Villa vacation rentals in La Mesa

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Top-rated villa rentals in La Mesa

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Guest favorite

Villa in Otay Mesa

4.94 out of 5 average rating, 68 reviews

Grand 5-Bedroom San Diego Home w/ Pool & Views!

Forget your worries in this spacious and serene space. Relax along the private poolside oasis while admiring the horizon ocean & skyline views! This home will be sure to impress with upgraded amenities, plenty of seating for all, & beautiful furnishings. 5 big bedrooms, plus loft room w/ bed & foosball game. Multigenerational families & non-rowdy groups will delight in this grand home. Enjoy all the sights of San Diego and come home for restful slumbers at this beautiful south San Diego retreat.

Guest favorite

Villa in Hillcrest

4.78 out of 5 average rating, 50 reviews

Vintage Home on the Canyon’s Edge

We’re excited to offer our beautiful home in University Heights- just 5 mins from downtown SD. Perched on the edge of a peaceful canyon, the house is surrounded by nature, offering a serene escape while keeping you close to the city’s best attractions. Home features: • 2 comfortable bedrooms • A dedicated study that can double as a third bedroom • 2 full bathrooms • Fully equipped kitchen • Smart TV, WiFi, washer & dryer • A private balcony overlooking the canyon and our inviting hot tub

Top guest favorite

Villa in San Diego

4.93 out of 5 average rating, 104 reviews

☆🏘 Breathtaking 180º Views 🏝Hot Tub🏝 5☆ Reviews

🏝Welcome to the Harbor View Villa! 🏘A 3,500sqft villa with 6 bedrooms, 4 bathrooms and a 800 sqft walk-out deck. Complete with private rooftop hot tub, backyard, outdoor & indoor living.  With 180º private day & night views from almost anywhere in the house! Make yourself at home in our Mission-Style Villa with stunning views of the boats in the Harbor, Downtown lights, and Coronado Island! 🗺Ideal for kids Perfect for MCRD & PLNU graduations (5min). Ask about early checkin / late checkout

Guest favorite

Villa in El Cajon

4.95 out of 5 average rating, 127 reviews

@ Fantastic villa, giant pool, guest house,golf !

This unique fantastic villa with a separate pool house sitting on 1 acre with a spacious living space with large windows. Main house has 4 bedrooms with 2 baths, and a guest house has 1 bedroom with 1 bath. +8 car parking, nice privacy and a fantastic view! Brand new giant size SALT pool with huge size jacuzzi , pool toys, golf zone, a huge grass event field, game field, pool table, foosball, ping pong, Nitendo,2 fire pits and more! Truly one-of-a-kind property don’t miss out! ToT:COSD-00749

Guest favorite

Villa in Allied Gardens

4.91 out of 5 average rating, 100 reviews

4-bed Paradise Villa ♨ Pool, hot-tub massage chair

*EV charging available Welcome to Casa Cerro-my incredible chic high-tech modern villa in San Diego! This stylish place to stay is perfect for families and group trips. Its open and airy layout can accommodate up to 11 people. This completely remodeled home is furnished with all the luxuries of home and more that is powered by an iPad for you to use. I love technology. But don't worry you don't have to use it to power up the house, everything has traditional switches/remotes if you choose.

Guest favorite

Villa in El Cajon

5 out of 5 average rating, 75 reviews

Zen Resort w Infinity Pool/Spa +360° Socal views

Relax, rejuvenate, & revive at your own hilltop paradise with no nearby neighbors and a private gated driveway. This hacienda offers a year round temp controlled Infinity edge pool & Spa complete with 360° views, outdoor fire-pit, custom tiki hut and a seamless indoor outdoor flow. Accommodation includes the main house, a charming casita, and an optional Airstream-sleeping 20+ guests in comfort. A perfect blend of seclusion, and resort-level amenities & just 15 min. from Downtown San Diego.

Superhost

Villa in Grant Hill

4.82 out of 5 average rating, 17 reviews

Bella Casa | Pool&Spa-King Bed-AC-Min to Downtown

Escape to this charming 2BR, 1BA home in the heart of San Diego! Enjoy a king-size adjustable bed, full-size bed, futon, and sofa bed. Stay comfortable with central AC & heat, resort-style amenities—pool, jacuzzi, outdoor lounge, and grill. The driveway fits two tandem cars and an electric gate for convenience. Shared laundry, plus a pack-and-play & high chair for little ones. Minutes from top attractions, beaches, dining, and airport access. Book now for the perfect San Diego getaway!

Guest favorite

Villa in Mission Hills

4.98 out of 5 average rating, 87 reviews

Hidden Villa with Beautiful Furnished Garden Patio

Close to everything, quiet and private. This beautiful 2 Bd Villa seems to be loved by all who stay here. The outdoor private patio feels like your in the forest. Gorgeous custom bath with large marble shower. Full size laundry. Great entertainment system,DVD's, Roku, Amazon Prime. The home has open beam ceilings, lots of light and a fabulous patio fully furnished for guests, outdoor dining and barbecuing. The home is private, fenced, furry friends are welcome.

Guest favorite

Villa in La Mesa

4.92 out of 5 average rating, 39 reviews

TooHotTooSettle•BigPool•HotTub•GameRoom•Spacious

Luxury Retreat in Mount Helix | Pool • Hot Tub • Games Welcome to your private oasis in beautiful Mount Helix! This stylish 4-bedroom home is designed for relaxation and entertainment, featuring a sparkling pool, a soothing hot tub, and a game area for endless fun. With spacious living areas, modern decor, and a fully equipped kitchen, this home is perfect for families, friends, or a weekend getaway. Book now and experience the best of San Diego in style!

Guest favorite

Villa in Pacific Beach

4.93 out of 5 average rating, 146 reviews

The Crown Jewel Villa with AC!Bikes,Kayak and SUP!

Escape to the peaceful and coveted beach community of Crown Point in San Diego! This highly sought after neighborhood boasts mostly permanent residents, creating a serene and tranquil environment for our guests. Right across the street from the home, you can find Ski Beach and Park, a favorite spot for families and kids. Explore the variety of local eateries and coffee shops, or take a short walk to popular Sail Bay and the ocean.

Superhost

Villa in Spring Valley

4.95 out of 5 average rating, 66 reviews

Modern 3-Bedroom Villa, Luxurious Outdoor Oasis

Welcome to Your Perfect Spring Valley Villa! Nestled in the heart of Spring Valley, our charming spacious 3-bedroom, 2-bath home offers the perfect blend of comfort, style, and modern amenities. Whatever your planning, our home provides an ideal setting for a memorable stay. Need a rental car? We have a 2019 Blue Jeep Wrangler Unlimited Sport available via Turo right outside ready for use. Link to book available inside.

Guest favorite

Villa in Mission Hills

5 out of 5 average rating, 83 reviews

1stResorts.com WATER VIEW FAMILY VILLA A w/ HOTTUB

Brand New FAMILY Villa with Water Views from the kitchen / living area! Special reduction for week long stay!! Two level Villa. Large deck attached. Hot Tub, Barbecue Grill, Fire pit! Beautiful sunsets!! Come stay with us and enjoy all of San Diego's finest. We are located close to Balboa Park, Coronado and so many great venues and experiences or just stay on site and enjoy your very own Oasis!