Vacation rentals in Depew

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Depew

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost
A cozy sleeping area features a spacious bed with a light-colored coverlet. Decorative pillows are arranged at the head of the bed, complemented by bedside tables and lamps. Natural light filters through sheer white curtains, enhancing the calming ambiance of the room.
Guesthouse in Cheektowaga
4.79 out of 5 average rating, 236 reviews

Warm & Cozy private Guesthouse/ Entire place.

Hi there! This is Aklima and Farhad, and we’re thrilled to have you stay at our guest house. It’s connected to our house, but both have their own private entrances. Just a friendly reminder, you might spot our kids playing in the backyard, so please be mindful of that. We love living here and meeting new people, which is why we started Airbnb. We’re committed to providing the best hospitality at an affordable price. This place is surrounded by nature and in a peaceful area! Enjoy your stay!

Top guest favorite
A spacious bedroom is highlighted by a high vaulted ceiling and large windows providing natural light. A king bed is dressed in neutral-toned bedding with decorative accents. A desk and chair are positioned nearby. Soft area rugs complement the dark floor, enhancing the overall aesthetic.
Loft in Williamsville
4.99 out of 5 average rating, 78 reviews

Stunning Studio Overlooking Glen Park

Perfectly situated walkable escape. Open modern 900 sq ft newly renovated loft with king bed. 2 patios overlook Glen Park, stately trees and lots of wildlife. Hiking trails lead along a stream to Glen Park Falls. 2 blocks to Main Street in the Village of Williamsville where you'll find restaurants, a brewery, shopping, ice cream and more. FIOS high speed internet. 3 miles from Buffalo Int’l Airport and 9 miles to downtown Buffalo. Relax & take in the beauty at this one-of-a-kind getaway.

Top guest favorite
The exterior of a two-story house is depicted, featuring grey siding and white trim. A well-maintained lawn surrounds the entrance, which is adorned with a seasonal wreath. Multiple large windows invite natural light, and landscaping includes shrubs and decorative stones.
Home in Lancaster
4.98 out of 5 average rating, 60 reviews

eye pleaser

Enjoy a stylish experience at this centrally-located home. Many guests come for the Buffalo Bills games. 25 minute ride to Highmark Stadium. 7 minutes from airport. 20 minutes to downtown Buffalo. Walking distance to the village of lancaster. The village offers restaurants, bars, shopping, coffee shop, barber shop etc. around the corner from the home offers a grocery store, liquor store, consumer beverages, and a gym. Enjoy our out door patio with grill, fire pit, as well as covered side patio.

Guest favorite
A living room is depicted featuring a white brick fireplace as a focal point, with a dark television mounted above. Grey sofas are positioned around a small wooden table, and bright plants add a touch of greenery. A large window allows light to fill the space.
Home in Lancaster
4.92 out of 5 average rating, 24 reviews

Mid-Century Modern Upper Unit

Experience the small-town charm in this centrally located Village of Lancaster property. Lancaster’s up-and-coming vibrant downtown offers access to local taproom and bodega, ample restaurant choices, and boutique shopping – all within walking distance! Looking for something to do outside the Village? This property is perfectly situated close to all of Buffalo’s Best Attractions: Bill’s Stadium - 21 mins; Airport - 12 mins; Buffalo Outer Harbor/Downtown - 22 mins; Chestnut Ridge Park - 25 mins

Top guest favorite
The kitchen features modern stainless-steel appliances and a spacious wooden island with seating for three. Bright lighting enhances the clean lines of the white cabinetry and subway tile backsplash. Sliding glass doors provide access to the outdoor space, allowing natural light to fill the room.
Home in Cheektowaga
4.97 out of 5 average rating, 58 reviews

Serene, Renovated 2BR near Airport w/ Yard

Welcome to our bright and freshly renovated single-level home central to all in Buffalo, NY! This cozy home offers a serene and relaxing atmosphere, perfect for a short-term stay and loaded with amenities. Whether you're here for business or pleasure, our home provides all the comforts you need for a memorable stay. Book now and experience the best of Western New York! ** Mins from Buffalo Niagara Airport ** 1 mi to Walden Galleria Mall ** 9 mi to downtown Buffalo ** 10 mi to Highmark Stadium

Top guest favorite
A living area is displayed, featuring a dark sofa alongside a patterned armchair. A decorative area rug covers the wooden floor. The background shows a kitchen space with bar seating and modern appliances, contributing to a welcoming atmosphere.
Apartment in Cheektowaga
4.94 out of 5 average rating, 254 reviews

Close to Niagara Falls and Airport, Mall nearby

Niagara Falls is only 30minutes away.Very nice neighborhood.4minutes from Galleria Mall. Plus many more stores nearby.Many places to eat and have some drinks! Sleeps-5 we have a clean pack and play for your little one. Has own key entry Couch in living room , roll away bed. One bedroom has a queen bed and tv.The 2nd bedroom has a twin bed and offers tv and a workspace. Very clean! Kid friendly and pet friendly.Pets can do their business out front. There are dogs that use the back yard.

