Santee vacation rentals

Apartment in Downtown Columbia

A modern studio apartment showcases an open layout with a fully equipped kitchen featuring stainless steel appliances. A small dining area is positioned beside a cozy workspace. Natural light filters through large windows, illuminating a comfortable sleeping area adorned with soft bedding.

4.89 out of 5 average rating, 113 reviews

*Tuscan Sun KING suite downtown FREE parking*

Perfectly situated in the heart of downtown! This studio is within walking distance of Main Street, The State House, USC campus and just a short drive to Williams Brice Stadium, Colonial Life Arena, medical facilities and so much more. The perfect stay for both long and short term guests. Wake up from a great night's sleep in our comfy KING bed to explore downtown, head out to see the Gamecocks play, or just sleep in! You’ll love staying at this stylish apartment! Permit No. STRN-004218-10-2023

4.93 out of 5 average rating, 15 reviews

A compact bathroom features a sleek toilet and a modern sink with a stylish black faucet. The walls are adorned with decorative tiles and framed wall art. A plush bathroom rug with a playful message is positioned in front of the toilet, enhancing the space's character.

Apartment in Florence

“Cozy Escape | Relax & Recharge”

Discover your perfect getaway in this beautifully furnished 2-bedroom, 1.5-bathroom retreat. Featuring sleek, updated appliances and the convenience of an in-unit washer and dryer, this space blends style and comfort effortlessly. Nestled in a prime, sought-after neighborhood, you’ll enjoy both tranquility and easy access to local hotspots. Conveniently located near Magnolia Mall. A perfect blend of shopping, dining. Book your stay and experience the best of home living with a touch of luxury!

4.85 out of 5 average rating, 155 reviews

A charming log cabin is nestled among trees, featuring a wraparound porch and large windows. A pathway leads through the fallen leaves, connecting the cabin to the outdoor space, where two wooden chairs are positioned around a fire pit.

Cabin in Chapin

Lakefront Cabin with Scenic Views

A quiet 1500 ft2 log cabin on a small cove of Lake Murray with beautiful views and room for the whole family. The back porch has an attached gazebo, another gazebo is at lakefront. The interior is wide open with magnificent cathedral ceilings, fireplace in the family room and master bedroom. Spiral staircase up to the loft with a study/extra sleeping. Public boat ramp & dock is approximately 3 miles away, making a short boat ride to be able to beach your boat at the cove. No pets or smoking.

4.78 out of 5 average rating, 104 reviews

A laundry area features a chrome rack displaying neatly rolled towels on a rustic wooden wall. A laundry basket stands beside the rack, providing additional storage. The warm tones of the wood enhance the cozy ambiance of the space.

Bungalow in Summerton

The Turtle's Nest

Locally known as the "Turtle's Nest", this getaway will let you be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Boatslip & ramp included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.

4.91 out of 5 average rating, 147 reviews

A spacious living area features a comfortable seating arrangement with soft furnishings, a wooden coffee table, and a cozy fireplace surrounded by brick. Large glass doors lead to the fenced backyard, allowing ample natural light to brighten the room.

Home in Cayce

Columbia’s Best Airbnb

Take it easy at this unique and tranquil getaway. Our Airbnbs are the nicest in each town. From our known luxurious mattresses to the best kept secret… 3D luxury digital Massage chairs relax you from any stressful situation. See why we are ambassador Airbnb host. Stay at this location and you are 5 to 10 minutes to the USC baseball, basketball and Football. Campus is same. Airport is 4 miles. Great kid activity at EdAdventure kid museum. I 26, I-77 and downtown Columbia are minutes away. G

A charming blue house showcases a welcoming front porch with white railings. Lush greenery surrounds the home, enhancing its inviting facade. The yellow door adds a pop of color, while well-maintained landscaping provides a pleasant entrance.

4.97 out of 5 average rating, 118 reviews

The Parkside Retreat

Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

4.93 out of 5 average rating, 44 reviews

A modern kitchen features white cabinetry and stainless steel appliances. A large window with multiple panes allows natural light to illuminate the space, highlighting the sleek countertops. Two black stools are positioned at a small breakfast bar, creating a cozy dining area.

