Guesthouse vacation rentals in San Diego County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in San Diego County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A modern multi-level building showcases white stucco exteriors and various balconies. Lush greenery and palm trees surround the property, providing a vibrant contrast against the bright architecture. Neighboring homes offer glimpses of a charming residential area, with the distant ocean visible beyond the rooftops.

Guesthouse in San Diego

5 out of 5 average rating, 183 reviews

Santorini-Inspired Cottage w/ Hot Tub + Views

*CHECK OUT OUR OTHER AIRBNB* Travel 16 steps up a Greek-inspired curving stairway with 2-story high walls to your tucked-away cottage built into the hillside villa of Alta Colina. With spectacular views, step onto the balcony to watch planes take off & boats sail around the harbor. End the night in front of your secluded back patio fireplace or climb the steps of your spiral staircase to the rooftop Jacuzzi. European-inspired design & details, it'll be hard to believe you’re still in San Diego!

Superhost

A rustic sleeping area features a spacious bed with a patterned coverlet. Large windows provide natural light and views of the outdoors. A cozy armchair adds seating, while shelves display various decorative items. A mirror and soft lighting enhance the inviting ambiance.

Guesthouse in Escondido

4.91 out of 5 average rating, 752 reviews

Hilltop cabin retreat with lake & mountain views

Rustic hilltop cabin overlooking Lake Hodges. Surrounded by open canyons & mountains, you will feel like you're a million miles away from everything as you take in the views from the cabin, deck or the outside shower, swim in the saltwater pool, or relax by the fire bowl. A short walk to lake with boating, fishing & miles of hiking/mountain biking trails. Property offers swimming pool, fire bowl, and shaded arbor. SD Zoo Safari Park, wineries, breweries, & ocean beaches all within easy reach.

Top guest favorite

A serene scene captures the stillness of a swimming pool reflecting soft hues of sunrise against a misty landscape. Lush palm trees and rolling hills create a tranquil backdrop, while the elegant railing frames the picturesque view.

Guesthouse in Escondido

5 out of 5 average rating, 147 reviews

Infinity Poolside Apt. In San Diego Wine Country

140 Perfect 5.0 Reviews-Amazing views, peaceful and beautiful space in a wine country setting. A perfect setting to celebrate a special occasion and create memories. Amazing sweeping views of wine country, lake, golf course and mountains on the 14th green of a golf course with full access to the estate pool, spa, covered parking, EV charger w/private European park. Large luxury suite with a Kitchen, Sitting Room, Bathroom, Steam shower/Sauna and bedroom with luxurious robes, linens and towels.

Top guest favorite

Guesthouse in San Diego

4.98 out of 5 average rating, 203 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

Welcome to your private 1,000 sq. ft. studio apartment, atop a scenic hill in La Jolla. Enjoy views of the ocean, bay, city lights and Sea World fire works display, creating the perfect backdrop for your getaway. Conveniently located just 5 minutes from the beautiful Windansea Beach and only 8 minutes from the vibrant village of La Jolla, where you can explore shops, dining, and cultural attractions. Experience the best of San Diego, with top attractions just minutes away. Your ideal getaway

Guest favorite

A welcoming entrance features red brick steps leading up to a solid wooden door, framed by dark wooden beams. Lush greenery and potted plants accentuate the pathway, while large windows on either side provide natural light to the area.

Guesthouse in San Diego

4.95 out of 5 average rating, 481 reviews

Modern Sweet Home Stay, Hillcrest, A/C Parking W/D

This quaint bungalow sits in a prime location of Hillcrest, a highly desirable area in San Diego. It is very quiet and private and sits directly behind our house(pictured) with a beautifully landscaped brick courtyard. You are within walking distance to "The Heart of Hillcrest" where you will discover many fabulous restaurants, coffee and boutique shops, and so much more. We are a short Uber drive to downtown and everywhere else San Diego has to offer. We hope you stay with us soon!

Top guest favorite

Guesthouse in Escondido

4.98 out of 5 average rating, 133 reviews

Garden Casita

Enjoy a unique private space with no shared walls on an acre of lush property. Stroll the grounds picking fresh oranges and watch all the beautiful birds that grace our large ash trees. Sip coffee and watch the sunrise on the private deck off the casita, or a glass of wine by the fire pit. There’s also a private side yard where you can grill and dine. We are tucked away, yet close to shopping, restaurants and the beautiful Orfila winery. Easy access, parking, & check-in. Come see us

Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 200 reviews

Cute studio, private entrance & reserved parking

Newly remodelled studio with private entrance and one reserved drive way parking spot in an upscale neighborhood. Bright color designs will bring you all good moods and energy. Neighborhood is quiet and safe, near Sorrento valley, La Jolla and Del Mar beach. So many good restaurants and markets around. I'm an interior designer and really care about how my guests feel during their stays. When I designed and built this unit, I choose all unique materials that bring you the best experience.

