
House vacation rentals in Orangeburg County
Find and book unique houses on Airbnb
Top-rated house rentals in Orangeburg County
Guests agree: these houses are highly rated for location, cleanliness, and more.

Theo's Place
Kick back and relax in this calm, stylish space. I'm happy to offer my 1st home as a host, providing all the amenities I've wanted as a guest in my years of successful stays on the AirBnB platform as a guest (laptop not included). My guest will find various comforts and additions to make their stay as comfortable as can be. I welcome your feedback. My home is available as a 1 Bedroom with a large Den, Living & Dining rooms, 2 Bathrooms, full Kitchen and Laundry room. All new appliances as well.

Ultimate Hideaway in the pines next to Lake Marion
Discover the hidden secrets of the midlands of South Carolina. Minutes away from fishing Lake Marion, and discovering hidden gems of both SC state and national parks. Surrounded by the serenity of nature, near the Palmetto trail and endless hiking and biking trails. Ramble the scenic byways and back roads of the area and discover our hidden small towns, historic sites and natural wonders. Convenient to visitors of Shaw Air force base and within reasonable distance to the charm of Charleston.

Trendy, cozy and casual
Total Renovation of 1235 square feet brick ranch with 1 car garage, screened in back porch and large fenced back yard. 2 baths, updated fully equipped kitchen, dishwasher, new floors, curtains & linens. Roku TV, wireless internet. Washer and Dryer Pet Notes: Pets have to be approved in advance of stay and pet fees will be charged per pet. Pets are welcome but there is a pet fee based on number of dogs and breed. Some breed are restricted by insurance company. Contact me before booking please.

The Grand Marshall
Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Santee lakefront home, big water right off I-95
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Ron's Siesta Airbnb
A beautifully renovated Cape Cod, reminiscent of the late 1940's is located near restaurants, groceries, and the universities; some of which are in walking distance. While located on a main thoroughfare, the home exudes a quiet and peaceful atmosphere. There are two bedrooms, bath, kitchen, eating and dinning area. A warn place to feel welcomed and at home. Universities: SCSU walk 18 min 1.0mil; Claflin University walk 15min. 0.8 mil; The Village Center walk: 3min 0.2mil.

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Perfect family vacation retreat at Lake Marion, SC
Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Roomy Home Near SCSU, CU, Edisto Gardens & Dining
Enjoy this entire one-story, renovated home which sits on two acres that overlook a huge five acre pond. — 2 minute drive to dining, groceries and shopping. — 10 - 12 minute drives to: • South Carolina State University • Claflin University • Edisto Gardens • South Carolina Motorplex • Orangeburg Country Club — Home has modern upgrades from roof to floor. — Located in a quiet community at the end of a cul de sac.

Rural Country Getaway
The home is a single-family home that contains 1,829 sq. feet. 4 bedroom and 2 full bathrooms. Located in Bowman, SC on 20 acres of farmland. The home has been fully renovated with a deck to support all your grilling and outdoor needs.
Popular amenities for Orangeburg County house rentals
House rentals with a pool

Colonial Farmhouse - 6 bedroom with a pool

The Sunset Chaser

Lake House Retreat

Lakefront Farmhouse Retreat+Pool

Lakeview Leisure-Face to the Sun

The Merry Inn @ Lake Marion

Heated Indoor Pool on Lake Marion with Dock

Lakefront Lookout
Weekly house rentals

Beautiful 3-Bedroom House

The Fishnet

Santee/Lizzie's Creek Lakefront

Lakefront home with boat ramp and game room

Cozy 3 bed 2 bath on the waterfront

Almost Heaven on Lake Marion, SC

No Cleaning Fee 3BR | Sleep 10 | Near Santee Lakes

Lake Marion Beauty w/ 5br/3ba
Private house rentals

In town cottage

Charming Bamberg Home Near Medical Centers!

RayneBow Royalty

The Pond House at Salkehatchie Farms

Lowcountry river life

Cozy 3 Bedroom Farmhouse

Lake House for Perfect Getaway

Reel Haven on the Water: Modern + Comfy Home!
Destinations to explore
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- Rentals with a hot tub Orangeburg County
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- Pet-friendly rentals Orangeburg County
- Rentals with pools Orangeburg County
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