Hotel vacation rentals in Florence County

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Top-rated hotel rentals in Florence County

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Hotel room in Florence

3.29 out of 5 average rating, 7 reviews

Florence Inn with King size bed, WiFi, bathroom

Welcome to Florence Inn & Suites, your cozy and convenient stop in Florence, SC. Located halfway between Miami and New York, we’re perfect for travelers, construction crews, and truck drivers. Our clean, pet-friendly rooms feature tile floors, ideal for both short and long stays. With a QuikTrip truck stop just 0.2 miles away, our location is unbeatable. Enjoy friendly service, a peaceful atmosphere, and all the comforts of home. Book your stay at Florence Inn & Suites today.

Hotel room in Florence

New place to stay

Suite w/ Kitchen + Free Parking & Outdoor Pool

Discover award-winning comfort at the Residence Inn by Marriott in Florence, SC, where every detail is designed with space and convenience in mind. Guests can enjoy a variety of amenities including an outdoor pool, putting green, free WiFi throughout the property, a 24-hour fitness center, guest laundry, and business center—all available around the clock. The location couldn’t be more convenient, sitting less than a mile from the junction of I-95 (Exit 160A) and I-20.

Hotel room in Florence

New place to stay

Studio w/ Kitchen | Free Breakfast & Parking

Superhost

Hotel room in Florence

4.83 out of 5 average rating, 24 reviews

Near Magnolia Mall | Gym. Outdoor Pool. Breakfast.

Craving space, sunshine, and a spot you can actually walk to from the action? Welcome to TownePlace Suites Florence—newly renovated and perfectly placed near the Florence Center. Whip up meals in your in-suite kitchen, catch a live show next door, dive into the pool, or hit Magnolia Mall just minutes away. With I-95 and I-20 right there, it’s the stay that keeps your trip smooth, local, and totally stress-free.

Superhost

Hotel room in Florence

Close to I-95 | Grill. Pool. Free Parking.

Hotel room in Darlington

4 out of 5 average rating, 5 reviews

Raceway Inn Darlington with King size bed, WiFi

Raceway Inn Darlington - Comfortable Stay Near the Heart of Racing Action Welcome to Raceway Inn Darlington, your ideal home away from home located just minutes from the legendary Darlington Raceway. Whether you’re here for the thrilling races, a business trip, or simply to explore the charming town of Darlington, our inn offers a comfortable and convenient stay.

Hotel room in Darlington

3.9 out of 5 average rating, 10 reviews

Hotel in Darlington with 2 full size beds, WiFi

Hotel room in Florence

3.95 out of 5 average rating, 21 reviews

Florence Inn with 2 full size bed, WiFi, bathroom

Welcome to Florence Inn & Suites, where comfort meets convenience in the heart of Florence, SC! Our charming hotel offers a perfect stopover for travelers, located halfway between Miami and New York. Nestled near major highways, we’re just a stone’s throw from local attractions, a bustling Publix, and a truck-friendly QuikTrip station