Guesthouse vacation rentals in Mission Bay, San Diego

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Top-rated guesthouse rentals in Mission Bay, San Diego

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Guest favorite

A modern living area features a spacious sectional sofa with decorative pillows, accompanied by a marble top coffee table. A bright kitchenette is visible, equipped with stainless steel appliances. Natural light streams through multiple windows, leading to an outdoor space with a view.

Guesthouse in Bay Park

4.96 out of 5 average rating, 363 reviews

Private Guesthouse with Bay View Deck

The one bedroom, one bath unit was recently remodeled (in 2017) and includes all new kitchen, bathroom, full size laundry and air conditioning. The large 400 square foot private deck has new outdoor furniture with views of Mission Bay and gorgeous sunsets year round. Enjoy a show on the 50" 4K LG smart TV in the living room which offers Netflix, Amazon Video, and major network TV stations. Cook a delicious meal in the kitchenette complete with a mini-fridge/freezer, microwave, electric stove top, coffeemaker, and more. If you plan to head to the beach, the storage ottoman is secretly a "beach box" containing a couple of folding chairs, beach toys, towels and a small cooler. The unit is stocked with coffee, shampoo, conditioner, laundry supplies, iron, and more. Filtered water is provided via a faucet on the kitchen sink. Easy check-in via a numeric keypad on the front door with the code provided prior to arrival. Plenty of street parking is available. We love meeting new people and live next door in the main house so we are available most anytime. We are both from San Diego and still love to explore the latest new spots so we are happy to give recommendations. Bay Park is a great central neighborhood originally built in the early 1940s. It was recently voted the most livable neighborhood in a recent San Diego poll. Check out the restaurants on Morena Boulevard, which are just a few minutes' walk away or explore all of the major attractions of San Diego easily. The house has easy access to I-5 and is only 10-15 mins from downtown, Sea World, the San Diego Zoo and the airport. The private guest house is located across from Mission Bay and within walking distance to bay, market, restaurants and coffee shops. Uber/Lyft is $8 to $14 to most of San Diego's main attractions. There is a bit of white noise from the highway down the hill near Mission Bay when out on the deck but nothing too bad, just worthy of mention. The unit has double paned vinyl windows so it's quiet indoors.

Top guest favorite

A modern multi-level building showcases white stucco exteriors and various balconies. Lush greenery and palm trees surround the property, providing a vibrant contrast against the bright architecture. Neighboring homes offer glimpses of a charming residential area, with the distant ocean visible beyond the rooftops.

Guesthouse in Mission Hills

5 out of 5 average rating, 192 reviews

Santorini-Inspired Cottage w/ Hot Tub + Views

*CHECK OUT OUR OTHER AIRBNB* Travel 16 steps up a Greek-inspired curving stairway with 2-story high walls to your tucked-away cottage built into the hillside villa of Alta Colina. With spectacular views, step onto the balcony to watch planes take off & boats sail around the harbor. End the night in front of your secluded back patio fireplace or climb the steps of your spiral staircase to the rooftop Jacuzzi. European-inspired design & details, it'll be hard to believe you’re still in San Diego!

Guest favorite

A vibrant outdoor patio is visible through large sliding glass doors, surrounded by lush greenery. The space features a dining table and chairs for outdoor dining, with scenic views of the canyon and ocean in the distance. Comfortable seating is arranged in a bright living area.

Guesthouse in La Jolla

4.79 out of 5 average rating, 195 reviews

San Diego Shangri-La

This very comfy, 650 SF 1-bedroom house sits at the end of a cul-de-sac in a very QUIET neighborhood up on a hill. The property has good views of the canyon and the ocean in the background. It sits on a half acre lot across the street from the beautiful Kate Sessions Park where you'll find some great hiking trails and killer views of downtown, Mission Bay and SeaWorld. You'll love how cute and comfortable this place is! And just down the road are the sandy beaches of La Jolla and Pacific Beach.

Superhost

An open indoor space features a comfortable sofa adorned with decorative pillows. A large glass garage door leads to a private outdoor lounge area with natural greenery, seating, and a dining table, creating a seamless transition between indoor and outdoor living.

Guesthouse in Ocean Beach

4.89 out of 5 average rating, 330 reviews

Indoor/Outdoor Sanctuary in Ocean Beach

Open Design Concept with indoor/outdoor living! Concrete and hardwood floors throughout, with lots of natural light, including a huge glass garage roll-up door to a private enclosed outdoor lounge & dining area! Just fully renovated with carefully selected furniture to make your stay as comfortable as possible. The master bedroom (2nd level) has an ensuite bathroom and opens to a private sunny rooftop deck where you can enjoy the San Diego weather with outdoor lounging & beautiful sunset views!

Top guest favorite

Guesthouse in La Jolla

4.98 out of 5 average rating, 210 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

Welcome to your private 1,000 sq. ft. studio apartment, atop a scenic hill in La Jolla. Enjoy views of the ocean, bay, city lights and Sea World fire works display, creating the perfect backdrop for your getaway. Conveniently located just 5 minutes from the beautiful Windansea Beach and only 8 minutes from the vibrant village of La Jolla, where you can explore shops, dining, and cultural attractions. Experience the best of San Diego, with top attractions just minutes away. Your ideal getaway

Guest favorite

A welcoming entrance features red brick steps leading up to a solid wooden door, framed by dark wooden beams. Lush greenery and potted plants accentuate the pathway, while large windows on either side provide natural light to the area.

