Vacation rentals in Depew

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Top-rated vacation rentals in Depew

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The exterior of a two-story house is depicted, featuring grey siding and white trim. A well-maintained lawn surrounds the entrance, which is adorned with a seasonal wreath. Multiple large windows invite natural light, and landscaping includes shrubs and decorative stones.
Home in Lancaster
4.98 out of 5 average rating, 62 reviews

eye pleaser

Enjoy a stylish experience at this centrally-located home. Many guests come for the Buffalo Bills games. 25 minute ride to Highmark Stadium. 7 minutes from airport. 20 minutes to downtown Buffalo. Walking distance to the village of lancaster. The village offers restaurants, bars, shopping, coffee shop, barber shop etc. around the corner from the home offers a grocery store, liquor store, consumer beverages, and a gym. Enjoy our out door patio with grill, fire pit, as well as covered side patio.

Guest favorite
A living room is depicted featuring a white brick fireplace as a focal point, with a dark television mounted above. Grey sofas are positioned around a small wooden table, and bright plants add a touch of greenery. A large window allows light to fill the space.
Home in Lancaster
4.93 out of 5 average rating, 27 reviews

Mid-Century Modern Upper Unit

Experience the small-town charm in this centrally located Village of Lancaster property. Lancaster’s up-and-coming vibrant downtown offers access to local taproom and bodega, ample restaurant choices, and boutique shopping – all within walking distance! Looking for something to do outside the Village? This property is perfectly situated close to all of Buffalo’s Best Attractions: Bill’s Stadium - 21 mins; Airport - 12 mins; Buffalo Outer Harbor/Downtown - 22 mins; Chestnut Ridge Park - 25 mins

Top guest favorite
The living room features a flat-screen television mounted on the wall, with a modern black entertainment center and a small side table. Natural light enters through a window adorned with light curtains, while a patterned rug and various furnishings add to the space.
Apartment in Cheektowaga
4.98 out of 5 average rating, 45 reviews

Convenient cozy two bedroom apartment

Convenient newly furnished 2 bedroom apartment near Buffalo Airport, Centrally located near Buffalo and Niagara Falls. Close to University at Buffalo. Five minutes to Buffalo International Airport. Enjoy this private 2 bedroom apt. steps from a walking park & playground. Enjoy Buffalo cuisine from many local restaurants. Come cheer on the Bills or Sabres or attend one of the many festivals and music events Buffalo has to offer. The Galleria Mall is minutes away as well as supermarkets.

Top guest favorite
A single-story bungalow is showcased with a well-maintained lawn. The brick exterior is complemented by large windows that allow natural light. Neatly trimmed bushes and shrubs frame the entrance, while a pathway leads to the front door. A lamp post stands to the right, adding subtle illumination.
Home in Cheektowaga
4.94 out of 5 average rating, 105 reviews

Bungalow near BuffaloNiagara International Airport

Relax and unwind at this peaceful bungalow in suburban Buffalo. Comfortable 3-bedroom house located 2 miles from airport, 13.4 miles from Bills Stadium, 24 miles from Niagara Falls and only 15-minute drive from downtown Buffalo, NY. Two of the bedrooms are equipped with a queen-sized bed and the 3rd bedroom has a full sized bed. With plenty of storage space in the dressers and closets. Full kitchen/dining area. Laundry is available on site with a washer and dryer located in the basement.

Top guest favorite
Home in Cheektowaga
5.0 out of 5 average rating, 16 reviews

Cozy & Modern House in a Peaceful Neighborhood

Welcome to your home away from home. This beautifully maintained ranch-style residence offers the perfect balance of comfort, space, and modern convenience—ideal for both short getaways and extended stays. Located in a quiet, welcoming neighborhood, this single-family home features 1,327 sq. ft. Open-concept living space. The home includes three well-appointed bedrooms—one with a king bed and two with queen beds—making it a comfortable choice for families, groups, or business travelers.

