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Hotel vacation rentals in Panama City

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Panama City

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Casa particular in Panamá

New place to stay

Apartamento histórico - Balcón en Casco Antiguo

🇵🇦Vive la esencia del Casco Antiguo en este apartamento único, diseñado por el arquitecto Sebastián Paniza, conocido por su labor en restauración del Casco Histórico. Sus techos altos, ventanales coloniales y barandales de hierro forjado combinan historia y confort moderno. 🌿 Desde el balcón disfruta calles empedradas y fachadas coloniales. La sala con lámpara tipo candelabro, entrepiso abierto y cocina funcional es ideal para quienes valoran diseño, cultura y ubicación privilegiada.

A spacious room features a king bed with soft white linens and colorful striped accent pillows. The headboard is constructed from light wood, complementing the contemporary design. A view of the city skyline is visible in the artwork above the bed, enhancing the room's ambiance.

Hotel room in Panamá

4.82 out of 5 average rating, 11 reviews

Very Nice Downtown Panamá Hotel Free Parking

Welcome to the beautiful Aloft Panamá hotel This is a very nice and safe hotel located in the San Francisco area of Panamá with beautiful city views. King or 2 queen based on availability (Feel free to make request prior to booking if you have a preference) All rooms non smoking ($350 fine) No pets allowed Must be 21 with id to checkin Must have credit card for incidentals Checkin time starts at 3pm Checkout time before noon Free Parking Pool Bar/Lounge

An outdoor terrace features several lounge chairs and tables shaded by large umbrellas. A swimming pool extends along one side, with a backdrop of modern high-rise buildings under a partly cloudy sky. Lush greenery is present in planters, adding a touch of nature.

Hotel room in Marbella

4.63 out of 5 average rating, 8 reviews

En el corazón de la ciudad.

Hotel Mio Panamá somos un hotel 4 estrellas situado en la ciudad de Panamá, en el corazón del área financiera. Nuestro principal objetivo es satisfacer cualquier necesidad del cliente, ofreciendo los mejores servicios para garantizar una estancia cómoda y tranquila. Entre nuestras modernas instalaciones, encontrará una piscina, habitaciones amplias y cómodas, gimnasio, salas de reuniones y rooftop. Si le gusta viajar con su mascota, somos pet friendly.

A cozy hotel room is showcased with a spacious bed dressed in white linens and a red throw blanket. A wooden desk with two cups and a remote is positioned beside the bed. A soft lamp and a wall-mounted TV complete the inviting atmosphere.

Hotel room in El Cangrejo

4.73 out of 5 average rating, 33 reviews

Cuarto de hotel #3 a una cuadra del Metro.

Disfruta de acceso ràpido a los destinos más populares de Ciudad de Panamà, centros comerciales, restaurantes, y áreas turísticas. Cuarto de hotel con baño privado, aire acondicionado, cable TV, recepciòn con 24 horas de servicio y estacionamientos sujetos a disponibilidad. Cerca de restaurantes y casinos. A una cuadra de la estaciòn del Metro que lo lleva en 10 minutos a Albrook Mall, el Centro Comercial más grande de Panamà.

A close-up view of vibrant purple bougainvillea flowers is presented alongside a well-maintained pathway, leading to a charming building with arched windows and a wooden front door. Green foliage frames the entrance, enhancing the welcoming atmosphere.

Hotel room in Panamá

4.86 out of 5 average rating, 44 reviews

Habitaciones privadas Sofia's B&B Hostal Boutique

Alojamiento tipo hostal boutique, contamos con 7 cómodas habitaciones privadas con baño, para una capacidad total de 18 huéspedes. La tarifa mostrada por Airbnb para tu reserva distribuye 2 huéspedes por habitación, es decir, los huéspedes deberan compartir camas y/o habitaciones. Si requieres una distribución especial de habitaciones para tu grupo, contacta primero con el anfitrión, ya que la tarifa podría variar.

Private room in Santa Cruz De Chinina

5 out of 5 average rating, 4 reviews

Comfort and privacy Casa Orquídea

Casa Orquídea es un Hermoso Residencial ubicado en el corazón de la ciudad de Panamá. Bienvenido a la joya de Paitilla rodeada de edificios, mar, y de una hermosa vegetación, esta casa es el secreto mejor guardado en una de las zonas más exclusivas de la ciudad, con espacios seguros para caminar. Este es el paraíso urbano para los amantes de la naturaleza. ¡Desconéctate y relájate en medio de la ciudad!