Guest favorite

A charming garden patio is highlighted by an outdoor umbrella and cozy seating. Vibrant plants and flowers surround the entrance of the casita, which features double doors framed by soft ambient lighting. A decorative rug adds a colorful touch to the inviting space.

Guesthouse in San Diego

4.94 out of 5 average rating, 162 reviews

1BR Casita in the Heart of Kensington + EV Charger

Just blocks from Adams Avenue, this 1-bedroom San Diego casita is perfect for your vacation. It features a comfy queen bed, a 55" Roku 4K TV, a desk, and a private bathroom. The living area boasts high ceilings, a two-seater sofa, another 55" 4K TV, a bistro table, and a Euro-kitchen. Step out to your private succulent garden patio for a tranquil escape. Enjoy the convenience of a separate entrance and off-street parking. Perfect for exploring all that San Diego has to offer!

Top guest favorite

An outdoor seating area features two cushioned chairs and a cozy sofa beneath a shade umbrella. A circular fire pit sits at the center on a textured rug, surrounded by various plants and vibrant flowers, creating a welcoming space for relaxation.

Guesthouse in San Diego

4.95 out of 5 average rating, 106 reviews

Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV

This is the perfect Guest house with a salted & heated pool & hot tub. We are located in a super quiet & very safe neighborhood in beautiful San Diego, 15 minutes drive to Downtown, La Jolla, Beaches, Zoo, Sea World & Convention Center. Hike next door at Mission Trails & Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo and top quality finishes await you inside. Everything you need for memorable vacation! No smoking or vaping on the property.

Top guest favorite

A spacious bed is presented with an array of decorative pillows in orange and green hues. The headboard is adorned with a textured wall piece, and soft lighting from bedside lamps creates a calming environment. Natural light filters through a nearby window, partially covered by elegant curtains.

Guesthouse in Vista

5 out of 5 average rating, 271 reviews

New Tranquil Barn Retreat on a Peaceful Half Acre

The Buena Vista barn is a clean, quiet, and upgraded detached barn in Vista with everything you need for a peaceful and comfortable stay! Only 10 minutes to downtown Vista, you'll find great restaurants, breweries, shops, and a movie theater. Points of interest: • Downtown Vista: 10 minutes • Cal State San Marcos: 15-17 minutes • Beach: 20 minutes • Legoland: 22 minutes • Temecula and Wine Tasting: 30-40 minutes • Sea World: 47 minutes

Top guest favorite

An industrial-style bar features exposed wooden beams and a spacious layout, with patrons seated at high-backed stools. Multiple large screens display sports events, while rustic furnishings create a casual atmosphere. Natural light enters through large windows, highlighting the bar area where drinks are being served.

Guesthouse in San Diego

4.99 out of 5 average rating, 419 reviews

Mountain View Retreat in Gated Estate (Hot Tub)

Perched above a canyon with spectacular panoramic mountain views, this private guest house is a secluded retreat in one of San Diego’s most eclectic and desirable neighborhoods less than 6 miles from the Downtown San Diego airport. Enjoy a fully equipped kitchen, luxe king size bed and dual sliding glass doors that open to an expansive deck with patio seating, private hot tub and BBQ area.

Top guest favorite

A charming cottage is situated atop a landscaped hill, featuring steps leading up to its entrance. The exterior is a blend of natural materials, with large windows and a covered patio area offering shade. The surrounding landscape is well-maintained, contributing to a welcoming atmosphere.

Guesthouse in Lakeside

4.95 out of 5 average rating, 167 reviews

Sky Mesa-Adorable Cottage on the Hill

SkyMesa is a lovely space to unwind and relax after a busy day. Awake refreshed and ready for a day of exploring San Diego County in this quaint, sunny cottage with impressive views. Head out and wander east to the mountains and desert, or west to the many beautiful beaches. After a day of fun, grab a glass of wine, soak in the hot tub, and look out over the Cuyamaca Mountains.