Hotel vacation rentals in Saint Charles County

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Top-rated hotel rentals in Saint Charles County

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Guest favorite

A spacious room showcases a leather sofa and a wooden coffee table. A large window allows natural light, framing views of greenery. The sleeping area features a bed with crisp linens, and a small kitchenette is visible in the background.

Hotel room in St. Louis

4.76 out of 5 average rating, 103 reviews

The West End by Cortex, Forest Park, BJC & Zoo

Welcome to The West End, your ideal retreat in the heart of the Central West End! Just steps away from charming attractions like forest park. Great amenities are: - Fast and stable fiber internet connection - Communal kitchen with 2 sets of range, ovens, fridges, microwaves, and dishwashers. - Complimentary coffee - Secured Gated Parking $10/Night - Hot Tub - Great patio space with seating and a gas grill - Complimentary Netflix, Hulu, Disney+, and ESPN+, where available and local TV channel

Top guest favorite

A spacious bedroom features a king-size bed with a neutral-toned coverlet. Exposed brick walls add character, while a vintage bicycle is mounted above the bed. Natural light streams in through the window, complemented by curtains that frame the view. A decorative chest is situated at the foot of the bed.

Hotel room in Saint Charles

5 out of 5 average rating, 32 reviews

#2 Swiftwalker Parade LeVelo Inn

Make some memories at this unique and family-friendly place.Under the copper eyebrow on the front of the building, this door will lead you down a hallway that will take you to an original staircase of this historic building. Lots of natural light as well as an exterior door that exits out to a parade balcony to check out life on N 2nd Street. king-size bed, living area with large sectional couch for a comfortable stay extra guests with an extra thick queen mattress. Private kitchen/dining.

Top guest favorite

The spacious common area features an open kitchen with a dark granite countertop, blending modern functionality with historic charm. Two large stained glass windows cast colorful light throughout the room, while a grand staircase leads to an upper level, showcasing the building's architectural elegance.

Hotel room in St. Louis

4.98 out of 5 average rating, 44 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

Discover refined elegance in The Riverfront Suite, where Gothic grandeur meets contemporary comfort. This distinctive retreat showcases original stained glass windows and exotic wood finishes . A plush queen bed and ambient electric fireplace create an intimate atmosphere, while the luxurious en-suite bathroom features heated floors, designer tile work, and a 2-person soaking tub. Take in panoramic city views from the shared rooftop hot tub. Perfect for couples seeking a romantic escape.

Superhost

A spacious room features two queen beds, each topped with crisp linens. A soft quilt is neatly draped across one bed. A large window, dressed with light curtains, allows natural light to brighten the space. A flat-screen TV is mounted on a wooden dresser.

Hotel room in Brentwood

The Best of Suite Living! Ideal for Work & Leisure

By staying at our property, you can make the most of your trip, whether it's for work or pleasure. We are conveniently located near renowned destinations including Hanley Park, the St. Louis Children's Aquarium, and Oak Tree Park in the Brentwood neighborhood. We are close to Whole Foods Market, Applegate's Deli, and Camille's Sidewalk Cafe, among other well-known restaurants. You can grab a free breakfast in the morning and get a head start on your day. Enjoy the free parking and Wi-Fi.

An outdoor courtyard area is illuminated by warm lighting, featuring a decorative lantern on a stone surface. Surrounding potted plants add greenery, while stone and brick elements create a welcoming entrance to the nearby hotel building.

Hotel room in Earth City

4.56 out of 5 average rating, 27 reviews

Perfect Getaway Near The Airport | Free Shuttle

The Holiday Inn St. Louis Airport West Earth City is just 6 miles from the St. Louis-Lambert International Airport and offers a complimentary airport shuttle. Conveniently located near downtown St. Louis and Historic St. Charles, travelers and guests will be in an ideal location for shopping, dining, and entertainment. Visitors can dine or enjoy cocktails at Elements, our on-site restaurant and bar. A well-equipped fitness center and a relaxing heated indoor pool complete your stay.

Guest favorite

The spacious studio features high ceilings and large industrial steel-frame windows, allowing natural light to fill the room. A modern sofa and armchairs are arranged around a wooden coffee table. A dining area with seating is visible, complementing the minimalist design.

Hotel room in St. Louis

4.91 out of 5 average rating, 134 reviews

Chic Ultramodern Studio Loft w/ Designer Features

The Nash Loft is a stunning minimalist studio with 12’ ceilings + bright 7’ industrial steel-frame windows, a spacious open layout, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, an Edison-illuminated community courtyard, and a fully-equipped kitchen with black stainless appliances and quartz countertops. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

A well-arranged guest room features two spacious queen-sized beds with soft linens and olive green bedspreads. The room is accented by a textured light gray carpet and a large window with solid curtains. A cozy armchair sits beside a bedside table, enhancing the inviting space.

