House vacation rentals in Orangeburg County

Find and book unique houses on Airbnb

Top-rated house rentals in Orangeburg County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
The bedroom features a spacious bed dressed in white linens with red accents. A desk with dual monitors is positioned next to the bed. A dresser and a soft area rug add warmth, while natural light filters in through a window with light drapes.
Home in Orangeburg
4.95 out of 5 average rating, 38 reviews

Theo's Place

Kick back and relax in this calm, stylish space. I'm happy to offer my 1st home as a host, providing all the amenities I've wanted as a guest in my years of successful stays on the AirBnB platform as a guest (laptop not included). My guest will find various comforts and additions to make their stay as comfortable as can be. I welcome your feedback. My home is available as a 1 Bedroom with a large Den, Living & Dining rooms, 2 Bathrooms, full Kitchen and Laundry room. All new appliances as well.

Guest favorite
A spacious bedroom features a large, elegantly crafted bed adorned with patterned bedding and decorative pillows. Soft lighting is provided by two bedside lamps on matching nightstands. Natural light enters through a window covered by light curtains, contributing to a warm ambiance.
Home in Pinewood
4.94 out of 5 average rating, 86 reviews

Ultimate Hideaway in the pines next to Lake Marion

Discover the hidden secrets of the midlands of South Carolina. Minutes away from fishing Lake Marion, and discovering hidden gems of both SC state and national parks. Surrounded by the serenity of nature, near the Palmetto trail and endless hiking and biking trails. Ramble the scenic byways and back roads of the area and discover our hidden small towns, historic sites and natural wonders. Convenient to visitors of Shaw Air force base and within reasonable distance to the charm of Charleston.

Top guest favorite
A single-story brick ranch home is set in a green, well-maintained yard. A large palm tree is situated near the entry, with a few steps leading up to the front door. The front porch features two rocking chairs, enhancing the welcoming appearance of the home.
Home in Orangeburg
5 out of 5 average rating, 64 reviews

Trendy, cozy and casual

Total Renovation of 1235 square feet brick ranch with 1 car garage, screened in back porch and large fenced back yard. 2 baths, updated fully equipped kitchen, dishwasher, new floors, curtains & linens. Roku TV, wireless internet. Washer and Dryer Pet Notes: Pets have to be approved in advance of stay and pet fees will be charged per pet. Pets are welcome but there is a pet fee based on number of dogs and breed. Some breed are restricted by insurance company. Contact me before booking please.

Top guest favorite
A spacious living area features a large blue sectional sofa adorned with patterned cushions. A light wooden coffee table sits on a soft area rug, complemented by a small potted plant. Natural light filters through the windows, creating a bright and welcoming environment.
Home in Orangeburg
5 out of 5 average rating, 133 reviews

The Grand Marshall

Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

Superhost
The spacious screened-in porch features comfortable seating, a circular table, and ceiling fans. Soft lighting enhances the area, with panoramic views of Lake Marion visible through large screens. Vibrant sunset colors are seen in the sky, reflecting off the water in the background.
Home in Summerton
4.94 out of 5 average rating, 167 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite
A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.
Home in Santee
4.97 out of 5 average rating, 164 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Guest favorite
The exterior of a renovated Cape Cod home is visible, featuring a light-colored façade with dark trim. A brick chimney rises from the sloping roof. A front porch with decorative railing adds charm, while neat landscaping frames the property, enhancing its inviting presence.
Home in Orangeburg
4.9 out of 5 average rating, 31 reviews

Ron's Siesta Airbnb

A beautifully renovated Cape Cod, reminiscent of the late 1940's is located near restaurants, groceries, and the universities; some of which are in walking distance. While located on a main thoroughfare, the home exudes a quiet and peaceful atmosphere. There are two bedrooms, bath, kitchen, eating and dinning area. A warn place to feel welcomed and at home. Universities: SCSU walk 18 min 1.0mil; Claflin University walk 15min. 0.8 mil; The Village Center walk: 3min 0.2mil.

Guest favorite
An outdoor deck is presented with a black wooden dining table surrounded by six chairs. A cozy seating area with red and gray cushions invites relaxation. The fenced yard is visible in the background, surrounded by trees and distant homes.
Home in Santee
4.97 out of 5 average rating, 143 reviews

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Guest favorite
The exterior of the home is showcased, highlighting a charming façade with a mix of brick and siding. Large windows reflect natural light, and the welcoming porch features seating. A landscaped yard and tall trees provide a serene backdrop, complementing the overall inviting atmosphere.
Home in Summerton
4.83 out of 5 average rating, 110 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Top guest favorite
A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.
Home in Summerton
4.99 out of 5 average rating, 121 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Guest favorite
A serene pond is bordered by trees, with mist rising gently from the water's surface in the early morning light. Grass stretches out in the foreground, leading to the water's edge, highlighting the tranquil natural setting.
Home in Orangeburg
5 out of 5 average rating, 10 reviews

Roomy Home Near SCSU, CU, Edisto Gardens & Dining

Enjoy this entire one-story, renovated home which sits on two acres that overlook a huge five acre pond. — 2 minute drive to dining, groceries and shopping. — 10 - 12 minute drives to: • South Carolina State University • Claflin University • Edisto Gardens • South Carolina Motorplex • Orangeburg Country Club — Home has modern upgrades from roof to floor. — Located in a quiet community at the end of a cul de sac.

Guest favorite
A single-family home with a light blue exterior is surrounded by well-maintained greenery. The property features a manicured lawn, two distinct sections of the house, and large windows with black shutters. Trees provide natural shade in the background.
Home in Bowman
4.93 out of 5 average rating, 54 reviews

Rural Country Getaway

The home is a single-family home that contains 1,829 sq. feet. 4 bedroom and 2 full bathrooms. Located in Bowman, SC on 20 acres of farmland. The home has been fully renovated with a deck to support all your grilling and outdoor needs.

Popular amenities for Orangeburg County house rentals