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Vacation rentals in Mesilla

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Mesilla

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Guesthouse in Las Cruces
4.96 out of 5 average rating, 204 reviews

Quaint casita for 2

*Sep 2025 New bed/Aug 2024 New A/C mini split* Quiet cul-de-sac and peaceful landing spot within minutes to NMSU and Old Mesilla. Easy access to I-10 and I-25. Close to golf courses, shopping and the beauty of Las Cruces and Mesilla. Private entrance to casita, patio with dining table and a cozy bedroom, bathroom with tub/shower, WiFi, coffee station, refrigerator with small freezer, microwave. Wonderful hiking trails nearby and less than 60 minutes to White Sands National Park and ELP Airport.

Top guest favorite
Home in Mesilla Park
4.94 out of 5 average rating, 142 reviews

Conway Cottage 2

Step into your newly renovated one-bed, one-bath haven located at the heart of Mesilla Park. Enjoy a leisurely walk to Picacho Roasters for a delightful coffee experience, or hop on a cruiser bike for a charming ride to historic Mesilla. Immerse yourself in the local ambiance, sipping a drink to the backdrop of live music. As the morning sun rises, take a stroll amidst century-old trees that grace Conway Avenue. Welcome home to a blend of modern comfort and the timeless charm of Mesilla Park.

Superhost
A cozy living room is depicted, featuring a comfortable dark sofa with decorative cushions. A large piece of wall art displays two figures sitting on a bench, creating a sense of connection. An antique trunk and a decorative green vase enhance the inviting space.
Earthen home in Las Cruces
4.84 out of 5 average rating, 620 reviews

Southwest Mexican Adobe Casa Historic District

This wonderful adobe home with refrigerated air is located directly in the heart of the city the Mesquite Historic District of Las Cruces. This Mexican home combines the neighborhood classic adobe style. Directly across the street is a Mexican cafe and a coffee shop. Seven minute walk to downtown which has wonderful pubs and restaurants. This home is located directly across the street from my other two casitas that are listed in Airbnb. Dog fee $10.00 which can be left on the table.

Top guest favorite
The exterior of the guesthouse features a welcoming entrance with a turquoise door framed by two wooden columns. A small seating area with two chairs is positioned on the porch, accompanied by potted plants and a tiled floor. The sky above displays a gentle blend of blue and white hues.
Guesthouse in Mesilla
4.97 out of 5 average rating, 388 reviews

Getaway Guesthouse in Historic Mesilla

Welcome to our cozy guesthouse, just a few blocks away from the Historic Mesilla Plaza. You'll find unique shops, restaurants, bars, and art markets nearby, offering a delightful experience for all your senses! The mouth-watering scents of Chala's Wood Fired Grill and Spotted Dog Brewery will entice you, as they're just around the corner. You'll also hear the bells from one of the oldest churches in the area and enjoy live music from the neighborhood's restaurants and bars.

Top guest favorite
A spacious room features a regal four-poster bed adorned with golden bedding. Antique-style lamps on either side illuminate the space, while a cozy seating area in the corner invites relaxation. Exposed wooden beams and a decorative fireplace add to the historic Southwestern charm.
Guest suite in Mesilla
4.99 out of 5 average rating, 112 reviews

Josefina's King Suite in Mesilla Plaza.

Josefina's King Suite is located just off the Plaza in Historic Old Mesilla. Behind the thick adobe walls, you will find this tranquil retreat. Charmed by the ambiance of our historic Southwestern design and the Garden Greenhouse, our luxurious King Suite offers a cozy step back in time, weaving together old world charm and modern comforts like WIFI, mini fridge, AC, plush bathrobes and more. If the King is already booked, please check out our Queen Suite!

Top guest favorite
A spacious outdoor area showcases a desert landscape with gravel and low-lying plants. A large round table is accompanied by a bright red umbrella, offering shade. The casita's entrance features a patio with seating and a welcoming purple trim, enhancing the inviting exterior.
Home in Las Cruces
4.97 out of 5 average rating, 189 reviews

Charming Adobe One Block from the Mesilla Plaza

Beautiful, private casita built in the 1930's one block from the plaza. Historic charm with modern conveniences. Perfect for quiet retreat. Fenced flagstone patio in back yard fully equipped with gas grill, outdoor fireplace, outdoor dining area and french doors opening from the house. Large front yard fully enclosed. Full front porch creates shade. This house is peaceful but just steps from the fiestas and activities on the historical Mesilla Plaza.

Top guest favorite
A studio space features a queen bed with soft bedding, a seating area with two armchairs, and a small kitchenette equipped with a coffee maker and microwave. Natural light enters through a window, while a stylish circular mirror hangs on the wall, enhancing the room's openness.
Guesthouse in Las Cruces
4.96 out of 5 average rating, 158 reviews

Spacious studio near Mesilla

Forget your worries in this spacious and serene space in Mesilla Park, near Historic Mesilla. Centrally located, close to I10, without the noise! Stylishly decorated with a kitchenette that has all you will need to prepare basic food. Microwave, pressure cooker, hotplate, small fridge, coffee maker, and toaster oven. Stocked kitchen to include gourmet coffee, English muffins, and farm fresh eggs for making a quick breakfast are waiting for you!

Top guest favorite
A cozy interior space features a queen bed with a bright yellow throw pillow. A kitchenette with a microwave, mini-fridge, and sink is present. Natural light filters through the windows, which are adorned with blue curtains. A small table and chairs complement the room's design.
Guesthouse in Las Cruces
4.98 out of 5 average rating, 323 reviews

Cozy Casita w/private patio near Old Mesilla

This adorable casita is located just one mile from Historic Mesilla and 5 min from the interstate. The one bedroom 1 bath casita is perfect for visitors and travelers alike. Furnished with a queen bed, table and chairs and a outfitted kitchenette with microwave/air fry toaster oven/Keurig /double hot plate/ sink and mini-fridge. Also includes Wi-Fi , Smart TV (no cable), mini-split AC/ heater, and a private outdoor patio table and gas grill.

