Vacation rentals in St. James

1-bedroom tiny home located in historic Bloomfield

Kick back and relax in this calm and stylish space located minutes from the Missouri Veterans Cemetery and The Stars and Stripes Muesum and Library. 1bdrm/1bath comfortably sleeps 2 and is furnished with everything you need. Inside you will find all new appliances, bedding, and linens. Circle drive with parking. No smoking or pets allowed. Local restaurants include Las Brasis and Elderland. Or try out locally owned businesses just 6.5 miles drive to Dexter such as Hickory Log and Dexter BBQ!

Glamping Double Domes on Private Lake & Hot Tub!

Adventure meets comfort at the Space Cowboy Lake Domes — the ultimate glamping experience where rustic frontier charm collides with sleek modern design. This unique double-dome retreat features a full kitchen, bathroom, and space for up to four guests across two connected domes — one with a cozy living area and sleeper sofa, the other with a private queen bedroom. Step outside to your expansive lakefront deck with a hot tub, fire pit, grill, outdoor shower, and private lake access and kayaks.

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Cozy 2 Bedroom Cottage in Portageville - Sleeps 4

Looking for a cozy and comfortable Airbnb in Portageville? 🏡✨ This charming, newly updated cottage is the ideal destination for unforgettable memories with your loved ones. Conveniently located in a fantastic residential area right behind the town's elementary school, you're just moments away from local attractions, shopping, and dining spots. With ample parking, you can easily come and go as you please. Enjoy the comfort and convenience of our family-friendly home during your stay.

Rivertown Getaway

Great location in the middle of town. Easy walk to the downtown area that offers great history on area with a museum & historic one room schoolhouse, take a walk along the beautiful Mississippi River, check out Veterans Park, etc., so much do to and see! This home can sleep 4 comfortably and accommodate 2 more guest with a blowup air mattress that is on site. Inside you will find new appliances, bedding, and linens. The outside is a work in progress! No smoking or pets allowed.

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Modern Luxury Cabin, Fireplaces, Hot Tub Paducah

Shepherd’s Lantern Acres offers an unparalleled luxury retreat experience, featuring two cabins that seamlessly blend modern comfort with breathtaking natural beauty. Your cabin features unobstructed views of over 2 acres of seasonal wildflower meadows and pristine nature. Dogs are also welcome to enjoy their very own dog spa! With a beautiful master suite, well-appointed kitchen, and in unit laundry, we have ensured that all the comforts of home are at your fingertips.

Perfect Couples Retreat - firepit

Come stay at The Perch, a rare and memorable little hideaway perched on a hillside with the best sunset views in Western Kentucky. Cozy king loft, full bath, tiny kitchen, and a porch perfect for morning coffee or evening cocktails. Hang out at the fire pit and grill area while you take in the stars and fresh air. Our four fur off-leash babies love meeting new friends—so you gotta love pups too! Perfect for couples or solo travelers.

Family Home near the MS River with a toy Room

The whole group will enjoy easy access to everything from this centrally located place. 3 blocks from the New Madrid boat ramp / levee. Less than 5 miles from HWY 55. Large family style home - on the first level - living room, dining room, kitchen, laundry room, guest bathroom, main bedroom and main bathroom. The upstairs has 2 bedrooms and a toy room with another full bathroom upstairs.

Emma’s Cottage

Take it easy at this unique and tranquil getaway. Emma’s cottage is located in the historic north end of Sikeston, just minutes away from the local hospital and power plant, which makes it a perfect place for traveling professionals and people coming into town to visit friends and family. This cottage is 2 bedrooms, 1 bathroom, with a queen bed and a full bed.

The Peery House at Springhill Farms

The Peery House is our family home-place, built circa 1900, transformed into a quaint Airbnb. It is located on our farm, Springhill Family Farms in Western KY and is a great place for someone looking to get away from the busyness of life, looking for rest and relaxation or just looking for a unique, little farmhouse while passing through the area.

THE DREAMCATCHER

Beautiful brick home with lake view and access to Reelfoot Lake (no ramp), paved drive with ample parking for boat / trailer, back deck with table and chairs, open space kitchen and den, perfect for group fishing trip, hunting trip, or just sight seeing, (area known for its large population of eagles), quiet neighborhood, peaceful place to stay.