Guesthouse in San Diego

4.95 out of 5 average rating, 487 reviews

Modern Sweet Home Stay, Hillcrest, A/C Parking W/D

This quaint bungalow sits in a prime location of Hillcrest, a highly desirable area in San Diego. It is very quiet and private and sits directly behind our house(pictured) with a beautifully landscaped brick courtyard. You are within walking distance to "The Heart of Hillcrest" where you will discover many fabulous restaurants, coffee and boutique shops, and so much more. We are a short Uber drive to downtown and everywhere else San Diego has to offer. We hope you stay with us soon!

Guest favorite

Natural light brightens a serene sleeping area, featuring French doors that open to a lush view. A simple workspace with two woven chairs is present beside large windows, enhancing this inviting atmosphere.

Guesthouse in Clairemont Mesa

4.89 out of 5 average rating, 198 reviews

Serene San Diego Canyon Getaway

Our cozy studio-style guest house perched above a tree-filled canyon is a serene getaway in the center of San Diego, just a few minutes' drive to all local attractions and most of our other institutions (colleges, universities, hospitals). The casita is comfortable for two or a small family, with full kitchen capacity to prepare at-home meals. Our weather here is temperate, but if the weather gets hot, we have a silent mini-split A/C unit to cool the casita as needed.

Guest favorite

A casual pizzeria exterior is displayed, showcasing a warm brick facade and window signage. Red outdoor seating with metal chairs surrounds tables, inviting guests to relax. The restaurant name, 'Lefty’s Chicago Pizzeria,' is prominently featured above the entrance, creating a welcoming atmosphere for diners.

Guesthouse in Mission Hills

4.92 out of 5 average rating, 425 reviews

La Casita - Fully Updated Casita in Mission Hills

This well designed, fully updated detached studio casita is located in one of the most sought after neighborhoods in San Diego - Mission Hills. Surrounded by a serene garden courtyard with private entry and quiet patio. Close to great dining, grocery stores and shopping, and a mere 10 minutes or less to most of San Diego’s main attractions. If you are coming by car, there is plenty of free street parking - otherwise Ubers are plentiful and reasonably priced.

Guest favorite

Guesthouse in Mission Beach

4.9 out of 5 average rating, 742 reviews

South Mission Beach Zen-Like Studio

This fully furnished second story South Mission bayside studio offers relaxed beach living. This studio sleeps 2 (Queen Bed) & 2 Boogie Boards are provided; private off street parking on premise. Bbq grill on small balcony. The unit is steps to the bay and short three minute stroll to the beach. Two beach cruiser bicycles provided which is one great way to get around the area. Please note, access to the second story is via an outdoor spiral staircase.

Top guest favorite

A private outdoor seating area is showcased on a rooftop terrace, featuring two armchairs and a spacious couch, all adorned with decorative cushions. A wooden coffee table sits in the center, surrounded by lush greenery and palm trees. The sunset casts a warm glow over the scene.

Guesthouse in Hillcrest

5 out of 5 average rating, 104 reviews

Rooftop views 10min walk to Balboa Park/Zoo/Bars

Enjoy this peaceful second-story new guesthouse overlooking the treetops! A perfect day might be a morning stroll through Balboa Park, the cultural center of San Diego, surrounded by 58 miles of walking and running trails, followed by a short walk to the super fun bars and restaurants of Hillcrest, North Park, and University Heights. We LOVE this neighborhood and we are so excited to share the beauty, culture, and welcoming vibe of it with our guests!

Guest favorite

Guesthouse in Pacific Beach

4.96 out of 5 average rating, 191 reviews

Hosted by Christy

Cozy, quiet studio in the heart of Pacific Beach. Quick access to beaches, Pacific Beach Pier, Mission Beach, Mission Bay, shops, bars, and restaurants. Miles of walking and biking paths skirt the water; recreational opportunities abound. Fast & reliable WiFi and proximity to UCSD make this an ideal place for visiting professionals. We offer extended stay discounts as well, automatically applied.

Top guest favorite

Two beach cruiser bikes are parked against a vibrant blue wooden fence. The bikes feature distinct styles, with one displaying a light-colored frame and the other in black. The sturdy tires and comfortable seats suggest readiness for leisurely rides along the nearby beach.

Guesthouse in Mission Beach

4.98 out of 5 average rating, 324 reviews

2 Free Bikes + Parking • Walk to Ocean

🔹Steps to the Boardwalk, Beach and Bayside 🔸ONE min walk - 2 cafes, 2 bars, a mini-market grocery store, and a liquor store 🔹Dedicated Parking pot 🔸Beach cruiser bikes included 🔹FIVE min walk to Belmont Park amusement park 🔸NINE min drive to SeaWorld 🔹Cuban Tropicana Style 🔸Umbrella, Beach Chairs & Towels 🔹Fully Stocked Kitchenette 🔸Mixology set 🔹Spa like shower