Hotel vacation rentals in Panama

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Top-rated hotel rentals in Panama

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Guest favorite

A spacious sitting area is framed by large panoramic windows, offering sweeping views of lush greenery and distant mountains. The modern furnishings include two light-colored sofas and a glass coffee table, complementing the bright atmosphere created by natural light.

Hotel room in Boquete

4.98 out of 5 average rating, 42 reviews

La Residencia - Suite Bella Vista

This Impressive, extravagant, light flooded Suite with breathtaking view to the Baru Volcano is located just a 10-minute walk from the center of Boquete. Modern and contemporary style with a high sense of detail, located in the second floor of an extraordinary mansion. Luxurious 80m² suite (King-Size/Orthopedic mattress) with spacius private bathroom, huge walkin closet, private full equipped kitchenette, panoramic window, 2 air conditioners, free parking, fast Wifi, cable TV, Netflix, Spotify.

Guest favorite

A spacious bedroom features a wooden platform bed with a blue patterned mattress. Large glass doors open to a private patio, surrounded by lush greenery. Two chairs are positioned on the terrace, and a colorful framed artwork adorns the wall near a window.

Hotel room in PA

4.9 out of 5 average rating, 29 reviews

Treetop views of the Pacific in a boutique cabaña

No detail left unnoticed…our boutique cabañas are nestled in jungle gardens with private porches overlooking the Pacific, hammocks for lounging, indoor/outdoor concept bathrooms, stunning hardwood floors, and custom-made furniture. Each of our three cabañas has its own unique charm where comfort meets luxury. We are steps from the beach and minutes from consistent surf breaks and community yoga classes. A shared kitchen is on site, with individual cooking utensils provided for each room.

Superhost

A spacious room features a king bed with soft white linens and colorful striped accent pillows. The headboard is constructed from light wood, complementing the contemporary design. A view of the city skyline is visible in the artwork above the bed, enhancing the room's ambiance.

Hotel room in Panamá

4.82 out of 5 average rating, 11 reviews

Very Nice Downtown Panamá Hotel Free Parking

Welcome to the beautiful Aloft Panamá hotel This is a very nice and safe hotel located in the San Francisco area of Panamá with beautiful city views. King or 2 queen based on availability (Feel free to make request prior to booking if you have a preference) All rooms non smoking ($350 fine) No pets allowed Must be 21 with id to checkin Must have credit card for incidentals Checkin time starts at 3pm Checkout time before noon Free Parking Pool Bar/Lounge

Superhost

An outdoor terrace features several lounge chairs and tables shaded by large umbrellas. A swimming pool extends along one side, with a backdrop of modern high-rise buildings under a partly cloudy sky. Lush greenery is present in planters, adding a touch of nature.

Hotel room in Panamá

4.83 out of 5 average rating, 6 reviews

En el corazón de la ciudad.

Hotel Mio Panamá somos un hotel 4 estrellas situado en la ciudad de Panamá, en el corazón del área financiera. Nuestro principal objetivo es satisfacer cualquier necesidad del cliente, ofreciendo los mejores servicios para garantizar una estancia cómoda y tranquila. Entre nuestras modernas instalaciones, encontrará una piscina, habitaciones amplias y cómodas, gimnasio, salas de reuniones y rooftop. Si le gusta viajar con su mascota, somos pet friendly.

Superhost

A round wooden dining table is set for four, surrounded by light-colored chairs. A chandelier hangs above, casting a warm glow. Light enters through open doors, highlighting wall art and plants, creating a welcoming dining space.

Casa particular in Dolega District

5 out of 5 average rating, 4 reviews

Wanakaset Forest Haven 2BR, River & shared Pool

Casa Quetzal is a serene 2-bedroom retreat nestled in the lush forest of Wanakaset Panama, perfect for up to 4 guests. With its open-plan living space, modern bathrooms, and fully equipped kitchen, it offers comfort in a natural setting. Relax on the private terrace or enjoy the shared pool, just a short walk away. Surrounded by rivers and tropical greenery, it’s an ideal escape for nature lovers seeking tranquility and a peaceful getaway.

Guest favorite

The villa is situated amidst lush greenery, showcasing a modern design that blends with the surrounding jungle. Spacious outdoor areas are visible, with seating arrangements under the shade of trees, inviting a relaxed atmosphere for guests to enjoy their surroundings.