A cozy sleeping area features a plush bed with a light-colored quilt and dotted pillows. A bedside table holds a small lamp, providing soft lighting. The wall is adorned with a unique decorative panel, and a ceiling fan offers comfort.

Private room in Panamá

4.83 out of 5 average rating, 23 reviews

Desk & Dream Room

Disfruta de la comodidad de este alojamiento tranquilo y céntrico en el corazón de San Francisco, tiene escritorio dentro de la habitación para trabajar o estudiar en un ambiente relax, con las demás comodidades incluyendo televisor led HD de 32" Justo en la calle de al lado está el super mercado, farmacia al frente, restaurantes, tiendas de chinitos, panaderías, paradas del metro bus cercanas.

An outdoor swimming pool is situated on a rooftop terrace, surrounded by lounge chairs. The skyline of Panama City serves as a backdrop, illuminated by soft twilight hues. Palm plants are placed in decorative pots along the pool's edge, enhancing the space.

Hotel room in Obarrio

5 out of 5 average rating, 3 reviews

Marinn Place | Deluxe King | Cozy Work & Rest

Located in Panama City’s upscale Financial District near Via España and Bella Vista, Marinn Place offers modern comfort, a rooftop pool, and free valet parking in a vibrant urban setting. The spacious Deluxe Double features two plush queen beds, a separate living/sleeping area with a sofa bed, a work desk, and a walk-in glass shower—perfect for families or professionals.

Large green doors open to a charming balcony, revealing a view of a red-tiled roof and a small table with two chairs. A soft sofa is positioned nearby, complementing the inviting atmosphere of the space.

Hotel room in Panamá

4.85 out of 5 average rating, 107 reviews

Corcho rooms #2 - king room with balconies

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.

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Popular amenities for Panama City hotel rentals

Free parking on premises

Air conditioning

Family-friendly hotel rentals

A balcony is visible with two blue chairs positioned for relaxation. The view includes the waterfront, showcasing boats docked in the marina. Soft light fixtures illuminate the wall, creating a calm ambiance, and lush greenery is seen in the distance.

Hotel room in Panama City

4.5 out of 5 average rating, 4 reviews

Deluxe King at Marinn Tropical Vibes, Free Parking

A sleeping area features a spacious bed with a neutral-toned cover and a dark blue blanket folded at the foot. Simple wooden nightstands are mounted on either side, each equipped with bedside lighting. Soft natural light filters through a sheer curtain over a window.

Hotel room in Panamá

4.68 out of 5 average rating, 80 reviews

Tu segundo hogar en Panamá.

The exterior of the house features a two-story structure with a red tiled roof and a decorative balcony. Large windows provide natural light to the interior. A white gated entrance secures the property, while the surrounding area showcases a mix of paved and grass surfaces.

Private room in San Miguelito

Omega: Habitación+espacio común.

The sleeping area features two beds with decorative blue and white patterned bedspreads. A bedside table holds a telephone. Natural light enters from the window, accompanied by light curtains and deep red drapes. The walls are finished in a neutral tone.

Hotel room in Panamá

4.74 out of 5 average rating, 82 reviews

Habitación Familiar Triple sencilla

A spacious room features a double bed with a soft white blanket and two towels neatly arranged. Bedside tables with lamps flank the bed, while a decorative wall with patterned design adds a unique touch. A wooden door leads to another area, enhancing privacy.

Hotel room in Panamá

4.68 out of 5 average rating, 358 reviews

Habitación con baño privado en el centro de Panamá

The kitchen features a sleek black countertop with four modern green bar stools positioned around it. A range hood is installed above the stove, and light-colored cabinetry provides ample storage. A recliner is visible in the corner, and natural light enters through a window.

Hotel room in Panamá

Hotel el edén

A private pool is surrounded by lush greenery, providing a serene space for relaxation. Colorful round seating options are placed on the gravel path leading to the pool. A shaded area features a picnic table in the background, inviting social gatherings in a natural setting.

Private room in Panama City

4.67 out of 5 average rating, 78 reviews

El Puente

A small sleeping area features light green walls and a cozy bed with a striped linen cover. A single window is partially draped with green curtains, allowing natural light to illuminate a potted plant positioned on the windowsill.

Private room in Panama City

4.67 out of 5 average rating, 12 reviews

El Tornillo semi-private space.

