
Vacation rentals in Santa Fe River
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Santa Fe River
Guests agree: these stays are highly rated for location, cleanliness, and more.

Chai Tiny Home - Nature Retreat (near Temple of U)
CHAI TINY HOME at Alachua Forest Sanctuary 🌴 Located in a nature oasis. Enjoy a quiet retreat. 🚙 Very close for guests visiting Michael Singer's Temple of the Universe (about 1 mile away) 💦 25-45 minute drive to several stunning natural freshwater springs. 25 min to UF or downtown Gainesville. 15 min to shopping. 🐄 Please note the space and land is vegetarian. Please maintain a vegetarian diet when on the land, thank you! 🌝 Chai booked for your dates? Message host or check Shanti Tiny Home

Sand Lake Getaway
Enjoy stunning lake views while sipping your morning coffee on the back deck. Lots of paddling options exist here on spring-fed Sand Lake. Hosts offer a paddle boat, canoe, and paddle boards for your enjoyment. Practice yoga on your own private deck, fish from the dock, or star gaze around the campfire each night. Discover nearby Florida Springs and beaches all within 30 - 60 minutes. This 800 sq. ft cottage is centrally located between Gainesville & Saint Augustine. Netflix | Hulu | Wifi | BBQ

Family Treehouse on The Santa Fe River
Our front yard is the Santa Fe River. Come enjoy a nature retreat in this cypress log home! Right by Tree House spring and nestled between two state parks, but less than five minutes to downtown. Whether you are looking for rest and relaxation or recreation, our home offers both. Take in the scenery and catch your dinner from the riverbank. Recline in the sunshine on our dock (12’ x 12’). Keep an eye out for otters! It is a two hour float downriver to Poe Springs, Rum Island, and Blue Springs.

Unique Container "Caja Verde" 1 Mile UF & Downtown
Our home is less than a mile to UFHealth at Shands and the Malcom Randall Veterans Medical Center. We are a mile to the University of Florida campus. Amazingly, also a short bike ride (1-2 miles) to Downtown Gainesville. Close to Depot Park, art studios, restaurants, music venues, and theater. Nature parks close too. The bonus is we live on 2 acres, tucked back in a quiet neighborhood. Our pool is deep & cool; we have bikes to borrow. The container is perfect for a solo traveler, or a couple.

Charming Lakefront Log Home
Welcome to your perfect lake retreat! Located on a no public access lake. This charming log home has a private dock and boat ramp suitable for launching your boat for fishing or skiing. There are kayaks on premises for use. This is an ideal location to enjoy North Florida’s lake life with family, friends, or work retreat. Includes a fully stocked kitchen, covered porch, fire pit, gas grill, and WiFi if you feel the need to plug in. NOT suitable for parties or events. NO loud noise, please.

Modern Cottage on Private Spring Fed Lake
Nestled on a gorgeous spring-fed private lake in the woods, our charming cottage is your ideal retreat. Whether you're dreaming of peace and quiet, a romantic getaway, or fun with your kids, this is the place to be! Kayak around the serene lake as you witness breathtaking sunsets, take a dip in the cool water or simply unwind amidst the beautiful surroundings. As night falls, gather around a fire and gaze up at the many stars lighting the sky. Come and create many cherished memories ☀️

Little Love Shack
This house is TINY but it’s comfortable and fun. By tiny I mean it’s got a lot of 1950’s character squeezed into 690 square feet. The “official” dining table is outside on the patio so if you’re more than 2 people you should plan on spending quality time outside or out and about in Gainesville because the living space is limited. This is a GREAT rental for people who want to explore Gainesville, like being in the heart of 6th Street and prefer old school homes. No cable at this rental.

Renovated Private Studio - Walking Distance to UF
NEWLY RENOVATED - Enjoy your Gainesville stay in this mid-century modern studio 0.5 miles from UF and 2 miles from UF and HCA hospitals. No detail was overlooked in this beautifully designed detached guest house with an abundance of natural light, upscale finishes, and endless amenities - kitchenette, mini fridge/freezer, smart TV, and more! This conveniently located private and quiet space in the heart of Gainesville is perfect for anyone visiting for just one night or a few weeks.

