Villa vacation rentals in La Mesa

Find and book unique villas on Airbnb

Quick stats about villa rentals in La Mesa

  • Total vacation rentals

    Explore 10 vacation rentals in La Mesa

  • Nightly prices starting at

    La Mesa vacation rentals start at €52 per night before taxes and fees

  • Verified guest reviews

    Over 540 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Vacation rentals with a pool

    10 properties feature pools

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wi-Fi availability

    10 of La Mesa vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across La Mesa rentals

  • 4.7 Average rating

    La Mesa stays receive an average rating of 4.7 out of 5 from guests

Top-rated villa rentals in La Mesa

Guests agree: these villas are highly rated for location, cleanliness, and more.

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Superhost
Villa in Lakeside
4.93 out of 5 average rating, 43 reviews

Lux•6BR•7BA•Pool/SPA/Golf/Grill/Games

Make dreams come true w/ this luxurious resort-style home, packed w/amenities. From mini golf, pool, spa, playground, game room & arcades, relaxation & entertainment comes easy. 4,000 sq ft of living space on quarter acre, plenty of room for the whole family. Over 100 amenities Book Now 😊 19 min - San Diego Airport🛬/Downtown San Diego🏟️ 18 min - Balboa Park/Zoo🦁 23 min - Mission Beach/Pacific Beach 🏖️ 28 min - Mexico 🇲🇽 border 10 min - Barona Casino 🎰 5 min - Lake Jennings🎣 22 min - Sea World 🐳

Guest favorite
A modern kitchen features dark cabinetry and a large island with seating. Stainless steel appliances are integrated seamlessly, while natural light pours through multiple windows. A stylish chandelier hangs above the island, and artistic decor is arranged on the walls, adding character to the space.
Villa in San Diego
4.91 out of 5 average rating, 35 reviews

Fun Get Away, Vaulted Ceiling, Pool, Hot Tub, New.

Enjoy a stylish experience at this centrally-located place. Great place to stay for those seeking an experience close to the beach and mountains and anywhere in San Diego you'd like to visit. 5 min from trails and Cowles Mountain. 15 min to Sea World, Animal Park, beaches, parks, downtown, Balboa park, the Midway museum, Coronado, Torrey Pines, La Jolla Cove, and much more! 2 min to a kid playground. Nice Villa in a really nice and Quiet Neighborhood, but will also accommodate your best party!

A spacious balcony extends along the home, providing sweeping views of the surrounding landscape. The railing casts shadows on the floor, while lush greenery and distant hills are visible in the background under a clear blue sky.
Villa in El Cajon
4.61 out of 5 average rating, 75 reviews

*Huge HelixCastle-PanoramicView/20+guests welcome

Welcome to our exquisite 5-bedroom (3 stories) home in the desirable neighborhood of Mount Helix in San Diego! This stunning residence is the perfect blend of modern elegance and exceptional comfort, making it an ideal choice for your stay in America's Finest City. Whether you're visiting San Diego for a family vacation, a romantic getaway, or a business trip, our Mount Helix castle, provides the perfect setting for an unforgettable stay. Book your stay with us today to create lasting memories!

Superhost
A spacious outdoor area features a clear swimming pool surrounded by a patio. Lush palm trees and other greenery create a private atmosphere. A gazebo and dining seating area are visible, providing a relaxing space for gatherings and leisure.
Villa in San Diego
4.9 out of 5 average rating, 114 reviews

5-bed Paradise Villa Pool, hot-tub massage chair

*EV charging available Welcome to Casa Cerro-my incredible chic high-tech modern villa in San Diego! This stylish place to stay is perfect for families and group trips. Its open and airy layout can accommodate up to 14 people. This completely remodeled home is furnished with all the luxuries of home and more that is powered by an iPad for you to use. I love technology. But don't worry you don't have to use it to power up the house, everything has traditional switches/remotes if you choose.

Top guest favorite
A living area features a mix of seating options, including a blue sofa and a red chair. A wooden coffee table is positioned centrally. Floor-to-ceiling shelving holds a variety of books and DVDs. A dining area is visible, accompanied by natural light from nearby windows.
Villa in Mission Hills
4.98 out of 5 average rating, 108 reviews

Hidden Villa with Beautiful Furnished Garden Patio

Close to everything, quiet and private. This beautiful 2 Bd Villa seems to be loved by all who stay here. The outdoor private patio feels like your in the forest. Gorgeous custom bath with large marble shower. Full size laundry. Great entertainment system, Roku, Amazon Prime. The home has open beam ceilings, lots of light and a fabulous patio fully furnished for guests, outdoor dining and barbecuing. The home is private, fenced, furry friends are welcome. 2 gig internet w/high speed router

Guest favorite
Villa in Rancho San Diego
4.89 out of 5 average rating, 19 reviews

