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House vacation rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
An inviting living area features a grey reclining chair and a light wooden coffee table with decorative plants. In the background, a dining table set for four is visible, along with a stone accent wall that adds texture. Natural light fills the room through a nearby window.
Home in Panamá
4.95 out of 5 average rating, 38 reviews

Cantabria House - 10 minutes from the Airport

Spacious and comfortable home just 10 minutes from Tocumen Airport and only 200 meters from the Metro. Perfect for families, groups, or business trips. Fast 500 Mbps Wi-Fi, 3 bedrooms, 2 full bathrooms, fully equipped kitchen, air conditioning throughout the house, cable TV, patio with outdoor furniture, private parking, and self check-in. Long layover, family trip, or work in the city? This home has it all: comfort, location, and privacy. Book now and feel at home from the very first moment!

Guest favorite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
5 out of 5 average rating, 50 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Guest favorite
A spacious bed is featured with two decorative pillows against a textured headboard. Soft natural light streams through partially covered windows, while a minimalist side table and shelf are positioned nearby, providing additional storage and a clean aesthetic.
Home in Panamá
4.74 out of 5 average rating, 23 reviews

apartment-studio-kitchen-wifi6-tv-comfort-quiet

welcome to my home, designed especially for you! I tell you that our studio apartment cost with its private bathroom,very comfortable, a super comfortable double bed,with its air conditioning, a kitchen, a refrigerator. It has a digital lock for added security. 🙂 if you come for work we have the ideal table so you can work comfortable,the place is centrally located,very quiet and is just steps from the Este coast.. (business and tourist center). If you are interested, you can rent a car!

Guest favorite
A two-story residence features a light-colored facade with large windows allowing ample natural light. A spacious garage with a multi-car door is prominently displayed in front. The surrounding area is neatly paved, with a tranquil atmosphere suggested by the absence of heavy traffic.
Home in Punta Paitilla
4.77 out of 5 average rating, 98 reviews

Large Private Residence in an Excellent Area

House in the best areas of the country. Very quiet street, downtown, near restaurants, pharmacies, malls among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 Spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Opcion Kosher Disponible* House in one of the best area of ​​the country. Very quiet street, central, close to restaurants, pharmacies, mall and more. Large comfortable residence for groups.

Guest favorite
The façade of Casa Arango features a two-story colonial design with wooden doors and large, multi-paned windows. A charming balcony extends across the front, adorned with potted plants. The entrance is marked by a solid wood door, complemented by stone steps and decorative lanterns.
Home in Panama City
4.93 out of 5 average rating, 14 reviews

A Charming Colonial House in Casco Antiguo

Welcome to Casa Arango, a beautifully restored 19th-century gem in the heart of Casco Antiguo. Located on a quiet, picturesque street, this colonial house blends historic charm with modern comforts. Casa Arango offers three elegant rooms with private bathrooms, a front balcony, and a spacious patio with a barbecue and private bar. Perfect for families or groups of up to 8, the property also includes two private parking spaces—an exclusive luxury in the area.

Superhost
Home in Panamá
4.83 out of 5 average rating, 41 reviews

apartamento Lilia Airport 2

Bienvenidos a nuestro acogedor apartamento ideal para dos a tres personas! con un baño y una cocina equipada. Aunque solo tiene una ventana frontal, el apartamento está perfectamente climatizado con aire acondicionado y cuenta con ventiladores en ambos dormitorios. Disfrutarás de la tranquilidad y seguridad que ofrece nuestro vecindario, permitiéndote relajarte y descansar plenamente durante tu estadía. ¡Te esperamos para una experiencia inolvidable!

Top guest favorite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in Panama City
4.81 out of 5 average rating, 108 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Top guest favorite
A well-appointed game room features a classic pool table with a decorative overhead light fixture. The stone wall adds rustic charm, while framed art pieces and movie posters contribute to the artistic decor. Two wooden doors are visible in the background.
Home
4.88 out of 5 average rating, 25 reviews

Entire house, pool table, jacuzzi, private rooftop

¡Bienvenido a Casa Compadre, tu hogar ideal en el histórico Casco Viejo de Panamá! Esta espaciosa y elegante casa cuenta con 4 cómodas habitaciones y capacidad para hasta 10 personas. Perfecta para grupos o familias, ofrece una sala de billar para el entretenimiento, espacios bien decorados y todas las comodidades para una estancia inolvidable. Disfruta de una estadía inolvidable en un ambiente acogedor y completamente equipado.

Guest favorite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.93 out of 5 average rating, 128 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Top guest favorite
The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.
Home in Panamá
4.93 out of 5 average rating, 375 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Superhost
A modern kitchen is featured with sleek granite countertops and stainless steel appliances. Framed wall art adds a touch of style. A small dining table is visible in the background, alongside window blinds that filter natural light.
Home in San Miguelito
4.88 out of 5 average rating, 17 reviews

Casa Santa by SS • 3BR Perfect Stay Near City

This memorable place is anything but ordinary. This stylish place is perfect for group of persons or family trips. Conveniently located next to shopping malls and supermarkets you’re literally minutes from the train station and just minutes to the city. San Antonio is a safe place for families. Enjoy a cozy silent place with everything you can need for your stay.

Guest favorite
The interior showcases a cozy seating area with a brown sofa and two clear chairs around a glass table. A spacious bed with warm bedding is positioned against the wall. Natural light enters through large windows adorned with soft curtains, highlighting decorative shelves and artwork.
Home in Panamá
4.92 out of 5 average rating, 158 reviews

Golden Space | By Paradox

PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.

Popular amenities for Panama City house rentals

Quick stats about house rentals in Panama City

  • Total rentals

    470 properties

  • Nightly prices starting at

    € 9 before taxes and fees

  • Total number of reviews

    7.3K reviews

  • Family-friendly rentals

    180 properties are a good fit for families

  • Pet-friendly rentals

    160 properties allow pets

  • Rentals with a pool

    90 properties have a pool

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City
  5. House rentals