Guesthouse vacation rentals in Mount Pleasant

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Top-rated guesthouse rentals in Mount Pleasant

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
An open living area features modern furnishings, including a cozy sofa adorned with a colorful throw. A ceiling fan circulates air, and natural light filters through two windows. In the background, a full kitchen is equipped with stainless steel appliances, while a small dining area is visible.
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 306 reviews

#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!

#1 VOTED by AirBnB '21/'23! Newly built in 2018 fully furnished apartment. 700 sq ft one br w/Queen bed & walk-in closet. Spacious Living rm w/full size Futon. One bath w/shower & tub. Washer & dryer, full kitchen w/ stainless steel appliances. Modern amenities, WIFI, Netflix, all soaps, hair dryer, iron, luggage stands & a whole lot more. Private drive up parking! Our place in the Old Village is within stone's throw to Folly Beach, Downtown Charleston, and Sullivan's Island/Isle of Palms.

Top guest favorite
A spacious bedroom features a wooden bed frame adorned with a floral-patterned comforter. Two bedside tables with lamps are positioned on either side of the bed. Bright light filters in through a window, complemented by soft neutral walls and warm wood flooring.
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 151 reviews

5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!

The Treehouse is a private, cozy, modern retreat in the hippest area of Mt. Pleasant - right between downtown & the beaches for easy access to both. Located less than 5 mi. from Sullivan's Island, less than 2 mi. from the Cooper River Bridge (to downtown Charleston), and just a short walk from Shem Creek, you won't find a better place to stay in the Holy City. *Minimum age required to rent: 21 years old. Children welcome with adult accompaniment.*STR PERMIT #: ST250220 SC BUS. LIC #: 20104817

Top guest favorite
A bright and airy living area features a light blue sofa, accompanied by a small table and chair set. The fully equipped kitchen is visible in the background, showcasing modern appliances. Natural light floods the space through the windows, enhancing the inviting atmosphere.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 113 reviews

Coastal Charm: Village Hideaway

Charming two- bedroom, one bathroom cottage tucked away in a quiet neighborhood located close to both nature and local attractions. Our cottage was a thoughtfully designed space with attention to detail in every corner. We offer a fully equipped kitchen with modern appliances and a breakfast bar. PLEASE note, as a reminder to house rules: no smoking, vaping, e-cigarettes, or pets allowed in or outside of property. Owner has severe allergies. Thank you. STR Permit #: 250271 BL#: 20127320

Top guest favorite
A bright living area features a white sofa adorned with blue and white decorative pillows, alongside a leather recliner. Two woven tables sit in front of the couch on a textured rug. A flat-screen TV and kitchen are visible in the background.
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 310 reviews

Upscale Couple's Escape | Beach & Downtown CHS

Perfect getaway for anyone looking to relax and enjoy the beautiful Charleston beaches. We maintain the highest standards for luxury - including curated interior design touches to make you forget reality and enjoy some much needed R&R time. The Pump House is the ideal place to escape to and enjoy the outdoors, local restaurants, breweries, parks, and, of course, beaches! Our reviews speak for themselves - Always 5 stars and many return guests! Permit #ST250099 | Business License #20122954

Guest favorite
An outdoor lounge area features a spacious sectional sofa in dark upholstery, surrounding a low wooden coffee table. Potted plants add greenery around the space. A shed with blue siding and double glass doors sits in the background, framed by tall trees and a wooden fence.
Guesthouse in West Ashley
4.95 out of 5 average rating, 261 reviews

Quaint Cottage Studio in Ashley Forest (Avondale).

Take in the peace, calm, and hospitality of Charleston at this small, quaint, stand-alone cottage. The studio is situated on our property and shares an outdoor lounge and dining area. Located in the neighborhood of Ashley Forest, a small corner of Avondale, you are walking distance to breweries, cafes, wine bars, sushi restaurants and more. Downtown is a 10 minute ride share away, and there is also a bus stop five minutes from the property that will take you to the heart of King Street.

Top guest favorite
The exterior of the bungalow features a white-painted facade and a welcoming entrance, framed by lush landscaping with flowering shrubs. Two windows provide natural light, accompanied by a small porch covered by an awning. Nearby trees contribute to the serene atmosphere.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 558 reviews

Old Mt. Pleasant/Shem Creek close to Sullivans/DT

This 1 bed/1 bathroom bungalow sits among the Old Mt. Pleasant neighborhood off Coleman Blvd, which is only 3 mi. to Sullivans Island Beach, <1 mi. to Shem Creek! A quick ride will land you in bustling downtown Charleston. Close to the stunning Pitt St Bridge to watch the sunset. Walk popular Coleman Blvd which boasts restaurants, shops, boutiques and fitness venues alike, only 1 block away. 3 grocery stores <1 mi. Quiet, clean, and quaint! STR Permit #ST250014 MP Bus Lic #20132292

Top guest favorite
A modern two-story guest house is depicted, featuring a combination of white and light brown exteriors. A covered entryway with pergola extends over the front door. A tranquil pool is visible in the foreground, surrounded by landscaped greenery and stone paving.
Guesthouse in Mount Pleasant
4.96 out of 5 average rating, 148 reviews

