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Villa vacation rentals in Panama City

Find and book unique villas on Airbnb

Top-rated villa rentals in Panama City

Guests agree: these villas are highly rated for location, cleanliness, and more.

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Superhost
A welcoming private villa is surrounded by tall trees, showcasing a spacious layout. A swimming pool and trampoline are visible in the backyard, and the exterior features large windows allowing natural light. A green pathway leads to the entrance, emphasizing the serene, forested environment.
Villa in Panamá
4.79 out of 5 average rating, 24 reviews

Spacious Mountain Getaway in Paradise Cloud Forest

Private Villa located at Chagres National Park; a rainforest reserve only 30 minutes away from the airport and 50 minutes from Panama City. At 1,007 meters altitude, you will enjoy the perfect climate, bird watching, beautiful river walks, waterfalls, and many hiking trails full of wildlife, enjoy our mountain's pure air or simply relax in Nature. Bring the whole family to this great place with lots of room for fun. Bring your pets our land is completely fenced, they can run free in a vast space

Top guest favorite
A tranquil beachfront scene features several hammocks strung between palm trees on soft sand. Blue lounge chairs are positioned alongside the water, with gentle waves lapping at the shore under a clear sky.
Villa in Chame District
4.86 out of 5 average rating, 237 reviews

Surf Relax Play Pacific Ocean View Villa

White sand, surf-able waves, or just a comfortable chill vibe to enjoy the tropical weather of Panama. Playa Caracol is about an hour and 10 minutes drive from the city. This spacious, 2 bedroom, 2 bath villa with it's Pacific Ocean front location is the perfect place for you to enjoy an unforgettable family vacation. Walk out to the beach just steps from the villa, swim in the pool next to this villa or enjoy the resort pools and amenities. Or hike the nearby mountains with a local guide. PET

Top guest favorite
A modern outdoor area features a turquoise swimming pool surrounded by lush greenery. The space includes a partially covered patio with seating options and an outdoor bar area. Tall buildings are visible in the background against a clear blue sky.
Villa in Santa Cruz De Chinina
5 out of 5 average rating, 31 reviews

5BR House in Panama City w/ Pool & King Beds

Enjoy a family or friends' getaway in this modern, newly remodeled house. This property boasts 5 bedrooms, 4.5 bathrooms, 10 beds, and can comfortably accommodate up to 15 guests. The house also features a private outdoor pool, where you can soak up the sun and cool off on hot days, all while being in a central location, just meters away from malls, supermarkets and night life. It's fully furnished with everything you could possibly need to ensure your stay is as comfortable as possible.

An aerial view showcases a spacious villa surrounded by lush greenery. The infinity pool reflects the sky, while several guests relax on the patio with vibrant flowers in the foreground, adding color to the scenic setting.
Villa in Panamá
4.82 out of 5 average rating, 57 reviews

Villa La Vista-Panama's majestic mountain hideaway

Welcome to our Villa in Panama's Chagres National Park! We have installed a brand new spa heater in our pool (20Nov24) to enjoy breathtaking views of the surrounding mountain range. Take a dip in our stunning infinity pool, offering picturesque landscapes. Ultimate relaxation during sunset evenings in our inviting hot tub. A gym station you can stay fit. Jefferys Tamarin monkeys at our feeding station. Unwind in a hammock or enjoy a romantic poolside swing. Relax on the outdoor bar stools.

An infinity pool is framed by lush greenery, providing a serene view of the beach and ocean. A seated sculpture adds a unique touch to the pool deck, while palm trees surround the area, enhancing the tranquil atmosphere.
Villa
4.77 out of 5 average rating, 13 reviews

Casa Laguna - luxury beach front house with pool

Welcome to our little piece of paradise - Casa Laguna! The house - newly renovated in 2022 - sits right by the private-feel beach Playa Encanto on the beautiful island Saboga, Las Perlas Islands. The house features a large pool and jacuzzi, multiple terraces and a stunning beach and sunset view. The open concept house offers 3 double and one twin bedroom all with en-suite bathrooms and a lavish living room and kitchen. The highlight are the outdoor areas, the gym and the beach access.

