
Pet-friendly vacation rentals in Lee County
Find and book unique pet-friendly homes on Airbnb
Top-rated pet-friendly home rentals in Lee County
Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.

McGregor’s Gem• Heated Pool 3BR/2BA River District
🌴 Welcome to McGregor’s Gem—your ideal Southwest Florida retreat! Dive into relaxation in your private heated pool, spread out across three bedrooms and two baths, and enjoy the perfect blend of peaceful tree-lined neighborhood living just minutes from the charming Downtown Fort Myers River District, world-class beaches, and top local attractions.☀️ Whether you’re traveling with family, friends, or on business, this home offers all the modern comforts you need for a relaxing, stress-free stay
4.96 out of 5 average rating, 147 reviews
Excellent Location! Gulf Access, Heated Pool Chic!
Excellent location! Close to amenities: Ft. Myers airport 11 miles Ft. Myers, Sanibel, Captiva & San Carlos beaches 15 miles and the canal is 10 minutes to the River with NO bridges. NEAR FGCU & FSW. 2 kayaks to enjoy the canal for those relaxing moments. This home is off a dead-end street: very quiet and safe neighborhood. This home is located to all major restaurants, shopping and tourtist attraction. Guests have seen dolphins in the canal while fishing- Andirondack chairs replaced. FUN SPOT!!
4.94 out of 5 average rating, 53 reviews
Gulf Access | Heated Pool | Spa | 2x Kings Beds
Escape to this 5-bed, 3-bath oasis in Cape Coral’s canal system, just minutes from the Gulf of Mexico by boat. Relax in the lanai-covered saltwater pool and hot tub, surrounded by tropical landscaping. Perfect for families, pets, and biz travel, the home features a spacious kitchen, multiple TVs, cable TV, and water views. Just 5 mins to beaches, 10 mins to dining & shopping, and 35 mins to Fort Myers Airport—your ultimate Florida escape awaits! Moderate cancellation policy & no cleaning fee!
4.92 out of 5 average rating, 156 reviews
Paradise on Estero Bay
Welcome to Mullock Creek a Boater's dream! Southwest views boasting breathtaking sunsets overlooking gulf access canal from your spacious backyard, just minutes away from shopping and dining at Coconut Point, and Gulf Coast Town Center. This stunning Key West Style home has been beautifully maintained and updated offering a lovely front entrance, fully equipped kitchen, spacious Living Room, dining room, Wi-Fi, private driveway with access to the open garage, fully furnished and private pool.
4.94 out of 5 average rating, 163 reviews
Heated Pool + Hot Tub |3BR | Large Pool|Sleeps 10
•Prime Location: Just minutes from Sanibel & Captiva Islands • 10-minute walk to movie theaters, shops, and restaurants • 8 min to Fort Myers • 10 min to Cape Coral Water Park • 25 min to the airport • Perfect for families & remote work • 5 Smart TVs • Fast Wi-Fi • Family-friendly amenities & games • Fully equipped kitchen • Washer & dryer • Sofa bed • Beach towels & bathrobes • Outdoor living: • BBQ grill • Outdoor dining area • FREE onsite parking • Easy self check-in
4.96 out of 5 average rating, 101 reviews
Bohemian Bungalow / Washer + Dryer / Private
Your family will be close to everything when you stay at this centrally-located place. Stylish, yet comfortable - You have access to an additional spacious sun patio, a washer and dryer, and ample back and front yard. 10 miles to the beach, biking distance to Historic Downtown Fort Myers, this home is a renovated blast from the past. Terrazzo floors throughout kept the original Florida charm. The most peaceful neighborhood with walking distance to a restaurant with indoor/outdoor dining.
4.95 out of 5 average rating, 104 reviews
Key West Style Home w/ Hot Tub & Boat Lift
KEY WEST style stilted waterfront home in the heart of Matlacha! Visit all there is offer - walking distance to Blue Dog and Perfect Cup. Take a boat ride to Cabbage Key, Cayo Costa or Boca Grande! Upstairs and downstairs are screened in. The second floor is peaceful and tranquil overlooking the water and treetops. Home is a 2 bedroom, 2 bathroom, with additional bonus space with trundle bed. Home is perfect for boaters with double driveway, complimentary boat lift and cleaning station.
4.96 out of 5 average rating, 90 reviews
Chuly |8PPL | Top Location | Hot Tub | Gazebo |BBQ
We want to Be you Host in Cape Coral! Let us show you why you should book with us: - Top Location: - 2 Min to Sun Splash Family Water Park - 20 minutos to Fort Myers Beach - 20 minutos to Sanibel Beach - New Hot Tub - 5 Smart TVs - Fast WIFI - Terrace with Gazebo - Fully equipped kitchen - Dedicated work space - Free Onsite parking - BBQ - Outside dining - Washer & Dryer - Playground - Games Room - Mini Golf - Beach towels - Residential Neighborhood - 24/7 Available Hosts
4.99 out of 5 average rating, 146 reviews
Modern City Loft in Downtown River District
Welcome to Gun-Loft, a custom-designed modern sanctuary in the Downtown River District. This expansive 3500 square foot city loft is tailored for those seeking to embrace the cosmopolitan lifestyle, with the perfect blend of urban luxury and cultural richness. Whether it's a leisurely stroll to the Edison Ford Home, an exciting night out, or a culinary adventure in the restaurants nearby, Gun-Loft offers an unparalleled experience in the city's most coveted location.
4.99 out of 5 average rating, 104 reviews
Whole cozy house
Entire cozy house just for you friends and family. Perfect to spend a pleasant and relaxed moment. If you plan to have a party or event, this place is NOT for you. The neighbors are very strict in terms of noise and large groups of people. Well maintained house. CLEAN POOL BUT NOT HEATED. Walk in to a living area and separated dining. 20 minutes to airport, 25 minutes to the beach, fine dining and entertainment. For a virtual tour, click on the cover photo twice.
4.95 out of 5 average rating, 407 reviews
Sunny Pool Home Central Cape Coral
Enjoy a comfortable stay in this centrally located Cape Coral pool home, close to shopping, dining, groceries, entertainment and the Midpoint Bridge to Fort Myers. The home features 2 bedrooms, 2 full bathrooms, a king primary suite, queen bedroom, additional daybed sleeping space, full kitchen, living and dining areas, Smart TVs and direct access to the pool and patio. A great home base for relaxing, exploring Cape Coral or visiting Southwest Florida.
4.9 out of 5 average rating, 217 reviews
Luxury Riverfront:Pool, Tiki Bar & Outdoor Kitchen
Reconnect and relax at this spacious riverfront retreat, perfect for gathering with family and friends. This custom coastal home offers 4 bedrooms, 4 bathrooms, and 3 separate living areas, giving everyone room to spread out and unwind. Enjoy morning coffee while watching boats, dolphins, and manatees pass by, then spend the day soaking in the heated saltwater pool and spa. Guests may enjoy the views, but the dock is not available for boat use.
5.0 out of 5 average rating, 95 reviewsPopular amenities for Lee County pet-friendly home rentals
Pet-friendly house rentals

