Vacation rentals in Pamplico

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Top-rated vacation rentals in Pamplico

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The exterior of the hermitage is seen at dusk, highlighted by a warm glow from outdoor lights. The rich orange facade contrasts with the pink and purple hues of the sunset sky. Nearby trees frame the scene, and a landscaped area features decorative plants.
Place to stay in Effingham
4.98 out of 5 average rating, 178 reviews

Gated and Private Catholic Hermitage house

Saint Michael Hermitage and retreat is a serene, gated, private home that is for 1-3 guests looking for a quiet stay while traveling or as a retreat destination. You will self check into your Hermitage after you obtain a gate code. There is a prayer chapel close by on the property. It is pet friendly for a well trained pet. There is Catholic iconography throughout the home. It is warm and inviting. There is a full kitchen, washer/dryer for your convenience and complementary coffee/tea.

Top guest favorite
A welcoming hallway is shown, featuring hardwood floors and a natural fiber rug. A framed artwork of trees adorns the wall. An accent chair is positioned beside a console table, while doors lead to other rooms, creating an open and inviting layout.
Loft in Marion
4.99 out of 5 average rating, 286 reviews

The Loft at 109

located at 109 Arch Street in downtown Marion, South Carolina, is a fully furnished apartment that offers all the amenities of home -and more. Housed in a historic building in the heart of the Pee Dee, The Loft has charming character with exposed brick walls and original hardwood floors. Offered as a nightly rental, your experience begins as you're greeted with gas lanterns and continues inside where you'll find our 1,000 square foot living space. Conveniently located 20 minutes from I-95.

Top guest favorite
The exterior of a two-story house is nestled among tall trees, showcasing a deck with steps leading to the ground. Screened-in porches on both levels provide ample outdoor space and views of the surrounding greenery.
Home in Georgetown
4.98 out of 5 average rating, 188 reviews

Black River Refuge on the Water

The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

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Home in Florence
4.93 out of 5 average rating, 122 reviews

Charming Home in Florence, SC

Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.

Top guest favorite
The cozy interior features rustic wooden beams and a blend of warm tones. A spacious bed is positioned against a wall with a peacock artwork. A kitchenette area is visible, alongside a small dining table and a television, providing a comfortable, multifunctional living space.
Farm stay in Timmonsville
4.95 out of 5 average rating, 777 reviews

The Cottage at Dream Acres & Petting Zoo I-95/I-20

The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller studio space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

Top guest favorite
Home in Florence
4.97 out of 5 average rating, 86 reviews

Cozy Florence Retreat Near Civic Center & I-95

Welcome to your Florence getaway! This bright, modern, and cozy Welcome to your Florence getaway! This bright, modern, and cozy home is perfectly located near I-95, Downtown Florence, the Florence Civic Center, and Darlington Raceway. Enjoy shopping and dining at nearby Buc-ee's, or take a short 1.5-hour drive to Myrtle Beach. The home features a fully equipped kitchen, comfortable bedrooms, and convenient parking—ideal for road trips, events, family stays, or a relaxing Southern escape.

Top guest favorite
An entryway features a dark door adorned with a wreath, complemented by a porch mat. Two comfortable chairs are positioned beside the door, providing a cozy spot. The wooden porch flooring adds warmth, while surrounding greenery enhances the inviting atmosphere.
Cottage in Effingham
4.99 out of 5 average rating, 81 reviews

Timeless cottage, fresh air and private

This cottage stands out for the privacy and surroundings, perfect spot for a quick get away or for work. Located on an 80 acre farm on its own private spot, yet a short drive to Florence or Lake city. Enjoy amazing sunsets , an ocasional deer, and other wildlife from your front or back porch, no neighbors . Dine in one of the many restaurants in Florence, or stay in and grill out while sitting in your porch surrounded by nature , then wait for the sunset, it won’t disappoint !

Top guest favorite
Farm stay in Hemingway
4.96 out of 5 average rating, 250 reviews

Quiet farmhouse near the beach

The best memories are made on the farm. Life is just better away from the hustle and bustle of city lights and busy schedules. Come stay in this recently renovated fourth generation 1950s farmhouse on an 80 acre working farm. Unwind on the porch, walk trails, find millions of years old sharks teeth, build a bonfire, pick blackberries, swim in the ponds, collect walnuts, or just relax while you’re here but don’t forget to wish on a dandelion or a shooting star before you leave.

Top guest favorite
The exterior of a quaint cottage features white siding, green shutters, and a covered porch. An American flag is displayed, and two chairs sit on the porch. A gravel driveway leads to the home, surrounded by shade trees in a peaceful setting.
Cottage in Timmonsville
4.97 out of 5 average rating, 1108 reviews

King Bed Close to I-95

Located just 5 mins from I-95 and 12 minutes from Florence, this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, pls) but are not allowed on our beds. 🧺. King bed in master, 3 TV's (two 55” & one 32”), coffee bar with Keurig, strong WiFi. We also use 100% cotton sheets and quilts for your maximum sleeping comfort. ABSOLUTELY NO SMOKING OR VAPING ON OUR PROPERTY ($200 extra fee)!

Top guest favorite
A charming farmhouse exterior is seen, featuring light green siding and dark blue shutters. A welcoming front porch is framed by a small set of steps, with a decorative wreath on the door and potted plants on either side, under the shade of surrounding trees.
Farm stay in Johnsonville
4.9 out of 5 average rating, 60 reviews

The Hanna Farmhouse

Enjoy a peaceful stay in a rustic farmhouse on land owned by the Hanna family since the 1700s. This retreat spot has centuries-old live oak trees shading the back yard and walking trails around the contiguous farm. The community offers great local restaurants, a newly refurbished municipal golf course, unique shopping options, and friendly locals. Take a day trip to Myrtle Beach or Charleston or just sit under the oaks, build a fire and watch a gorgeous sunset.

Guest favorite
A bright living area is shown, featuring a striped black and white rug that contrasts with warm wooden floors. A white fireplace is centered on a wall beneath a mounted TV. Colorful drapes surround tall windows, and a chandelier adds a touch of elegance.
Home in Lake City
5.0 out of 5 average rating, 11 reviews

The Coop

Welcome to The Coop! This is a cozy, family-friendly retreat in the heart of Lake City. Inspired by local charm and the town’s love for art, our home was created for our family and now yours. Enjoy a fully stocked kid’s playroom, comfy beds, and inviting spaces for all ages. Just minutes from downtown shops, dining, and galleries, it’s the perfect spot for a peaceful getaway or visit with loved ones.

Top guest favorite
The kitchen features modern appliances situated alongside a contrasting dark countertop and light cabinets. The brick wall adds texture to the space, enhanced by natural light from the window above the sink. A coffee maker and utensils are neatly arranged for convenience.
Cottage in Hemingway
4.98 out of 5 average rating, 110 reviews

Peaceful cozy country cottage

Welcome to Black Mingo Country Cottage! This 1950's cottage has been recently renovated and newly furnished. You are sure to find this setting restoring and peaceful! The tranquil property is surrounded by Live Oak trees, Pecan trees and Camillias. The area is wonderful for bird watching and stargazing. If you need a break from the everyday, this is the place to come.

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