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Guesthouse vacation rentals in Mesa

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Mesa

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
The exterior showcases a charming guest house with a stucco finish, surrounded by lush greenery. A cozy seating area is positioned on the porch, featuring colorful cushions and side tables. Soft lighting from string lights enhances the welcoming ambiance, while potted plants add a touch of nature.
Guesthouse in Tempe
4.97 out of 5 average rating, 164 reviews

Private yard - Short walk to Mill - Historic House

Reliably operated by a top AZ Superhost with 2,250+ 5 star stays. A TRUE find! Best location in Tempe - walkable to downtown, bars and restaurants on Mill, ASU (1.5 miles), Tempe Beach Park, etc. Hidden-away historic guest house with a private yard (and even a secret outdoor shower). Professionally designed and setup with guest comfort in mind - everything is here for you - premium bed, a dedicated workstation, fast speed WiFi, fully stocked kitchen, an outdoor seating space with bistro lights.

Top guest favorite
A spacious California King bed is centered in the room, adorned with a white quilt. Two pillows rest against the headboard. Natural light filters through a window with blinds, illuminating the inviting sleeping area.
Guesthouse in Gilbert
4.93 out of 5 average rating, 437 reviews

Spacious Casita, Quiet, Peaceful Home - No Stairs!

Cozy Casita in a beautiful, quiet neighborhood. California King bed sleeps two comfortably. 50 inch TV has cable, Netflix, DVD player with assortment of movies. Keurig coffee pot, fridge and microwave. Dining table inside. Outdoor seating opens to peaceful, scenic backyard. Parking available in the driveway. Park to the left of 2 car garage. Our Casita is a modest room that we have done our best to make comfortable for travelers who want an alternative to an impersonal hotel. No pets allowed.

Guest favorite
A private outdoor patio is featured, highlighted by a dining table and game set on a grassy area. Large glass doors reveal a spacious interior with visible furnishings. Soft lighting and greenery add a touch of warmth to the setting.
Guesthouse in Scottsdale
4.97 out of 5 average rating, 138 reviews

Entire Private Guest House with King Master

•Location, Location, Location! Extremely safe/social neighborhood just minutes from Oldtown! 5- minute drive by car and 10 minutes by E-scooters! •Bordered by lush greenery, your private backyard/covered patio is a perfect place to enjoy the outdoors •Recently built in 2022 with luxury, comfort, and entertainment in mind ~ you'll love the vibe of your private small backyard and small yet spacious 520sqft space. This guest house has its own private, yet beautiful entrance TPT 21476951 AZ 2026023

Top guest favorite
Guesthouse in Tempe
4.99 out of 5 average rating, 105 reviews

Walk to ASU | Downtown Retreat + Private Yard

Welcome to The Studio at Maple Ash - your private hideaway—perfect for ASU parents, visiting professors, business travelers, couples, and solo travelers. Located in the heart of downtown Tempe, inside the iconic Maple Ash neighborhood, just 10 minutes from Sky Harbor Airport. Walk to ASU, Gammage Auditorium, and Tempe Beach Park in minutes. Whether you're visiting your ASU student, catching a music festival, Spring Training game, or attending a Broadway show, this is the perfect home base.

Top guest favorite
A private room features a spacious bed with layered bedding, complemented by two decorative pillows. A small dining table with two chairs sits in the corner. Large windows with wooden shutters frame a view of greenery outside, and landscape artwork adorns the wall.
Guesthouse in Chandler
4.98 out of 5 average rating, 103 reviews

Cozy Casita with kitchenette

Bright, comfortable, private room with queen bed, TV, internet, A/C, bath & kitchenette (electric skillet, refrig/freezer, microwave, toaster, Cuisinart coffee maker (single cup or pot), water filter, sink). Add herbs from our courtyard to your stir-fry. Separate casita is located in a small, quiet community near freeways (101, 202). Restaurants & entertainment options nearby in Chandler or Gilbert. Drug store, grocery and fast food all within walking distance (half mile). Community pool.

Guest favorite
A light and airy living area features a contemporary white leather sofa, complemented by a wooden coffee table. Natural light fills the space through two windows adorned with light curtains. A dining table with elegant chairs is visible in the background, surrounded by decorative plants.
Guesthouse in Mesa
4.92 out of 5 average rating, 125 reviews

Luxury Modern Executive Retreat

Northeast Mesa location close to Tonto National Forest, the Salt River and Saguaro lake. 5 minutes from Boeing, Nammo Talley or MD Helicopter. 25 minutes from downtown Phoenix or Scottsdale. Nestled at the base of the Goldfield mountains. Contemporary open floor plan with modern design. Private entrance and single parking spot in front of the main house. Fast WiFi. Roku and cable TV. Beautiful, quiet neighborhood close to city amenities as well as biking and hiking trails. TPT# 21558238

Top guest favorite
The inviting kitchen area showcases white cabinetry and a granite countertop, complemented by a microwave. A cozy sleeping nook is visible in the background, integrating seamlessly with the living space. Natural light enters through an open door leading to the outdoor area.
Guesthouse in Gilbert
4.94 out of 5 average rating, 288 reviews

Private Cozy Cottage in Gilbert. Close to it all!