Guest favorite
A living area features a wall-mounted television above a rustic wooden table. A small ladder shelf stands to the left, adorned with decorative items. The kitchen area is visible in the background, showcasing wooden cabinets and coffee-making equipment.
Apartment in Depew
4.8 out of 5 average rating, 431 reviews

The Shecave - 2 Bedroom Apt

This is perfect for your staycation or for a cozy pit stop. If you’re looking for a short term, no frills, respite, or workplace area, this is the place for you. This is not intended as a party house. Plenty of take out, pick up, or delivery of food. We PRIDE ourselves on the CLEANLINESS of our spaces. Great for a visit to Niagara Falls. Close to Galleria Mall. Quiet and safe neighborhood. **Please be at least 25 book.** **Photo ID will be required from you after booking.**

Superhost
A light-filled living area features a comfortable beige sectional sofa and a coffee table, positioned on a neutral-toned area rug. A dining table with four chairs is visible in the background, alongside large windows that allow natural light to brighten the space.
Apartment in Lancaster
4.86 out of 5 average rating, 29 reviews

Highland Space

Entire private 2nd floor apartment with 2 bedrooms ft 2 queen memory foam beds and 1 bathroom. Located in a quiet, family-oriented neighborhood we are just a 10 min drive from the Buffalo Airport. There is plenty to do during your stay: 20 minutes to downtown Buffalo and Highmark Stadium, a short drive to Niagara Falls, and minutes to major shopping centers. If you are looking to enjoy nature we are near a beautiful nature reserve and a 4-mile bike path is right around the corner.

Superhost
A living area is shown with a light-colored sofa and a brown ottoman placed in front. A dark armchair with a patterned cushion adds contrast. A tall green plant is positioned beside a window, enhancing the natural light in the room. Neutral wall colors contribute to a calm atmosphere.
Apartment in Depew
4.72 out of 5 average rating, 36 reviews

Clean + Efficient! Airport - 10 Min Downtown - 20

PLEASE READ ALL LISTING DETAILS Great for 1-2 people traveling for business or visiting family and friends. Centrally-located and just a few blocks from The Lancaster Village, this location has shops, restaurants and parks nearby - and is only 10 minutes to the airport and thruway access. NOTE: Apartment is accessible only by a sharply pitched staircase with narrow steps and limited foot space. Individuals with balance or mobility limitations may find them challenging.

Guest favorite
A spacious living area is designed with a modern aesthetic, featuring a large area rug atop polished hardwood floors. Elegant furniture includes a sectional sofa and two accent chairs, arranged around a round coffee table. Natural light filters through large windows adorned with sheer curtains.
Home in Cheektowaga
4.98 out of 5 average rating, 51 reviews

Deco House

Bring the whole family and friends to this comfy and spacious modern look home in Cheektowaga, NY. It has transformed into the perfect space to retreat , relax, and entertain. Enjoy the peace and quite of suburbia while being just 5 minutes away from the Shopping Mall, 8 minutes to Buffalo International Airport, and 30 minutes Niagara Falls, NY and Ontario, Canada. 15 minutes to Downtown Buffalo and few Beaches in the Western New York.

Guest favorite
A modern living area features a dark sofa adorned with decorative cushions. A large television is mounted on a media console, while two abstract art pieces hang on the wall. Natural light enters through the nearby doorway, highlighting the warm wood flooring.
Apartment in Depew
4.85 out of 5 average rating, 80 reviews

Modern 2-bedroom upper apartment with free parking

Enjoy a stay in our updated, modern apartment! This is the perfect place for professionals on business or for couples or families visiting the area. Conveniently located within 10 minutes of the Buffalo Airport and the Galleria Mall and within 20 minutes of KeyBank Center and Highmark Stadium. You're guaranteed a great stay in our cozy modern space! Apartment comfortably sleeps four.

Superhost
The living room features a grey sofa and a brown leather couch, complemented by a wooden coffee table with decorative items. A framed artwork is displayed on the wall, and light streams through the windows with wooden trim, enhancing the cozy atmosphere of the space.
Home in Depew
4.84 out of 5 average rating, 45 reviews

Home sweet home away

Welcome to this newly remodeled bright gem in the village of Depew. Perfect for anyone who wishes to be close to most of what Buffalo has to offer! Spacious enough for a family and not too overwhelming for the traveling professional. This house has everything you need to feel like you are at home.

Popular amenities for Depew vacation rentals