
Pet-friendly vacation rentals in Florence County
Find and book unique pet-friendly homes on Airbnb
Top-rated pet-friendly home rentals in Florence County
Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.

Kuker Cottage Downtown Florence-Near I95 & I20
Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20
4.86 out of 5 average rating, 644 reviews
Peaceful cabin retreat! Collins Quarters
In the middle of town, this unique place has a style all on its own. Inspired by Mountain Bungalows and Spanish accents, this one of a kind home sits directly beside MUSC in Florence SC. Close to everything you can possibly need, amenities include: 1 King bed, 1 Queen bed, 1 twin bed, 1 Full Size sofa bed, a full kitchen with living room and dining area, outdoor shower, and a nice sizable front porch to sit and sip your morning coffee looking over a beautiful landscaped front yard. Dog friendly!
4.95 out of 5 average rating, 83 reviews
Quiet Townhome | King Bed | Easy I-95/I-20
Style meets Southern comfort in this West Florence gem. Sleeping up to 6, our quiet rowhome is the ultimate sanctuary after a long drive. Enjoy the luxury of a King-sized bed in the primary suite, outlets on every nightstand and a Smart TV in every room (Cable TV), or sip morning coffee on the private back patio. Tucked away from foot traffic yet only minutes from I-20/I-95, Florence Center, and the Florence Soccer Complex, we offer the perfect blend of total tranquility and city convenience.
5.0 out of 5 average rating, 56 reviews
Cozy 2BR Near McLeod & MUSC | Pet-Friendly
Perfect for traveling professionals or vacationers, this 2BR/1BA home is quiet, comfortable and minutes from the heart of Florence. Enjoy fast Wi-Fi, on-site parking, and a fully furnished pet-friendly space in a layout ideal for solo travelers or shared stays. Unwind on the spacious front porch or private deck in a space set up to support your stay. The central location of this home and nearby amenities make it perfect for short stays or extended assignments. Please inquire about pet fees.
4.96 out of 5 average rating, 27 reviews
Gated and Private Catholic Hermitage house
Saint Michael Hermitage and retreat is a serene, gated, private home that is for 1-3 guests looking for a quiet stay while traveling or as a retreat destination. You will self check into your Hermitage after you obtain a gate code. There is a prayer chapel close by on the property. It is pet friendly for a well trained pet. There is Catholic iconography throughout the home. It is warm and inviting. There is a full kitchen, washer/dryer for your convenience and complementary coffee/tea.
4.98 out of 5 average rating, 179 reviews
“Feels Like Home” Near I-95, King Bed
Located just 5 mins from I-95 , this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, pls) but are not allowed on our beds. King bed in master, 3 TV's, coffee bar with Keurig, strong WiFi. We use 100% cotton sheets and quilts for your maximum sleeping comfort. NOTE- OUR COTTAGE IS NOT TO BE USED AS A VENUE FOR GATHERINGS OF ANY KIND. ABSOLUTELY NO SMOKING OR VAPING ON OUR PROPERTY ($200 fine!)
4.97 out of 5 average rating, 1117 reviews
Charming Home in Florence, SC
Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.
4.9 out of 5 average rating, 126 reviews
The Cottage at Dream Acres & Petting Zoo I-95/I-20
The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller studio space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!
4.95 out of 5 average rating, 784 reviews
Boho Private Downtown Stay Near I-95 & Hospital
Comfort, cleanliness, privacy, and personality! Perfect for overnight stays or longer terms. Come enjoy our Boho hideaway in the heart of Florence. Our place has all the amenities of a hotel with the comfort and privacy of your own home including covered parking for two vehicles. We are located within walking distance to downtown Florence and a 5 minute drive to all of the restaurants and shopping that Florence has to offer. Come stay at our guest house and make yourself at home!
4.98 out of 5 average rating, 983 reviews
Quiet farmhouse near the beach
The best memories are made on the farm. Life is just better away from the hustle and bustle of city lights and busy schedules. Come stay in this recently renovated fourth generation 1950s farmhouse on an 80 acre working farm. Unwind on the porch, walk trails, find millions of years old sharks teeth, build a bonfire, pick blackberries, swim in the ponds, collect walnuts, or just relax while you’re here but don’t forget to wish on a dandelion or a shooting star before you leave.
4.96 out of 5 average rating, 251 reviews
Cottage by the Pool: Close to Interstates
Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, full sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.
4.94 out of 5 average rating, 1011 reviews
Highway Oasis in Florence, Darlington & Hartsville
Welcome to this charming new house ideally situated close to both a major highway i 95 and i20 and the serene Myrtle beach, offering the perfect blend of convenience . Nestled in a great neighborhood, this residence boasts easy access to shopping center, ensuring that all your daily needs are just moments away. Very close to Florence Civic Center, 15 minutes to Buc-ee's Myrtle beach in 1 hr of a drive and shopping amenities.
4.98 out of 5 average rating, 250 reviewsPopular amenities for Florence County pet-friendly home rentals
Pet-friendly house rentals

Come Stay A While.
4.89 out of 5 average rating, 44 reviews
Sleeps on the Creek!
4.95 out of 5 average rating, 95 reviews
Home Sweet Home!
4.94 out of 5 average rating, 16 reviews
Crystal Place Near MUSC and Mcleod Hospital
4.89 out of 5 average rating, 28 reviews
Can do condo!
4.96 out of 5 average rating, 26 reviews
* NEW * Cozy and Clean 3B/2Bath
5.0 out of 5 average rating, 30 reviews
Go With the Flo
4.73 out of 5 average rating, 11 reviews
Beautiful place in the wild
5.0 out of 5 average rating, 45 reviewsPrivate, pet-friendly home rentals

Vintage Cottage at I-95 & I-20
5.0 out of 5 average rating, 36 reviews
Saved by Grace Retreat 2 Rustic Creekside Cabins
4.98 out of 5 average rating, 43 reviews
The Hanna Farmhouse
4.9 out of 5 average rating, 62 reviews
Cozy & Convenient 1 Bd 1 Bath Apt. with/ Courtyard
4.76 out of 5 average rating, 46 reviews
Woodland Country Camper Near Florence & I-95
4.96 out of 5 average rating, 25 reviews
The Hideaway at Fox Fields
5.0 out of 5 average rating, 78 reviews
Modern 1 bedroom condo near downtown Florence
4.95 out of 5 average rating, 60 reviews
Private apartment minutes from Darlington Raceway
5.0 out of 5 average rating, 32 reviewsDestinations to explore
- Myrtle Beach Boardwalk
- Garden City Beach
- Broadway at the Beach
- Huntington Beach State Park
- Myrtle Beach State Park
- Family Kingdom Amusement Park
- Myrtle Beach SkyWheel
- Myrtle Waves Water Park
- Caledonia Golf & Fish Club
- Lakewood Camping Resort
- Murrells Inlet Marsh Walk
- WonderWorks Myrtle Beach
- Hollywood Wax Museum
- The Bowery
- Captain George's Seafood Restaurant
- Pelicans Ballpark
- Atalaya Castle
- Medieval Times Dinner & Tournament
- Topgolf
- Broadway Grand Prix
- Wild Water & Wheels
- Oceanside Village
- Ripley's Aquarium of Myrtle Beach
- Conway Riverwalk