Top guest favorite
A modern interior features a wooden dining table with two black chairs, accompanied by a decorative bowl. A wall hanging adds texture, while a metal rack displays clothing and a woven basket. Natural light filters through a nearby window, highlighting the clean lines of the space.
Guesthouse in Las Cruces
4.99 out of 5 average rating, 195 reviews

Yucca Casita in Historic Mesilla

Mesilla STR Permit #0830 We have created a sustainable design, including rainwater harvesting and water saving landscaping, solar energy, energy saving and efficient construction, electric vehicle charger (which is solar powered), composting, organic gardens, firepit, and labyrinth.This is the 3rd unit (Yucca Casita) that we've completed, the 1st being our home and 2nd our other vacation rental property - Ocotillo Casita.

Top guest favorite
A charming casita features a turquoise door and a light exterior, framed by subtle landscaping. The sky is filled with vibrant orange and yellow hues as the sun sets, creating a striking contrast against the white walls and windows.
Guesthouse in Las Cruces
4.99 out of 5 average rating, 184 reviews

Cozy Casita De Mesilla (Mesilla Cottage)

Cozy casita just steps from Old Mesilla’s historic plaza and coffee shops. Unwind in your private courtyard with a hot tub, or curl up by the fireplace inside the guesthouse. A kitchenette adds comfort for longer stays. Mesilla Bosque State Park by the Rio Grande is only 4 minutes by car—or a short bike ride—perfect for birdwatching, sunsets, and peaceful walks. The ideal spot for a romantic getaway or quiet retreat.

Top guest favorite
The exterior of a single-story casita is shown, featuring a light pink stucco facade and a red-tile roof. A gated entrance is visible, along with a small lawn and a concrete walkway leading to the door. A garage door is also seen on the left.
Guesthouse in Las Cruces
4.95 out of 5 average rating, 1,081 reviews

Cozy Casita with Patio

Cozy casita (guest house) with patio in nice quiet neighborhood close to NMSU, Convention center, Memorial Hospital, Mountain View Hospital, Old Mesilla, ,wine country, shopping, convenient to White Sands, hiking, etc. Casita has private entrance, private bath, small refrigerator, TV, coffee maker, microwave, and wifi

Guest favorite
The living area features an inviting floral-patterned sofa, complemented by a wooden side table and decorative artwork on the walls. Natural light fills the space through a large window, and a ceiling fan enhances the openness of the high ceiling.
Apartment in Las Cruces
4.95 out of 5 average rating, 582 reviews

Casa Susana

Beautiful one bedroom apartment just minutes from historic Mesilla plaza. This modern space is on the 2nd floor of a lovely red barn located on 5 acres. View acres of pecan trees, in the fertile Mesilla Valley. Close to shopping and restaurants.

Popular amenities for Mesilla vacation rentals

When is the best time to visit Mesilla?

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Frequently Asked Questions

  • Do house rentals in Mesilla have free parking?

    Absolutely! We offer over 20 house rentals with free parking in Mesilla. Enjoy a tailored experience with all the comforts you desire.

  • How much does it cost to stay in house rentals in Mesilla?

    Experience the best of Mesilla with our house rentals, starting at about $60 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there pet-friendly vacation rentals in Mesilla?

    Four-legged friends are welcome in Mesilla. Choose from more than 30 vacation rentals for guests traveling with pets.

  • Do house rentals in Mesilla have a kitchen?

    Absolutely! We offer over 20 house rentals with a kitchen in Mesilla. Enjoy a tailored experience with all the comforts you desire.

  • Are there vacation rentals with a dedicated workspace in Mesilla?

    Yes! Work meets play with ease at over 30 vacation rentals in Mesilla featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • What are the most popular amenities for House Rentals in Mesilla?

    Enhance your stay in our House Rentals with the most popular amenities: over 20 homes with air conditioning, over 20 homes with free parking, over 20 homes with a kitchen, over 20 homes with wifi, and more. Indulge in the ultimate retreat, tailored to your preferences.

  • Are there Mesilla vacation rentals on Airbnb with pools?

    Yes! Dive into the perfect getaway at one of over 20 vacation homes with pools in Mesilla, available on Airbnb. Make a splash and soak up the sun in style!

  • Do house rentals in Mesilla have air conditioning?

    Absolutely! We offer over 20 house rentals with air conditioning in Mesilla. Enjoy a tailored experience with all the comforts you desire.

  • Where should I stay in Mesilla?

    Make yourself at home in Mesilla by choosing from our most frequently booked neighborhoods. We have over 210 vacation rentals in Mesilla, and over 520 vacation rentals in Avienda de Mesilla.

  • Are there family-friendly vacation rentals in Mesilla?

    Mesilla has more than 40 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

Quick stats about vacation rentals in Mesilla

  • Total vacation rentals

    Explore 70 vacation rentals in Mesilla

  • Nightly prices starting at

    Mesilla vacation rentals start at € 34 per night before taxes and fees

  • Verified guest reviews

    Over 7,480 verified reviews to help you choose

  • Family-friendly vacation rentals

    40 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 30 rentals that welcome pets

  • Vacation rentals with a pool

    20 properties feature pools

  • Rentals with dedicated workspaces

    30 properties have a dedicated workspace

  • Wi-Fi availability

    70 of Mesilla vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Mesilla rentals

  • 4.9 Average rating

    Mesilla stays are highly rated by guests—averaging 4.9 out of 5!

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