Guesthouse vacation rentals in Panama City

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Top-rated guesthouse rentals in Panama City

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Panamá

4.92 out of 5 average rating, 38 reviews

Home Harmony 15 min. Aeropuerto.

"Experimenta una estancia cómoda y conveniente en nuestro acogedor apartamento, ubicado a solo 10 minutos del aeropuerto Tocumen. Equipado con todas las comodidades necesarias para tu descanso, desde conexión WiFi hasta una cocina equipada, este espacio te ofrece la oportunidad de relajarte y recargar energías. Disfruta del confort del aire acondicionado, agua caliente/fria en el baño, una cama y sofá cama para tu comodidad, televisión con cable , y toallas y sobrecama para tu conveniencia.

Guesthouse in Panama City

4.73 out of 5 average rating, 83 reviews

Efficiency Bungalow - Metropolitan Natural Park

Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park. A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

Superhost

Guesthouse in Panamá

Trendy Tiny Apartment in Ancon

Nestled in the former Canal Zone, this cozy apartment offers comfort, nature, and city access. Near the City of Knowledge, The Panama Canal and Albrook, it’s perfect for exploring history and culture. We proudly welcome LGBTQ+ travelers and allies to a safe, inclusive space where you can relax and feel at home. Whether you're a solo traveler, a couple, or a digital nomad, you’ll find a warm, affirming environment here. Enjoy tropical hikes, city views, and local events. 🌈

Superhost

Guesthouse in Panamá

4.75 out of 5 average rating, 4 reviews

The Black Studio near airport & city

This unique PRIVATE place has a style all its own. This stylish place is anything but ordinary. It is affordable and its perfect for a couple or business trips. Conveniently located next to shopping malls and supermarkets you’re literally 3 minutes from the train station and just 20 minutes to the city. Don Bosco is a safe place. Enjoy a cozy place with everything you can need for your stay. This place is private with its private entrance. IT IS NOT SHARED!

Guest favorite

Guesthouse in Panamá

4.76 out of 5 average rating, 243 reviews

Garden Cottage in Panama City

Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

Guest favorite

Guesthouse in El Cangrejo

4.78 out of 5 average rating, 18 reviews

Charming City Hideaway with Private Green Space

A peaceful, art-filled retreat in the heart of El Cangrejo. This ground-floor apartment features a private green yard — perfect for relaxing or spotting hummingbirds. There is an outdoor furniture dining set (available upon request). Steps from cafés, galleries, parks, and nightlife, yet quiet and tucked away. Only one neighbor on site. Thoughtfully decorated with pieces from local artisans. Watch the video: “El Cangrejo – Unique Oasis Apartment” on YouTube.

Superhost

Guesthouse in Panamá

4.5 out of 5 average rating, 16 reviews

Convenient, centrally located suite with parking

This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

Guesthouse in Panamá

4.8 out of 5 average rating, 85 reviews

Cool Guesthouse + WiFi + Pool + TV + AC @ Panama Canal

✔️Superhost Verified! Your stay will be in the best hands Guest House, Close to the City of Knowledge 🇵🇦 📍 In the tropical forest of the ancient Clayton base, with amenities, parks, sports and gastronomy. Close to town, shopping malls, Miraflores Locks and the Transoceanic Railway🇵🇦 We offer: 💧 Hot Water 📶 Wi-Fi. ❄️ AC 🏊‍♂️ Swimming pool 📺 TV Smart y Cable 🚗Carport This strategic location, with a high level of security in the area.

Guest favorite

Guesthouse in Panamá

4.93 out of 5 average rating, 42 reviews

CASA PINO, a forest in the city

Excellent independent studio apartment with everything you need, private bathroom, kitchenette, fridge, and WiFi. Very safe. You can use machines in the park to exercise. We are located in a privileged area on the banks of the Canal, with lots of vegetation and forests, but very close to all the recreational amenities of the City of Knowledge. Very central, 10 minutes by metro-bus to Albrook Mall, 10 minutes from the Panama Canal.

Guesthouse in Panamá

4.79 out of 5 average rating, 19 reviews

Private studio-type annex near Costa del Este

Very nice little annex and cozy studio type (all in a single area) very cozy super nice, clean. Adjacent to our house, private and independent with all the comforts inside it for your stay , with split air conditioning, smart TV, wifi,spacious shower bathroom with hot water, kitchen with all its appliances, parking area. Located in a very quiet residential area, very good area. Great location. A few minutes from the East Coast.

Top guest favorite

Guesthouse in Distrito San Miguelito, Brisas del Golf, Panama City

5 out of 5 average rating, 26 reviews

Apartment in a safe residential area

You will be Close to everything when you stay in this central home. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, on the way to Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether traveling for business, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We're available if you need any additional information.

Guest favorite

Guesthouse in Gamboa

4.87 out of 5 average rating, 54 reviews

Private guest house in Ancón

Enjoy the simplicity of this cozy, quiet and central accommodation. Close to sights such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.