
Vacation rentals with lake access in Santee
Find and book unique lake access rentals on Airbnb
Quick stats about vacation rentals with lake access in Santee

Total vacation rentals
Explore 20 vacation rentals in Santee

Nightly prices starting at
Santee vacation rentals start at €86 per night before taxes and fees

Verified guest reviews
Over 60 verified reviews to help you choose

Family-friendly vacation rentals
20 properties offer extra space & kid-friendly amenities

Vacation rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
20 properties have a dedicated workspace

Wi-Fi availability
20 of Santee vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Santee rentals

4.8 Average rating
Santee stays are highly rated by guests—averaging 4.8 out of 5!
Top-rated lake access rentals in Santee
Guests agree: these lake access rentals are highly rated for location, cleanliness, and more.

Archie's Lake Daze Cottage No pets
Soak up the beautiful lake views from a rocker on the porch or the 2-person hammock between the pine trees. This cozy cottage has 3 BR and 2 Baths and a stocked kitchen to make you feel right at home. Enjoy fishing from your private dock or take a spin in the paddle boat or kayaks provided. After a long day on the lake, you can enjoy a game of pool, classic arcade games, darts, or board games. WiFi is provided as well as 3 smart TVs. There is plenty of parking for your vehicles and water toys.

Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

Lake Life Living-W/Boat waterfront condo
Nestled in a cozy cove along the shores of Lake Marion, this pet friendly retreat offers an escape for anglers, boaters, and golfers seeking both tranquility and convenience. This 2-bed, 2-bath condo is conveniently located off I95, making it an excellent base for exploring nearby areas. Lake Marion ranks among the largest lakes in the US offering world-class fishing. Santee also provides an exceptional golfing challenge making this a premier vacation destination for the golf enthusiasts.

The Turtle's Nest
Locally known as the "Turtle's Nest", you will be close to all the action. Located on Goat Island, 2nd row back, right off the big water. Boat ramp, boatslip, and restaurant only .3 miles away. Ramp and beach picnic area included. Remodled to a farmhouse feel, this 3 bedroom, 1 bath has 2 king beds & two singles. Two single beds share the same space as living room. Great retreat after a long day of fishing, or hanging out with family and friends. Be back fast to unwind by the firepit.

Docked Paddlewheel Houseboat| Fishing & Kayaking
Experience a stay on a one-of-a-kind stationary paddlewheel boat on Lake Marion. Once a passenger vessel, this floating retreat blends comfort and charm in a truly unique setting. Wake up to peaceful water views, cast a line from the dock, or sip coffee on the upper deck. Relax by the fire pit, grill on the deck, or take the kayaks out for a sunset paddle. Whether you’re here for a fishing trip, romantic getaway, or peaceful reset, this floating escape promises an unforgettable stay.

Relaxing Comfortable Waterfront Family Dock Suite
Bring your family or group to this 3 bedroom 1+ bath place in the large trees with lots of room for relaxing and fun (….if you are a jeans and sweatshirt kind of person. It is not the Hilton!) TVs in each room, and 2 covered decks. Fish, or just sit out on the dock, watch the boats run by, and appreciate the lake. We rarely use the dock ourselves. 600’ from our public boat ramp with a park and small beach. Please also note that we do have cameras installed that monitor outside only.

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

A Great Lake house. Near Manning, SC and I-95.
Secluded and serene, our private lakefront property in South Carolina's Lake Marion region offers a community feel with minimal traffic and noise. The fenced-in property has 2 cozy bedrooms, a large open floor plan, and a screen porch with a beautiful lake view. Enjoy the private dock, kayaks, and floats, and relax with a bonfire and grill. Conveniently located just 20 minutes from Manning and I-95, our retreat is perfect for travelers looking to unwind and recharge.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Sunset Serenity Pool/Swim Spa
Experience next-level lakefront luxury in this brand-new 5BR/3BA custom home featuring a massive open-concept layout, chef’s kitchen, two master suites, and resort-style amenities like 20x40 infinity pool, swim spa, and fire pit. Enjoy a private dock, multiple lounge spaces, dual laundry sets, paddleboard/kayaks, and designer finishes throughout. Every detail of Sunset Serenity was designed for comfort, beauty, and unforgettable moments on Lake Marion.

Lake Marion | Chill, Cruise, or Cast a Line for 8!
Wake up to quiet mornings, sip coffee by the water, cast a line, and let the day slow down. This Lake Marion home is all about relaxing, fishing, and unplugging with your favorite people. This is the perfect place to reset, recharge, and enjoy the simple things. No rush. No noise. Just lake life, done right. PS: this IS a fresh water lake in SC with a lot of wildlife, including alligators...swim, fish, and play at your own risk.

Reelaxation-At Lake Marion
Unplug and enjoy the laid back charm of this cozy 2BR cabin near Lake Marion. Located in a gated community, it features a private boat ramp, boat parking, and plenty of space to relax and grill after a day of fishing on the lake or golfing at one of local golf courses. Enjoy peaceful mornings, family and friend time, and quiet evenings on the porch. Perfect for anglers, golfers, and family getaways.
Popular amenities for Santee lake access rentals
Lake access house rentals

Lakefront Retreat | Dock, Firepit & Pet Friendly

Lake House at Lake Marion

Lake Marion - Majestic Big Water Views

Lake House Getaway

Heated Indoor Pool on Lake Marion with Dock

The Cypress House

Lakeview Leisure-Face to the Sun

Wyboo Retreat at Lake Marion W/Pool
Lake access apartment rentals

Dockside Villa Lake Marion

Lake and pool side vacationing

Ophir Oasis Unit #1

Our Place at the Lake.

3-Bedroom Dlx @ Lake Marion Resort

Lake Marion Resort 1 Bedroom Unit

Lakeside Bliss 2BR/2BA Suite Wyndham Lake Marion

Come on Down to Goat Island!
Lake access cottage rentals

Big Mama's Lakeside Cottage Lake Marion

Quiet Waterfront 3 Bedroom on the Lake

Three Little Birds- Canal Home

Relaxing 2-bedroom cottage, Dorchester, S.C.
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- Congaree National Park
- University of South Carolina
- North Charleston Coliseum & Performing Arts Center
- Riverbanks Zoo and Garden
- Magnolia Plantation & Gardens
- Middleton Place
- Williams Brice Stadium
- Cypress Gardens
- South Carolina State House
- South Carolina State Museum
- Charleston Southern University
- Colonial Life Arena
- Columbia Museum of Art
- West Columbia Riverwalk Park and Amphitheater
- Sesquicentennial State Park
- Columbia Metropolitan Convention Center
- Wannamaker County Park
- Edventure
- Riverfront Park
- Soda City Market
- Whirlin' Waters Adventure Waterpark
- Koger Center for the Arts
- Segra Park
- Azalea Park