Private oasis

Enjoy this gorgeous farmhouse style two story home with 2 master suites and your own private getaway oasis with amazing views from every window, no neighbors around, pool, spa, a large brand new kitchen with a huge entertainment island and pretty much everything you need for your next getaway. Despite being super secluded, it’s located a block away from a taco shop, 2 blocks from 7 Eleven, 3 minutes drive from main shopping areas with grocery stores, and restaurants as well as the 94 and 8

A serene outdoor space features a jacuzzi surrounded by lounge chairs. Colorful umbrellas provide shade, while a stunning view of the city and sunset fills the background, creating a sense of tranquility and connection with nature.
Villa in La Mesa
4.78 out of 5 average rating, 63 reviews

Luxury Dream Home Stunning 360 Views of SD

┏━━━━✦❘༻ WELCOME HOME ༺❘✦━━━━┓ ✦ Arguably the most stunning views in San Diego ✦ This Villa with a private Guesthouse captures all of San Diego including the Beaches, Coronado & Downtown ✦ Lounge in the numerous outdoor areas ✦ Walk the expansive wrap-around deck and choose where you'd like to see the sunsets and sunrises ✦ One of the few properties where you can see both! Climb the historic rock and be at the top of San Diego ✦ Famous Landmark - A piece of San Diego History

Top guest favorite
Villa in Jamul
4.97 out of 5 average rating, 116 reviews

@ Paradise villa, Top view, 4600sqrt on 10 acres

TOT #COSD-00749 Experience stunning 360-degree views from every corner of this spacious villa, which spans 4,600 square feet on 10-acre lot. This is the perfect place for family gatherings and celebrations. The house features five oversized bedrooms and four bathrooms. There is parking +25 cars. Max 50 guests. Enjoy a massive pool, deck, golf, chess, pool table, foosball, ping pong, Nintendo game, and screen projector. This truly one-of-a-kind property is not to be missed!

Guest favorite
An inviting outdoor entertainment area features a heated saltwater pool surrounded by elegant lighting and stylish lounge furniture. Inflatable swan floats rest in the water, while vibrant umbrellas provide shade over seating. Lush landscaping enhances the serene environment, making it ideal for relaxation.
Villa in Rancho San Diego
4.92 out of 5 average rating, 215 reviews

Enchanted Paradise! Pool+Spa+Outdoor Kitchen

Brand New Property! Massive garden of Eden style resort home with sprawling outdoor entertainment area and spacious open concept inside, perfect for large families with kids and responsible adults. Updated top to bottom with all new outdoor and indoor furniture, modern upgrades in all bedrooms and common areas. Centrally located and 20 minutes from the beach and all of SD's top attractions! 8 person hot tub, sparkling saltwater pool and new outdoor kitchen. Don't miss out!

Guest favorite
Villa in El Cajon
5.0 out of 5 average rating, 5 reviews

San Diego 4BR family home| Pool| Deck| RV Parking|

Relaxing Retreat - Pool | Deck | RV Parking | • Entire private Home/ Sleep 9 • 4 bedrooms / 2.5 bathrooms/ 5 beds • Spacious living room and dining area • Family Room with fireplace • Fully equipped kitchen • Large Private Pool • Large Turfed backyard • Private Upper 14x18 Deck with views • Free driveway parking & Gated RV parking • Quiet neighborhood • Washer/dryer available • Easy famous attraction & beaches access Perfect for family & group travel

Superhost
A spacious saltwater pool is surrounded by paved deck areas and palm trees, offering unobstructed views of rolling hills. The pool area features various seating options and a nearby gazebo, creating a serene outdoor retreat for relaxation and recreation.
Villa in Jamul
4.8 out of 5 average rating, 41 reviews

10AcreVilla,Heated*SaltPool,MtnView,Mini-Golf,BBQ

Enjoy hilltop rolling hills & city views featuring Pueblo architecture 30 min from DT San Diego! Inside find cathedral ceilings, split & open floor plan, big rooms, king beds, infinite tankless hot water, smart TV's, Starlink 100mb internet, natural well water, & unobstructed views in every room. Exterior features a triple-heated* salt-water pool, a jacuzzi*, horse shoes, croquet, golf teeing area, & tennis/bball court*. A true secluded Southern California experience.

Guest favorite
Villa in Kensington
4.83 out of 5 average rating, 18 reviews

The Kensington Canyon Estate

Welcome to The Kensington Canyon Estate, a beautifully restored 1927 Tudor with 5 bedrooms, 4 baths and a private resort-style setting above a peaceful San Diego canyon. Enjoy a saltwater pool & spa, built-in BBQ kitchen, firepit, layered decks and dramatic renovated interiors. Walk to Kensington Village and Adams Avenue, with Balboa Park, the Zoo, downtown and beaches just minutes away. Historic character, modern luxury and peaceful canyon privacy.

Popular amenities for La Mesa villa rentals