
House vacation rentals in Pickens County
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Top-rated house rentals in Pickens County
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Pickens County house rentals
House rentals with a pool

Keowee Key Luxury Condo - Stunning Views!

The Hawks Nest

Lake Keowee condo by marina&pool close to Clemson

Lake Keowee Access-Dock-Pool-Grill-Clemson 17 Min

Lake Keowee Home near Clemson, boating, and hiking

Clemson football 15 minutes away. 2 night minimum.

Historic Pendleton SC

Golf view, lake access, 3 pools!
Weekly house rentals

Singing Pines Cottage

12 min to Clemson | Quiet home in small town S.C.

Taking it Easley/FirePit/Near Dwn GVL/HtTub/Silos

Robin’s Nest- Cottage in the Woods

Lake Keowee SC Lakehouse Escape

Frankie’s Place

Cozy Brick House

Respite House
Private house rentals

Lake Keowee Beach Club Cabin

Elegant 3BR Near Wed Venu | Grill+ Golf Next Door

Ivy Cottage

Cozy 3 Br Family Home • 5 min to Clemson Campus

Rare 1930’s Riverfront Cottage

Lakefront luxury home w/panoramic view & Boat Slip

DockTales - Panoramic Views & Private Dock

Keowee Key Retreat | Lake, Pools & More!
Destinations to explore
- Rentals with a washer and dryer Pickens County
- Rentals with an EV charger Pickens County
- Rentals with breakfast Pickens County
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- Rentals with a fire pit Pickens County
- Waterfront rentals Pickens County
- Rentals with lake access Pickens County
- Cabin rentals Pickens County
- Condo rentals Pickens County
- Rentals with outdoor seating Pickens County
- Pet-friendly rentals Pickens County
- Rentals with a kayak Pickens County
- Rentals with a patio Pickens County
- Rentals with a hot tub Pickens County
- Rentals with a fireplace Pickens County
- Rentals with pools Pickens County
- Apartment rentals Pickens County
- Kid-friendly rentals Pickens County
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- Blue Ridge Parkway
- River Arts District
- Black Rock Mountain State Park
- Gorges State Park
- Table Rock State Park
- Tryon International Equestrian Center
- Mountaintop Golf & Lake Club
- Tugaloo State Park
- Tallulah Gorge State Park
- Chimney Rock State Park
- The North Carolina Arboretum
- Jump Off Rock
- Wade Hampton Golf Club
- Ski Sapphire Valley
- Old Edwards Club
- Maggie Valley Club
- French Broad River Park
- Biltmore Forest County Club
- Lake Lure Beach and Water Park
- Victoria Valley Vineyards
- Vineyards for Biltmore Winery
- Carl Sandburg Home National Historic Site
- Haas Family Golf
- Discovery Island