the entire lake front of the home. The front yard is large and perfect for cornhole, frisbee, and other activities. This cove is known for excellent kayaking, fishing, boating, and watersports. We have included 2 Kayaks and we work directly with a pontoon rental company if you would like a boat delivered. The .4 acre lot has plenty of parking for all guests.

Top guest favorite

An aerial view captures the lakeside property surrounded by lush greenery and mature trees. The mobile home sits adjacent to the water, featuring a landscaped yard and access to a private boat launch. Nearby structures and pathways are also visible.

Home in Cross

5 out of 5 average rating, 14 reviews

Fish Haven

Looking for a quiet, yet charming lakeside property? Look no further! Come enjoy this three-bedroom home with direct access to the diversion canal and a private boat launch. Great space for fisherman, families or couples. Ample space for your boat and hitch. Enjoy your days fishing, savor your afternoon by having a beverage and grilling out on the back patio. Spend the evenings playing cornhole and relaxing by the fire pit. It is the perfect setting to create wonderful memories!

Guest favorite

The exterior of the home is showcased, highlighting a charming façade with a mix of brick and siding. Large windows reflect natural light, and the welcoming porch features seating. A landscaped yard and tall trees provide a serene backdrop, complementing the overall inviting atmosphere.

Home in Summerton

4.83 out of 5 average rating, 110 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Top guest favorite

A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.

Home in Summerton

4.99 out of 5 average rating, 112 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Superhost

The backyard features a fenced area with a heated saltwater pool surrounded by loungers and shaded seating. A large deck with patio furniture is visible, alongside lush greenery and trees that offer a peaceful, natural setting. The sky displays soft sunset hues.

Home in Summerton

5 out of 5 average rating, 4 reviews

Lakefront Farmhouse Retreat+Pool

Welcome to your serene lakefront getaway in Summerton, SC—where farmhouse charm meets upscale coastal living! Nestled on a double lot with panoramic views of the scenic Fish Hatchery and just minutes from Taw Caw Park, this one-of-a-kind retreat is packed with everything you need for a luxurious, laid-back stay. Enjoy a private heated saltwater pool, putting green, spacious interior with 5 large bedrooms which can comfortably accommodate 14 guests.