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Hotel vacation rentals in Santa Cruz de la Sierra

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Santa Cruz de la Sierra

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Superhost
A spacious hotel room is featured, showcasing a seating area with a circular dining table and a sofa. Large windows allow natural light to enter, providing views of the surrounding area. The sleeping area includes a large bed and a wall-mounted flat-screen TV.
Hotel room in Centro
4.6 out of 5 average rating, 30 reviews

"Feel at Home"Breakfast buffet !

The room is in the heart of the financial and business district of Santa Cruz ,just a few minutes walk from the main square of the city .Guest will find many shops , supermarket and restaurants nearby and places to go out at night ,only 5 minutes walk from accommodation . Featuring free wifi ,free parking,air conditioning , private bathroom ,cable , american breakfast free of charge ! Guest can relax by the pool , the jacuzzi or make use of the sauna .Fitness facilities are also available!

The spacious living area features a round dining table surrounded by four elegant chairs. A chandelier hangs overhead, illuminating the space. A comfortable sofa is positioned along a wall with a large window that provides natural light and access to a balcony.
Hotel room in Centro
4.75 out of 5 average rating, 68 reviews

Luxurious 5 Star Hotel Suite in Equipetrol area

Located in the best neighborhood in the city, Barrio Equipetrol. You'll be staying in a 118m2 Suite at a 5-Star hotel where you can enjoy the safety and comfort of a top-rated hotel. Work trip? With a co-work space and blocks away from the Business Area of the city. Coming to explore Santa Cruz? Only steps away of San Martin Avenue to visit the most trendy restaurants, shopping malls and social experiences in Santa Cruz. Also located only 10 minutes away from the historical center of the city

Top guest favorite
Private room in Santa Cruz de la Sierra
5 out of 5 average rating, 7 reviews

Private room

Disfruta de una habitación privada y confortable en una ubicación estratégica y segura a solo media cuadra de una avenida principal, a pasos de centros comerciales, supermercados, mercados y bancos, lo que te garantiza comodidad y fácil acceso a todo lo que necesitas. Contarás con cama queen de 2 plazas ideal si vienes con tu pareja, Smart TV, Wi fi, baño privado con calefón, una sala con un sofá cama, frigobar y una mesita para merendar. ¡Perfecta para pasar unos días en Santa Cruz!

A modern living area is depicted, featuring a sleek black sofa bed facing a glass dining table with two chairs. Light beige walls complement the clean tile flooring. Natural light enters through large windows, and framed photographs are displayed on the wall.
Hotel room in Santa Cruz de la Sierra
4.8 out of 5 average rating, 5 reviews

Furnished apartment for executives in Equipetrol

40mts apartment, 1 bedroom, 1 bathroom, living /dining room, and kitchen. 1 flat screen TV, cable TV with 100 channels, air conditioning heat/cold in all environments, digital safe, 2 wifi signals with fiber optic. It has an excellent location (100 meters from the Tajibos Hotel Convention Center, 200 meters from the Business Center and 400 meters from the Ventura Mall). In addition to a team for your attention 24 hours a day, during your visit.

Top guest favorite
Private room in Centro
5 out of 5 average rating, 23 reviews

Quiet and close to everything.

Enjoy this cozy, quiet and central accommodation, where you can rest comfortably, as well as being a perfect starting point to explore the city since we are just a few minutes from the center, we also have shared spaces within the house, such as a kitchen where you can prepare your food and we will also include a delicious welcome breakfast from the second day of your stay so that you can enjoy it as it should be!

Guest favorite
Private room in Valle Sánchez
4.86 out of 5 average rating, 69 reviews

A few minutes from the airport.

After an exhausting trip, nothing better than resting in a quiet and peaceful place while waiting for your next destination. If you are an animal and plant lover, you will feel especially loved, accompanied by nature and our pets if you wish. As the hammock sways, you can read a good book, listen to music, or enjoy a delicious grilled meat with vegetables and have some delicious juices with seasonal fruits.

An outdoor seating area is presented under a covered patio, featuring a stone accent wall and comfortable sofas arranged around a low coffee table. Vibrant pink bougainvillea plants add a touch of color, while the grassy area offers a peaceful setting.
Casa particular in Santa Cruz de la Sierra
4.81 out of 5 average rating, 21 reviews

Very comfortable house with 3 bedrooms

Very comfortable house with three spacious bedrooms and 2 full baths, kitchenette, dining room, shared pools, shared pools, shared churrasqueras, green trails, large gardens, Polo courts, tennis, soccer and basketball and a beautiful natural lagoon. has free parking, WiFi, TV. Located 20 minutes from downtown very close to Viru Viru Airport

Guest favorite
A light-filled room features a spacious bed with soft bedding and a side table adorned with a vase of fresh flowers. Large glass doors open to a garden, enhancing the connection to nature, while neutral walls and wooden flooring provide a calming setting.
Private room in Santa Cruz de la Sierra
4.81 out of 5 average rating, 16 reviews

Your oasis of comfort (La Galería)

Just 5 minutes from Viru Viru Airport, ideal for travelers looking for a quick, safe, pleasant and hassle-free stay. Enjoy an automated room with voice-activated lights and curtains and a relaxing garden view.

Guest favorite
An aerial view of a modern high-rise building surrounded by a lush green landscape. The multi-story structure features a sleek glass façade, reflecting the sunlight, and is positioned near a tree-lined area, providing a natural contrast to its contemporary design.
Hotel room in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviews

Costanera Suites

Costanera Suites discover an upscale experience, where modern design and hospitality combine to provide you with an unforgettable stay. Strategically located ideal for business and leisure getaways.

Superhost
A cozy room is shown with a spacious bed dressed in a light quilt and a burgundy accent. A small round table and two chairs are placed near a window that provides a view of the outdoor greenery. A wooden dresser and a television complete the layout.
Hotel room in Centro
4.5 out of 5 average rating, 4 reviews

Room with breakfast, comfortable and centrally located

Comfortable room with a private bathroom and breakfast included. It's in an excellent location. Close to the Foianini Clinic and Cainco. It also has free parking on the premises.

A bright guest room features a spacious bed covered with a colorful floral blanket. Two pillows are arranged at the head of the bed. Sheer curtains frame the window, allowing natural light to fill the room.
Private room in Santa Cruz de la Sierra
4.83 out of 5 average rating, 6 reviews

Guest Room in P.H.

Guest room in family Pent House, located in Hamacas, one of the best areas in the city, with access to terrace and kitchen/dining room use availability. Safe and comfortable.

Superhost
Private room in Santa Cruz de la Sierra

Independent Apartment

This unique home has plenty of space for you to enjoy with your own. Apartment with separate entrance and parking. With work areas and easy access to all points in the city.

Popular amenities for Santa Cruz de la Sierra hotel rentals

Quick stats about hotel rentals in Santa Cruz de la Sierra

  • Total vacation rentals

    Explore 100 vacation rentals in Santa Cruz de la Sierra

  • Nightly prices starting at

    Santa Cruz de la Sierra vacation rentals start at € 9 per night before taxes and fees

  • Verified guest reviews

    Over 160 verified reviews to help you choose

  • Family-friendly vacation rentals

    20 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Vacation rentals with a pool

    50 properties feature pools

  • Rentals with dedicated workspaces

    60 properties have a dedicated workspace

  • Wi-Fi availability

    100 of Santa Cruz de la Sierra vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santa Cruz de la Sierra rentals

  • 4.6 Average rating

    Santa Cruz de la Sierra stays receive an average rating of 4.6 out of 5 from guests

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