
Vacation rentals with lake access in Santee
Find and book unique lake access rentals on Airbnb
Top-rated lake access rentals in Santee
Guests agree: these lake access rentals are highly rated for location, cleanliness, and more.

Amazing Studio Guesthouse in COLA suburb.
Just 10 mins off of route 77, Fort Jackson & Downtown COLA only 20-30 min drive. Studio’s located in a beautiful family-friendly, suburban Lake community in Columbia SC with grocery stores & gas stations within minutes. Enjoy a night in equipped with movie screen & projector, then finish the night by melting your worries away into an incredibly soothing king size memory foam bed. Let our all-in-one washer/dryer do the work for you and wake up to a finished cycle and sounds of SC’s native birds.

The Historic Selwood Cottage @theselwoodcottage
Private, historic cottage with screened in porch. Sleeps 5 in 2 bedrooms with full, furnished kitchen. PET FRIENDLY. Property owners on shared property available to help with any needs. Enjoy over an acre of private land in the heart of the city. Lake Murray within walking distance as well as Harbison shopping area 5 miles away and downtown Columbia 15 miles away. *NO PARTIES TOLERATED NO SMOKING INSIDE OR OUTSIDE* If your dates are unavailable ask about our other Airbnb “Otto the Airstream.”

Archie's Lake Daze Cottage No pets
Soak up the beautiful lake views from a rocker on the porch or the 2-person hammock between the pine trees. This cozy cottage has 3 BR and 2 Baths and a stocked kitchen to make you feel right at home. Enjoy fishing from your private dock or take a spin in the paddle boat or kayaks provided. After a long day on the lake, you can enjoy a game of pool, classic arcade games, darts, or board games. WiFi is provided as well as 3 smart TVs. There is plenty of parking for your vehicles and water toys.

Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

The Turtle's Nest
Locally known as the "Turtle's Nest", this getaway will let you be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Boatslip & ramp included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.

The Farmhouse @ Goat Daddy's
Nestled on 66 acres with a gorgeous pond/farm view, you will find Goat Daddy's Farm and Animal Sanctuary. Our luxurious tiny house has everything you need to make your farm stay comfortable and relaxing. Guests will have access to the farm during specific hours, as well as over 2.5 miles of paths and two ponds to explore. With your feet in the sand, by a fire, in the hot tub, on the trails, or getting some goat/animal therapy, The Farmhouse and Sanctuary has something to offer for all.

Santee lakefront home, big water right off I-95
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Lakefront Paradise W/Pool/hot tub/outdoor kitchen
Brand new heated saltwater pool, hot tub and outdoor kitchen area. This upgraded home is ready to host your family or large group! Enjoy breathtaking sunsets year round from your private beach directly on the big waters of Lake Marion. Spends evenings out on the dock fishing or pull your boat right up to the beach. Ping pong and bumper pool tables, fast wifi and big screen tv's make for the perfect entertaining space for large groups.

Pool House on a tidal creek
Relax with the whole family at this peaceful place to stay on a tidal creek in Hanahan. 15 minutes from anywhere you want to go. One queen bed, micro kitchen with microwave and mini fridge, and a micro loft great for the kids. There is also a bean bag that unfolds into a fluffy queen size mattress. Relax watching the water and wildlife from the deck.

Beautiful Lake Marion Townhome
Forget your worries in this spacious and serene space. Enjoy the beautiful lake view from our patio. 3 large bedrooms and 3 spacious bathrooms, along with a fully equipped kitchen and comfortable family room make this townhome an outstanding family retreat. 3 golf courses and beautiful Lake Marion make this a fine place to visit on a yearly basis.

Lured Away to our lakefront home
Enjoy some peace and forget your worries at our beautiful home on Lake Marion. Whether your pastime is golfing, fishing or boating this lake front home is the place. Private boat dock, plenty of boat parking and public boat landing within walking distance. Perfect for day trips to Columbia or Charleston.
Popular amenities for Santee lake access rentals
Lake access house rentals

Lakefront home on Lake Murray with private dock

Tie One On! at 4 Bdr Waterfront Lake Marion

Lakefront home with boat ramp and game room

Perfect Family OFF THE GRID retreat at Lake Marion

Lake Murray Family Retreat | BIG Water View Chapin

Lakefront w/ dock at Mill Creek

Eagle Point Retreat W/Pool

Lake House Getaway
Lake access apartment rentals

Lakeside Bliss 2BR/2BA Suite Wyndham Lake Marion

Efficiency on the Lake!

Lake and pool side vacationing

Home away from Home

Relaxation is the plan

Come on Down to Goat Island!

Our Place at the Lake.

3-Bedroom Dlx @ Lake Marion Resort
Lake access cottage rentals

Three Little Birds Canal Cottage

Relaxing 2-bedroom cottage, Dorchester, S.C.

Quiet Waterfront 3 Bedroom on the Lake

Big Mama's Lakeside Cottage Lake Marion

A Great Lake house. Near Manning, SC and I-95.

Windsor Pond Cottage
Quick stats about vacation rentals with lake access in Santee

Total vacation rentals
Explore 20 vacation rentals in Santee

Nightly prices starting at
Santee vacation rentals start at € 84 per night before taxes and fees

Verified guest reviews
Over 50 verified reviews to help you choose

Family-friendly vacation rentals
20 properties offer extra space & kid-friendly amenities

Vacation rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wi-Fi availability
20 of Santee vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Santee rentals

4.9 Average rating
Santee stays are highly rated by guests—averaging 4.9 out of 5!
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- Rentals with lake access Orangeburg County
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- Riverbanks Zoo and Garden
- Middleton Place
- South Carolina State House
- Congaree National Park
- Columbia Museum of Art
- South Carolina State Museum
- University of South Carolina
- Magnolia Plantation & Gardens
- Colonial Life Arena
- Columbia Metropolitan Convention Center
- Edventure
- North Charleston Coliseum & Performing Arts Center
- Williams Brice Stadium
- West Columbia Riverwalk Park and Amphitheater
- Soda City Market
- Charleston Southern University
- Cypress Gardens
- Riverfront Park
- Wannamaker County Park
- Sesquicentennial State Park




