
Guesthouse vacation rentals in Panama City
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Top-rated guesthouse rentals in Panama City
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Rare City Oasis with Private Green Space
No more construction. Wake up to the sound of birds in this peaceful retreat in the heart of trendy "El Cangrejo". Housed on the ground-floor apartment of a 2-story building built in the 50's. Features a private green yard — perfect for relaxing or spotting hummingbirds. There is an outdoor dining set. Steps from cafés, galleries, parks, metro, and nightlife, yet quiet and tucked away. Only one neighbor on site. Private parking. Thoughtfully decorated with pieces from local artisans.

Efficiency Bungalow - Metropolitan Natural Park
Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park. A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

Trendy Tiny Apartment in Ancon
Nestled in the former Canal Zone, this cozy apartment offers comfort, nature, and city access. Near the City of Knowledge, The Panama Canal and Albrook, it’s perfect for exploring history and culture. We proudly welcome LGBTQ+ travelers and allies to a safe, inclusive space where you can relax and feel at home. Whether you're a solo traveler, a couple, or a digital nomad, you’ll find a warm, affirming environment here. Enjoy tropical hikes, city views, and local events. 🌈

The Black Studio by SS • near airport & city
This unique PRIVATE place has a style all its own. This stylish place is anything but ordinary. It is affordable and its perfect for a couple or business trips. Conveniently located next to shopping malls and supermarkets you’re literally 3 minutes from the train station and just 20 minutes to the city. Don Bosco is a safe place. Enjoy a cozy place with everything you can need for your stay. This place is private with its private entrance. IT IS NOT SHARED!

Garden Cottage in Panama City
Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

Convenient, centrally located suite with parking
This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

Cool Guesthouse + WiFi + Pool + TV + AC @ Panama Canal
✔️Superhost Verified! Your stay will be in the best hands Guest House, Close to the City of Knowledge 🇵🇦 📍 In the tropical forest of the ancient Clayton base, with amenities, parks, sports and gastronomy. Close to town, shopping malls, Miraflores Locks and the Transoceanic Railway🇵🇦 We offer: 💧 Hot Water 📶 Wi-Fi. ❄️ AC 🏊♂️ Swimming pool 📺 TV Smart y Cable 🚗Carport This strategic location, with a high level of security in the area.

CASA PINO, a forest in the city
Excellent independent studio apartment with everything you need, private bathroom, kitchenette, fridge, and WiFi. Very safe. You can use machines in the park to exercise. We are located in a privileged area on the banks of the Canal, with lots of vegetation and forests, but very close to all the recreational amenities of the City of Knowledge. Very central, 10 minutes by metro-bus to Albrook Mall, 10 minutes from the Panama Canal.

Private studio-type annex near Costa del Este
Very nice little annex and cozy studio type (all in a single area) very cozy super nice, clean. Adjacent to our house, private and independent with all the comforts inside it for your stay , with split air conditioning, smart TV, wifi,spacious shower bathroom with hot water, kitchen with all its appliances, parking area. Located in a very quiet residential area, very good area. Great location. A few minutes from the East Coast.

2 bedrooms in tropical garden
Quiet sleep surrounded by lush greenery 20 minutes from Panama spacious accommodation suitable for 2 couples or family of 4 people 1 queen bed and 2 twins with each en-suite private bathroom, provision of an umbrella bed Rest room hammock , equipped kitchen dining room, a saltwater pool to entertain you facing the ocean whose only users you are surrounded by a large garden Workspace with fast wifi Water sports, hiking nearby

Apartment in a safe residential area
You will be Close to everything when you stay in this central home. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, on the way to Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether traveling for business, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We're available if you need any additional information.

Private guest house in Ancón
Enjoy the simplicity of this cozy, quiet and central accommodation. Close to sights such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.
Popular amenities for Panama City guesthouse rentals
Family-friendly guest house rentals

Spectacular double room for 4 people

Comfort & Privacy room 8/Panamá

Private Ensuite Room

Cozy room7/ GuesthousePanamá

Family Room 6/Guesthouse Panamá

ExpC7 Social Vibes • Budget Stay • Easy Check-in

Private Room 1, Bella Vista/Panamá

Private Room in Smart Hostel
Guest house rentals with a patio

Luxury Ecolodge

A house on the river in Cerro Azul, Panama

Accommodation near Tocumen Airport

Room+Parking+TV+Kitchen+Work Area+WiFi@PanamáCity

Private Room 5/guesthouse Panamá

Room with private entrance and private bathroom.

Private suite

Spacious room with hostel-like price
Guest house rentals with a washer and dryer

Cabin inside a beautiful property.

My home

WHERE YOYI

Smart Stay by SS • Budget Studio 3+ Airport & Mall

Room, nature, sauna and eveything, near the sea.

Smart Stay by SS • Budget Studio 5+ Airport & Mall

Rent a furnished room in San Antonio

Ocean front Apartment by San Francisco, PTY
Quick stats about guesthouse rentals in Panama City

Total vacation rentals
Explore 80 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at € 9 per night before taxes and fees

Verified guest reviews
Over 1,490 verified reviews to help you choose

Family-friendly vacation rentals
10 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 20 rentals that welcome pets

Vacation rentals with a pool
10 properties feature pools

Rentals with dedicated workspaces
30 properties have a dedicated workspace

Wi-Fi availability
70 of Panama City vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Panama City rentals

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
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