Mansion vacation rentals in Panama

Find and book unique mansions on Airbnb

Top-rated mansion rentals in Panama

Guests agree: these mansions are highly rated for location, cleanliness, and more.

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Superhost

A private pool reflects the soft glow of the evening sky, with the exterior of the house revealing large glass doors. The inviting living area and dining space are visible inside, illuminated warmly, surrounded by lush greenery.

Home in Las Lajas

4.94 out of 5 average rating, 16 reviews

Villa Topi - The Perfect Getaway

Embark on a coastal escape in the heart of Coronado, just a 3-minute stroll from the sun-soaked beach. Our lavish 5-bedroom, 5.5-bathroom retreat boasts 11 beds, a private pool, enchanting garden, and inviting patio. Bask in seaside serenity within the sunlit living room and explore culinary delights in the fully-equipped kitchen. This luxurious haven offers elegance and proximity to the Coronado beach, ensuring a dream getaway in this charming town. Welcome to your perfect retreat by the sea!

Top guest favorite

Cottage in Panama City

4.95 out of 5 average rating, 21 reviews

Cerro Azul Mountain Retreat a magical home.

Disfruta de la comodidad y el lujo en esta espaciosa casa con 6 habitaciones y 5 baños. La terraza perfecta para relajarte al aire libre, mientras que el comedor ideal para compartir momentos especiales con tus seres queridos. El invernadero es un oasis de ingredientes frescos, listos para inspirar deliciosas y saludables creaciones en la cocina, esto añade un toque encantador, permitiéndote conectar con la naturaleza desde la comodidad de tu hogar. Cuenta con cuarto de juegos mesa de billar.

Top guest favorite

Villa in Punta Paitilla

5 out of 5 average rating, 13 reviews

5BR House in Panama City w/ Pool & King Beds

Enjoy a family or friends' getaway in this modern, newly remodeled house. This property boasts 5 bedrooms, 4.5 bathrooms, 10 beds, and can comfortably accommodate up to 15 guests. The house also features a private outdoor pool, where you can soak up the sun and cool off on hot days, all while being in a central location, just meters away from malls, supermarkets and night life. It's fully furnished with everything you could possibly need to ensure your stay is as comfortable as possible.

Top guest favorite

A large outdoor pool is surrounded by tropical palm trees, creating a tranquil atmosphere. Comfortable lounge chairs are arranged along the edges of the pool, inviting relaxation. The clear blue water reflects the sky, contributing to a serene outdoor setting.

Apartment in El Chirú

4.95 out of 5 average rating, 100 reviews

Buenaventura Golf & Beach Resort Lux Apartment

280 m2 apartment features 3 bedrooms and a service room with its own bathroom (may also be used as an office/additional bedroom). Every room has its own bathroom and a superking bed, big screen TV in the living room, TV in the bedrooms, a fully equipped kitchen with a dishwasher and a microwave, a big fridge, everything necessary for cooking, a large terrace with a BBQ (gas), high speed internet. When booking 7 NIGHTS or more we are offering the guests the use of the MULE (free of charge).

Guest favorite

A serene outdoor space is viewable, featuring manicured grass and several chairs arranged around a small table. Lush trees provide shade, while the beach and ocean are visible in the background, creating a tranquil setting for relaxation.

Home in Nueva Gorgona

4.95 out of 5 average rating, 20 reviews

Spectacular seaside property with beach access

Spectacular property with private access to the beach, garden, hammocks and panoramic view of the bay, just over an hour's drive from Panama City. A place with a lot of privacy and nature, it is perfect to relax, have a barbecue with the family, walk on the beach, lie in a hammock and enjoy the beautiful sunset with the sound of the sea. There are two wonderful caretakers in the property who are in charge of security, cleaning, and can answer questions and help you with anything you need.

Top guest favorite

A spacious terrace features a sleek granite bar with ample counter space. Large windows provide unobstructed views of the surrounding green hills and cityscape. Natural light brightens the area, enhancing the inviting open layout.

