Vacation rentals in Santee River

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Top-rated vacation rentals in Santee River

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Top guest favorite
A cottage sits elevated on a wooden deck, surrounded by lush greenery and vibrant flower beds. A fire pit is framed by four white Adirondack chairs, offering a cozy gathering space. The two-story structure features a welcoming front door and ample outdoor space for relaxation.
Guesthouse in Summerville
5 out of 5 average rating, 81 reviews

2 King bed 2 Bath*Walkable* Downtown Summerville

Hidden away amidst lush azaleas and towering pines, you will find yourself at the heart of small-town Southern Living. This two-story Guest House provides you with the perfect combination of secluded garden landscapes and downtown accessibility. Modern amenities and a whimsical interior design will make your stay in our charming cottage a time to remember. You'll be within a short walk of local shops and restaurants and an easy drive to downtown Charleston and surrounding beaches and attractions

Top guest favorite
The spacious interior of the loft is characterized by a high ceiling with exposed wooden beams. A large, swinging sofa offers comfortable seating, while a rustic coffee table and a well-equipped kitchen with wooden cabinetry are visible in the background. Natural light filters through large windows.
Guesthouse in Summerville
4.98 out of 5 average rating, 759 reviews

★Delightful guest house near historic plantations★

Nestled in the Historic Plantation District between Summerville & Charleston, our timberframe "bunkhouse" offers privacy, comfort & convenience. This 850+ sq ft retreat includes full kitchen & bath, 2 dbl beds, twin bed & plenty of living space. There's a private entrance, so come & go as you please (we're right next door if you need us). Minutes from Middleton Place, Drayton Hall & Magnolia Gardens, an easy drive to dntn Charleston, historic S'ville, beaches & golf courses. *Now with WiFi*

Top guest favorite
An elegantly decorated sitting area is presented with a detailed mural ceiling and rich purple drapes. A plush loveseat and two accent chairs surround a circular rug in the center. Windows allow natural light to fill the space, highlighting the ornate moldings.
Apartment in North Charleston
4.96 out of 5 average rating, 143 reviews

Bridgerton inspired fantasy 2 min from park circle

Live out your Bridgerton fantasy in this stunning historic space. The apartment features antique furnishings/art, a private entrance and patio with lounge and a hot tub (The hot tub is available Apr through Nov). Off street parking. A sumptuous bathroom with an oversized soaking tub and a kitchenette. There is also a 55 inch frame tv in the bedroom including WiFi. Available for photo shoots upon request rates may differ please contact host prior. Bridal pics by Olivia Allain Permit#2026-0414

Guest favorite
A modern kitchen features sleek white cabinetry and a marble countertop. Stainless steel appliances are positioned for convenience. Pendant lights hang above the island, complementing the warm wood ceiling. A window allows natural light, framing a view of the outdoors. A rug adds softness to the floor.
Home in Moncks Corner
4.97 out of 5 average rating, 114 reviews

The Boho Barndo

Take it easy at this unique and tranquil getaway. The Boho Barndo is the perfect spot to get away. Well stocked to make your stay comfortable. We are just 20 min from Downtown Summerville, 30 min from the Charleston International Airport and 5 min from shopping and dinning. The barndo is located on a large 5 ac. tract. The entrance is gated and you will have your own designated parking area. The main house is located about 250 yrds away from the barndo and allows you to enjoy peace and quite

Superhost
A view of a houseboat docked at a marina, accessible by a wooden walkway. Nearby, a gazebo offers shaded seating. The clear blue sky contrasts with the calm water, while lush greenery lines the distant shore, creating a serene landscape.
Home in Georgetown
4.89 out of 5 average rating, 159 reviews

Maggie Jo’s paradise on the river !

Reconnect with nature at this unforgettable escape. Maggie jo is a 1970 completely restore houseboat. She has got a full size refrigerator , gas range ,microwave and toaster oven. Out on the back deck she has a gas grill. The aft berth has 2 full beds that are extremely comfortable. Galley dinette make into bed and the couch in the saloon pulls out also. While on the decks you will see eagles, dolphins , gator or fishing jumping out of the water. I also have 2 tandem kayaks for your use.

Guest favorite
An open living area is visible, featuring a gray sectional sofa and a wooden table set for casual dining. Natural light fills the space through multiple windows. A kitchen area is seen in the background, with appliances neatly arranged for convenience.
Farm stay in Nesmith
4.94 out of 5 average rating, 166 reviews

Country farm cottage

Enjoy a beautiful and fun stay at the farm and get to know over 100 rescued farm animals! 60 acres and only about 5 miles from Backwoods quail club and river landing. Wake up to the roosters crowing and the birds chirping. Settle in for the night with the sound of the crickets and if nature plans for it some really beautiful sunsets. 4 beds in upstairs loft. Sofa pulls out to a bed. 1 hour to Myrtle Beach. 1.5 hour to Charleston. Occasional cricket or bug may sneak in. It’s a farm.