Hotel rentals with a pool

Hotel room in Panamá

New place to stay

Hacienda mi montañita

A spacious Jr Suite features a large bed adorned with colorful pillows, complemented by natural wood accents. A small wooden table and chairs are positioned nearby. A ceiling fan circulates air in the bright room, which is illuminated by a striking lamp and natural light from a doorway.

Hotel room in Panamá

4.25 out of 5 average rating, 4 reviews

Jr. Suite Rm #3- Cerro Azul

A tranquil outdoor pool is surrounded by lush tropical vegetation. The bright turquoise water contrasts with the greenery, while a clear glass barrier enhances the views of the hills and trees. A person is seated at the pool's edge, enjoying the serene atmosphere.

Hotel room in Panamá

4.45 out of 5 average rating, 20 reviews

Rainforest Suite with Breakfast! 15 min from city

A well-appointed sleeping area is equipped with two spacious beds, each dressed in crisp white linens and topped with red accent blankets. Soft lighting is provided by wall-mounted lamps, and floor-to-ceiling curtains frame the window, adding privacy and warmth to the space.

Hotel room in El Cangrejo

4.77 out of 5 average rating, 13 reviews

Suite Doble-Apartamento Hotel Príncipe

A spacious room features a queen-sized bed with a light-colored duvet and decorative pillows. A large window with sheer curtains allows natural light to brighten the space. A small bedside table with a lamp and an art piece adorn the wall, complemented by a minimalist clothing rack.

Private room in Panamá

Double Studio - Viajero Hostels

A tranquil pool area is surrounded by lush greenery, with palm trees and tropical plants creating a serene environment. Colorful circular seating stones are arranged near the edge of the pool, inviting relaxation. The pool's clear water reflects the sunlight, enhanced by the natural landscaping.

Private room in Panamá

4.65 out of 5 average rating, 48 reviews

El Canal

A cozy bedroom features a spacious bed dressed in a light blue quilt. Two bedside tables with soft lamps flank the bed, providing gentle illumination. A green accent wall and a piece of leaf-themed artwork add a touch of natural beauty to the room.

Hotel room in Panamá

Tropical Tranquility - Coconut Lodge

Private room in Panama City

New place to stay

Hacienda El Edén

Hotel rentals with a patio

A spacious sleeping area features a four-poster bed dressed in neutral linens, accented by a vibrant red pillow. A comfortable red couch is positioned near large glass doors, which provide natural light and views of the surrounding greenery.

Private room in Panamá

4.75 out of 5 average rating, 4 reviews

Harpy Eagle Room in Treehouse

Hotel room in Panamá

Charming Hotel in Casco Viejo Santa Ana Deluxe

A calming bedroom features a spacious bed adorned with soft linens. A large wall art piece depicting a serene face adds depth to the navy-blue walls. Natural light filters through draped curtains, and two decorative lamps provide gentle illumination beside the bed.

4.67 out of 5 average rating, 3 reviews

Suite Room in the ORHO Hotel

A spacious guestroom features wood-paneled walls and a ceiling fan. Two beds are positioned against a light-toned wall. Natural light enters through large windows with beige shades. A closet and a small work area with a mirror are also included, enhancing the room's functionality.

Private room in Panamá

3.8 out of 5 average rating, 5 reviews

Kakún Hab 12, Cable Tv, Nevera, Aire/A.

Hotel room in Panamá

Royal Suite

A modern room features a spacious bed with neutral bedding, complemented by a light-colored accent wall. A small dining table with two chairs is positioned near a floor-to-ceiling window, which is framed by soft curtains. A flat-screen TV is mounted on the opposite wall.

Hotel room in Santa Cruz De Chinina

5 out of 5 average rating, 3 reviews

Eshel Panama Suites, Atlantic suite 04

A spacious bedroom is presented with a large bed, complemented by soft pillows and a neutral bedspread. A small circular table with two upholstered chairs is positioned nearby. A large window allows natural light to fill the room, enhancing the warm red wall.

Hotel room in Panamá

Excelente habitación privada

The bright sleeping area features two double beds with stylish headboards and decorative accent pillows. A textured area rug is placed on the hardwood floor. Natural light floods the room through large windows with sheer curtains, complementing the exposed brick wall.

Hotel room in Panamá

Charming Studio w Two Double Beds

Quick stats about hotel rentals in Panama City

Total rentals
120 properties
Nightly prices starting at
€ 9 before taxes and fees
Total number of reviews
3.2K reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
20 properties allow pets
Rentals with a pool
30 properties have a pool

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