
Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.

Casa Coco - Beautiful Mountain Villa With AC
Elegant and modern, our home strikes the perfect balance between luxury and warmth. With ample space to accommodate large groups and families, as well as cozy and inviting for smaller groups. The yard features a covered social area, ideal for relaxing or entertaining. A lush garden adorned with vibrant greenery includes a charming mango tree and mountain peak views. A 5 minute walk to restaurants and the open air market. If you have a group larger than 12- please reach out to us directly.
4.93 out of 5 average rating, 103 reviews
Spacious Over-Water Home with Private Plunge Pool
Perched over the water in Bastimentos Bay, this well-appointed four-bedroom and three-bath single-family home combines classic Caribbean architecture with modern sensibilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, look for the dolphins, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten-minute trip to Bocastown.
4.83 out of 5 average rating, 143 reviews
Spacious 6BR House w/ Pool, Gym & King Beds
Enjoy a spacious private home in the heart of Punta Paitilla, one of Panama City’s most central neighborhoods. Perfect for families and groups, the house features 6 bedrooms, 5.5 bathrooms, 9 beds, a private pool, and plenty of space to relax, comfortably accommodating up to 17 guests. Walk to supermarkets, restaurants, and nearby synagogues, or reach Multiplaza and other popular areas of the city within minutes. A comfortable and convenient home base for enjoying Panama City together.
4.98 out of 5 average rating, 120 reviews
Spacious House | Garden and Terrace | Pet Friendly
Discover the pleasure of staying in a private, elegant, and light-filled villa within the exclusive Playa Blanca Beach & Lagoon. Start your day with the tropical breeze on the terrace, relax by the pool, and enjoy a short 10-minute walk to the beach. Perfect for families and travelers seeking rest, security, and resort-style comfort. Ideally located 10 minutes from Scarlett Martínez Airport and 2 hours from Panama City, it's the perfect place for an unforgettable getaway by the sea.
4.98 out of 5 average rating, 146 reviews
OceanView-Rooftop Jacuzzi&Pool | Concierge Service
Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.
4.94 out of 5 average rating, 155 reviews
Beach House with Pool/Gazebo in Punta Chame!
"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"
4.97 out of 5 average rating, 154 reviews
Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.
4.92 out of 5 average rating, 196 reviews
Tropical Haven with Pickleball/Yoga Platform
Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.
4.98 out of 5 average rating, 234 reviews
BirdHouse — Gamboa, Panama Canal Rainforest
BirdHouse: Let's inhabit the space. Designed for people who want to experience the tropics, not shut them out. Open the screens, feel the breeze, listen to the rain, cool off in the pool, and wake to birds and howler monkeys. Located in historic Gamboa, BirdHouse is a place to slow down and experience one of the world’s richest tropical forests from the comfort of a thoughtfully designed home.
4.86 out of 5 average rating, 111 reviews
Infinity Pool Boutique Villa on The Point Break
Our Private Boutique Style Yoga and Surf Villa features comfortable rooms, many with unobstructed ocean views. Each room is airconditioned with a private bathroom. Our guests are like family, spend downtime between yoga, surf, and the infinity pool, relishing spectacular sunset views.
4.9 out of 5 average rating, 119 reviews
Unique Historic House in Casco
Hip five bedroom house in the heart of Casco Antiguo. Designed by world renowned restoration architect; this house is a perfect spot for exploring Panama's wonders. Ideal for families wanting to spend some time around the vibrant historic area.
4.95 out of 5 average rating, 179 reviews
Casa del Mar - eco aqua villa
Dolphin Bay, Archipelago of Bocas del Toro, Panama Welcome to your private carbon-neutral Carribean over-the-water villa. You will have access to intrepid adventures or just relax in a hammock overlooking the sea.
4.99 out of 5 average rating, 102 reviewsPopular amenities for Panama mansion rentals
Luxury mansion rentals

Spacious 4Br Beachside Getaway at Playa Escondida
4.95 out of 5 average rating, 149 reviews
Club House facing the lake with dock, jacuzzi and BBQ
5.0 out of 5 average rating, 6 reviews
Luxury Beachfront Home • Private Pool • Coronado
4.89 out of 5 average rating, 18 reviews
24o Penthouse Unique Design 2 Balconies Oceanview
5.0 out of 5 average rating, 35 reviews
Villa Papagayo, Playa Morrillo, Veraguas
4.82 out of 5 average rating, 22 reviews
Luxury beachfront villa!
4.94 out of 5 average rating, 33 reviews
Luxury Beachfront Escape | Playa Escondida Resort
5.0 out of 5 average rating, 19 reviews
Beachfront | Rooftop | Amazing Villa in PuntaChame
4.91 out of 5 average rating, 45 reviewsPet-friendly mansion rentals

#1 Villa with a swimming pool, jacuzzi, pool table, and ping pong.
4.97 out of 5 average rating, 128 reviews
Costa Blanca Beach & Golf Villa by Decameron
4.9 out of 5 average rating, 254 reviews
Pacific View | Jacuzzi, Pool, Views and Alexa
4.82 out of 5 average rating, 110 reviews
Exclusive apartment steps from the sea in Puntarena
4.99 out of 5 average rating, 146 reviews
Cozy Lagoon View Apartment | BBQ
4.98 out of 5 average rating, 179 reviews
Luxurious country house, pleasant climate, with fireplace, jacuzzi, pool table, barbecue area, fire pit and more...
4.81 out of 5 average rating, 108 reviews
Laguna Fun and Sun: Your Escape Awaits
4.85 out of 5 average rating, 102 reviews
Villa GiGi - Beach Home Panama Santa Clara
4.78 out of 5 average rating, 102 reviewsMansion rentals with a pool

Stylish & Quiet ~ Breathtaking Laguna Views ~Pool
4.96 out of 5 average rating, 145 reviews
Playa Escondida with the Best Direct Ocean View
4.99 out of 5 average rating, 95 reviews
Nice duplex house with a swimming pool.
4.97 out of 5 average rating, 61 reviews
Cerro Azul Mountain Retreat un hogar mágico.
4.95 out of 5 average rating, 41 reviews
5BR Mansion w/ Private Pool & Skyline Views
4.92 out of 5 average rating, 76 reviews
4 Rec - Piscina climatizada - *Free Late-Check Out
4.91 out of 5 average rating, 34 reviews
Oceanfront views/access w/ Pool, Privacy & Space
4.81 out of 5 average rating, 21 reviews
Cerro Azul, Country House with Heated Pool.
4.9 out of 5 average rating, 42 reviewsDestinations to explore
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