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House vacation rentals in Mesa County

Find and book unique houses on Airbnb

Top-rated house rentals in Mesa County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Top guest favorite

A spacious porch features wooden flooring and is lined with tranquil seating options, including a set of chairs and a swing. Natural light filters through the surrounding trees, enhancing the peaceful outdoor space.

Home in Delta County

4.96 out of 5 average rating, 263 reviews

2 Bedroom Ranch House

Just a bit off of Highway 65 sits Tongue Creek Ranch. The Ranch is located in the fertile valley junction of Tongue Creek and Surface Creek. Enjoy your own private 2 bed 1 bath ranch house. Both bedrooms have a super comfy pillow top queen size bed. WIFI is a fast 1gig fiber optic line. Enjoy a full kitchen, washer and dryer, and a sleeper sofa in the family room. The front patio is always in the shade. Ask about the optional cabin on site for use as a private detached room for overflow family.

A private hot tub is illuminated with soft blue light, positioned under a shelter. A cozy seating area features comfortable chairs adjacent to a fire pit, with warm flames flickering. Twinkling string lights provide a welcoming ambiance against the night sky.

Home in Palisade

4.92 out of 5 average rating, 245 reviews

Peach Pad! hot or cool tub 2 bedrooms 2 bathrooms

Sandstone views, outdoor area with private hot tub, can be kept cool in hot weather just message your preference. Bedrooms with en-suite bathrooms and are situated on opposite sides of the home for privacy. 7-10 minute bike ride to downtown, 5-10 minute walk to three vineyards,. Orchard surrounds 900 sq ft bedrooms and the living room have smart TVs, the kitchen is well equipped. The fenced yard has shaded outdoor areas to BBQ and enjoy sunsets. Best for 4 guests comfortable roll away bed for 5.

The front porch features a spacious sitting area with blue adirondack chairs and a small table. The entrance is highlighted by a welcoming blue door, and outdoor lighting adds a cozy touch to the structure. Surrounding greenery creates a relaxing atmosphere.

Home in Grand Junction

4.85 out of 5 average rating, 762 reviews

Happy Hippie House

Welcome to our beautiful, 1950 home known by our guests as the Happy Hippie House! Our home's interior has been updated, giving it a fresh, chic hippie vibe. The eclectic decor creates a light & airy interior. Come hang out on the front porch! Discover wineries, skiing, hiking, biking, kayaking & rafting. Minutes from CMU, hospitals, & a lovely downtown area. Free Wi-Fi & Roku w/Netflix. Electronic lock for easy late check-in. LGBT & 420 friendly (outside)! Earns 5 stars for convenient location.

Top guest favorite

A two-story house is surrounded by vibrant autumn foliage, featuring warm orange and yellow leaves. The structure is composed of wooden siding and large balconies, creating an inviting presence amidst nature. The peaceful setting is ideal for enjoying views of the surrounding landscape.

4.96 out of 5 average rating, 207 reviews

Laura's View Tower - King, Birders' Paradise, Desk

Nestled on a hillside with unique sweeping views, the Tower is the perfect destination for romantic escapes, remote work & family or group getaways. Entire house is yours! Laundry included. The spacious two-story house boasts a versatile open floor plan and is designed for ultimate comfort. Upstairs, enjoy the sunny private deck, king-sized bed, twin sofa couch, office desk and a spacious bathroom with oversized bathtub. The well-equipped downstairs kitchen includes range & oven plus dishwasher.

A rustic carport features a vintage vehicle with weathered paint, under a metal roof. An American flag hangs from one post, while colorful hanging planters add a touch of greenery. The surrounding open area is dotted with sparse grass and low shrubs.

Home in Orchard City

4.95 out of 5 average rating, 533 reviews

The Orchard House

**A devastating freeze in October 2020 killed all 400 of our sweet cherry trees and many of our peach trees. Sadly, our orchard is not the lush green jewel it once was. We are planting new cherry trees in the Spring of 2022. While the orchard views have changed, the Orchard House continues to offer a very comfortable place to rest and recharge. Come enjoy fresh air and quiet whether you are stopping through on a road trip or staying longer for local adventure. Fast WiFi for telecommuting!

Top guest favorite

Home in Grand Junction

4.98 out of 5 average rating, 178 reviews

Resort-like Adobe At Colorado Monument!

