
House vacation rentals in La Mesa
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Top-rated house rentals in La Mesa
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Family Fun! Game Garage + Big Yard + Free Parking
Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

XTRA 10% OFF until Nov: Pool, outdoor fire pits, c
Find your family's dream spot in San Diego! Our cozy house sits on a quiet hill, offering privacy and amazing sunset views. Dive into our pool year-round (heating at an additional cost), roast marshmallows by the fire, and cook up fun meals together. With 3 bedrooms and 2 bathrooms, it’s perfect for families, accommodating up to 9 guests. Plus, we're close to all the best attractions. Want a vacation you'll always remember? Send us a message to make it happen! 🌅🏠 We have 3 comfy beds that can

Hidden King Suite with Garden, Parking - 4 Guest
Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Tropical Oasis: spa, solar heated pool, waterslide
This home is ideal for FAMILY trips and QUIET friend groups Hours of entertainment in the private backyard that includes heated pool, waterslide, grotto, spa, gazebo, half bath, BBQ, and more. Clean and spacious home with over 2,100 sqft of living space. Minutes from everything San Diego has to offer. Distance to main attractions: SDSU- 5 mi Downtown/PetcoPark park-11 mi SD Zoo/balboa park-12 mi SD Airport- 13 mi Old town- 14 mi Coronado-15 mi Belmont park/Mission beach-18mi Sea world- 18mi

Terra Mesa - Charming Retreat
Welcome to TerraMesa! This charming studio boasts a thoughtfully designed space, blending modern comfort with a touch of rustic elegance. With a fully equipped kitchenette, a plush queen bed, and a stylish sitting area, it’s perfect for couples seeking a romantic getaway or solo travelers exploring the San Diego area. Sip a cup of coffee or glass of wine in your private little patio. Centrally located in scenic Lakeside, you’ll have easy access to downtown, beaches or our local mountain towns.

Sunny & Spacious 3BR Retreat w/ Parking & A/C
Centrally located in La Mesa is this newly refurbished home ideal for business or pleasure with all of life’s little luxuries waiting for you to enjoy. The home features open concept living with a gourmet kitchen, a chic dining space, 3 beautiful bedrooms, 2 modern bathrooms and an expansive yard with an outdoor lounge. Walk 10 mins to Grossman Center with a Target, restaurants, cafes, a cinema & Walmart or drive to the heart of San Diego and all its attractions just 20 mins from your door.

Travel Writer's Pad
Hello, Bonjour, Hola, Ciao, Ni Hao! For the past two decades my career as a travel journalist has taken me around the globe. I’ve stayed at thousands of accommodations, where I learned personal touches create a comfortable home away from home. Certain places I visited offered extra special amenities, such as Green tea at a Japanese Ryokan & chardonnay infused bath salts at a Mexican posada. These kinds of touches are in the home. I welcome you, but no parties or events at the house. Thanks!

Clean 1BR/1BA Guest House Peaceful Private Casita
Discover the perfect home away from home in San Diego! Our cozy and tranquil guest house is located just a short drive from the city's top attractions, including the San Diego Zoo and beautiful beaches. Relax and unwind in the comfortable living room and enjoy all the amenities you need for a peaceful stay. With a comfortable queen-sized bed, full kitchen, and fresh towels, you'll have everything you need to feel at home. Book your stay with us today and experience the best of San Diego!

Cottage in the Garden! New! Modern!
COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Zen Retreat: 3-Bedroom Oasis near La Mesa Village
Relax in this charming 3-bedroom, 1-bathroom home located just 1 mile from the heart of Historic Downtown La Mesa Village. Nestled in a quiet, central neighborhood, this cozy retreat offers easy access to major freeways, top-rated restaurants, and the local trolley line making it a breeze to explore the best of San Diego. Within 10 to 15 miles, you’ll find yourself in iconic destinations like Downtown San Diego, Balboa Park, Coronado Island, scenic beaches, and beautiful mountain trails.

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub
Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Mid-Century Style Family House with Spa
Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas, Desert Inn 3/4 acre.Less than 20 minute drive to beaches/Zoo/Sea World/Downtown, . With a swimming pool/hot tub, whole House have AC to. surrounded by California Oak/orange/lemonpomegranate trees and herb garden this home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. No loud parties please, this is a quite community.
Popular amenities for La Mesa house rentals
House rentals with a pool

Views - Quiet Mt. Helix Home - Pool -Sleeps 11

Your Modern Lux Pool Resort in the Heart of SD

Lionhead - Private Boutique Home

University Heights Oasis Getaway

Mid-Century Modern and Contemporary House

Custom Guesthouse, Balboa Park/Zoo/Hillcrest& pool

Designer Luxury Rental With Pool

Luxe Home w. Serene Backyard Spa
Weekly house rentals

Tiny Home with a View

Escape to tranquility: the perfect retreat

Cozy 1BR Home with Lovely Front Yard

Jamul Hacienda | Couples Retreat | Pool & Views!

Lavish pool Villa In Mt. Helix, close to beaches

XLarge Artist's Retreat w/private patio/parking

Hilltop luxe retreat with breathtaking views

Golden Hour Bliss: Pool, Hot Tub & Firepit
Private house rentals

Surreal Serenity Escape wIth Game Room, Pool & Spa

Serenity in San Diego

SDSU/Downtown <10 Min | Pet Friendly | Game Room

San Diego's Finest Retreat

Cozy quiet getaway, great mattress (1-br)

Modern, Private, & Stylish Home

ModernCoastal I View I Pool ITub

Private House in the Hills, Pool, Pickleball court
Quick stats about house rentals in La Mesa
Total rentals
300 properties
Nightly prices starting at
€ 17 before taxes and fees
Total number of reviews
13K reviews
Family-friendly rentals
190 properties are a good fit for families
Pet-friendly rentals
100 properties allow pets
Rentals with a pool
80 properties have a pool
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