Villa in Panamá

4.98 out of 5 average rating, 49 reviews

Breathtaking Views Mansion w/King Beds

Book your next thrilling Panama City vacation at our dreamy 11,500 sq. foot multi-story family mansion, superbly located on a hilltop high above the metropolis in this affluent neighborhood. Ideal for longer stays. Discover the vibrant buzz of Cinta Costera or explore the UNESCO world heritage sites at Casco Viejo – all under 5 km away from your doorstep. Enjoy a refreshing dip into the swimming pool and admire the sublime views of the Panama City Skyline from our unique roof terrace.

Guest favorite

Home in San Carlos

4.95 out of 5 average rating, 117 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base price covers 4 guests (additional charge $40 per person). Sleeps up to 25 guests.

Superhost

An outdoor space features a serene private pool with a connecting hot tub, surrounded by sleek lounge chairs. A shaded seating area is visible in the background, offering ocean views. The clear sky complements the tranquil atmosphere of the luxurious setting.

Home in Vista Mar Golf, Beach & Marina

4.88 out of 5 average rating, 246 reviews

Luxurious Beach House - Private Pool Golf & Marina

Vista Mar Golf, Beach & Marina is a gated community with private security, with direct access to a state of the art golf course designed by J. Michael Poellot. It also has marina, heliport, tennis courts, direct private beach access, bars and restaurants. The house comes with an outdoor private pool & hot tub, also a amazing private outdoor kitchen, and an amazing sea view with spectacular sunrises and sunsets. any inquiry please contact 66168596

Superhost

Villa in Juan Gallego

4.77 out of 5 average rating, 22 reviews

Fantastic KasaKai Villa

Nestled as the prime choice for beachfront living near Panama City, this exclusive Villa boasts unparalleled views of the Caribbean Sea. With a private entrance to the sea and a verdant green area for relaxation or private barbecues, it offers the epitome of luxury for discerning guests seeking a nature-infused escape. Perfectly blending tranquility with top-tier amenities, it's an oasis for those craving the serenity of waterfront living.

Guest favorite

An outdoor swimming pool reflects the sky, surrounded by lush mountain views. Two lounge chairs are positioned nearby, inviting relaxation. Tropical plants add vibrant color to the scene, enhancing the serene atmosphere of the open space.

Cottage in Altos del Maria

4.94 out of 5 average rating, 145 reviews

Mountain Cottage with Great View and Heated Pool

Mountain Cottage, with spectacular views of the Altos del María Mountains, perfect for relaxing or spending time with the family. It features a heated pool, spacious outdoor spaces, Smart TV and A/C in all rooms and living room, Wi-Fi throughout the property, and is fully equipped. Includes Prime Video service. It also has a fire pit and a gas BBQ. Complimentary late checkout is available for rentals departing on Sundays.

Guest favorite

Home in Cocle

4.96 out of 5 average rating, 105 reviews

Panama del Mar

Panama del Mar, nestled in center of Buenaventura, is truly a tropical paradise with a variety of pools, cabanas, pristine beach, restaurants, spas, and everything that makes your vacation relaxing. This spacious home accommodates 12 guests and includes all the conveniences of home. Any further questions can directed to Sandra to 507-6980-1314.

Guest favorite

An open-concept living and dining area features a comfortable seating arrangement with natural light flooding through large windows. A dining table for eight is positioned next to the pool view, creating an inviting space surrounded by lush greenery.

Villa in Farallon

4.91 out of 5 average rating, 222 reviews

4-Bedroom Costa Blanca Golf & Beach Villa

Spacious 4 bedroom, 4.5 bathroom, 250m detached villa overlooking the 7th putting green on Mantaraya Golf Course. Accommodation provided for up to 12 people within 4 bedrooms. The 15m long swimming pool plus shallow area in rear garden is totally private. Villa guests have access to the Property Owners Beach Club and Restaurant.