This newly renovated adobe style home will make you feel like you’re in a resort with amazing views. Perfect for a family vacation, girls/guys trip, mountain biking trip, romantic getaway, wine tasting or just a weekend getaway this is the perfect home. Close to many outdoor activities including hiking, fishing, mountain biking, Paddle boarding/kayaking/tubing, golfing. Located 5 mins to Two Rivers and 25 mins to Palisade vineyards. We are offering the complete Colorado outdoor experience.

A welcoming entrance features wooden steps leading to a front door framed by greenery. The façade is complemented by natural stone accents and surrounded by lush grass and aspen trees, creating an inviting connection to the outdoors.

4.91 out of 5 average rating, 111 reviews

Powderhorn Grand Mesa Classy Family Cabin

Enjoy the outdoor recreation paradise of Powderhorn and the Grand Mesa from your spacious, cozy home. Winter brings downhill and cross-country skiing, snowshoeing, ice fishing and beautiful snowy vistas. Summer allows hiking and all things outdoors sounded by million acres of public lands. The 800 square mile top of the Grand Mesa hosts 300 lakes for fishing as well as paddle boarding and other small watercraft. Hiking trails galore and Powerhorn mountain supports summer mountain biking.

An open living and dining area features a spacious layout, hardwood flooring, and modern furnishings. A large dining table is set with light blue placemats. A contemporary chandelier hangs above, with a cozy seating area adjacent to a large television mounted on the wall.

Home in Grand Junction

4.94 out of 5 average rating, 393 reviews

🌞Sunny & Chíc🌞 Downtown Oasis

Walk to downtown from this unique, newly remodeled 1930's home in a safe quiet neighborhood. You’ll have plentiful off street parking, a fenced in backyard, a large fully-stocked kitchen and spacious bedrooms with comfy memory foam beds. 1-2 miles to CMU, Lincoln Park and St Mary's Hospital. 10 min drive to the Lunch Loops mountain bike trail system and hiking and climbing in the Colorado National Monument. Please note this home is kept comfortably cool with an evaporative cooler, not AC.

Top guest favorite

The farmhouse, featuring a classic white exterior and a sloped metal roof, is surrounded by lush greenery and colorful flower beds. A path leads from the gravel driveway to the welcoming entrance. In the backdrop, rugged cliffs rise, adding to the scenic rural setting.

Home in Palisade

4.98 out of 5 average rating, 183 reviews

A Peach of a Farmhouse

Located on the Scenic Fruit and Wine Byway, our newly remodeled air-conditioned farmhouse is on a three-acre peach farm within easy biking distance to Palisade. Enjoy downtown Palisade's farmers market, distillery, and brewery. We're moments from many wineries and trailheads including Mt. Garfield & Palisade Rim. Begin, end or spend your day lounging on the front porch in the shade of mature peach trees or enjoying views of the rugged Palisades seeming to rise just outside the back door.

Top guest favorite

A well-lit bedroom is adorned with light green walls and two windows dressed in sheer purple curtains. A spacious bed sits centered, layered with decorative pillows and a plush blanket. A small desk and chair are positioned near a cozy seating area, with floral decor enhancing the inviting atmosphere.

Home in Grand Junction

4.92 out of 5 average rating, 309 reviews

Colorful 2 bedroom pet friendly home

Make some memories at this unique and family-friendly place. Our home welcomes you and your pet/s to enjoy our 2 newly decorated bedrooms with blackout curtains, remodeled luxurious bathroom with 2 showerheads, full kitchen , laundry, pet door, dog run, back porch to sit and relax, and lovely backyard to enjoy. We encourage you to walk downtown, only 6 blocks away. The Colorado National Monument, regional airport, CMU, library, Science Center for kids, and bike trails are very close.

Top guest favorite

A contemporary home is presented with a wooden exterior, surrounded by a gravel area. Large glass doors offer views into the interior space. Two outdoor chairs are positioned on the patio, with wildflowers and vegetation framing the scene.

5 out of 5 average rating, 595 reviews

Fruita/Loma Guest House at the Perfect Day Getaway

This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

A modern living area features a comfortable dark sofa with yellow accent pillows. A glass coffee table sits in the center. Green drapes frame the window, allowing natural light to fill the space. Artwork adorns the walls, adding a touch of color to the neutral decor.