Hotel room in Cottleville

5 out of 5 average rating, 3 reviews

Double Queen Room 203

Room 203 features two queen-sized beds Oak Street Inn & Lounge, 8 Room Boutique hotel situated in the bustling center of downtown Cottleville. Oak Street Inn & Lounge will offer an elegant restaurant and craft cocktail lounge on the ground floor Indulge in room service from Pink Willow Cafe, or dine in! Come up to the rooftop patio on the third level for a cocktails, small bites and breathtaking views of Cottleville. Look for our Hidden Gem the Speakeasy in the lower level!

A private suite features a large bed with a plaid blanket. The room is furnished with a dresser and has a workspace with a chair in an adjoining area. Natural light filters through the windows, illuminating the decorative fireplace, which adds historical charm.

Hotel room in Saint Charles

4.78 out of 5 average rating, 251 reviews

1st Capitol Mansion Boutique Hotel - Suite 201

This unit is a hotel style unit that is located in the heart of downtown historic St. Charles. It's located right across the street from a coffee shop, wine bar and the oldest local pub in St. Charles. It is just a few blocks away from all of the shopping and restaurants on Main St. The mansion was built in 1902 and still holds all of the charm from back then. This is a private suite with it's entrance from the rear of the building right off the parking lot.

The exterior of Seven Gables Inn is showcased, featuring a distinctive Tudor-style architecture with steeply pitched roofs and decorative half-timbering. The entrance is framed by trees, while outdoor seating is visible, inviting guests to relax. Modern buildings are seen in the background, providing a contrast to the historic charm.

Hotel room in St. Louis

4.63 out of 5 average rating, 8 reviews

Clayton’s Hidden Gem for Elegant Stays | Dining

Welcome to Seven Gables Inn ✨ Stay steps from shops, galleries, and top dining in Clayton’s historic district. Just 10 minutes from downtown St. Louis and 15 minutes from Lambert Airport, this boutique hotel blends 1920s Tudor charm with modern luxury. Enjoy elegant rooms, a charming courtyard, complimentary Wi-Fi, and authentic dining at SEVEN restaurant. A timeless St. Louis experience awaits!

A bright seating area features large windows allowing ample natural light. A cozy sofa rests against the wall, accompanied by a wooden dining table surrounded by upholstered chairs. A painting of a natural landscape completes the aesthetic, adding a calming element to the space.

Hotel room in Saint Charles

4.54 out of 5 average rating, 13 reviews

The Opulent Owl Suite

The Owl Suite at the Divine Otter Hotel offers a stylish 1-bedroom escape, sleeping up to 2 guests. Enjoy upscale furnishings, a modern design, and a spacious full bathroom with plenty of natural light. Located in the heart of Historic Main Street Saint Charles, you’ll be steps away from shops, dining, and more. This impressive suite is the perfect blend of comfort and location!

Top guest favorite

The exterior of a historic Victorian house is presented, featuring a light-colored facade with decorative motifs around the windows. Lush greenery frames the entrance, with manicured hedges leading to the front steps. The building showcases multiple stories and distinctive architectural details.

Hotel room in St. Louis

4.97 out of 5 average rating, 68 reviews

Napoleon's Retreat - Lafayette Room - Lafayette Sq

Lafayette square has the largest collection of renovated victorian houses in America and this is one of them. Dating to 1876, this historic home offers quality amenities. We are located near: America's Center Convention Complex - 2 Miles Bush stadium - 1.5 Miles Stifel Theatre - 1.4 miles Gateway Arch - 2.1 Mi Enterprise Center - 1.2 Mi Delmar Hall - 7 Mi

The exterior of the hotel is showcased in warm evening lighting, with a modern facade featuring large windows and welcoming entryways. The entrance includes outdoor seating under a covered area, while flags are displayed prominently at the front.

Hotel room in Clayton

4.91 out of 5 average rating, 11 reviews

Less than 2 miles from St. Louis Galleria Mall

Find us a mile from I-170 and less than two miles from St. Louis Galleria Mall and Washington University in St. Louis. St. Louis Zoo and Forest Park are a 10-minute drive away, while The Pageant on Delmar Loop is a 6-minute drive from our door. Enjoy daily free hot breakfast served daily, a drink at Danielle's Bar, free WiFi, and our indoor mineral pool.