Guesthouse vacation rentals in Mission Bay, San Diego
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Mission Bay, San Diego
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay, San Diego guesthouse rentals
Family-friendly guest house rentals
Guesthouse in San Diego
4.77 out of 5 average rating, 880 reviewscharming, colorful, close to beach
Feb 22 – Mar 1
Guesthouse in Point Loma Peninsula
4.69 out of 5 average rating, 274 reviewsSan Diego Studio perfect for Getaway, Close to All
Oct 23 – 30
Guesthouse in La Jolla
4.77 out of 5 average rating, 601 reviews$100-150 night--Windansea #3
Nov 14 – 21
Guesthouse in San Diego
4.97 out of 5 average rating, 251 reviewsThe Coziest Retreat in N. PB
Aug 19 – 26
Guesthouse in San Diego
4.89 out of 5 average rating, 183 reviewsSun-filled cottage w/roofdeck
May 28 – Jun 4
Guesthouse in Mission Hills
4.91 out of 5 average rating, 355 reviewsLa Casita - Fully Updated Casita in Mission Hills
Aug 15 – 22
Guesthouse in Pacific Beach
4.83 out of 5 average rating, 220 reviewsPacific Beach Cottage Blocks from Beaches/La Jolla
Nov 17 – 24
Guesthouse in San Diego
4.93 out of 5 average rating, 503 reviewsModern Surf Cottage
Jan 11 – 18
Guest house rentals with a patio
Guesthouse in San Diego
4.91 out of 5 average rating, 151 reviewsCentral studio w/ private outdoor space & parking
Feb 1 – 8
Guesthouse in La Mesa
4.98 out of 5 average rating, 251 reviewsLa Mesa Suite
Oct 28 – Nov 4
Guesthouse in Lakeside
4.94 out of 5 average rating, 100 reviewsSky Mesa-Adorable Cottage on the Hill
Jan 8 – 15
Guesthouse in San Diego
4.99 out of 5 average rating, 151 reviewsAdorable cottage in Talmadge
Jan 24 – 31
Guesthouse in San Diego
4.99 out of 5 average rating, 142 reviewsMission Hills-Entire Guest House-Center of it All
Guesthouse in La Mesa
4.97 out of 5 average rating, 130 reviewsDa Hui Hut-Beachy home/La Mesa’s best view and spa
Oct 16 – 23
Guesthouse in San Diego
4.99 out of 5 average rating, 109 reviewsModern Guest House with Patio, Parking, & Laundry
Oct 20 – 27
Guesthouse in La Mesa
4.97 out of 5 average rating, 119 reviewsSan Diego Newly Built Private Guesthouse (Sleep 5)
Sep 4 – 11
Guest house rentals with a washer and dryer
Guesthouse in San Diego
4.88 out of 5 average rating, 304 reviewsRockaway North - Family Friendly, Garage Parking & Laundry
Aug 28 – Sep 4
Guesthouse in Bay Park
4.97 out of 5 average rating, 329 reviewsPrivate Guesthouse with Bay View Deck
Aug 1 – 8
Guesthouse in Ocean Beach
4.89 out of 5 average rating, 282 reviewsRefurbished Indoor/Outdoor Sanctuary in Ocean Beach
Jan 20 – 27
Guesthouse in San Diego
4.91 out of 5 average rating, 166 reviewsBrand New Cozy Detached Casita w/AC & heat
Sep 21 – 28
Guesthouse in San Diego
4.93 out of 5 average rating, 106 reviewsThe studio apartment in Clairemont - New AC unit
Jun 26 – Jul 3
Guesthouse in North Park
4.98 out of 5 average rating, 185 reviewsNorth Park Garden Retreat Casita
Oct 22 – 29
Guesthouse in San Diego
4.96 out of 5 average rating, 117 reviews1BR Casita in the Heart of Kensington!
Sep 16 – 23
Guesthouse in San Diego
4.86 out of 5 average rating, 233 reviewsSea Star Cottage
Apr 9 – 16
Quick stats about guesthouse rentals in Mission Bay, San Diego
Total rentals
20 properties
Popular amenities
Kitchen, Wifi, and Pool
Wifi availability
20 properties include access to wifi
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Total number of reviews
2.4K reviews
Nightly prices starting at
€ 93 before taxes and fees
Destinations to explore
- House rentals United States
- Guesthouse rentals United States
- Guesthouse rentals San Diego
- House rentals San Diego
- Guesthouse rentals San Diego
- House rentals San Diego
- House rentals California
- Guesthouse rentals California
- Guesthouse rentals Palm Springs
- House rentals Palm Springs
- Guesthouse rentals Anaheim
- House rentals Anaheim
- Rentals with beach access Mission Bay
- Family-friendly rentals Mission Bay
- House rentals Mission Bay
- Cottage rentals Mission Bay
- Wheelchair accessible rentals Mission Bay
- Rentals with a washer and dryer Mission Bay
- Bungalow rentals Mission Bay
- Rentals with a hot tub Mission Bay
- Apartment rentals Mission Bay
- Hotel rentals Mission Bay
- Condo rentals Mission Bay
- Rentals with outdoor seating Mission Bay
- Rentals with pools Mission Bay
- Monthly Rentals Mission Bay
- Rentals with an EV charger Mission Bay
- Rentals with lake access Mission Bay
- Pet-friendly rentals Mission Bay
- Rentals with a patio Mission Bay
- Smoking-friendly rentals Mission Bay
- Beachfront rentals Mission Bay
- Fitness-friendly rentals Mission Bay
- Townhouse rentals Mission Bay
- Rentals with a fireplace Mission Bay
- Kid-friendly rentals Mission Bay
- Rentals with a fire pit Mission Bay
- Rentals with a kayak Mission Bay
- Waterfront rentals Mission Bay
- House rentals San Diego County
- Guesthouse rentals San Diego County
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom