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Guesthouse vacation rentals in Lee County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Lee County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Lee County guesthouse rentals
Family-friendly guest house rentals
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Guesthouse in Fort Myers
4.81 out of 5 average rating, 54 reviewsQuiet Area close to Beaches, shopping and FGCU
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Guesthouse in Fort Myers
4.92 out of 5 average rating, 105 reviewsThe Hummingbird House: life's simple pleasures!
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Guesthouse in Fort Myers
4.97 out of 5 average rating, 282 reviewsChameleon Guest Cabana
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Guesthouse in Fort Myers
4.98 out of 5 average rating, 624 reviewsHints of Key West in Fort Myers' Historic District
Guest house rentals with a patio
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Guesthouse in Cape Coral
4.89 out of 5 average rating, 19 reviewsrelaxation house
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Guesthouse in Fort Myers
5 out of 5 average rating, 16 reviewsTropical Oasis Loft
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Guesthouse in Alva
4.77 out of 5 average rating, 26 reviewsCharming Alva Efficiency
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Guesthouse in Fort Myers
4.83 out of 5 average rating, 46 reviews"Arlington Rental" Your Affordable Guesthouse
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Guesthouse in Bonita Springs
5 out of 5 average rating, 32 reviewsBeachy Airstream Oasis with Bikes
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Guesthouse in Bonita Springs
4.93 out of 5 average rating, 15 reviewsHouse by the river
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Guesthouse in Bonita Springs
5 out of 5 average rating, 11 reviewsSpacious 1 Bedroom Suite
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Guesthouse in Bonita Springs
5 out of 5 average rating, 14 reviewsSpacious & updated living 1.5 miles to beach
Guest house rentals with a washer and dryer
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Guesthouse in Estero
4.9 out of 5 average rating, 29 reviewsAdorable Cottage with Heated Pool -Jaccuzi - Sauna
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Guesthouse in Cape Coral
4.82 out of 5 average rating, 44 reviewsBright and Cozy 1-Bedroom Guesthouse
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Guesthouse in Fort Myers
5 out of 5 average rating, 70 reviewsGuesthouse
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Guesthouse in Fort Myers
5 out of 5 average rating, 72 reviewsCharming Carriage House in Historic Neighbourhood
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Guesthouse in Fort Myers Beach
4.95 out of 5 average rating, 19 reviewsLil Lavender
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Guesthouse in Cape Coral
5 out of 5 average rating, 12 reviewsLuxury on the Lake
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Guesthouse in North Fort Myers
4.97 out of 5 average rating, 32 reviewsFish, Hunt, Sleep, Repeat!
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Guesthouse in Bonita Springs
4.95 out of 5 average rating, 78 reviewsPrivate guest house Coconut Point
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