Inn Season Cottage-Cozy Florida Living
5.0 out of 5 average rating, 103 reviews
WF Oasis~Htd Pool~Spa~Pets4Free~BBQ~Big Lanai~Dock
4.99 out of 5 average rating, 116 reviews
Luxury Home, Steps to the Sand! Pet Friendly!
4.98 out of 5 average rating, 112 reviews
AquaLux Smart Home
4.91 out of 5 average rating, 90 reviews
TikiTime Tropical Riverfront Retreat
4.85 out of 5 average rating, 26 reviews
3 bed/2 bath Saltwater Pool House Near Everything
5.0 out of 5 average rating, 25 reviews
Heated Pool & Spa | Game Room | Walk to Sun Splash
5.0 out of 5 average rating, 14 reviews
Boater’s Paradise in Bokeelia!
4.91 out of 5 average rating, 47 reviewsPet-friendly home rentals with a pool

100+ 5 Star Reviews and Right on The Beach!
4.95 out of 5 average rating, 121 reviews
River Views / Luxury 2BR/2BA, Pool, Walk downtown
5.0 out of 5 average rating, 13 reviews
Luxury Oasis w/ Heated Pool, Theater Room & Dock!
4.97 out of 5 average rating, 33 reviews
Dolphin Cove Villa • Heated Pool • Hot Tub •Tiki
5.0 out of 5 average rating, 36 reviews
Cape Coral Escape: Heated Pool, Hot Tub, Game Room
5.0 out of 5 average rating, 14 reviews
Newly Remodeled 4BR Home with Private Heated Pool
5.0 out of 5 average rating, 16 reviews
Renovated 4/4 with Fishing, Pool, Boating, Beach
4.96 out of 5 average rating, 24 reviews
Yacht Club Beauty....walking distance to the beach
5.0 out of 5 average rating, 63 reviewsPrivate, pet-friendly home rentals

Waterfront Matlacha Cottage - Sunsets & Fishing!
4.93 out of 5 average rating, 58 reviews
Farm Stay at Misty Morning Farms
5.0 out of 5 average rating, 58 reviews
Offshore Oasis Cottage
4.98 out of 5 average rating, 50 reviews
Modern 2BR Near Sanibel & FM Beach • Sleeps 6
4.98 out of 5 average rating, 56 reviews
Kid-friendly beachy house off Sanibel & FM Beach
4.89 out of 5 average rating, 87 reviews
3 BR Heated Pool House with Boat Lift
4.98 out of 5 average rating, 84 reviews
Marino Home II Luxury
5.0 out of 5 average rating, 11 reviews
Seahorse guesthouse Entire house close toSanibel
4.95 out of 5 average rating, 87 reviewsDestinations to explore
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