Vacation rentals in Santo Domingo

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santo Domingo

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Guesthouse in Pedasi

5.0 out of 5 average rating, 24 reviews

A Remote Paradise in nature - Ocean View

'Tres-Palmas' sea and nature at its best! A remote hideaway on the Pacific Coast of Panama, but yet close enough to nearby towns and entertainment, Tres Palmas is the perfect place for an invigorating holiday. It is more than just a place to stay, we offer our guests personalized attention through fully equipped facilities and services for your comfort and well being. We enjoy getting to know our guests, sharing life stories and greeting you with an authentic smile for an unforgettable stay.

Aug 5 – 12

€ 137 per night

Guest favorite

Cabin in Cambutal

5.0 out of 5 average rating, 14 reviews

Charming Cabaña on the beach

If you're looking for a place to relax and experience the magic of Cambutal with its lush jungle and stunning beaches, look no further. Nestled amongst the trees and overlooking one of the best swimming bays around, this rustic wooden cabaña has everything you need to make your stay unforgettable. Wake up to the sounds of the ocean on your doorstep, spend your days swimming in the warm ocean, or try other exciting activities, such as horse riding, hiking, yoga, surfing, diving and snorkelling.

Dec 17 – 24

€ 95 per night

Superhost

Home in Pedasí

4.9 out of 5 average rating, 40 reviews

Pedasí :Andromeda Boroda 4-6 p. Beach, swimm. pool

In the park of Andromeda. The house is suitable for 4-6 people, there are two bedrooms, two bathrooms with hot and cold water and a sofa bed (1,87 x 1,13) in the living room; for 1 adult or 2 small childeren. The master bedroom has a king-size bed, the second has two single beds. The covered carport for for 2 cars; has a (standard outlet) charging for an electric car. Bedrooms and living room are equipped with air conditioning and wireless internet. Shared pool and beach club are a 5 min. walk.

Sep 16 – 23

€ 132 per night

Guest favorite

Villa in Playa Venao

5.0 out of 5 average rating, 22 reviews

Villa Verde - Luxury&Cozy Villa 1BR #26 BlueVenao

Relax & Calm in a cozy villa with an amazing view of the mountains, located in Playa Venao Beach The villa is fully equipped with 1 Queen size bed and a Sofa bed, High Speed Wi-Fi, Netflix, kitchen cooking tools and appliances like stove, oven, dishwasher, microwave, coffee maker, toaster and blender. Also, you will find a complete laundry with washer and dryer, towels for use inside the Villa, as well as for the pool & beach. Bedrooms come with complete bedding clothes/linens and pillows

Sep 19 – 26

€ 217 per night

Guest favorite

Home in Pedasí

4.94 out of 5 average rating, 112 reviews

3 min to Pedasi, 5 min to the Beach, Private Pool!

Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Aug 17 – 24

€ 108 per night

Guest favorite

Apartment in Las Escobas del Venado

4.98 out of 5 average rating, 66 reviews

LUXURY Apartment in BLUE Playa Venao D-32

Brand new 2 bedrooms luxury apartment, fully equipment, well organized for families, friends or even just for you. All you need for the perfect relaxed vacation, just bring your clothes and good energy and we will take care for the rest. Located in the best location, in the middle of everything (but still very quiet) and one minute walking from the beach (with direct access), restaurants, bars, shops, supermarket, surfing schools, Yoga & wellness centers, horses riding, ATM and gas station.

May 7 – 14

€ 178 per night

Guest favorite

Villa in Playa Venao

4.98 out of 5 average rating, 61 reviews

Casa Aqua: Amazing beach front house - Playa Venao

Exceptional beach front property, Casa Aqua sits right on the beach of Playa Venao Bay where you can enjoy great surfing, fishing, whale watching and many other outdoor activities. Casa Aqua is a very spacious 3,500ft home with all amenities you could dream of. You will love to eat/lounge outside in the spacious covered terrasse or swim in the large infinity pool. And if you don't feel like cooking, there are some quality restaurants close by a short walk on the beach from Casa Aqua.

Aug 4 – 11

€ 594 per night

Guest favorite

Home in Chitré

4.88 out of 5 average rating, 42 reviews

Country House Like in the City / La Casita

Villa Oregon les ofrece una casa, fresca rodeada de árboles y naturaleza. Cuenta con áreas amplias para descansar. Ubicación céntrica, cerca de Centros comerciales, restaurantes, estación de autobuses y acceso directo a una ciclovía en Chitré. Tenemos facilidades como entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, aire acondicionado, agua caliente y WiFi. Los huéspedes contarán con fruta de bienvenida! ENG, POR, FRE and ITA Spoken!

Dec 29 – Jan 5

€ 62 per night

Guest favorite

Tiny home in Playa Los Destiladeros

4.87 out of 5 average rating, 38 reviews

Casita Brisa del Mar

Casita Brisa del Mar ~ Welcome to this special space which we have poured our hearts, souls, hopes and dreams into creating. 2 minute walk from one of the most beautiful beaches in Panama. Pacific Ocean views from every room (except the bathroom). We are also a drive away from limitless adventures on the Azuero Peninsula. This is generally a quiet neighborhood. FULL DISCLOSURE, there is currently construction happening next door to this property. The lowered price reflects this.

Jul 5 – 12

€ 83 per night

Guest favorite

Home in Playa Venao

5.0 out of 5 average rating, 15 reviews

Casa Samambaia - sea view tropical paradise w pool

With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

Jun 7 – 14

€ 261 per night

Guest favorite

Guesthouse in La Enea

4.95 out of 5 average rating, 42 reviews

Villa de Los Abuelos in Guararé

Get out of the capital city and come and enjoy Panamanian folklore in a rustic yet cozy space with an autochthonous experience. Lounge in the pool or lounge in a hammock, breathe fresh air, close to the ocean, surrounded by wide, natural gardens for a good walk. Close to the Port of Guararé where you will enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian polleras.

Jun 1 – 8

€ 89 per night

Superhost

Home in Playa Venao

4.9 out of 5 average rating, 115 reviews

Beautiful Home Directly on Playa Venao Sleeps 8-10

This is our personal home and we take good care to make sure you thoroughly enjoy your stay! This home is located on the best surfing beach in the entire country. Walk out of your back door onto the sandy beach filled with wildlife and the best beach break for beginners to pros. This home offers luxury accommodations. This home is for families and respectful renters only. We do not accept groups who want to use the home to party.

Aug 1 – 8

€ 425 per night