Guest favorite
A living area features a wall-mounted television above a rustic wooden table. A small ladder shelf stands to the left, adorned with decorative items. The kitchen area is visible in the background, showcasing wooden cabinets and coffee-making equipment.
Apartment in Depew
4.8 out of 5 average rating, 436 reviews

The Shecave - 2 Bedroom Apt

This is perfect for your staycation or for a cozy pit stop. If you’re looking for a short term, no frills, respite, or workplace area, this is the place for you. This is not intended as a party house. Plenty of take out, pick up, or delivery of food. We PRIDE ourselves on the CLEANLINESS of our spaces. Great for a visit to Niagara Falls. Close to Galleria Mall. Quiet and safe neighborhood. **Please be at least 25 book.** **Photo ID will be required from you after booking.**

Guest favorite
A spacious living area is designed with a modern aesthetic, featuring a large area rug atop polished hardwood floors. Elegant furniture includes a sectional sofa and two accent chairs, arranged around a round coffee table. Natural light filters through large windows adorned with sheer curtains.
Home in Cheektowaga
4.98 out of 5 average rating, 53 reviews

Deco House

Bring the whole family and friends to this comfy and spacious modern look home in Cheektowaga, NY. It has transformed into the perfect space to retreat , relax, and entertain. Enjoy the peace and quite of suburbia while being just 5 minutes away from the Shopping Mall, 8 minutes to Buffalo International Airport, and 30 minutes Niagara Falls, NY and Ontario, Canada. 15 minutes to Downtown Buffalo and few Beaches in the Western New York.

Top guest favorite
The studio features an open layout with a cozy seating area including a gray sofa and matching chairs. A dining table accommodates four, and a spacious bed is present in the corner. Natural light filters through the window treatments, highlighting the neutral color scheme.
Guest suite in Lancaster
4.91 out of 5 average rating, 202 reviews

Work or Play this is your Home Away!

Newly remodeled private studio with private entrance. Lots of parking space. 700sq ft.of living space for you to enjoy! Private balcony overlooking stunning backyard views with a pond. Only 13 min away from Buffalo airport! Shopping centers within a mile. Downtown Buffalo- 20 min. drive Flix Movie Theater- 2 min. drive New Era field- 20 min. drive Niagara Falls- 40min. drive Galleria Mall- 12 min. drive

Guest favorite
A modern living area features a dark sofa adorned with decorative cushions. A large television is mounted on a media console, while two abstract art pieces hang on the wall. Natural light enters through the nearby doorway, highlighting the warm wood flooring.
Apartment in Depew
4.85 out of 5 average rating, 84 reviews

Modern 2-bedroom upper apartment with free parking

Enjoy a stay in our updated, modern apartment! This is the perfect place for professionals on business or for couples or families visiting the area. Conveniently located within 10 minutes of the Buffalo Airport and the Galleria Mall and within 20 minutes of KeyBank Center and Highmark Stadium. You're guaranteed a great stay in our cozy modern space! Apartment comfortably sleeps four.

Top guest favorite
A charming cottage is set against a vibrant sunset sky, with soft hues illuminating the surrounding trees. The front entrance is framed by a welcoming porch, leading to a grassy area that gradually slopes away from the building.
Cottage in East Aurora
4.92 out of 5 average rating, 230 reviews

Charming 2 bedroom cottage on the EA golf course

Welcome to The JerBnb! Relax at this quiet and quaint 100 year old 2 bedroom/1 bathroom guest cottage located right on the East Aurora Country Club less than a mile outside of the village. 15 minutes from Bills games. 20 minutes from downtown Buffalo. 20 minutes from skiing. Private off street parking. Self check-in anytime after 3pm. (Sorry. No pets.)

Superhost
The living room features a grey sofa and a brown leather couch, complemented by a wooden coffee table with decorative items. A framed artwork is displayed on the wall, and light streams through the windows with wooden trim, enhancing the cozy atmosphere of the space.
Home in Depew
4.78 out of 5 average rating, 51 reviews

Home sweet home away

Welcome to this bright gem in the village of Depew. Perfect for anyone who wishes to be close to most of what Buffalo has to offer! Spacious enough for a family and not too overwhelming for the traveling professional. This house has everything you need to feel like you are at home.

Guest favorite
A duplex apartment is displayed with a light grey exterior and brick accents. A well-maintained lawn features manicured shrubbery on either side of the front entrance. A clear pathway leads to the front door, while two vehicles are visible in the driveway and nearby street.
Home in Cheektowaga
4.88 out of 5 average rating, 105 reviews

Cozy Duplex Near Airport | Niagara Falls |Highmark

Welcome to Our Home! This is a spacious duplex apartment featuring two bedrooms (one with a king bed with a baby crib and the other with two twin beds) and one bathroom, along with a sunroom to relax. Parking: One car on the driveway and FREE street parking.

Popular amenities for Depew vacation rentals