Farm Glamping Retreat
Escape to a unique glamping experience on our picturesque 500 acre ranch, where you can immerse yourself in nature and wildlife. Offering a one-of-a-kind retreat that's perfect for animal lovers and outdoor enthusiasts alike. Explore the beauty of our ranch with serene ponds, winding hiking trails, and stunning views at every turn. Whether you're looking to disconnect from the hustle and bustle or simply seeking a new adventure, Book now and create memories that will last a lifetime.

Santa Fe Getaway on Santa Fe River.
We are next door to Rum Island Park which is a swimming spring, kayak and canoe pick up/ drop off/boat ramp location. It is a private cottage. 1 bdr Sleeps 4. 1 Bedroom with a sleeper sofa. You’ll love my place because of the location. The river is in the backyard. You can launch your personal canoe or kayak. Sit by the fire pit or enjoy the deck and cook out with friends and family. We have a no pet policy due to our allergies. Town of High Springs and Gainesville near by

Log Cabin Amish Built in Spring Country WiFi - TV
New Hideaway Western Theme Cabin Amish made real log cabin nestled among trees and wildlife (lots of deer) Minutes away from Ginnie, Ichetucknee, Poe, and Blue Springs Kayakers and Canoes love our convenience to rivers and springs Fire pit and FREE FIREWOOD onsite(enough for one fire) FREE WIFI INSIDE CABIN Large private property with lots of trees Relax on the porch or around the fire and make some awesome memories in your private log cabin This is a no pet cabin

Azalea Guesthouse - Close to UF and downtown
Lots of character in this brand-new guest house located in the heart of town on a quiet canopied neighborhood and walking distance to UF, stores and coffee shops. Wake up in the morning to birds singing in the lush backyard, enjoy your coffee on the deck, or an evening stroll around the quiet neighborhood. Just a few blocks from UF and downtown, this retreat is perfect for your next Gator game weekend or to enjoy the nature, art and culture Gainesville has to offer!
Popular amenities for Santa Fe River vacation rentals
Santa Fe River cabin rentals

Space Camp

Reality Check / Salt Springs with a view

A charming cedar log cabin tucked in the woods.

ROMANTIC RIVERFRONT CABIN~ BRING BOAT ~ SLEEPS 2

Tiny Farmhouse on The Grove

Rest, relax, revive-lovely 1 bedroom cabin

Cabin on Aree Pond

Shiloh's cottage Alpha
Other great vacation rentals in Santa Fe River

Moonwake on Drayton Island "The Real Old Florida"

River Front Home with Dock, kayaks and tubes!!

The Perch at Misty Hollow

The Glass House

Blue Heron Hideaway @Cross Creek

Pristine Santa Fe River Front

Glamping GeoDome • 4 min to Springs •Firepit+Grill

Modern Micanopy Lakeside
Destinations to explore
- Seminole Vacation rentals
- Central Florida Vacation rentals
- St Johns River Vacation rentals
- Orlando Vacation rentals
- Atlanta Vacation rentals
- Fort Lauderdale Vacation rentals
- Four Corners Vacation rentals
- Tampa Vacation rentals
- Kissimmee Vacation rentals
- Tampa Bay Vacation rentals
- Panama City Beach Vacation rentals
- Charleston Vacation rentals
- EverBank Stadium
- Ginnie Springs
- Ichetucknee Springs State Park
- Gilchrist Blue Springs State Park
- Paynes Prairie Preserve State Park
- Depot Park
- Eagle Landing Golf Club
- Ravine Gardens State Park
- Fanning Springs State Park
- Ironwood Golf Course
- Ocala National Golf Club
- Ocala Golf Club
- Bent Creek Golf Course
- Florida Museum of Natural History
- Museum of Southern History
- Autobahn Indoor Speedway & Events - Jacksonville, FL
- Friendship Fountain
- Riverfront Park




