Vacation rentals in St. James

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

The Hillandale Farmhouse 4 BR/3 BA Extended Stay

The Hillandale Farmhouse — single-level, ramp entry, room to breathe on a working Kentucky farm. Built for comfort, ease, and real living, this spacious home offers wide doorways and an accessible primary suite with a low-curb shower. The layout gives families and groups room to spread out, backed by a fully stocked kitchen, a washer and dryer near the main entrance, and ample truck and trailer parking for work crews, hunters, and longer stays. Any pets must be noted in the reservation.

Rivertown Getaway

Great location in the middle of town. Easy walk to the downtown area that offers great history on area with a museum & historic one room schoolhouse, take a walk along the beautiful Mississippi River, check out Veterans Park, etc., so much do to and see! This home can sleep 4 comfortably and accommodate 2 more guest with a blowup air mattress that is on site. Inside you will find new appliances, bedding, and linens. The outside is a work in progress! No smoking or pets allowed.

Waterfront Duck & Fishing Lodge -Private Dock

Welcome to your 2025 waterfront home base for adventure. This brand-new 4BR, 2BA private lodge sleeps large groups comfortably and includes linens, essentials, tankless hot water, washer/dryer, and modern finishes. Covered porches protect gear, with ample parking for 3 boat trailers plus vehicles. Enjoy a private dock for fishing or guide pickup. Minutes from major boat ramps, Blue Bank, local restaurants, and Walton’s gas station. Perfect for hunters, anglers, families, and retreats.

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Gloria’s on Exchange-Entire Home-3rd bedroom opt

Welcome to Gloria’s on Exchange, a cozy home away from home located in a quiet historic neighborhood. The bones of our home date to 1910, but this little house has received a loving renovation. Local art gives off a “rustic” feel, but all is completely tricked out with smart technology and very cozy furniture and bedding. 2 BEDROOMS/2 BATHS ARE INCLUDED IN THE LISTED PRICE. ADD ON OPTION for 3rd bedroom access w queen bed for $30 per night.

Newly Renovated 3 Bedroom 2 Bath Home - Sleeps 9

Looking for a spacious and welcoming Airbnb in Sikeston? 🏡✨ This gorgeous, newly renovated 3 bedroom, 2 bathroom home is the ideal destination for unforgettable memories with your loved ones. The house sleeps up to 9 guests comfortably, making it perfect for families and groups. Conveniently located in a fantastic residential area, you're just moments away from local attractions, shopping, and dining spots.

Family Home near the MS River with a toy Room

The whole group will enjoy easy access to everything from this centrally located place. 3 blocks from the New Madrid boat ramp / levee. Less than 5 miles from HWY 55. Large family style home - on the first level - living room, dining room, kitchen, laundry room, guest bathroom, main bedroom and main bathroom. The upstairs has 2 bedrooms and a toy room with another full bathroom upstairs.

Emma’s Cottage

Take it easy at this unique and tranquil getaway. Emma’s cottage is located in the historic north end of Sikeston, just minutes away from the local hospital and power plant, which makes it a perfect place for traveling professionals and people coming into town to visit friends and family. This cottage is 2 bedrooms, 1 bathroom, with a queen bed and a full bed.

The Peery House at Springhill Farms

The Peery House is our family home-place, built circa 1900, transformed into a quaint Airbnb. It is located on our farm, Springhill Family Farms in Western KY and is a great place for someone looking to get away from the busyness of life, looking for rest and relaxation or just looking for a unique, little farmhouse while passing through the area.

THE DREAMCATCHER

Beautiful brick home with lake view and access to Reelfoot Lake (no ramp), paved drive with ample parking for boat / trailer, back deck with table and chairs, open space kitchen and den, perfect for group fishing trip, hunting trip, or just sight seeing, (area known for its large population of eagles), quiet neighborhood, peaceful place to stay.

La Center country house

This is our vacation home from busy lives. It has been completelly renovated. Your family will be enjoying 4 bedroom 2 bathroom house with amazing fully stock kitchen and fenced in backyard with patio. Grocery 2 min walking distance. Also couple local restaurants within walking distance. This is trully amazing house with everything you need!!