Home in Charleston

Newly Renovated Charleston Colonial Sleeps 10

Our spacious 4 bedroom 2.5 bath getaway is your home away from home. Located in a quiet community but close to everything. Short drive from the airport, restaurants & shops w/ lots of entertainment nearby. Amenities include: ✔ Quiet Neighborhood ✔ 4 Comfortable Bedrooms with memory foam mattresses ✔ Fully stocked kitchen ✔ Patio with lots of seating and a fenced in yard for safety ✔ High-Speed Internet ✔ Completely renovated throughout! ✔ Sleeps up to 10 people ✔ Pack & play available

The exterior of a modern log home is visible by the water, surrounded by tall trees. A wooden fishing pier extends toward the water, leading to a sandy area with seating. The sky exhibits shades of purple and pink during sunset, creating a serene atmosphere.

4.97 out of 5 average rating, 148 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

4.9 out of 5 average rating, 29 reviews

Home in Ladson

Charleston King Suite Hot Tub Fire Place Patio 1

👍PRIME CENTRALIZED LOCATION to explore all Charleston has to Offer! ✅ NO Cleaning Fees! ✅ 2 mins to Summerville Medical Center ✅ 9 mins from I26 ✅ 35 mins from downtown Charleston and beaches🏖 ✅ 10 mins to Airport/Convention Center/Performing Arts ✅ 3 mins from Publix Grocery and many restaurants ✅ Hot Tub 💦 ✅ King Suite ✅ Covered Picnic Table ✅ Weber gas 🍔 Grill ✅ Fire🔥Place ✅ Fire Pit ✅ High Chair & Pack n Play 🍼 ✅ Foosball Table ✅ 3 Smart TVs 📺 ✅ K cup/Coffee PotTea ☕️

4.9 out of 5 average rating, 166 reviews

Two individuals relax in a hot tub, surrounded by lush greenery. The hot tub water glistens under natural light, enhancing the tranquil environment. The setting invites relaxation and social interaction, perfect for unwinding after a day of exploring.

Home in Ladson

Charleston HotTub FirePit FirePlace Patio Hammock

👍PRIME CENTRALIZED LOCATION to explore all Charleston has to Offer! ✅ NO Cleaning Fees! ✅ 2 mins to Summerville Medical Center ✅ Featured in Relative Race Reality TV show! ✅ 10 mins from I26 ✅ 35 mins from downtown Charleston and beaches🏖 ✅ 18 mins to Airport/Convention Center/Performing Arts ✅ 3 mins to Publix Grocery/restaurants ✅ Hot Tub 💦 ✅ Fire🔥Pit ✅ BBQ 🍔 Grill ✅ Fire🔥Place ✅ Hammock 🌴 ✅ High Chair & Pack n Play 🍼 ✅ Air Hockey Table 🏒 ✅ K Cup/Coffee Pot ✅ EV plug

A wooden dock extending over calm water invites outdoor activities. The pathway leading to the dock is flanked by lush green grass, with soft shadows cast by nearby trees. Gentle waves reflect the clear sky, creating a serene lakeside environment.

4.83 out of 5 average rating, 109 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

4.98 out of 5 average rating, 124 reviews

A wooden rocking chair is positioned on a spacious porch overlooking a lush, wooded area. A peaceful yard is visible with trees surrounding the space, complementing the tranquil outdoor setting. Natural light gently illuminates the wooden flooring.

Cottage in Hopkins

Charming Country Cottage Nestled in the Woods

Cedar Creek Cottage is conveniently located to everything Columbia & Sumter, SC has to offer, while nestled in a wooded setting for a peaceful stay. Newly renovated with lots to offer: comfy beds & linens, fully stocked kitchen, Wi-Fi, keyless entry, fire pit, back-up generator & 2 large porches. Master bedroom has a queen bed and private full-bath. Two additional bedrooms (1 queen, 1 full) with shared full-bath. Washer, dryer, iron, ironing board and steamer are available.

Vacation rentals for every style

Get the amount of space that is right for you

Houses

A space thats all yours, with room for everyone

Apartments

Convenient locations with everyday essentials

Hotels

Stylish accommodations and amenities

Popular amenities for Santee vacation rentals

Self check-in

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Stay near Santee's top sights

Clark's Restaurant5 locals recommend

Captains Quarters Seafood and Steak5 locals recommend

Armando’s Mexican Restaurant7 locals recommend

Lake Marion Golf Course10 locals recommend

Golf Santee10 locals recommend

Craig's Place Cafe & Deli5 locals recommend

Santee house rentals

4.68 out of 5 average rating, 22 reviews

The exterior of the home is viewed from the front, featuring a stone facade and a brick accent. A concrete porch area is visible, bordered by landscaping with mulch and shrubs. Modern fixtures provide subtle lighting along the pathway, welcoming guests to the entrance.

