Pet-friendly vacation rentals in Lake City

Find and book unique pet-friendly homes on Airbnb

Top-rated pet-friendly home rentals in Lake City

Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.

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Superhost

The charming facade of Kuker Cottage is framed by lush greenery and trees, featuring a covered porch with colorful seating. Large windows are positioned symmetrically, and the brick columns add character to the entrance, inviting guests to relax in a tranquil outdoor space.

Home in Florence

4.87 out of 5 average rating, 520 reviews

Kuker Cottage Downtown Florence-Near I95 & I20

Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20

Superhost

The outdoor area features a sparkling pool and a hot tub, both illuminated in soft blue tones. A wooden pier extends over the water, with lights reflecting off the lake's surface, creating a serene nighttime ambiance.

Home in Manning

4.9 out of 5 average rating, 112 reviews

Luxury Lakefront Chalet W/Pool, Hot Tub & Beach

Bring the whole family to this gorgeous lakefront chalet with tons of guest amenities in a quiet neighborhood on Wyboo Creek. Sleeps 2 families comfortably w/ 4 large BR, 2 bathrooms, a game room, a fully equipped kitchen, living area, & screened porch. Enjoy the in ground pool w/ tanning ledge, hot tub, built-in fire pit, outdoor grilling & dining area, private sandy beach, & pier on open water. Launch your boat at the public ramp at the end of the street (.2 miles) & dock at the private pier.

Top guest favorite

The cottage is surrounded by greenery, showcasing a welcoming front porch with white railings. Two planters are placed at the entrance, and a swing is visible on the side. The entrance is accessible from a paved pathway leading to the door.

Cottage in Sumter

4.97 out of 5 average rating, 479 reviews

Restful Lakeside Getaway Cottage -Dogs allowed

This pond-side cottage is a peaceful place to relax and unwind. Sit on the enclosed porch and watch the water or enjoy the front porch swing where you can listen to the birds and frogs. We are 12 min. from downtown Sumter and 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens and Poinsett State Park. It is only 2 hours to Myrtle Beach and Charleston, SC & 3 hrs to the mtns. While it is conveniently located, this cottage offers a quiet place to put your feet up and rest.

Top guest favorite

A charming country estate is highlighted with a wrap-around porch surrounded by lush greenery. The architectural details feature brick and wood elements, with a tall chimney visible. Sunlight gently illuminates the exterior, showcasing the inviting atmosphere of the property.

Home in Kingstree

4.95 out of 5 average rating, 112 reviews

magical 1840s farm house getaway

Centuries old country estate with magical ambiance, art and antiques, beautiful views and wrap around porches. Relax in the hot tub in your own private oasis or gather with friends and family around the fire pit. Multiple bird feeders and grand live oaks, magnolias, fruit trees and a kitchen garden. Chefs kitchen will be stocked with fresh eggs, herbs and seasonal veggies. Sit and sip on the porch while enjoying the views of farmer's field and listing to the moos of the cows. Groups welcome!

Top guest favorite

The exterior of a quaint cottage features white siding, green shutters, and a covered porch. An American flag is displayed, and two chairs sit on the porch. A gravel driveway leads to the home, surrounded by shade trees in a peaceful setting.

Cottage in Timmonsville

4.97 out of 5 average rating, 975 reviews

*Cottage Near Florence and I-95* 3 Bedrooms

Located just 5 mins from I-95 and 12 minutes from Florence, this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, pls) but are not allowed on our beds. 🧺. King bed in master, 3 TV's (two 55” & one 32”), coffee bar with Keurig, strong WiFi. We also use 100% cotton sheets and quilts for your maximum sleeping comfort. Absolutely no smoking ON OUR PROPERTY ($200 extra fee). Come stay with us!! 😊

Top guest favorite

The exterior of the hermitage is seen at dusk, highlighted by a warm glow from outdoor lights. The rich orange facade contrasts with the pink and purple hues of the sunset sky. Nearby trees frame the scene, and a landscaped area features decorative plants.

