
Villa vacation rentals in La Mesa
Find and book unique villas on Airbnb
Top-rated villa rentals in La Mesa
Guests agree: these villas are highly rated for location, cleanliness, and more.

Amazing WaterView Penthouse w/AC
AMAZING WATER VIEW PENTHOUSE!! Over 300 5 star reviews from our listings! Perfect for Executives, Quiet mature couples, Healthcare Professionals, Physicians/Traveling Nurses. Immaculate Luxury/Centrally-located. Peaceful, family friendly, every amenity. Private hot tub/private deck/patio furniture/private bbq grill/private fire pit/5 Star Resort Experience/robes/slippers, hot tub towels, fully stocked kitchen/pots/pans/spices/cookware/stemware/dishes/flatware/WiFi/Smart TVs/cable/Netflix/YouTube

Fun Get Away, Vaulted Ceiling, Pool, Hot Tub, New.
Enjoy a stylish experience at this centrally-located place. Great place to stay for those seeking an experience close to the beach and mountains and anywhere in San Diego you'd like to visit. 5 min from trails and Cowles Mountain. 15 min to Sea World, Animal Park, beaches, parks, downtown, Balboa park, the Midway museum, Coronado, Torrey Pines, La Jolla Cove, and much more! 2 min to a kid playground. Nice Villa in a really nice and Quiet Neighborhood, but will also accommodate your best party!

Vintage Home on the Canyon’s Edge
We’re excited to offer our beautiful home in University Heights- just 5 mins from downtown SD. Perched on the edge of a peaceful canyon, the house is surrounded by nature, offering a serene escape while keeping you close to the city’s best attractions. Home features: • 2 comfortable bedrooms • A dedicated study that can double as a third bedroom • 2 full bathrooms • Fully equipped kitchen • Smart TV, WiFi, washer & dryer • A private balcony overlooking the canyon and our inviting hot tub

*Huge HelixCastle-PanoramicView/20+guests welcome
Welcome to our exquisite 5-bedroom (3 stories) home in the desirable neighborhood of Mount Helix in San Diego! This stunning residence is the perfect blend of modern elegance and exceptional comfort, making it an ideal choice for your stay in America's Finest City. Whether you're visiting San Diego for a family vacation, a romantic getaway, or a business trip, our Mount Helix castle, provides the perfect setting for an unforgettable stay. Book your stay with us today to create lasting memories!

6-bed Paradise Villa Pool, hot-tub massage chair
*EV charging available Welcome to Casa Cerro-my incredible chic high-tech modern villa in San Diego! This stylish place to stay is perfect for families and group trips. Its open and airy layout can accommodate up to 11 people. This completely remodeled home is furnished with all the luxuries of home and more that is powered by an iPad for you to use. I love technology. But don't worry you don't have to use it to power up the house, everything has traditional switches/remotes if you choose.

Enchanted Paradise! ♨ Pool+Spa+Outdoor Kitchen ☀
Brand New Property! Massive garden of Eden style resort home with sprawling outdoor entertainment area and spacious open concept inside, perfect for large families with kids and responsible adults. Updated top to bottom with all new outdoor and indoor furniture, modern upgrades in all bedrooms and common areas. Centrally located and 20 minutes from the beach and all of SD's top attractions! 8 person hot tub, sparkling gas heated saltwater pool and new outdoor kitchen. Don't miss out!

Casa Charles, Tropical backyard, Pool & Pizza oven
This beautiful family home is a entertainment paradise with a large gourmet kitchen with plenty of pots and pans, dished and kitchen ware, even the spices to cook up a delicious family dinner. but you'll be sure to enjoy the tropical backyard with a bocce court, that includes a pool, a hot tub, an outdoor wood fireplace, a gas fire pit and even a wood fire pizza oven - You're freeway close to everything San Diego has to offer when you stay at this centrally-located retreat.

Gorgeous Beach Villa | Ocean Views + Sleeps 12!
Experience the ultimate family retreat in our spacious 6-bedroom, 4-bath home with breathtaking views of Mission Bay and the Pacific Ocean. Perfect for groups, it features two kitchens, multiple balconies, and a large backyard with a fire pit and grill. Walk to Ocean Beach and Sunset Cliffs or explore nearby attractions like SeaWorld and Balboa Park. Unwind with sea breezes, sunsets, and the sparkle of SeaWorld fireworks. Your unforgettable San Diego getaway starts here!

Backyard Oasis • Pool • Hot Tub • Games • MiniGolf
If you’re looking for a place where everyone can relax and have fun, this is it. Designed for memorable stays, enjoy pool days, hot tub nights, games, and mini golf in the spacious backyard. Inside, bright, modern interiors offer comfort and space to unwind. Located in one of San Diego’s safest and most family-friendly neighborhoods, this home delivers resort-style vibes in a private setting made for enjoying time together. Ideal for families, friends, and groups!

Hidden Villa with Beautiful Furnished Garden Patio
Close to everything, quiet and private. This beautiful 2 Bd Villa seems to be loved by all who stay here. The outdoor private patio feels like your in the forest. Gorgeous custom bath with large marble shower. Full size laundry. Great entertainment system,DVD's, Roku, Amazon Prime. The home has open beam ceilings, lots of light and a fabulous patio fully furnished for guests, outdoor dining and barbecuing. The home is private, fenced, furry friends are welcome.