Recently updated- the Cozy Cottage is perfect for your AZ stay and has everything needed to make your trip as comfortable as possible. Ideal for couples and young families. Safe for solo travelers. The neighborhood is upscale and a great location. Walk to the Gilbert Riparian a nature lovers paradise just 1/4 mile away. Shopping, restaurants, nightlife are 10 minutes away. 20 mins to Phx, Scottsdale or desert hiking. We are here to answer any questions or help with any issues 24/7.

Top guest favorite
A bright and airy studio space features a comfortable bed with crisp white bedding and a cozy sitting area with a plush sofa. Natural light fills the room through the window, and a small bedside table with a lamp adds a touch of warmth.
Guesthouse in Mesa
4.99 out of 5 average rating, 232 reviews

Private, Convenient Studio Apartment

Discover the perfect blend of location and comfort in our newly renovated studio apartment. Nestled centrally between Mesa, Scottsdale, and Tempe, you're at the heart of abundant dining choices, shopping convenience, and grocery store accessibility. Just 15 minutes from Sky Harbor and a swift 30 minutes from Mesa Gateway, your travels are a breeze. Enjoy total privacy with your exclusive entrance, ensuring a tranquil, personal escape in the midst of the city's best offerings.

Top guest favorite
The image depicts a serene outdoor setting featuring a large pool surrounded by lounge chairs and palm trees. Covered seating areas and a dining space can be seen in the background, under a twilight sky that casts a soft glow on the scene.
Guesthouse in Mesa
4.88 out of 5 average rating, 333 reviews

Casita/ Heated Pool, Hot Tub, Amazing Amenities

Private Casita with an amazing steam room and upscale shower. Heated large pool and hot tub along with three covered outbuildings: full outdoor kitchen with BBQ, full stove, MW, Hot Water Sink and large bar area; living room and dining room with wood burning fireplace. A full set of dishes, pots and pans are in this area for your use. Lots of private sitting areas or just hang out in the orchard and pick citrus fruit from the 40 plus trees.

Top guest favorite
A spacious bedroom is highlighted by natural light from a door leading outside. The room features a queen size bed covered with a blue striped comforter, flanked by two bedside tables with lamps. Framed artwork adorns the walls, adding character to the space.
Guesthouse in Mesa
4.95 out of 5 average rating, 280 reviews

Cozy, Private Mid-Century Casita

Enjoy your stay in the Valley of the Sun at this 350 sq. ft. stand-alone private casita with full bathroom & kitchenette. The bedroom features incredible natural light, but also the ability to block it out if you wish. Rest easy on the comfortable queen size bed and catch up on your favorite shows on the HD smart TV. WiFi is available, & for business travelers there is a laptop desk. Please, no children or animals.

Top guest favorite
A well-lit bedroom features a king size bed adorned with a floral blue and white duvet. Natural light streams in through plantation shutters. A minimalist armchair and lamp complement the space, while a simple rug adds warmth underfoot.
Guesthouse in Mesa
4.96 out of 5 average rating, 530 reviews

Mesa Casita with King Bed

Casita with a king size bed and kitchenette located in a quiet Mesa neighborhood. The room is a dedicated Airbnb space in a separate building from the main house with it’s own entrance, private bath, and kitchenette perfect for a quick breakfast or a bite to eat. We are minutes from local freeways. A 15 min drive to Scottsdale, Tempe, Chandler, and Gilbert.

Top guest favorite
A welcoming guest house is presented with a blend of white siding and natural stone accents, framed by lush greenery. A pathway leads to the entrance, flanked by well-maintained gardens. An American flag is displayed, contributing to the property’s inviting exterior.
Guesthouse in Mesa
4.94 out of 5 average rating, 151 reviews

The White Barn @ Freedom Farms

Kick off your boots and relax in this calm, stylish, private guest house on Freedom Farms! Explore the natural swimming pond on the property, venture out to the Sonoran desert for a nature hike, tube down the salt river or mountain bike in Usery! You'll find our location close to the city but not in the city.

Popular amenities for Mesa guesthouse rentals

When is the best time to visit Mesa?

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Avg. price€ 87€ 98€ 102€ 82€ 75€ 71€ 71€ 66€ 70€ 81€ 83€ 82
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Quick stats about guesthouse rentals in Mesa

  • Total vacation rentals

    Explore 150 vacation rentals in Mesa

  • Nightly prices starting at

    Mesa vacation rentals start at € 26 per night before taxes and fees

  • Verified guest reviews

    Over 12,060 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 30 rentals that welcome pets

  • Vacation rentals with a pool

    40 properties feature pools

  • Rentals with dedicated workspaces

    70 properties have a dedicated workspace

  • Wi-Fi availability

    150 of Mesa vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Mesa rentals

  • 4.9 Average rating

    Mesa stays are highly rated by guests—averaging 4.9 out of 5!

  • Nearby attractions

    Mesa's top spots, include Sloan Park, Golfland Sunsplash, and Hohokam Stadium

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