Vacation rentals in Carlisle

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Carlisle

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

A spacious wooden patio deck features several light blue chairs and small tables. Green umbrellas provide shade, while a colorful outdoor game set stands ready for use. Lush greenery and trees surround the area, creating a tranquil outdoor setting.

Home in Carlisle

A Taste of Southern Comfort!

Here is a taste of Southern Comfort in the little quite town of Carlisle, S.C. Located 15 minutes from Union; 30 minutes from Newberry; 2BR/3BA, 2 Master Bathrooms (1 King Size Bed and 1 Queen Size Bed). Direct TV and WIFI. Keycode lock entry. Built in 1917, on 2 acres. Fully stock kitchen, 2 refrigerators, mudroom, workstation, patio deck, washer and dryer, fire pit, tree swing, gas and charcoal grills w/utensils, games. NO CATS. Some dogs are allowed per request. Sorry-No Hunters Camp.

4.86 out of 5 average rating, 22 reviews

Top guest favorite

The entrance features large, rustic double doors opening to reveal a stylishly decorated bedroom. A crystal chandelier hangs above a beautifully crafted bed with an intricate headboard. Two decorative topiary plants frame the doorway, adding a touch of greenery to the warm wooden floor.

Treehouse in Waterloo

#1 most loved AirBnB in SC! *Old Soul Treehouse*

The Old Soul Treehouse is a fabulous destination for couples looking to have a unique getaway! This is a waterfront treehouse on Lake Greenwood with a private dock, heat/AC, hot tub, king size bed, & a fully equipped kitchen & bathroom. Take a dip in the lake during the day or at night enjoy a soak in the hot tub on the peaceful porch under the stars. Book with us and you will soon be enjoying luxury by the water during this intimate experience with the one you love. We would love to have you!

4.99 out of 5 average rating, 257 reviews

Guest favorite

The outdoor area showcases a tranquil pool surrounded by lush greenery, with comfortable lounge chairs positioned nearby. A pastel sunset provides a serene backdrop, while inflatable pool accessories add a playful touch to the inviting atmosphere.

Home in Simpsonville

Luxury Retreat & Heated Pool Downtown Simpsonville

Luxury Pool House in the Heart of Simpsonville – Perfect for Gatherings! Designed for comfort, fun, and relaxation. 2 minutes from Downtown Simpsonville and 15 minutes from Downtown Greenville, this luxury retreat feels like a private resort with all the warmth of home. With nature views and countless amenities, you’ll have everything you need for an unforgettable stay. Up to 8 guests with 4 Spacious Beds and 2.5 Baths. Indoor & Outdoor Entertainment, Well-Equipped Kitchen, Cozy Living Room!

4.93 out of 5 average rating, 107 reviews

Top guest favorite

The front porch of the house is illuminated at night, showcasing tall columns and a wide entryway. Soft lighting highlights the architectural details, while rocking chairs are visible on the porch. Lush greenery lines the pathway leading to the entrance.

Home in Newberry

The Inspiration House

Ryan and I are certain you will love Newberry's friendly "small town" atmosphere. Our home was built in the late 1800's. It provides visitors with an eclectic blend of "old house" charm and modern updates within walking distance to the Newberry Opera House and wonderful downtown restaurants. The house features over 3,600 square feet of high ceilings, heavy pocket doors for privacy, three fireplaces, four bedrooms with three queen and two twin beds, 3.5 baths..and a wonderful front porch.

4.94 out of 5 average rating, 162 reviews

Top guest favorite

A charming farmhouse stands in the background, featuring a green metal roof and a wide porch. In the foreground, various ducks and chickens are seen grazing on lush grass, while structures for the animals are visible nearby, creating a serene farm atmosphere.

Guest suite in Pomaria

Farm Getaway

Come and experience the beauty of life on a farm! This beautiful space has its own private exterior entrance off of the picturesque wrap around farmhouse porch and is complete with all the classic and simple farmhouse touches. We are a working livestock farm raising cows, sheep, chicken, ducks, pigs & more. This space is perfect for some outdoor adventure time while still being close to historic downtown Newberry, home of the Newberry Opera House, & not far from Greenville and Columbia.

4.95 out of 5 average rating, 122 reviews

Guest favorite

An outdoor game area features a pool table, with a set of colorful balls arranged on the surface. The scene includes a grassy lawn leading to the water, where a sunset illuminates the landscape. Two red chairs and a picnic-style setup are visible nearby.

