Vacation rentals in Santa María District

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Top-rated vacation rentals in Santa María District

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Top guest favorite

Lush greenery surrounds the charming casitas, with vibrant tropical plants in various colors dotting the landscaped garden. Mountains rise in the background under a partly cloudy sky, creating a serene backdrop for this tranquil retreat.

Guesthouse in El Valle de Antón

5 out of 5 average rating, 27 reviews

The Retreat in El Valle - Mountain House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Top guest favorite

An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.

Home in Costa Esmeralda

4.98 out of 5 average rating, 164 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise. Majestic Sands is located in a private beach community in Costa Esmeralda, San Carlos District, Panama. It is located a few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, Santa Clara and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.

Guest favorite

The exterior of the cabin is depicted, featuring a stone wall and a metal roof. A manicured grass area surrounds the structure, with pine trees in the background against a bright blue sky, creating a serene environment.

Cabin in Chicá

4.93 out of 5 average rating, 236 reviews

Horizonte Cabin by Casa Amaya

Take it easy at this unique and tranquil getaway at Cabaña Horizonte. Casa Amaya is a complex of 6 cabins located in Chicá de Chame, a cool climate between 18 and 24 degrees, where you can connect with nature and relax with your partner, friends or family. https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya We have an electric generator in case of power outages.

Top guest favorite

An aerial view captures a charming retreat nestled in lush greenery. The red-tiled roof of the cabin stands prominently surrounded by colorful gardens and fruit trees. A winding path leads to the property, with a vehicle parked nearby, highlighting the spacious natural surroundings.

Tiny home in Cocle

4.93 out of 5 average rating, 123 reviews

Cozy 2 Bedrooms, el Cope/ Retreat at the Mountains

Hermosa cabaña de dos habitaciones y dos baños , den panorámico ubicada a unos 50 minutos de Penonome, Provincia de Cocle, en el Area del Parque Nacional Omar Torrijos Herrera , temperaturas entre 22 y 25 grados C a orillas del turístico Chorro de las Yayas en la comunidad de Barrigon del Cope, distrito de La Pintada. Agradable ambiente rodeado de árboles frutales y hermosas cascadas. Ideal para disfrutar de la naturaleza y relajarse. Cuenta con internet satelital de rápida velocidad .

Guest favorite

A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.

Earthen home in El Cope, Penonome

4.92 out of 5 average rating, 179 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

Top guest favorite

The cabin features a distinctive A-frame structure with a sloped red roof, situated on elevated concrete pillars. Surrounding greenery enhances the natural setting, while a wooden staircase leads to a covered balcony. Large windows provide views of the forest, creating a bright and open atmosphere.

Cabin in Penonome

4.97 out of 5 average rating, 106 reviews

Aqeel cabin in the nature

Relax at this unique and tranquil getaway surrounded by nature. If you're lucky, you may wake up to see white-faced capuchins from your bedroom window and spot an abundance of birds, such as the crested oropendola or a toucan. The property offers river access with a sandy, beach-like area, and there is a 1 km walking trail alongside the river. With satellite high-speed internet access, you'll stay connected, though the river and sandy area may not be accessible during rainy days.

Guest favorite

An outdoor terrace is showcased, featuring a cozy hammock draped with red fabric. The space is illuminated by subtle lighting along the edge, enhancing the serene atmosphere. Lush greenery and distant mountains are visible, creating a peaceful setting as the evening approaches.

Cabin in Cerro Santa Cruz

4.86 out of 5 average rating, 37 reviews

Magical getaway in nature

Sunrise Glamping is a charming retreat where nature and comfort intertwine. A container transformed into a cabin welcomes you with its private bathroom, hot water, and a fully-equipped kitchenette. Relax on its terrace or on the catamaran net while enjoying panoramic views of spectacular sunrises. The small swimming pool and barbecue complete this magical space, ideal for disconnecting, exploring and experiencing unforgettable moments in a unique and peaceful environment.

Guest favorite

A geodesic dome is nestled among lush greenery, surrounded by tall trees. The structure features a wooden deck that extends into the natural landscape, providing a seamless connection with the environment. Mist shrouds the distant hills, enhancing the tranquil setting.

Dome in Altos del Maria

4.92 out of 5 average rating, 65 reviews

Los Domos Panama, Domo Fuego, Glamping en Altura.

Immerse yourself in a natural oasis where the connection to nature becomes palpable. Surrounded by trees and coffee plantations, our space offers a unique experience for those looking to reconnect with nature. From the singing of the birds to the pure air that is breathed, every moment here is an invitation to harmony. We have a private river of totally cool spring water and immerse yourself in the evening experience with our hot outdoor jacuzzi.

Top guest favorite

A bright dining area features a round wooden table surrounded by six turquoise chairs. Large windows allow natural light to fill the space, showcasing a cozy atmosphere. A wooden dresser and potted plants add touches of comfort. Arched openings lead to other rooms.

Home in El Valle de Antón

4.95 out of 5 average rating, 158 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Guest favorite

An inviting infinity pool is positioned on a spacious patio, overlooking a sweeping mountain view. Two lounge chairs are arranged on the deck, facing the water, while lush greenery and colorful blooms enhance the serene environment surrounding the pool area.

Cottage in Altos del Maria

4.94 out of 5 average rating, 152 reviews

Mountain Cottage with Great View and Heated Pool

Mountain Cottage, with spectacular views of the Altos del María Mountains, perfect for relaxing or spending time with the family. It features a heated pool, spacious outdoor spaces, Smart TV and A/C in all rooms and living room, Wi-Fi throughout the property, and is fully equipped. Includes Prime Video service. It also has a fire pit and a gas BBQ. Complimentary late checkout is available for rentals departing on Sundays.

Superhost

A tranquil garden scene is depicted, featuring a winding pathway of smooth stones and pebbles. Surrounding areas are adorned with various flowering plants and a small pond, enhancing the peaceful ambiance. Lush greenery is visible in the background, contributing to the serene atmosphere.

Farm stay in Santa Fe

4.9 out of 5 average rating, 292 reviews

Santa Fe villa with a espectacular view

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Top guest favorite

A modern cabin structure is nestled among trees, showcasing a mix of wood and glass. Large windows enhance the natural light and provide views of the surrounding landscape. The gradual incline of the driveway leads to the entrance, framed by greenery.

Cabin in Altos del Maria

5 out of 5 average rating, 13 reviews

Blue Sky Lodge; the best view in Altos del María

This newly built luxury mountain cottage offers a modern design, high quality finishes, and panoramic 180° mountain and sea views. It is located in a secure gated community, surrounded by a green garden, with large glass windows that favor connection with nature. The climate is pleasant, with temperatures between 22°C and 28°C.