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse

LOCATION, LOCATION, LOCATION! Welcome to Persimmon Place, a brand new guesthouse in the heart of Old Village in Mt. Pleasant. Historic Old Village is one of Charleston's most beautiful neighborhoods, central to all Charleston has to offer. This 2BR 1 BA is the perfect spot for your Lowcountry visit. -Walk to Shem Creek with bars, restaurants, & water activities -Less than 4 miles(8 min drive)to Sullivan's Island Beach -5 miles(9 min drive)to downtown Charleston ST250213 BL20137971

Top guest favorite
A spacious bedroom features a black metal bed frame adorned with white bedding. Two stylish chairs are positioned beside large windows offering views of the surrounding landscape. A wooden dresser and a woven area rug add elements of comfort and warmth to the room.
Guesthouse in West Ashley
4.99 out of 5 average rating, 214 reviews

Large Guesthouse with Private Dock & Marsh Views

This newly built carriage house is separate from the main house. The cottage is about 1,200 sqft so it very open and spacious and great views of marsh and our tidal creek. We have a separate work area with desk and a massive dinning table if you need more room to work or to gather with friends. Full kitchen, washer and dryer, massive shower, the list goes on. You may not want to leave! Feel free to go sit and have coffee or cocktails on the dock. PERMIT# OP2024-04998

Top guest favorite
A tranquil waterfront view features a dock extending into calm waters, framed by lush greenery and trees. A hammock can be seen suspended from the dock, inviting relaxation. The sunlight glistens on the water's surface, creating a serene atmosphere.
Guesthouse in Daniel Island
4.99 out of 5 average rating, 319 reviews

Spacious Daniel Island Apartment

Fully furnished 1 bedroom (queen bed) apartment on Daniel Island. We are able to bring a single mattress out to the apartment for guests bringing a child, so the apartment can accommodate up to three (two adults and a child). Full kitchen with glass cook top, dish washer, full-sized refrigerator/freezer, toaster oven, etc. Includes linens, dishes and utensils. Washer/dryer en suite. Has Youtube TV, HBO Max, and wifi. 15 mins from airport, downtown Charleston, and beaches.

Top guest favorite
A light blue living area features a comfortable sofa facing a coffee table and an entertainment setup with a mounted television. The open layout includes a dining bar with stools and a well-equipped kitchen, with a door leading to a bathroom visible in the background.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 377 reviews

Ocean Inspired Village Hideaway Old MP

STR PERMIT # ST250230 BUS. LIC.# 20132278 Kick back on a sofa in a light blue living room amid oceanic coastal decor. This gem is only 3 miles from Sullivans Island beach and 7 miles to downtown Charleston. After a day at the beach, take a stroll down to the Pitt Street bridge and watch a beautiful sunset on the water. Come experience this cute coastal cottage escape, tucked away in Old Mount Pleasant. One of the oldest and most charming neighborhoods east of the cooper.

Top guest favorite
A newly-built guest cottage is depicted, elevated on pilings and surrounded by lush greenery. Light-colored siding is complemented by green shutters. Steps lead up to a welcoming porch with a railing, providing access to the spacious entry and large windows that invite natural light.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 206 reviews

Stunning Couples Cottage with Creek Dock!

You will fall in love with this stunning, newly-built guest cottage nestled under the canopy of a majestic 400-year-old live oak tree! Providing ultimate comfort, convenience and serenity, this is the perfect place to launch your Charleston adventure – 10 minutes to Shem Creek, & 15 minutes to Sullivan's Island or Downtown Charleston. PLUS, come enjoy our brand new dock on the creek! A picture-perfect spot to relax and enjoy the stunning Lowcountry scenery!

Top guest favorite
A stylish living area features a green velvet sofa paired with a round wooden coffee table. Decorative items are placed atop the table, while a floor lamp provides soft lighting. Large windows allow natural light to illuminate the space, which is accented by framed artwork and a potted plant.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 115 reviews

Old Village Guesthouse walkable, close to beach/DT

Location. Location. Location! It's trite, but it's true. You’ll be minutes from downtown Charleston and the beach at Sullivan’s Island when you stay with us in the historic Old Village of Mount Pleasant. Walk to some of the town’s best restaurants and waterfront bars or seize the moment to relax in our breezy, modern guest house in one of the oldest, most beautiful neighborhoods in the country. STR permit number: ST250100 Business license number: 20122246

Popular amenities for Mount Pleasant guesthouse rentals

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Quick stats about guesthouse rentals in Mount Pleasant

  • Total vacation rentals

    Explore 50 vacation rentals in Mount Pleasant

  • Nightly prices starting at

    Mount Pleasant vacation rentals start at € 78 per night before taxes and fees

  • Verified guest reviews

    Over 7,080 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    50 of Mount Pleasant vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Mount Pleasant rentals

  • 5 Average rating

    Mount Pleasant stays are highly rated by guests—averaging 5 out of 5!

  • Nearby attractions

    Mount Pleasant's top spots, include Shem Creek Park, Isle of Palms Marina, and Pitt Street Bridge

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