Some info has been automatically translated. Show original language

Guesthouse vacation rentals in Santa Cruz de la Sierra

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Santa Cruz de la Sierra

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

%{current} / %{total}1 / 1
A multi-story building is showcased, featuring a distinctive red facade with decorative archways. Balconies extend from the upper floors, providing outdoor space. The ground level houses various storefronts, while utility poles and street signs are visible, indicating a lively urban environment.
Guesthouse
4.42 out of 5 average rating, 12 reviews

Cozy family home in Santa Cruz de la Sierra

Family house of 320 square meters, on the second floor, with all the utensils and home clothes, wonderful views from its 30 meters of terrace. Ideal for families who want to have a quiet stay of any duration in the City of Santa Cruz de la Sierra. Very well connected with several bus lines that take you to the entire city and surroundings and very close to the Santuario de Cotoca. Nearby has all kinds of services, breakfasts, meals, markets, shops, etc.

A cozy living space is presented with a comfortable sectional sofa featuring decorative cushions. A coffee table sits in front, with a sleek television mounted on a modern cabinet. Natural light enters through large windows, and a potted plant adds a touch of greenery.
Guesthouse in Santa Cruz de la Sierra

Horizontal duplex in backyard of house with pool

Enjoy a horizontal duplex (complete) in the backyard of my house. With its own entrance to the duplex, it shares entrance to the property. Located in a safe and quiet area easily accessible, close to shops, markets, supermarkets, pharmacy, public transportation (blocks from the main avenues), by car 10 min. from the center, 5 min. from the Fexpo, 30 to 40 min. from the airport, 1 block walk from the society of engineers SIB, clinic Montalvo and Urbari.

A cozy living area features a comfortable sofa adorned with decorative cushions. A wooden side table is placed beside it. Large windows allow natural light to brighten the space, with a view into the adjacent room. Textured brick walls add warmth to the atmosphere.
Guesthouse in Santa Cruz de la Sierra
5 out of 5 average rating, 33 reviews

COTTAGE SURROUNDED BY NATURE

It is the second cabin on our land. It was an old house house, which we completely expanded and refurbished. You'll be independent of us in a totally safe environment. You also have other amenities, such as lavaropas, the pool and the aromatic herb garden. Obviously it has wifi (fiber internet) and TV. All windows have mosquito mesh, so these insolent bugs don't disturb your sleep.

Guest favorite
Private room in Centro
4.86 out of 5 average rating, 7 reviews

Room in the center, two minutes away from everything!

Experience staying in the heart of Santa Cruz, just 3 blocks from the main square. Our bright and cozy room awaits you in a safe and lively area: museums, cafes, bars, shops, and historical spots are just a few steps away. Ideal for those looking for comfort, style and an unbeatable location. With WiFi, details designed for your rest and attention that will make you feel at home.

A spacious common area features comfortable seating arrangements with a mix of sofas and chairs. A central table is set with placemats, while a ceiling fan and air conditioning unit contribute to a comfortable environment. Light filters through large windows, enhancing the welcoming feel.
Guesthouse in Santa Cruz de la Sierra

Spacious house with a patio and parking

Guest house, with a large patio and grill (churrasquera), in a very quiet area. Air conditioning in all environments, thermotanque (hot water), spacious living room. Suite with private bathroom. Common bathroom, sofa bed and spacious sofa on the ground floor. (Can sleep comfortably up to 4 people) Address: km 8, Barrio 14 de Agosto, Calle 3 Between double guard and 17 ½ and 5 ½

Guesthouse

Complete centric apartment with garden and pool

Complete centric apartment with an enormous garden and pool. Private apartment with fully staffed kitchen, private bathroom and a bedroom with a queensized bed. You'll also have access to the big garden and the pool to relax and refresh yourself. By choosing our accommodation, you’re also supporting Ñañope, a local NGO dedicated to empowering household workers in Santa Cruz.

Private room in Centro
4.5 out of 5 average rating, 4 reviews

Double or Full Room in Downtown

New and elegant building located just 2 blocks from the main square, surrounded by shopping malls, restaurants, cafes, jewelry, perfumerias, perfumerias, it is located a couple of blocks from the house of culture, the cathedral, museums, 1 block, banks, 7 street market and various shops and locals.

Private room in Santa Cruz de la Sierra

room #4 with private bathroom

Enjoy the simplicity of this quiet and centrally located place. 5 blocks from the monument "El Cristo" and five minutes from the city center. 50 meters from the main avenue Cristo Redentor, where multiple transport lines pass.

Guest favorite
A cozy bedroom features a spacious bed dressed in neutral linens, accompanied by decorative cushions. Two wooden chairs are positioned beside a round table near a window with light curtains. A wooden nightstand stands beside the bed, contributing to the room's welcoming atmosphere.
Guesthouse in Centro
4.88 out of 5 average rating, 112 reviews

Private Apartment In Downtown

Welcome to our cozy guest house in one of the most beautiful and safe areas of the center! Just 6 blocks from Plaza 24 de Septiembre, our historic neighborhood offers you a unique experience.

Guesthouse in Santa Cruz de la Sierra

Casa Portal Holístico # 1

Enjoy this mystical space of tranquility and harmony where your nights will be restored and revitalizing with the energy of the Holistic Portal

Private room in Santa Cruz de la Sierra
New place to stay

department to share TamisaIII

Disfruta de la sencillez de este alojamiento tranquilo y céntrico.

Private room in Santa Cruz de la Sierra
New place to stay

Apartment-style room

Disconnect from your concerns in this spacious and serene space.

Popular amenities for Santa Cruz de la Sierra guesthouse rentals

Quick stats about guesthouse rentals in Santa Cruz de la Sierra

  • Total vacation rentals

    Explore 50 vacation rentals in Santa Cruz de la Sierra

  • Nightly prices starting at

    Santa Cruz de la Sierra vacation rentals start at € 9 per night before taxes and fees

  • Verified guest reviews

    Over 350 verified reviews to help you choose

  • Pet-friendly vacation rentals

    Find 10 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    50 of Santa Cruz de la Sierra vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Santa Cruz de la Sierra rentals

Destinations to explore