The Crown Jewel Villa with AC!Bikes,Kayak and SUP!
Escape to the peaceful and coveted beach community of Crown Point in San Diego! This highly sought after neighborhood boasts mostly permanent residents, creating a serene and tranquil environment for our guests. Right across the street from the home, you can find Ski Beach and Park, a favorite spot for families and kids. Explore the variety of local eateries and coffee shops, or take a short walk to popular Sail Bay and the ocean.

Beautiful house in mira mesa
Get ready to enjoy a bright and spacious home right in the heart of Mira Mesa! Just 20 minutes from downtown, the airport, top attractions, and plenty of shopping, it’s the perfect spot for large families or groups of friends eager to experience the best of San Diego. Here, you’ll feel right at home while soaking up all that sunny San Diego has to offer For your safety,security camera in the front door
Popular amenities for La Mesa villa rentals
Private villa rentals

Amazing WaterView Penthouse w/AC

Lux Villa: Heated Pool, Sauna, & Gym

Stay&Play SDSU- Pool •HotTub •GameRoom •SunsetView

Casa Charles, Tropical backyard, Pool & Pizza oven

Backyard Oasis • Pool • Hot Tub • Games • MiniGolf

The Crown Jewel Villa with AC!Bikes,Kayak and SUP!

Hidden Villa with Beautiful Furnished Garden Patio

TooHotTooSettle • HotTub • Pool • GameRoom • Spacious
Luxury villa rentals

Spacious 4BD | La Jolla • Ocean Views • Jacuzzi

Sanctuary 4BR Church & Deck Near Downtown (18 ppl)

NEW! Mediterranean-Style Villa in Point Loma

3680 Bayside Walk, A Bayside Marina

Cheerful 4-bedroom villa with free parking.

1stResorts.com WATER VIEW FAMILY VILLA A w/ HOTTUB
Villa rentals with a pool

Stay&Play SDSU- Pool •HotTub •GameRoom •SunsetView

1 PRIVATE OCEAN VIEW ROOM IN LUXURY COASTAL HOUSE

Villa L'Auberge - 5 star hotel

🦄Paradise View SD (Private Escape) 🌄 86'' TV

Private oasis

Apartment in hilltop villa: Torrey Pines Suite

TooHotTooSettle • HotTub • Pool • GameRoom • Spacious

LUX Vaca•Spacious Pool•GameRoom•Jaccuzi•Sleep16
Quick stats about villa rentals in La Mesa

Total vacation rentals
Explore 10 vacation rentals in La Mesa

Nightly prices starting at
La Mesa vacation rentals start at € 52 per night before taxes and fees

Verified guest reviews
Over 410 verified reviews to help you choose

Family-friendly vacation rentals
10 properties offer extra space & kid-friendly amenities

Vacation rentals with a pool
10 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wi-Fi availability
10 of La Mesa vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across La Mesa rentals

4.7 Average rating
La Mesa stays receive an average rating of 4.7 out of 5 from guests
Destinations to explore
- Southern California Vacation rentals
- Los Angeles Vacation rentals
- Stanton Vacation rentals
- Channel Islands of California Vacation rentals
- Las Vegas Vacation rentals
- San Diego Vacation rentals
- Phoenix Vacation rentals
- Palm Springs Vacation rentals
- San Fernando Valley Vacation rentals
- Scottsdale Vacation rentals
- Henderson Vacation rentals
- Big Bear Lake Vacation rentals
- Guesthouse rentals La Mesa
- Pet-friendly rentals La Mesa
- Fitness-friendly rentals La Mesa
- Apartment rentals La Mesa
- Rentals with a washer and dryer La Mesa
- Family-friendly rentals La Mesa
- Smoking-friendly rentals La Mesa
- Rentals with a fireplace La Mesa
- Rentals with breakfast La Mesa
- Rentals with a patio La Mesa
- Rentals with an EV charger La Mesa
- House rentals La Mesa
- Private suite rentals La Mesa
- Rentals with a fire pit La Mesa
- Rentals with outdoor seating La Mesa
- Rentals with a beach view La Mesa
- Rentals with beach access La Mesa
- Rentals with pools La Mesa
- Rentals with a hot tub La Mesa
- Villa rentals San Diego County
- Villa rentals California
- Villa rentals United States
- Rosarito Beach
- Oceanside City Beach
- LEGOLAND California
- SeaWorld San Diego
- Torrey Pines State Beach
- Tijuana Beach
- University of California-San Diego
- San Diego Zoo Safari Park
- Pacific Beach
- Balboa Park
- Pechanga Resort Casino
- La Misión Beach
- Moonlight State Beach
- Liberty Station
- Oceanside Harbor
- Belmont Park
- Coronado Shores Beach
- Sesame Place San Diego
- Black's Beach
- Law Street Beach
- Torrey Pines Golf Course
- USS Midway Museum
- Mission Beach
- La Jolla Cove