Home in Columbia

Cozy Col - home near downtown/ Fort Jackson/

A cozy living area features a light-colored sectional sofa adorned with colorful throw pillows, accompanied by two wooden chairs. A vibrant red patterned rug covers the floor, while a wooden sideboard and a large flat-screen TV are positioned along the wall.

5 out of 5 average rating, 69 reviews

The Oasis

4.98 out of 5 average rating, 100 reviews

A spacious patio area features a round dining table surrounded by metal chairs. Nearby, a swing chair and a lawn are visible, framed by trees with hanging Spanish moss. A shed is situated in the background, complementing the tranquil outdoor setting.

Home in Goose Creek

Charming Ranch House

4.77 out of 5 average rating, 151 reviews

A cozy living room is presented with red walls and hardwood flooring. Two comfortable sofas and a coffee table with a decorative surface are arranged, complemented by a floor lamp and an entertainment center. Natural light flows through multiple windows, enhancing the welcoming ambiance.

Home in Cayce

3/1.5 house in Cayce Close to USC, Ft Jackson, CAE

A spacious living area features a high ceiling, two lamps providing warm lighting, and a comfortable seating arrangement that includes a large sofa and armchairs. A coffee table occupies the center, adorned with decorative items. Natural light enters through a nearby window.

4.95 out of 5 average rating, 43 reviews

LODGING @ OLD TOWNE LANDING SUITE A

4.86 out of 5 average rating, 21 reviews

A single-story brick home is featured, showcasing large blue shutters on the front windows. A green lawn leads to a covered porch with steps. An attached garage is visible on the right, with vehicles parked inside.

Home in Dalzell

Beautiful Home Away from Home Near Shaw AFB

4.83 out of 5 average rating, 23 reviews

A stylish living area features a tan leather sofa adorned with decorative pillows, set against a lush green patterned wallpaper. A wooden coffee table sits atop an intricate area rug, complemented by a sleek side table and indoor plants adding a touch of nature.

Home in West Columbia

Unit B: Whimsical 2-bedroom Home w/ Fast WiFi

4.91 out of 5 average rating, 354 reviews

The exterior of the home is illuminated with vibrant red and pink lights, creating an inviting atmosphere at night. The house features a traditional design with large windows and a pathway leading to the front door, surrounded by a peaceful outdoor setting.

Home in Irmo

Enchanting 3-Bedroom home with nightly light shows

Show all

Other great vacation rentals in Santee

The kitchen features gray cabinetry complemented by light-colored countertops. A sink is positioned between the countertop and a white oven. A refrigerator and a microwave are also visible. The floor is laid with tiled patterns, and a small mat is placed in front of the sink.

4.93 out of 5 average rating, 102 reviews

Welcome! a relaxing retreat...home away from home

4.96 out of 5 average rating, 145 reviews

A covered balcony features a table and four chairs, looking out over the lake and a swimming pool below. The view reveals a clear sky and lush greenery lining the shore, creating a serene outdoor space for relaxation.

Condo in Santee

Beautiful lakefront condo overlooking Lake Marion.

The image showcases a scenic view of a calm lake from a deck area. Several outdoor chairs are positioned along a railing, with lush green grass and trees framing the water. A private dock is visible, extending into the lake.

4.99 out of 5 average rating, 106 reviews

Cheerful 3 bedroom home on the lake

Condo in North Charleston

An electric fireplace is framed by a black surround, featuring glowing blue and orange flames. A decorative log piece lies within the firebox, and a sign reading 'HOME SWEET HOME' rests below, adding a touch of warmth to the living area.

4.96 out of 5 average rating, 51 reviews

2 Beautiful Master Suites

A spacious deck is highlighted by lounging chairs and a large dining table, offering views of the serene lake waters. Two trees frame the area, complementing the outdoor relaxation space. A dock is visible in the distance, contributing to the tranquil waterfront setting.

5 out of 5 average rating, 22 reviews

The Heron Lake House

4.88 out of 5 average rating, 34 reviews

A view of several homes along the shoreline, surrounded by trees, is captured from the water. The calm surface of the lake reflects the clear blue sky and lush greenery. Various docks and boats are visible near the water's edge.

Home in Chapin

Summerset The Heart of Lake Murray

4.8 out of 5 average rating, 41 reviews

A sandy beach area is bordered by tall trees, illuminated by string lights. A tranquil lake is visible in the background, complementing a dock with a seating area. A shaded red umbrella rests over a seating area, enhancing the outdoor space's inviting feel.

Place to stay in Chapin

Revival Beach Micro-Resort & Jet Ski rental