
Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.

Spacious, Over the Water Home with Plunge Pool
Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.

Casa Coco - Beautiful Mountain Villa With AC
Elegant and modern, our home strikes the perfect balance between luxury and warmth. With ample space to accommodate large groups and families, as well as cozy and inviting for smaller groups. The yard features a covered social area, ideal for relaxing or entertaining. A lush garden adorned with vibrant greenery includes a charming mango tree and mountain peak views. A 5 minute walk to restaurants and the open air market. If you have a group larger than 12- please reach out to us directly.

OceanView-Rooftop Jacuzzi&Pool | Concierge Service
Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Beach House with Pool/Gazebo in Punta Chame!
"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Beautiful House in Panama w/ King Beds + Pool
Beautiful home in Punta Paitilla featuring 6 bedrooms, 5.5 bathrooms, and 8 beds, comfortably accommodating up to 16 guests. Enjoy a private pool, in-home gym, and spacious, modern living areas designed for families, groups, or business travelers. The layout offers both privacy and comfort across two levels. Located in one of Panama City’s most exclusive neighborhoods, just minutes from restaurants, shopping centers, supermarkets, and the Cinta Costera.

Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Tropical Haven with Pickleball/Yoga Platform
Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

BirdHouse — Gamboa, Panama Canal Rainforest
BirdHouse: Let's inhabit the space. Designed for people who want to experience the tropics, not shut them out. Open the screens, feel the breeze, listen to the rain, cool off in the pool, and wake to birds and howler monkeys. Located in historic Gamboa, BirdHouse is a place to slow down and experience one of the world’s richest tropical forests from the comfort of a thoughtfully designed home.

#1 Villa with a swimming pool, jacuzzi, pool table, and ping pong.
Spectacular villa a few minutes from the beach by car, super spacious, ideal to share with family, friends or corporate meetings. The property is full of surprises and with many things to do including its swimming pool, jacuzzi, pool table, ping pong table, domino table, hammocks, large green areas, gas BBQ, variety of board games and a fully equipped kitchen.

Infinity Pool Boutique Villa on The Point Break
Our Private Boutique Style Yoga and Surf Villa features comfortable rooms, many with unobstructed ocean views. Each room is airconditioned with a private bathroom. Our guests are like family, spend downtime between yoga, surf, and the infinity pool, relishing spectacular sunset views.

Unique Historic House in Casco
Hip five bedroom house in the heart of Casco Antiguo. Designed by world renowned restoration architect; this house is a perfect spot for exploring Panama's wonders. Ideal for families wanting to spend some time around the vibrant historic area.

Casa del Mar - eco aqua villa
Dolphin Bay, Archipelago of Bocas del Toro, Panama Welcome to your private carbon-neutral Carribean over-the-water villa. You will have access to intrepid adventures or just relax in a hammock overlooking the sea.
Popular amenities for Panama mansion rentals
Luxury mansion rentals

Luxury beachfront villa!

Luxury Beachfront Home • Private Pool • Coronado

Beachfront | Rooftop | Amazing Villa in PuntaChame

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura

Beachfront Home | En-Suites + Chef & Tours Avail

Villa Vita Oceanfront Mansion

Villa Papagayo, Playa Morrillo, Veraguas

Charming House in Casco Viejo
Pet-friendly mansion rentals

Spacious House | Garden and Terrace | Pet Friendly

Costa Blanca Beach & Golf Villa by Decameron

Pacific View | Jacuzzi, Pool, Views and Alexa

Exclusive apartment steps from the sea in Puntarena

Cozy Lagoon View Apartment | BBQ

Luxurious country house, pleasant climate, with fireplace, jacuzzi, pool table, barbecue area, fire pit and more...

Villa GiGi - Beach Home Panama Santa Clara

Spectacular Beachfront House
Mansion rentals with a pool

Spacious 4Br Beachside Getaway at Playa Escondida

Playa Escondida with the Best Direct Ocean View

Nice duplex house with a swimming pool.

Cerro Azul, Country House with Heated Pool.

Buenaventura | Luxury Beach Apartment | Panama

Spectacular apartment in Playa Blanca Resort.

Cottage + Pool + Wi-Fi + AC + Beach @Playalosdestiladeros

Live an adventure in Taboga 2
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