Vacation rentals in De Soto

Gorgeous Cabin close to SIU/wineries/Shawnee

Beautiful cabin sitting in the middle of woods w/ a large entertaining deck that makes you feel like are " away from it all" even though you are 3 mins away from SIU! Features 4 bedrooms & 2 full baths with an open floor plan with plenty of room for family and friends! Enjoy the large deck to grill or to just enjoy a glass of wine from one of our local wineries. Large master suite with jacuzzi tub to unwind. Make use of the concrete party pad with firepit & bar/ game room. Location is perfect!

Homestead Cottage

Enjoy tiny farmhouse life in this adorable 375 sq. foot cottage. Loaded with everything you need this little cottage is nestled privately behind some trees on our 11 acre farm. You will soon forget how close you are to town with the beautiful view from your windows and the pasture fence just steps out the back door. Whether you’re here for the wineries, amazing hiking, an SIU event (3 miles) or to visit with family, the Homestead Cottage will provide a comfortable retreat from any adventure.

Embers of Murphysboro

Escape to the beauty of Embers of Murphysboro.  The sprawling landscapes and cabin with high end amenities have everything to offer for a weekend getaway or larger gathering.  Sucumb to the beauty of nature around you that will awaken your inner senses and relax your mind.  Nestled upon a  26 acre property the cabin will astound you with picturesque landscapes and a lodging infused with both character and luxury.  Explore local wineries, hiking trails, fishing,  boating , dining and more...

Farm Views From Cozy Guesthouse

Enjoy this comfortable guesthouse/duplex located on the edge of a peaceful 11 acre family homestead just down the road from Walker’s Bluff Casino! You are just 1.5 mi from Walker’s Bluff Casino, 3.4 mi to Carbondale, 5.5 mi to SIUC, and 13 mi to Giant City State Park, and close to the Wine Trail! All three bedrooms offer new memory foam mattresses. The large eat-in kitchen has all of the basics that you might need to make a delicious meal at home. On-site laundry available in the unit.

Awesome House in DeSoto

Welcome to this Awesome Home centrally located in Southern Illinois available for your enjoyment while in the area. Featuring a Large Furnished Kitchen, Livingroom, Laundry Room, Three Fully furnished Bedrooms, including TVs, Two Bathrooms, Large Driveway, Extended Wi-Fi Service, and Large Fenced in Backyard with Secure Gated Access for RV's, with 30-amp Electric Plugs and Water available for slight upcharge. I am personally available to ensure that your check-in and stay is enjoyable.

The Windbreak

This is a spacious apartment, the lower/first level of a 3-level house. It is a peaceful place at the end of a woodsy, country lane, not far from two state parks, five lakes, wine trail, Southern Illinois University and other interesting features of this area. The 1st level apartment is large, sleep six, has a fully equipped kitchen, dining room, 2 bedrooms, living room/bedroom with a pull-out queen bed, a full bath, and a utility room, 2 exterior doors, one to a patio with a fire pit.

Frank Lloyd Wright design inspired house

PET FRIENDLY-Frank Lloyd Wright design. This home is Unique and spacious! It is conveniently located near interstate 57, and 12 minutes from the Lake of Egypt. It is also close to Shawnee Hills National Forest for beautiful hiking trails and picnics as well as 12 local wineries! After your adventures, Relax in the rustic outdoor area that provides plenty of privacy. Or in the theatre room that has a large tv and recliners to watch your favorite movies or cheer on your favorite team!

Charming 3 bedroom retreat

Four friends have joined forces to create this cozy space for you to feel right at home in. We've made the space fun, with each bedroom having a unique theme. Our coffee bar also offers a variety of mugs, so each person can pick their favorite. We had your comfort in mind when we selected new queen mattresses, soft bedding, and plush towels. The couch and extra seating are very comfy. For our likeminded germaphobe friends, we chose light bedding to ensure utmost cleanliness.

Charmful Cabin Artist respite next to refuge

*No cleaning or pet fees. This Veteran owned Charmful Cabin is stocked with fine Art supplies and ready for your creative Oasis. Sip on your favorite cocktail on the balcony. 1 bedroom, 1 bathroom whole home sanctuary. We are walking distance to the Crab Orchard Wildlife Refuge. A short drive to the Artsy community of Makanda. and an even shorter drive to the food and fun in the college town of Carbondale, LOVE the wine trail? We are aptly located near many wineries.

Relaxing 3 Bedroom Cottage in Quiet Neighborhood

This happy 3 bedroom duplex will be a family favorite on your next trip to Southern Illinois. You'll enjoy 3 cozy bedrooms each equipped with a TV, 1 bathroom, ample deck space and firepit. We are located on a quiet street within walking distance of all Carbondale has to offer – Downtown Carbondale, restaurants and pubs (.8 miles), the Memorial Hospital of Carbondale (.5 miles), Carbondale Civic Center (.8 miles), Amtrak Station (.9 miles), and SIU (1.1 miles).

Cozy Ranch on Brookside/Serene Country Getaway

Nestled in a peaceful setting and surrounded by open farmland, this home offers the perfect blend of comfort and quiet. With wide-open views and a cornfield just beyond the backyard, you’ll enjoy a level of privacy and calm that’s hard to find. Wake up to quiet mornings and unwind in the evening under the stars. Whether you're visiting nearby wineries, exploring the area, or simply needing a break from the busy pace of life, this is the perfect place to relax.

*The Hilltop Haven* close to SIU & Wine Trails

Escape to this spacious 3-bedroom, 2-bath hilltop retreat just minutes from Carbondale and Murphysboro. Sleeping up to 8 with 4 queen beds, the home features vaulted ceilings, a fully equipped kitchen, large deck, dedicated workspace, and plenty of private parking. Tables and chairs are available for small gatherings like bridal showers, baby showers, graduations, and family celebrations. Perfect for relaxing or exploring Southern Illinois.