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Vacation rentals in Guadalupe

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Guadalupe

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
An open living area is observed, featuring a futon couch, a dining table, and a television. A neatly arranged kitchenette is equipped with essential appliances, and a spacious bed is seen in the corner. Ample natural light enters through two windows.
Loft in Nipomo
4.94 out of 5 average rating, 859 reviews

Upstairs Guest Loft~EV Charge/Non-smoking/Pet-free

Private upstairs loft includes kitchenette, full bathroom, deck, and separate entrance. Grizzl-E Classic 40A EV Level 2 charger (Type 1/SAE J1772) with NEMA 14-50 and 6-50 plugs. Non-smoking, pet-free property. In the heart of CA's Central Coast between Los Angeles and San Francisco. Only 2 miles off Highway 101. Close to Pismo Beach, wineries, and golf at Monarch Dunes, Black Lake, and Cypress Ridge courses. Easy access for road trips, weekend getaways, and relaxing stays year-round. No AC.

Guest favorite
Apartment in Guadalupe
5 out of 5 average rating, 9 reviews

All-Inclusive | Private Entry | Full KTCHN + W/D

All-Inclusive Pricing – Save on the Airbnb Service Fee. Travel Nurses, Military (Vandenberg SFB), & Contract Workers. Located off Highway 1 for quick access to Santa Maria/Lompoc. Secure parking, in-unit laundry, and fast Mbps WiFi."Ideal private home for Travel Nurses on assignment. We offer blackout curtains for day sleepers and "Perfect for Vandenberg Military TDY personnel. Quick 27-min commute to the gate. Enjoy the convenience of fully stocked kitchen for your long-term, 28+ night stay.

Top guest favorite
The guesthouse is framed by blooming trees and colorful flowers, set amidst natural landscaping. A pathway leads to the entrance, with a soft blue sky and gentle hills visible in the background, creating a harmonious connection with the surroundings.
Guesthouse in Arroyo Grande
5 out of 5 average rating, 175 reviews

Central Coast Country Retreat

My husband Mike and I are artists. We searched for 10 years to find the perfect spot for our retirement years. We found 7 1/2 acres here, on the Central Coast, with spectacular views of verdant trees covering rolling hills that reach all the way to the distant mountains south and east of Arroyo Grande Village. Come and stay in our Guesthouse, relax, explore the property, walk the quiet country lanes. For a rural setting, we are surprisingly close to all amenities, beaches, and wineries.

Top guest favorite
A spacious living area features a large sectional sofa in dark leather, situated near multiple windows allowing natural light. A wooden coffee table is placed at the center, accompanied by decorative items. A flat-screen TV is mounted on the wall, adding to the entertainment space.
Guesthouse in Santa Maria
4.97 out of 5 average rating, 155 reviews

Private top floor spacious 1 bedroom retreat

Forget your worries in this spacious and serene space. Following CDC guidelines, we make sure your stay is a safe & enjoyable one. Equipped with a gas range stove, microwave, and washer/dryer. Relax in a full size tub, walk-in closet & plenty of space to store your items & gear. Enjoy hiking, biking & disk golf at near by Waller Park! Private entrance & exit. Please read our rules below before booking: 2 guests max 1 car parking No Parties No Smoking No Pets Additional fees may apply

Top guest favorite
The spacious interior of the RV features a cozy seating area with a sofa and decorative pillows. A dining table for four is set adjacent to the kitchen, which includes modern appliances and a marble countertop. Large windows allow natural light to brighten the space.
Camper/RV in Arroyo Grande
4.92 out of 5 average rating, 298 reviews

Glamping on the Central Coast- (fully sanitized)!

As 30-time Superhosts-we welcome you to the Central Coast! Clean, comfortable coastal glamping in the countryside. Enjoy the Central Coast at a low price but with plenty of space in this 29 foot-long RV/trailer home. Country living neighborhood with plenty of eucalyptus trees, birds and various other wildlife nearby. Hosts are on the same property about 30 yards away and can make sure you enjoy your stay and answer any questions you might have but make sure to respect your privacy.

Top guest favorite
A small outdoor table is situated in a serene garden setting, featuring two wine glasses filled with red wine and a bottle nearby. A potted succulent adds a touch of greenery, surrounded by various plants, creating a tranquil atmosphere for relaxation.
Home in Santa Maria
4.96 out of 5 average rating, 139 reviews

Cozy Plant-Filled Loft in Orcutt

Stylish, plant-filled loft on the Central Coast! Relax under cozy lights surrounded by greenery in this peaceful, thoughtfully designed studio with everything you need. Enjoy a comfy living area with TV, kitchenette, WiFi, and private entrance for easy access. Located just minutes from Old Orcutt’s coffee shops, wine tasting rooms, and restaurants, with quick access to Solvang, SLO, and beaches. Perfect for a quiet getaway, work stay, or exploring the beautiful Central Coast.