Top guest favorite
A brick front exterior is shown, featuring a covered porch with a bench and two rocking chairs. Potted plants are arranged neatly on either side, while a flower bed adds color at the base. The grassy lawn extends toward a driveway.
Home in Moncks Corner
4.92 out of 5 average rating, 108 reviews

Our Home is Your Home!

Home in a safe environment on a tidal creek joining the Cooper River. Extra parking on the two lots adjoining the home. 5 to 15 minutes away from Lake Moultrie, river access, and all local restaurants, grocery stores, and Walmart. Experience Berkeley County with a convenient app as a guide to discover local history and plan your outdoor activities. 20 minutes from Summerville and 45 minutes from historic downtown Charleston and the Dock Street Theater ( the first theater in the US).

Top guest favorite
Farm stay in Georgetown
4.98 out of 5 average rating, 65 reviews

Lo & Billy’s Place a Historic 1940s Newlywed Cabin

This romantic cabin located on our small farm just outside of town in the country offers a history all its own. Lo was Billy’s nickname for Lorene Ella. Lo & Billy got married in the 1950s and lived here. Renovated after meeting Lo and hearing her stories. We pay homage to the rich history of Georgetown and the Southerners that have called Lo & Billy’s Place home. Heavy on coziness & design. Full kitchen; good coffee; & comfy queen bed w/high end linens. The perfect escape.

Top guest favorite
Home in Moncks Corner
4.98 out of 5 average rating, 84 reviews

The Brown Trailer

Welcome to The Brown Trailer in Pinopolis. It's a peaceful 3 bedroom, 2 bathroom older trailer that’s been well taken care of, sleeps up to 9 (7 in beds) with views of a pasture, use of a large backyard, and parking. Bring your boat as lake accesses to Moultrie start a 1/4 mile away with Cooper River accesses near by. Somerset, Wampee, Pineland Place, 108 W Main, Santee Canal as well as MC Regional Complex are minutes away, Summerville is 20’, and Downtown Chas is 45’. Come enjoy!

Superhost
A wooden dock extends into the calm waters of the lake, surrounded by green landscaping. A path leads up from the dock to a grassy area with seating arrangements. Trees frame the scene, providing a natural setting for relaxation.
Cottage in Manning
4.74 out of 5 average rating, 166 reviews

A Great Lake house. Near Manning, SC and I-95.

Secluded and serene, our private lakefront property in South Carolina's Lake Marion region offers a community feel with minimal traffic and noise. The fenced-in property has 2 cozy bedrooms, a large open floor plan, and a screen porch with a beautiful lake view. Enjoy the private dock, kayaks, and floats, and relax with a bonfire and grill. Conveniently located just 20 minutes from Manning and I-95, our retreat is perfect for travelers looking to unwind and recharge.

Top guest favorite
A field of blooming yellow flowers is displayed in the foreground, with delicate petals and green stems. In the background, a white farmhouse is visible, providing a serene country setting. The scene captures the tranquility of the flower field adjacent to the cottage.
Tiny home in Moncks Corner
4.95 out of 5 average rating, 160 reviews

The Goose Cottage at Wild Goose Flower Farm

Located next to the family farmhouse at Wild Goose Flower Farm, The Goose Cottage was designed to immerse guests in our calm and peaceful country life. We are located 15 minutes from the hearts of Cane Bay, Nexton and Exit 194 on I-26, and 45 minutes from Downtown Charleston. Two can sleep in the queen size bed but the sofa also extends into a queen-sized sleeper. Please reach out with further questions or if you would like to inquire about an extended stay.

Top guest favorite
Home in Cordesville
5 out of 5 average rating, 73 reviews

The Wrenn’s Nest - Quaint National Forest Getaway

The Wrenn's Nest is a cozy two-bedroom cottage in the Francis Marion National Forest. Perfect for outdoor activities like hiking, fishing, and birdwatching, it offers a peaceful retreat with modern comforts. Located in Cordesville, SC, just 15 minutes from Moncks Corner, it’s surrounded by nature with few neighbors. Enjoy amenities like a laundry nook, fire pit, and a spacious lot. Guests are our priority, and we’re always here to help!

Popular amenities for Santee River vacation rentals