House vacation rentals in Panama City

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Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Panamá

4.95 out of 5 average rating, 38 reviews

Cantabria House - 10 minutes from the Airport

Spacious and comfortable home just 10 minutes from Tocumen Airport and only 200 meters from the Metro. Perfect for families, groups, or business trips. Fast 500 Mbps Wi-Fi, 3 bedrooms, 2 full bathrooms, fully equipped kitchen, air conditioning throughout the house, cable TV, patio with outdoor furniture, private parking, and self check-in. Long layover, family trip, or work in the city? This home has it all: comfort, location, and privacy. Book now and feel at home from the very first moment!

Guest favorite

Home in Panama City

5 out of 5 average rating, 50 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Guest favorite

Home in Punta Paitilla

4.77 out of 5 average rating, 98 reviews

Amplia Residencia Privada en Excelente Zona

Casa en las mejores zona del país. Calle muy tranquila, céntrico, cerca de Restaurantes, Farmacias, Mall entre otros. Amplia Residencia cómoda para grupos o Familias. Estacionamiento Privado de hasta 2 autos 4 Recamaras espaciosas , 2 cómodos estudios, Sala Comedor, Desayunador, Amplia Terraza. *Opcion Kosher Disponible* House in one of the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall and more. Large comfortable residence for groups.

Guest favorite

Home in Panamá

4.87 out of 5 average rating, 31 reviews

King Beds | 4BR | BBQ & Garden | pets ok!

Nestled in a prime central location, this lovely house offers guests unparalleled convenience and uniqueness. Find yourself just a swift 10-minute Uber ride away from the bustling heart of downtown, making exploration and nightlife easily accessible. One of the standout features of our home is the exclusive view of the Metropark, which you can relish from both the backyard and balcony – a serene panorama that's hard to beat. Finally sleep in supreme comfort with king-sized beds featured.

Guest favorite

Home in Panamá

4.8 out of 5 average rating, 41 reviews

Naturaleza maravillosa

Disfruta de un retiro familiar en plena naturaleza, donde la tranquilidad te envuelve. Este acogedor alojamiento, rodeado de un hermoso jardín en el Parque Natural Metropolitano, te ofrece un escape único a solo 3 minutos del Albrook Mall y 5 minutos del centro. Despierta con el canto de las aves y la visita de ñeques, mientras te relajas en un ambiente exclusivo y lleno de vida. ¡La escapada perfecta para desconectar y disfrutar de la naturaleza con todas las comodidades!

Guest favorite

Home in Panama City

4.93 out of 5 average rating, 14 reviews

A Charming Colonial House in Casco Antiguo

Welcome to Casa Arango, a beautifully restored 19th-century gem in the heart of Casco Antiguo. Located on a quiet, picturesque street, this colonial house blends historic charm with modern comforts. Casa Arango offers three elegant rooms with private bathrooms, a front balcony, and a spacious patio with a barbecue and private bar. Perfect for families or groups of up to 8, the property also includes two private parking spaces—an exclusive luxury in the area.

Top guest favorite

Home in Panamá

4.93 out of 5 average rating, 373 reviews

Estudio Privado a 10 Min del Aeropuerto !

Apartamento Entero a 10 MINUTOS del Aeropuerto! El apartamento está completamente amueblado incluyendo electrodomésticos y artículos de cocina , productos de aseo , sala comedor ,mesa de trabajo y demás. A sólo minutos caminando de la Estacion de METRO SAN ANTONIO, restaurantes, centros comerciales,lavanderias,supermercados y farmacias. Ofrecemos Tours a San Blas para que aproveches al maximo tu viaje. Nuestra casa es Tu casa en Panamá 🇵🇦

Top guest favorite

Home in Panama City

4.81 out of 5 average rating, 108 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Top guest favorite

Home in Panamá

4.88 out of 5 average rating, 24 reviews

Casa completa, Billar, jacuzzi, rooftop privado

¡Bienvenido a Casa Compadre, tu hogar ideal en el histórico Casco Viejo de Panamá! Esta espaciosa y elegante casa cuenta con 4 cómodas habitaciones y capacidad para hasta 10 personas. Perfecta para grupos o familias, ofrece una sala de billar para el entretenimiento, espacios bien decorados y todas las comodidades para una estancia inolvidable. Disfruta de una estadía inolvidable en un ambiente acogedor y completamente equipado.

Guest favorite

Home in Panamá

4.93 out of 5 average rating, 127 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Superhost

Home in San Miguelito

4.88 out of 5 average rating, 17 reviews

Casa Santa by SS • 3BR Perfect Stay Near City

This memorable place is anything but ordinary. This stylish place is perfect for group of persons or family trips. Conveniently located next to shopping malls and supermarkets you’re literally minutes from the train station and just minutes to the city. San Antonio is a safe place for families. Enjoy a cozy silent place with everything you can need for your stay.

Superhost

Home in Panamá

4.92 out of 5 average rating, 158 reviews

Golden Space | By Paradox

PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.