Place to stay in Effingham

4.97 out of 5 average rating, 142 reviews

Gated and Private Catholic Hermitage house

Saint Michael Hermitage and retreat is a serene, gated, private home that is for 1-3 guests looking for a quiet stay while traveling or as a retreat destination. You will self check into your Hermitage after you obtain a gate code. There is a prayer chapel close by on the property. It is pet friendly for a well trained pet. There is Catholic iconography throughout the home. It is warm and inviting. There is a full kitchen, washer/dryer for your convenience and complementary coffee/tea.

Top guest favorite

The exterior of a two-story house is nestled among tall trees, showcasing a deck with steps leading to the ground. Screened-in porches on both levels provide ample outdoor space and views of the surrounding greenery.

Home in Georgetown

4.99 out of 5 average rating, 162 reviews

Black River Refuge on the Water

The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Top guest favorite

The cozy interior features rustic wooden beams and a blend of warm tones. A spacious bed is positioned against a wall with a peacock artwork. A kitchenette area is visible, alongside a small dining table and a television, providing a comfortable, multifunctional living space.

Farm stay in Timmonsville

4.95 out of 5 average rating, 664 reviews

The Cottage at Dream Acres & Petting Zoo I-95/I-20

The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

Top guest favorite

A living area is shown featuring a large brown sectional sofa with decorative pillows. A green coffee table sits on a light-patterned rug, with a television displaying an underwater scene. The space is illuminated by soft lighting from a dining area visible in the background.

Guesthouse in Florence

4.98 out of 5 average rating, 837 reviews

Boho Private Downtown Stay Near I-95 & Hospital

Comfort, cleanliness, privacy, and personality! Perfect for overnight stays or longer terms. Come enjoy our Boho hideaway in the heart of Florence. Our place has all the amenities of a hotel with the comfort and privacy of your own home including covered parking for two vehicles. We are located within walking distance to downtown Florence and a 5 minute drive to all of the restaurants and shopping that Florence has to offer. Come stay at our guest house and make yourself at home!

Guest favorite

The covered porch features wooden flooring and a railing with views of the surrounding landscape. Two white rocking chairs provide cozy seating, while a small metal table and a decorative crate add functional elements to the space. Sunlight filters through the open areas, creating a serene atmosphere.

Farm stay in Hemingway

4.96 out of 5 average rating, 209 reviews

Quiet farmhouse near the beach

The best memories are made on the farm. Life is just better away from the hustle and bustle of city lights and busy schedules. Come stay in this recently renovated fourth generation 1950s farmhouse on an 80 acre working farm. Unwind on the porch, walk trails, find millions of years old sharks teeth, build a bonfire, pick blackberries, swim in the ponds, collect walnuts, or just relax while you’re here but don’t forget to wish on a dandelion or a shooting star before you leave.

Guest favorite

An open living area is visible, featuring a gray sectional sofa and a wooden table set for casual dining. Natural light fills the space through multiple windows. A kitchen area is seen in the background, with appliances neatly arranged for convenience.

Farm stay in Nesmith

4.94 out of 5 average rating, 137 reviews

Country farm cottage

Enjoy a beautiful and fun stay at the farm and get to know over 100 rescued farm animals! 60 acres and only about 5 miles from Backwoods quail club and river landing. Wake up to the roosters crowing and the birds chirping. Settle in for the night with the sound of the crickets and if nature plans for it some really beautiful sunsets. 4 beds in upstairs loft. Sofa pulls out to a bed. 1 hour to Myrtle Beach. 1.5 hour to Charleston. 30 mins to Georgetown.

Top guest favorite

A charming blue house is situated in a friendly neighborhood, featuring a welcoming front porch with hanging plants and an American flag. The home is flanked by two adjacent houses, surrounded by greenery and well-maintained lawns, contributing to a pleasant street view.

Home in Georgetown

4.97 out of 5 average rating, 128 reviews

Pepe's Place

This charmer is located in the historical district of Georgetown, SC. This home has been updated and should be the perfect place for your stay when visiting. This home is a comfortable and inviting place to spend your time when not exploring the waterfront, great restaurants, or whatever is bringing you to this beautiful historical city. You can also enjoy our closest beach located in Pawley's Island or even take a day trip to Charleston.