Home in Grand Junction

4.96 out of 5 average rating, 261 reviews

New, Clean & Cheerful Townhome

Enjoy your stay at this fully-stocked, clean and centrally located townhome in Grand Junction, CO! This newer, EnergyStar® rated home includes comfortable beds, 2 baths, one with large walk-in shower and the other with soaker tub. SmartTv and access to SlingTV with fast WiFi access. Full-size washer and dryer, and 1-car garage access features bike racks, workstation and tools for the mountain biking enthusiasts! Enjoy the covered patio with included BBQ grill and table seating area!

Vacation rentals for every style

Get the amount of space that is right for you

Apartments

Convenient locations with everyday essentials

Cottages

Quaint homes, peaceful surroundings

Cabins

Kick off your hiking boots at these rustic lodgings

Popular amenities for Mesa County house rentals

Free parking on premises

Air conditioning

House rentals with a pool

A vibrant outdoor area features a sparkling private pool, surrounded by lounge chairs and colorful umbrellas. String lights create a warm ambiance above a tiki bar, while a large inflatable swan floats in the water. Lush greenery complements the tranquil setting.

Home in Grand Junction

4.95 out of 5 average rating, 41 reviews

Pool~Hottub~MiniGolf~Gameroom~SoccerCourt~TikiBar

Top guest favorite

A spacious backyard features a heated pool surrounded by lounge chairs on a stone patio. A hot tub is positioned nearby, with rocky landscaping and potted plants enhancing the area. The two-story home looms in the background, framed by trees and an open sky.

Home in Grand Junction

5 out of 5 average rating, 79 reviews

Pool, hot tub, views and close to everything

A sparkling pool occupies the foreground, surrounded by a spacious patio area with several lounge chairs. In the background, expansive views of rolling hills and clear blue skies enhance the outdoor setting, with well-maintained green lawns visible beyond the fence.

Home in Clifton

4.97 out of 5 average rating, 39 reviews

The Prickly Pear @ Palisade Legends

A spacious pool area is framed by a white privacy fence, with a clear blue sky overhead. The pool features a diving board and is surrounded by sun loungers and landscaped greenery, creating a serene outdoor atmosphere. The backdrop includes rocky cliffs that enhance the natural beauty of the setting.

Home in Palisade

4.83 out of 5 average rating, 71 reviews

Palisade Peach Orchard Farmhouse w/Pool & Spa 18+

A spacious living area features a red leather sofa and a decorative area rug, inviting relaxation. Natural light filters through the windows, illuminating a dining table nearby. Wall art and curtains add character to the room, creating a comfortable atmosphere for gathering.

Home in Grand Junction

4.8 out of 5 average rating, 40 reviews

Adventure Home Base - 7 Blocks to Downtown!

The exterior of a single-story house is presented, featuring a green and brick façade. Large windows allow natural light to enter. A clear driveway extends in front, and trees are positioned nearby, complementing the outdoor space within a fenced yard.

4.92 out of 5 average rating, 12 reviews

Rustic Refuge - minutes from downtown Fruita

A private saltwater pool glistens under a sunset sky, surrounded by lounge chairs and umbrellas. The house features a two-story façade with large windows and a spacious deck area decorated with comfortable seating, blending relaxation with serene outdoor views.

Home in Grand Junction

5 out of 5 average rating, 9 reviews

Pool/Theater/Game Room/Hot tub/Quiet Retreat

An indoor pool area is shown, featuring a smooth tiled surface surrounding the clear water. The space is illuminated with soft wall lights, and the walls are painted in a calming blue hue, enhancing the serene ambiance.

Home in Grand Junction

4.88 out of 5 average rating, 8 reviews

Lakeside Retro 4BR 2 BA, Pool, Hot Tub whole house

Weekly house rentals

The exterior of a single-family house is viewed from the front, featuring a light blue facade and a white door. A slate walkway leads to the entrance, and a small planter is positioned beside the door. A well-maintained lawn is visible in the foreground.

Home in Grand Junction

4.86 out of 5 average rating, 138 reviews

Cozy 2-Bedroom House on a quiet Residential Street

Top guest favorite

An expansive view of the West Elks mountain range is visible from the front porch. A wooden railing frames the scene, while a fire pit area is situated on the ground below. Lush fields and rolling hills stretch toward the mountains under a clear blue sky.

Home in Crawford

4.98 out of 5 average rating, 101 reviews

Needle Rock View Retreat

Top guest favorite

The living room features a comfortable sectional sofa arranged around a central coffee table. A modern fireplace adds visual interest near the windows, which allow for natural light. A TV is mounted on the wall, enhancing the cozy atmosphere. An entry door is visible.

