
House vacation rentals in Panama City
Find and book unique houses on Airbnb
Top-rated house rentals in Panama City
Guests agree: these houses are highly rated for location, cleanliness, and more.

Cantabria House - 10 minutes from the Airport
Spacious and comfortable home just 10 minutes from Tocumen Airport and only 200 meters from the Metro. Perfect for families, groups, or business trips. Fast 500 Mbps Wi-Fi, 3 bedrooms, 2 full bathrooms, fully equipped kitchen, air conditioning throughout the house, cable TV, patio with outdoor furniture, private parking, and self check-in. Long layover, family trip, or work in the city? This home has it all: comfort, location, and privacy. Book now and feel at home from the very first moment!

Mountain Retreat
Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

apartment-studio-kitchen-wifi6-tv-comfort-quiet
welcome to my home, designed especially for you! I tell you that our studio apartment cost with its private bathroom,very comfortable, a super comfortable double bed,with its air conditioning, a kitchen, a refrigerator. It has a digital lock for added security. 🙂 if you come for work we have the ideal table so you can work comfortable,the place is centrally located,very quiet and is just steps from the Este coast.. (business and tourist center). If you are interested, you can rent a car!

Large Private Residence in an Excellent Area
House in the best areas of the country. Very quiet street, downtown, near restaurants, pharmacies, malls among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 Spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Opcion Kosher Disponible* House in one of the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall and more. Large comfortable residence for groups.

A Charming Colonial House in Casco Antiguo
Welcome to Casa Arango, a beautifully restored 19th-century gem in the heart of Casco Antiguo. Located on a quiet, picturesque street, this colonial house blends historic charm with modern comforts. Casa Arango offers three elegant rooms with private bathrooms, a front balcony, and a spacious patio with a barbecue and private bar. Perfect for families or groups of up to 8, the property also includes two private parking spaces—an exclusive luxury in the area.

apartamento Lilia Airport 2
Bienvenidos a nuestro acogedor apartamento ideal para dos a tres personas! con un baño y una cocina equipada. Aunque solo tiene una ventana frontal, el apartamento está perfectamente climatizado con aire acondicionado y cuenta con ventiladores en ambos dormitorios. Disfrutarás de la tranquilidad y seguridad que ofrece nuestro vecindario, permitiéndote relajarte y descansar plenamente durante tu estadía. ¡Te esperamos para una experiencia inolvidable!

Spacious Panama House in the 'heart of the city'
You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Entire house, pool table, jacuzzi, private rooftop
¡Bienvenido a Casa Compadre, tu hogar ideal en el histórico Casco Viejo de Panamá! Esta espaciosa y elegante casa cuenta con 4 cómodas habitaciones y capacidad para hasta 10 personas. Perfecta para grupos o familias, ofrece una sala de billar para el entretenimiento, espacios bien decorados y todas las comodidades para una estancia inolvidable. Disfruta de una estadía inolvidable en un ambiente acogedor y completamente equipado.

Exceptional three-story building with sea view
This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Private Studio 10 Min from the Airport!
Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Casa Santa by SS • 3BR Perfect Stay Near City
This memorable place is anything but ordinary. This stylish place is perfect for group of persons or family trips. Conveniently located next to shopping malls and supermarkets you’re literally minutes from the train station and just minutes to the city. San Antonio is a safe place for families. Enjoy a cozy silent place with everything you can need for your stay.

Golden Space | By Paradox
PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.
Popular amenities for Panama City house rentals
House rentals with a pool

Luxury beachfront villa!

Luxury Home with Pool in the Best Neighborhood

house 2 bedrooms, 2, kitchen, dining room, in ancon

A beautiful apartment with a swimming pool, BBQ area, and gym

Beautiful house in Brisas del Golf

Villa Helena 3 Bedrooms Los Altos de Cerro Azul

House of the waterfalls

Airbnb - Vacation
Weekly house rentals

HOUSE Panama City Albrook 3 story house 3 bedroom

LovelyviewPty House 15 minutes away from the airport

Cabin in Cerro Azul with Forest View

Casa de Montaña Altos de Cerro Azul

La Canelita at Cerro Azul, Panama

My Blue Escape

Spacious & cozy 4 bedroom home.

Margaritaville Charm Suburban Retreat in Panama
Private house rentals

House conveniently located near the airport

Country house in Altos de Cerro Azul

Modern and minimalist Altos de Cerro Azul

two-person tent

Specious house that can accommodate up to seven

A nice house equipped for rest or home office

Family House | 4 floors | BBQ | 20 Pax | Views

Live in nature 2
Quick stats about house rentals in Panama City
Total rentals
470 properties
Nightly prices starting at
€ 9 before taxes and fees
Total number of reviews
7.3K reviews
Family-friendly rentals
180 properties are a good fit for families
Pet-friendly rentals
160 properties allow pets
Rentals with a pool
90 properties have a pool
Destinations to explore
- Cartagena Vacation rentals
- San Andrés Vacation rentals
- Puerto Viejo de Talamanca Vacation rentals
- Uvita Vacation rentals
- Boquete Vacation rentals
- Coveñas Vacation rentals
- Playa Blanca Vacation rentals
- Bahía Ballena Vacation rentals
- Limón Vacation rentals
- Ancón Vacation rentals
- Cahuita Vacation rentals
- Valle de Anton Vacation rentals
- Rentals with outdoor seating Panama City
- Rentals with a sauna Panama City
- Fitness-friendly rentals Panama City
- Rentals with a fire pit Panama City
- Rentals with a patio Panama City
- Rentals with a home theater Panama City
- Loft rentals Panama City
- Pet-friendly rentals Panama City
- Guesthouse rentals Panama City
- Rentals with a hot tub Panama City
- Apartment rentals Panama City
- Beachfront rentals Panama City
- Hotel rentals Panama City
- Smoking-friendly rentals Panama City
- Rentals with breakfast Panama City
- Rentals with an EV charger Panama City
- Rentals with an accessible height bed Panama City
- Waterfront rentals Panama City
- Rentals with beach access Panama City
- Rentals with a washer and dryer Panama City
- Boutique hotel rentals Panama City
- Family-friendly rentals Panama City
- Rentals with a fireplace Panama City
- Townhouse rentals Panama City
- Bed and breakfasts Panama City
- Ski-in/ski-out rentals Panama City
- Hostel rentals Panama City
- Serviced apartment rentals Panama City
- Rentals with pools Panama City
- Rentals with lake access Panama City
- Condo rentals Panama City
- Villa rentals Panama City
- Cabin rentals Panama City
- House rentals Panamá Province
- House rentals Panama
- Things to do Panama City
- Sports activities Panama City
- Art and culture Panama City
- Tours Panama City
- Food and drink Panama City
- Sightseeing Panama City
- Nature and outdoors Panama City
- Things to do Panamá Province
- Tours Panamá Province
- Sightseeing Panamá Province
- Nature and outdoors Panamá Province
- Sports activities Panamá Province
- Art and culture Panamá Province
- Food and drink Panamá Province
- Things to do Panama
- Sightseeing Panama
- Nature and outdoors Panama
- Art and culture Panama
- Tours Panama
- Sports activities Panama
- Entertainment Panama
- Food and drink Panama