The exterior of the villa showcases a modern design with large arched windows and a white façade. Lush greenery surrounds the property, highlighted by blooming flowers. A spacious patio area with outdoor seating overlooks the inviting pool, complemented by a well-maintained lawn.
Villa in Santa Cruz De Chinina
4.91 out of 5 average rating, 32 reviews

Beachfront | Rooftop | Amazing Villa in PuntaChame

Relax in this spacious beachfront villa with a private pool, rooftop terrace, and palm-lined path straight to the beach. Perfect for families, groups, or special events — whether you’re sharing BBQ nights, watching sunsets on the rooftop, or simply soaking up the tropical atmosphere. Just 2 hours from Panama City and 5 mins to Punta Chame Beach! • Beachfront Villa with Direct Access • Private Pool + Palm Garden • Rooftop with 360° Sunset Views • Fast Wi-Fi & Dedicated Workspace

Superhost
An outdoor dining area is shown with a glass-top table surrounded by six woven chairs. A view of the beach and ocean is visible in the background, framed by tall palm trees under a clear sky.
Villa in Chame
4.84 out of 5 average rating, 110 reviews

Ocean front Villa (C5-1C) 2 bed, 2 bath

Unique Villa steps away from the ocean and fully furnished ground floor unit 2 bed/2 bath apt has an open concept living, dining & kitchen space with sofa bed (6 guests). This is a unique villa apartment over looking the picturesque Playa Caracol coast with ocean front and majestic mountain views. Playa Caracol is located on the beach of Chame and is a newly developed area with expansion for the property and amenities. 1km of beach to offer you the best beach experience around.

Guest favorite
A spacious swimming pool is framed by lounge chairs, with a bright pink float positioned in the water. The villa's exterior is visible in the background, showcasing a large parking area and covered terrace with a red roof, surrounded by greenery.
Villa in Portobelo
4.92 out of 5 average rating, 26 reviews

Villa with a swimming pool, soccer field, and stream

Quiet and spacious villa in Portobelo, Buenaventura. Enjoy a villa with a giant garden, river, soccer court, pool with waterfall and slide , 2 boyos, barbecue areas, terrace. 1 Master Bed with King Bed and Private Bathroom 2 bedrooms with 2 full beds. 1 bathroom in the room. 1 bathroom in the pool area and external shower. Living Room, Dining Room. Cable TV. Equipped kitchen. Hammocks. * The house is equipped with beds for 10 people, bring air mattresses with sheets.

Top guest favorite
A serene swimming pool is depicted surrounded by lush palm trees, with the tranquil sea visible in the background. The water's clear blue tiles reflect the sky and nearby greenery, while the gentle curvature of the pool edge invites relaxation.
Villa in Portobelo
5 out of 5 average rating, 74 reviews

Entire Villa with pool in front of beach!

Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

Top guest favorite
The image shows a bright outdoor area featuring a clear blue swimming pool bordered by light stone paths and lush green grass. A tall palm tree provides shade in the foreground, while the backyard includes a single-story house and an open patio area under a roof.
Villa in Santa Cruz De Chinina
4.97 out of 5 average rating, 135 reviews

Beach House with Pool/Gazebo in Punta Chame!

"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Guest favorite
A bright living area features a neutral-colored sofa adorned with a decorative throw. A round coffee table occupies the center, while a television is mounted on a wooden accent wall. A dining table with black chairs is visible in the background, along with an open kitchen.
Villa in Chame District
4.97 out of 5 average rating, 34 reviews

​Villa Playa Caracol, 3 Bedrooms, Pet Friendly

¡Welcome to your perfect beach getaway! This charming ground-floor villa awaits you just 100 meters from the golden sand and refreshing waves of the sea. This home offers an ideal retreat for families and groups of friends looking to relax and enjoy the sun and sea breeze. Enjoy the pool right in front of the villa, where you'll also find a playground for everyone to enjoy. ¡Book now and experience a dreamy seaside vacation!

Guest favorite
A private pool area features a large swimming pool and a smaller hot tub, surrounded by lush greenery. Potted plants and tropical foliage enhance the setting, while a lounge chair is positioned beside the pool. The space is framed by a charming stone wall and an elegant railing.
Villa in Panamá
5 out of 5 average rating, 5 reviews

Villa Helena 2 Bedrooms Cerro Azul

Forget your worries in this spacious and serene space surrounded by nature in a gated community. A home away from home. 2 bedrooms for 4 adults. Your own kitchen, dining/living area, 2 washrooms and 2 bedrooms in a private villa with a pool. Cook your own food, BBQ on a gas grill or check out the restaurants in the community.

Popular amenities for Panama City villa rentals

Quick stats about villa rentals in Panama City

  • Total vacation rentals

    Explore 10 vacation rentals in Panama City

  • Nightly prices starting at

    Panama City vacation rentals start at € 69 per night before taxes and fees

  • Verified guest reviews

    Over 340 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Vacation rentals with a pool

    10 properties feature pools

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wi-Fi availability

    10 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

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