Home in Grand Junction

4.97 out of 5 average rating, 153 reviews

NEW! Heart of Downtown: The Hill Oasis

A modern kitchen is highlighted by sleek white cabinetry and stainless steel appliances. A large island with a granite countertop serves as a focal point, adorned with a vase of colorful flowers. Ample natural light streams through a window, illuminating the well-equipped cooking space.

Home in Grand Junction

4.88 out of 5 average rating, 302 reviews

Monument Paradise on golf course

Top guest favorite

A dining area features a custom wood table surrounded by a built-in bench and stools. Natural light fills the space through large windows. Unique light fixtures hang from a wooden beam above, while a chalkboard wall adds a creative touch to the room.

Home in Palisade

4.97 out of 5 average rating, 174 reviews

Downtown Palisade Charmer

A covered porch features a small round table, surrounded by wooden railings. Sunlight streams through, illuminating the area and casting soft shadows. The view includes a fenced yard and trees in the distance, creating a serene outdoor space.

Home in Grand Junction

4.88 out of 5 average rating, 113 reviews

Cozy 3 bedroom Home. Close to it all!

A wooden dining table is surrounded by six chairs, positioned against a soft green wall. A large antlered deer head is mounted in a frame above the table, while a chandelier hangs from the ceiling. Verdant plants are displayed near the window.

Home in Grand Junction

4.9 out of 5 average rating, 105 reviews

Two King Beds, Downtown, Full Kitchen, Fenced Yard

Top guest favorite

The exterior of the home features a modern design with a dark-colored façade. A gravel driveway leads to a large garage. Decorative elements, including a vintage wagon wheel and stone slabs, enhance the front yard, set against a bright sky with scattered clouds.

Home in Grand Junction

4.97 out of 5 average rating, 101 reviews

Squeaky Clean~Like New~Comfy 3 Bedroom Home

Private house rentals

A modern cottage exterior is presented, showcasing a welcoming entrance with a neutral-toned front door. Large windows allow natural light to flood the interior, surrounded by a gravel pathway and greenery. Mature trees provide shade and enhance the serene setting.

4.87 out of 5 average rating, 30 reviews

Mesa Creek Cottage

A modern kitchen area features white cabinetry and stainless steel appliances. A cozy seating area includes a navy sofa, red accent pillows, and a circular table. Decorative bicycle-themed accents and warm lighting create a welcoming ambiance.

4.96 out of 5 average rating, 206 reviews

Handlebar Heaven! Cute Cottage in Downtown Fruita

Top guest favorite

A spacious living area features a comfortable sofa and a wooden coffee table layered on a patterned rug. A modern kitchen with stainless steel appliances and a dining counter is visible in the background, complemented by natural light from the nearby windows.

Home in Grand Junction

4.97 out of 5 average rating, 63 reviews

The Park Place! (Pet Friendly)

Top guest favorite

A bright and open room features a spacious bed with light bedding and plush pillows. Natural wood ceilings complement large windows that provide ample light and views. A cozy sofa and a small dining table are also visible, contributing to a comfortable and inviting living space.

Home in Palisade

5 out of 5 average rating, 39 reviews

Peach Palace

A modern two-story home is surrounded by desert landscape, featuring large windows that provide panoramic views. An elevated deck is seen with a putting green below, lined with stones. Bicycles are parked nearby, complementing the outdoor recreational space.

4.97 out of 5 average rating, 96 reviews

Horsethief Hideout |Hot Tub, Firepit, Grill, Views

Top guest favorite

A stylish living area features a decorative fireplace adorned with intricate tile. A modern gray armchair sits beside a round wooden table that holds books and a vase of yellow flowers, while large windows invite natural light and provide views of the outdoor landscape.

Home in Palisade

4.98 out of 5 average rating, 66 reviews

Modern Pali Farmhouse & Vineyard with hot tub

Top guest favorite

Home in Palisade

5 out of 5 average rating, 39 reviews

Lily of the Valley~Welcome home!

An aerial view presents a charming house surrounded by well-maintained greenery. Outdoor seating areas are visible under large umbrellas, with a winding pathway leading through manicured lawns. Several lounge chairs are arranged invitingly on the grass, adding to the tranquil ambiance of the property.

5 out of 5 average rating, 14 reviews

Private Cozy Cottage Retreat Peaceful & Romantic

Destinations to explore