Home in Prosperity

Sunset Cove-Beautiful Lake views

Your home away from home on Lake Murray! Spacious, modern clean, home with 3 levels of living -3 spacious decks, screen porch, and sunroom all with massive lake views! Plenty to do at Sunset Cove relaxing with family and friends and toys galore! "Wow just wow, best Airbnb ever..Sarah, June 2026. "..clean, beautiful view and so many fun games..Lisa, Oct 2025."Perfect setting for a quiet getaway. The house was amazing, clean, and had all the amenities we were looking for.."Jay, Sept 2025

4.91 out of 5 average rating, 107 reviews

Top guest favorite

A single-story home is nestled among tall trees, set on a spacious plot with natural landscaping. A covered front porch is visible, providing a welcoming entryway. A gravel path leads to the home, surrounded by a peaceful, wooded environment.

Home in Newberry

Completely Furnished CLEAN Comfortable Quiet Home

If you are looking for a very clean and comfortable stay just a few minutes from downtown Newberry and very close to interstate 26, this is the place. It is on a safe dead end road. It’s in a country setting just off Highway 176 and an easy drive to the Sumter National Park, Palmetto Trails and the Jenkinsville VC Summer plant. We take great pride in providing a place to relax while visiting Newberry and surrounding areas. ALL dogs MUST be approved before booking . Thank you

4.97 out of 5 average rating, 240 reviews

Top guest favorite

The exterior of a yellow cottage is visible, surrounded by trees. A wooden railing leads to the entrance. A gravel pathway meanders through the yard, bordered by landscaping stones. Outdoor seating is arranged to the side, blending with the peaceful, natural surroundings.

Home in Union

Cozy Cottage in Union, SC

Our cozy cottage is half a mile from Foster Mill Park and only minutes from budding downtown Union. Sitting at the end of a cul-de-sac surrounded by trees for privacy, natural light shines through the whole home while offering a place to sit and relax inside or outside. Sofa and smart tv in the den, full kitchen (minus dishwasher) and laundry. The bedroom offers a full bed with storage for clothing & blackout curtains. The bathroom offers a shower with vanity storage.

4.91 out of 5 average rating, 70 reviews

Top guest favorite

The exterior of the home features a welcoming entrance with a sturdy handrail and a small set of steps leading to the front door. Flanking the door are two modern wall sconces, and the house number is displayed prominently above.

Home in Newberry

The Gem of Newberry | Sleeps 6

Welcome to our Airbnb located in Newberry, South Carolina! Located just a few minutes away from downtown Newberry and Newberry College, this Airbnb is conveniently located to some of the city's best dining, shopping, and entertainment options. The property is also just a short drive away from Lake Murray, one of South Carolina's most popular recreational destinations. Come and experience the best of modern living in this beautiful Airbnb in Newberry, South Carolina!

4.99 out of 5 average rating, 158 reviews

Top guest favorite

An open layout showcases natural wood finishes throughout, with a kitchen area featuring dark appliances and granite countertops. Bar stools are positioned at the counter. A dining table is set nearby, while a staircase leads to the loft area above.

Home in Ridgeway

Marcy's Place

Take it easy at this unique and tranquil getaway surrounded by acres of wooded land and privacy. This Tiny House with porch was constructed of Logs in 2022. The outside logs are painted gray to blend in with nature. The inside is beautiful natural pine, with 3 bedrooms/1 bath/2 queen and 2 bunk beds with a loft, washer/dryer. It's conveniently located 4 miles off Interstate I 77 and 2 miles from the 1770 Historical town of Ridgeway, SC off Hwy 21 north.

4.97 out of 5 average rating, 173 reviews

Guest favorite

A historic log cabin is nestled among tall trees, with lush greenery surrounding it. The cabin's porch overlooks a serene lake, reflecting the natural beauty of the landscape. Sunlight filters through the leaves, creating a tranquil outdoor space by the water.

Cabin in Prosperity

Historic Log cabin on private fishing lake

Magnificent historic Log Cabin located on the shores of a private 10 acre lake surrounded by over hundreds of acres of forested isolation. One mile into the woods and away from the stress, hustle and bustle of everyday life. Access to 100 acre parcel for walking trails, fishing, canoeing, swimming, campfire and wildlife. Great opportunity to unplug from the stress and engage with family and friends! A great spot for an artist retreat!

4.91 out of 5 average rating, 197 reviews

Top guest favorite

A well-maintained backyard features a wooden pergola providing shade over a small dining area. Complementing the setting are neatly arranged garden beds and a pathway that leads through the lush, green lawn to the wooded area beyond. Comfortable seating is spaced among the trees.

Home in Lake Murray

The Westwood Backyard - Retreat or remote working

Kick back and relax at The Westwood Backyard in Chapin SC! This new charming and cozy 3 Bedroom, 2 bathroom home adjacent to a new neighborhood with a wooded backyard is modern and well decorated. It is an ideal home for family vacation. Lake Murray, Timberlake country club, and Dreher Island State park are nearby. Restaurants, grocery stores, and local night spots, are close by. Columbiana mall is 20 min and Columbia is 25 min away!

4.99 out of 5 average rating, 142 reviews