Hotel room

4.95 out of 5 average rating, 20 reviews

Boutique Inn_The Hill 2_Private Entry_Tripple_+16

The Hill Panama, our Boutique Inn Adult Only (16+) is proud to be featured on Architectural Digest Magazine, located in the heart of enchanted Cambutal Beach, just a 5 five-minute walk to the beach, surrounded by several surf spots, balance between mountain and sea, hidden amongst the jungle canopy. This listed Room 2 was designed as a boutique hotel room with separated private entry and communal kitchen.

Guest favorite

A cozy sleeping area features a plush bed with a light-colored quilt and dotted pillows. A bedside table holds a small lamp, providing soft lighting. The wall is adorned with a unique decorative panel, and a ceiling fan offers comfort.

Private room in Panamá

4.83 out of 5 average rating, 23 reviews

Desk & Dream Room

Disfruta de la comodidad de este alojamiento tranquilo y céntrico en el corazón de San Francisco, tiene escritorio dentro de la habitación para trabajar o estudiar en un ambiente relax, con las demás comodidades incluyendo televisor led HD de 32" Justo en la calle de al lado está el super mercado, farmacia al frente, restaurantes, tiendas de chinitos, panaderías, paradas del metro bus cercanas.

Guest favorite

A serene outdoor seating area is featured on a wooden dock above the water, illuminated by soft string lights. Guests are seen relaxing under thatched umbrellas, with a picturesque sunset reflecting on the calm surface of the sea.

Hotel room in Bocas del Toro

4.99 out of 5 average rating, 71 reviews

BarrBra / Double Bed / Priv. Bath. / Ac

- house built right over the Caribbean sea - bedroom with double sized bed & balcony - private bathroom (hot water shower) - air conditioning included - a la carte breakfast included (between 8 - 9:30 a.m.) - guest kitchen - sunset orientated (yes, we're facing west! :)) - ocean access from our private dock - in-house kayak, bike and snorkel gear rentals - gay-friendly place

A wooden cabana sits elevated on stilts, topped with a thatched roof. Steps lead up to the open side, revealing a cozy interior. Surrounding foliage includes a variety of trees and plants, contributing to the natural setting of the community.

Nature lodge in Darién Province

4.7 out of 5 average rating, 20 reviews

La Chunga

La Chunga is in a difficult access indigenous community without electricity or roads. Come see this gem of a community and the indigenous way of life. You’ll love this place because of the nature walks, the wildlife, the gastronomy, and the people. We have a number of guided tours and adventures. My place is good for adventurers trying to see something new and exciting.

Guest favorite

A comfortable bedroom features a spacious bed with layered bedding, including throw pillows in various patterns. The nightstands are equipped with pendant lighting, adding to the inviting ambiance. Fresh towels are neatly arranged at the foot of the bed, while natural light filters through a nearby window.

Hotel room

4.78 out of 5 average rating, 139 reviews

Private Room in Boquete

Enjoy the simplicity of this quiet and central accommodation in town, just a few steps from grocery stores, restaurants, bars, coffee shops, with easy access to public or private transportation. This room has a comfortable bed, private bathroom with hot water ample space, the kitchen is perfectly equipped to share with two other rooms, the garden is beautiful.

Guest favorite

Large green doors open to a charming balcony, revealing a view of a red-tiled roof and a small table with two chairs. A soft sofa is positioned nearby, complementing the inviting atmosphere of the space.

Hotel room in Panamá

4.86 out of 5 average rating, 105 reviews

Corcho rooms #2 - king room with balconies

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.

Guest favorite

A double bed with crisp white linens is positioned against a light-colored wall. Air conditioning is mounted above, providing comfort. A handmade garment rack is visible to the side, along with a decorative piece and a doorway leading outside.

Private room in Santa Catalina

4.95 out of 5 average rating, 22 reviews

Casa Manila Doble Room with terrace

Welcome to our calm place in front of the ocean. The place is perfect for relaxing on your private terrace and offers breathtaking views of the pacific ocean. In our freshly renovated rooms with A/C you can enjoy a cold breeze after a sunny day. At the end of the day you will be surprised by the best sunset in Santa Catalina.