
Vacation rentals in Depew
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Depew
Guests agree: these stays are highly rated for location, cleanliness, and more.

Charming Neighborhood Retreat
This suite is the entire second floor of our home. Three bedrooms, one has an adjoining door to a larger room, box car style. Private, full bath plus 1/2 bath, kitchenette - microwave, small refrigerator. Main entrance is shared with owners (classical musicians) who live downstairs. Within walking distance: restaurants, bakeries, and 10 minutes from UB campuses and airport. Quiet neighborhood, sorry no parties. We do charge $10 per additional person so we can keep our cleaning fees lower!

Cozy Carriage House on Elmwood
Beautiful Airbnb inside a historic carriage house. Located directly on Elmwood Avenue but tucked back & secluded for a peaceful stay. Cozy interior with coffee bar included. The cottage’s prime location is within walking distance to many restaurants, bars, cafes, boutique shops, Delaware Park, the AKG and Birchfield Penney art museums, and more. Off-street parking allows easy access to adventure outside of the village with Niagara Falls & the Bills Stadium just a 20-30 min. drive/Uber away!

Charming Lancaster Home with Modern Amenities
Welcome to our beautifully renovated home, located in the historic Village of Lancaster! Perfectly situated within walking distance of the heart of Lancaster, where you can take a stroll down Central Avenue to explore charming shops, restaurants, and historical landmarks that make this town so special. Comfortable sleeping space perfect for 4, all new stainless steel appliances, off-street parking for 3 vehicles, and spacious backyard make this the perfect location to explore Western NY.

*HOME GYM in Neighborhood home Near Airport*
New Listing with Superhost Co-Host! Relax and unwind in this private and comfortable, home away from home, located in a quiet family-friendly neighborhood. You’ll be close to anything and everything you may need while staying in the Buffalo area! Buffalo Niagara International Airport: 10 min Wegmans: 4 min Village of Williamsville: 10 min Buffalo Niagara Medical Campus: 13 min Downtown Buffalo: 15 min KeyBank Center: 18 min Highmark Stadium: 23 min (Go Bills! 🏈) Niagara Falls: 32 min

The Shecave - 2 Bedroom Apt
This is perfect for your staycation or for a cozy pit stop. If you’re looking for a short term, no frills, respite, or workplace area, this is the place for you. This is not intended as a party house. Plenty of take out, pick up, or delivery of food. We PRIDE ourselves on the CLEANLINESS of our spaces. Great for a visit to Niagara Falls. Close to Galleria Mall. Quiet and safe neighborhood. **Please be at least 25 book.** **Photo ID will be required from you after booking.**

Secluded Carriage House in The Village.
This unique place has a style all its own. Welcome to your home away from home! Secluded carriage house in the Village of Williamsville. Central to downtown Buffalo, The Buffalo Airport and all attractions WNY has to offer. Garage parking with Tesla Charger! The upstairs features a cozy living area with one bedroom. Williamsville is a walking community and this property is a five minute walk to Britesmith Brewing Co and other great restaurants. Don't forget to check out Glen Falls!

**Village Home In Buffalo- BEST LOCATION!**
Welcome “home” and discover why Buffalo is called the ‘City of Good Neighbors’! Whether it’s for a day, week, or even longer, feel comfortable and cozy, in this 1 bedroom apartment. Being less than 2 miles from the Buffalo Niagara Int’l airport, a quick Uber ride will bring you to Williamsville and offer you a true Buffalo experience. Enjoy the small town vibe of the village, and allow Williamsville to be your gateway to adventure! (Downtown Buffalo- 9mi, Niagara Falls- 17mi. )

Carriage house 1-bedroom at Glen Falls
Make yourself at home in this clean 1-bedroom upper apartment in the village of Williamsville! Just a short distance from everything, including the Buffalo Airport, some of the best restaurants/pubs WNY has to offer, Niagara Falls, & downtown Buffalo. All basic amenities are provided: 55" Smart-TV, WIFI, full bathroom, full kitchen including a coffee station, stove, refrigerator, and microwave. Private entrance & driveway. Self check-in. Close to I-290 (Exit 7 Main Street)

South Prince Space
Entire private 2nd floor apartment with 1 bedroom ft 2 queen memory foam beds and 1 bathroom. Located in a quiet, family oriented neighborhood. We are a 15 min drive from the Buffalo Airport. There is plenty to do during your stay: downtown Buffalo and Niagara Falls are both a 35 min drive, and our quiet, safe neighborhood is the perfect place to relax for the evening. Minutes to major shopping outlet options.

Work or Play this is your Home Away!
Newly remodeled private studio with private entrance. Lots of parking space. 700sq ft.of living space for you to enjoy! Private balcony overlooking stunning backyard views with a pond. Only 13 min away from Buffalo airport! Shopping centers within a mile. Downtown Buffalo- 20 min. drive Flix Movie Theater- 2 min. drive New Era field- 20 min. drive Niagara Falls- 40min. drive Galleria Mall- 12 min. drive

Bright, Charming, Private Home
This corner-lot Cape Cod is the perfect spot for 1-6+ who are looking for a centrally-located stay in WNY. Our home is five minutes from the airport, 10 minutes to downtown/waterfront, 15 minutes to Highmark Stadium and 20 minutes to Niagara Falls. This space has been renovated over the past two years including an updated kitchen and bathroom, new floors and finished hardwood.

Peaceful, spacious apartment. Non-smoking.
Traditional South Buffalo lower in the Irish Heritage District. NOT suitable for children aged 1-12. NOT pet-friendly. 10 minutes from Canalside, Key Bank Center, Sahlen Field, Harbor Center, Riverworks and downtown. 20 minutes from Highmark Stadium. 30 minutes from Niagara Falls. Stumbling distance from the Buffalo Irish Center.
Popular amenities for Depew vacation rentals
Other great vacation rentals in Depew

Centrally Located Comfort Cove

Cozy Home - Safe Area & close to Everything

Modern Loft at Cornerstone Plaza

Warm & Cozy private Guesthouse/ Entire place.

Garden House Apartment

Private House, off Main Street, parking, pets

Serene, Renovated 2BR near Airport w/ Yard

9mins 🚗to ✈buffalo Niagara International Airport
Destinations to explore
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- Holiday Valley Ski Resort
- Letchworth State Park
- Six Flags Darien Lake
- Niagara Falls State Park
- Buffalo RiverWorks
- Casino Niagara
- Fallsview Indoor Waterpark
- Jackson-Triggs Niagara Estate
- Niagara Falls
- Highmark Stadium
- MarineLand
- Keybank Center
- Brock University
- Whirlpool Golf Course
- Butterfly Conservatory
- Lakeside Park Carousel
- Vineland Estates Winery
- University at Buffalo North Campus
- Wayne Gretzky Estates
- Kissing Bridge
- 13th Street Winery
- Balls Falls Conservation Area
- Henry of Pelham Family Estate Winery
- Frank Lloyd Wright's Martin House




