Guesthouse vacation rentals in Panama City

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Panama City

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guesthouse in Panamá

4.8 out of 5 average rating, 85 reviews

Cool Guesthouse+WiFi+Pool+Tv+AC @Canal de Panama

✔️SuperAnfitrion Verificado! Tu estadía estará en las mejores manos Casa de huespedes, Cerca al Ciudad del Saber 🇵🇦 📍 En el bosque tropical de la antigua base de Clayton, con comodidades, parques, deportes y gastronomía. Cerca de la ciudad, centros comerciales, las Esclusas de Miraflores y el ferrocarril transoceánico🇵🇦 Ofrecemos: 💧 Agua Caliente 📶 Wifi ❄️ AC 🏊‍♂️ Piscina 📺 Tv Smart y Cable 🚗Parqueadero Esta localización estratégica, con un alto nivel de seguridad en el área.

Guest favorite

Guesthouse in Veracruz

4.94 out of 5 average rating, 17 reviews

2 chambres dans jardin tropical

Dormir au calme entouré de végétation luxuriante à 20 minutes de panama logement spacieux adapté à 2 couple ou famille de 4 personnes 1 lit Queen et 2 twins avec chacun salle de bains privée attenante , mise à disposition d’un lit parapluie Salle de repos hamac , salle de repas cuisine équipée, une piscine eau salée pour vous divertir face à l’océan dont vous êtes les seuls utilisateurs entourés d’un grand jardin Espace de travail avec Wifi rapide Sports nautiques, randonnées à proximité

Guesthouse in Panamá

4.79 out of 5 average rating, 19 reviews

Anexo privado tipo estudio cerca de Costa del Este

Pequeño anexo muy lindo y acogedor tipo estudio (todo en una sola área) muy acogedor súper agradable, limpio. Anexo adyacente a nuestra casa, privado e independiente con todas las comodidades dentro de él para su estancia , con aire acondicionado split, smart tv, wifi,Amplio baño ducha con agua caliente , cocina con todos sus electrodomésticos, área para estacionar un auto. Ubicado en un área residencial muy tranquila, muy buena zona. Excelente ubicación. A pocos minutos de Costa del Este.

Guest favorite

Guesthouse in Panamá

4.92 out of 5 average rating, 38 reviews

Home Harmony 15 min. Aeropuerto.

"Experimenta una estancia cómoda y conveniente en nuestro acogedor apartamento, ubicado a solo 10 minutos del aeropuerto Tocumen. Equipado con todas las comodidades necesarias para tu descanso, desde conexión WiFi hasta una cocina equipada, este espacio te ofrece la oportunidad de relajarte y recargar energías. Disfruta del confort del aire acondicionado, agua caliente/fria en el baño, una cama y sofá cama para tu comodidad, televisión con cable , y toallas y sobrecama para tu conveniencia.

Guesthouse in Panama City

4.73 out of 5 average rating, 83 reviews

Efficiency Bungalow - Metropolitan Natural Park

Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park. A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

Superhost

Guesthouse in Panamá

Trendy Tiny Apartment in Ancon

Nestled in the former Canal Zone, this cozy apartment offers comfort, nature, and city access. Near the City of Knowledge, The Panama Canal and Albrook, it’s perfect for exploring history and culture. We proudly welcome LGBTQ+ travelers and allies to a safe, inclusive space where you can relax and feel at home. Whether you're a solo traveler, a couple, or a digital nomad, you’ll find a warm, affirming environment here. Enjoy tropical hikes, city views, and local events. 🌈

Superhost

Guesthouse in Panamá

4.75 out of 5 average rating, 4 reviews

The Black Studio near airport & city

This unique PRIVATE place has a style all its own. This stylish place is anything but ordinary. It is affordable and its perfect for a couple or business trips. Conveniently located next to shopping malls and supermarkets you’re literally 3 minutes from the train station and just 20 minutes to the city. Don Bosco is a safe place. Enjoy a cozy place with everything you can need for your stay. This place is private with its private entrance. IT IS NOT SHARED!

Guest favorite

Guesthouse in Panamá

4.76 out of 5 average rating, 243 reviews

Garden Cottage in Panama City

Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

Guest favorite

Guesthouse in El Cangrejo

4.88 out of 5 average rating, 17 reviews

Charming City Hideaway with Private Green Space

A peaceful, art-filled retreat in the heart of El Cangrejo. This ground-floor apartment features a private green yard — perfect for relaxing or spotting hummingbirds. There is an outdoor furniture dining set (available upon request). Steps from cafés, galleries, parks, and nightlife, yet quiet and tucked away. Only one neighbor on site. Thoughtfully decorated with pieces from local artisans. Watch the video: “El Cangrejo – Unique Oasis Apartment” on YouTube.

Guest favorite

Guesthouse in Gamboa

4.87 out of 5 average rating, 54 reviews

Casa de huésped privada en Ancón

Disfruta de la sencillez de este acogedor alojamiento tranquilo y céntrico. Cerca de lugares de interés como el edificio de la Administración del Canal de Panamá, Amador Causeway, Albrook Mall, y varios restaurantes. Personalmente decorado para proporcionar comodidad... grandes ventanales en el dormitorio proporcionan iluminación natural y una vista del jardín y el área verde a través de las ventanas; aun así mantiene la privacidad y la tranquilidad deseada.

Superhost

Guesthouse in Panamá

4.5 out of 5 average rating, 16 reviews

Conveniente Suite céntrica y con estacionamiento

This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

Guest favorite

Guesthouse in Panamá

4.93 out of 5 average rating, 42 reviews

CASA PINO, bosque en la ciudad

Excelente Aparta-estudio independiente con todo lo necesario, Baño Privado, Cocineta Nevera y WIFI. Con mucha seguridad. Pueden utilizar máquinas en el parque para hacer ejercicios. Estamos ubicados en un área privilegiada en las revieras del Canal, con mucha vegetación y bosques, pero muy cerca de todas las amenidades recreativas de la Ciudad del Saber. Muy céntrico, a 10 minutos en metro-bus hasta Albrook Mall, a 10 minutos del Canal de Panamá.