Guest favorite
A modern living area features a cozy gray couch with decorative cushions, accompanied by a small circular table. Framed artwork adorns the white walls, and natural light brightens the space. A bar with two stools is visible, leading into a kitchen area.
Tiny home in Guadalupe
4.84 out of 5 average rating, 58 reviews

Cozy Tiny House Near The Beach

Consider this studio your home away from home while you visit the BEAUTIFUL Central Coast. This cool and pleasant space features 1 queen bed in the bedroom and a cozy living room with a couch that can sleep an additional guest(s). The Living room and bedroom are equipped with 50-inch TV's connected to the Wi-Fi for YouTube etc. Enjoy the convenience of a shower, hair dryer, iron, and Wi-Fi during your stay. The unit you will be staying in is equipped with a full kitchen.

Guest favorite
Home in Santa Maria
4.95 out of 5 average rating, 61 reviews

Home, comfortable to rest and relax. Welcome

Forget your worries in this spacious and serene space. In a quiet neighborhood where you can relax with your whole family, easy to find, near entrances and exits for the Freeway, very close to the shops where you can do your shopping easily. Everything is centrally located. No drugs are allowed in this home. If you break the rules, you will be immediately evicted from this home. If you meet the requirements. Welcome, thank you, and have a nice day!

Top guest favorite
A well-appointed sleeping area features a spacious bed dressed in a light-colored patterned coverlet. Stylish decorative pillows are arranged neatly at the head of the bed. A round table with a single chair sits nearby, surrounded by floral drapes that frame the window.
Guesthouse in Santa Maria
4.99 out of 5 average rating, 1,716 reviews

French Country Casita - Breakfast Included

This stand-alone casita sits in the privacy of our rear yard and has a separate entrance. We are three minutes from highway 101 in the newer La Ventana community. Surrounded by beautiful mountain views on the Central Coast and close to many flourishing wineries, this residence is 20 minutes south of Pismo Beach, 30 minutes from San Luis Obispo, one hour north of Santa Barbara, close to the beautiful Danish city of Solvang and Santa Ynez.

Top guest favorite
A cozy living space features a built-in seating nook with striped cushions, surrounded by large windows that invite natural light. A round table with a woven tray and a plant adds a touch of greenery, while a mirror reflects the warm wood ceiling.
Tiny home in Nipomo
4.98 out of 5 average rating, 130 reviews

Modern + Cozy Oaks Hideaway

At our special spot, you get the best of both worlds: clean, modern and comfortably appointed tiny home on an oak-studded ranch surrounded by nature. Close enough to town, beaches, wineries, and restaurants for convenience while being far enough away to relax. Check out the creative and flexible spaces on the inside (living space coverts via Murphy bed to a queen bed sleeping area) and the comfy back patio for outdoor enjoyment.

Guest favorite
A bright living room is presented with natural light streaming through a window. Two comfortable chairs with soft throw blankets face a modern TV mounted on a pale wall. Decorative plants enhance the space, complemented by a wooden coffee table and light hardwood flooring.
Home in Arroyo Grande
4.93 out of 5 average rating, 260 reviews

Mid-century home in the heart of Arroyo Grande.

Welcome to the Eman House! I can't wait to host you at the 1950's mid century in Arroyo Grande, CA. Enjoy the beautiful remodeled kitchen, private backyard and patio, and two cozy bedrooms while soaking up the best of the central coast. Just a 10 minute walk to the historic Arroyo Grande village, a 5 minute drive to the beaches of Grover, and tucked away in one of Arroyo Grande's most peaceful cul-de-sacs.

Guest favorite
A modern two-story home is depicted, showcasing a light-colored exterior with dark trim. The front yard features low-maintenance landscaping with desert plants. A driveway leads to the garage, and neighboring homes are visible in a suburban setting under a clear blue sky.
Home in Guadalupe
4.85 out of 5 average rating, 261 reviews

Beach home near golf, wineries, dunes & Vandenburg

This Pasadera home has three bedrooms two and a half bathrooms with a loft which has a fold out couch. The downstairs couch will sleep 2 more if needed so 9 people will fit. It’s just a few miles away from Trilogy and Blacklake golf course, the beach, shopping , golf courses and many wineries! It’s a perfect beach community. About 20 minutes to Vandenburg Air Force base.

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