Vacation rentals in Santa Clara, Panama City

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Top-rated vacation rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite

A cozy living area with a large window offering a panoramic view of the city lights at night. A comfortable sofa is positioned to face a television, creating a relaxed space. The room's walls are softly illuminated, enhancing the viewing experience.

Apartment in Panamá

4.98 out of 5 average rating, 124 reviews

The Spot Panama - Comfy, great view & much more

Ideally located in Panama City Panama 🇵🇦 we're just 15-20 minutes from Tocumen Airport 🛩 . Approximately 10 minutes from Albrook Mall, SoHo Mall, Alta Plaza, Multiplaza and much more! Enjoy easy access to supermarkets and restaurants!. Experience peace of mind with 24/7 security and outstanding facilities: pool, gym, and free parking! More than a stay, it's a chance to shop, unwind, and soak in Panama City views. Don't hesitate- Book instantly or contact us if you have any questions.

Guest favorite

A comfortable sleeping area is presented with a spacious bed covered in a soft, patterned blanket. Lively artwork featuring tulips adorns the wall above, while bedside tables with lamps provide gentle illumination. Dark curtains frame the window, and air conditioning is installed overhead.

Loft in Panama

4.94 out of 5 average rating, 51 reviews

Modern apartment 20 minutes from the airport

Comfortable and cozy apartment on Av. la Pulida, 8 minutes from the Cincuentenario metro station. For business travelers and couples, this apartment features a bedroom with a full bed, a TV in the room, a full bathroom with hot water, a fully equipped kitchen, a living-dining room, a Smart TV, air conditioning, a laundry room, and a closet. It's just 8 minutes from the metro station and offers easy access to any point in the city. Centrally located, yet quiet. Enjoy a perfect stay!

Superhost

A panoramic view of the Panama City skyline is displayed, showcasing a lively urban landscape at dusk. The dark water reflects city lights, while notable icons for air conditioning, kitchen amenities, and WiFi are presented prominently, representing essential features of the accommodation.

Apartment in Panamá

4.93 out of 5 average rating, 27 reviews

Cozy Apt+WiFi+Kitchen+AC+Laundry+TV+Parking@Panamá

✔️ SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! Apartamento en Panamá, Panamá 📍Excelente ubicación 🏡 Espacio limpio, cómodo y seguro. 💬 Estoy disponible para ayudarte durante toda tu estancia. 🔑 ¡Reserva hoy y siéntete como en casa en Panamá! 👨‍👧‍👧 Ideal para todo tipo de turista El apartamento ofrece: 🌐 Wifi 📺 TV 🍳 Cocina 💻Zona de trabajo 🌬️Aire acondicionado 🚗Estacionamiento 🌸Lavadora 🧖‍♂️🧖‍♀️ducha con agua caliente

Guest favorite

The kitchen features modern cabinetry and a granite countertop, equipped with stainless steel appliances. A dining table with stylish chairs is set elegantly with plates and glasses. Fresh flowers are placed in a vase, adding a touch of color to the dining area.

Apartment in Costa del Este

5 out of 5 average rating, 16 reviews

Luxury Apartment in Panama | 2BR + Views + Pool

Live a Luxury Experience in the Heart of Panama City 🏙️✨ Welcome to your home away from home: a modern and elegant apartment designed to offer you the highest level of comfort, style, and functionality. Perfect for tourists, business travelers, or remote workers, every space has been thoughtfully designed to ensure an unforgettable stay. We look forward to welcoming you and offering you a luxurious and comfortable experience.

Guest favorite

A well-lit bedroom features a spacious bed dressed in a light quilt. Two bedside tables with lamps sit on either side. Blue decorative pillows add a pop of color against the neutral walls, while an air conditioning unit and a vibrant artwork piece enhance the atmosphere.

Guesthouse in Distrito San Miguelito, Brisas del Golf, Panama City

5 out of 5 average rating, 28 reviews

Apartment in a safe residential area

You will be Close to everything when you stay in this central home. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, on the way to Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether traveling for business, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We're available if you need any additional information.

Guest favorite

Apartment in Panamá

4.98 out of 5 average rating, 125 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Guest favorite

The living area features a light blue accent wall and a cozy gray sectional sofa accompanied by a round ottoman. A large window with striped awnings allows natural light to fill the space. Wall art and a small shelf with a clock add functional decor.

Apartment in Distrito de Panamá

4.76 out of 5 average rating, 17 reviews

Hippodrome Suites

Hippodrome Suites is located in a safe gated community in the suburbs of Panama City, just a short drive 🚘 from the Tocumen International Airport (✈️PTY), Santa Maria and Costa del Este Budiness District. City views, 24-hours security and covered parking. It is ideal for resting and working, business trips or layover nights. This condo offers a perfect mix of comfort, convenience, and tranquility.

Top guest favorite

The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.

Home in Panamá

4.94 out of 5 average rating, 385 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Guest favorite

A modern living room is depicted, featuring a wall-mounted television above a black media console. Two light-colored armchairs are positioned beside a round coffee table, which is adorned with decorative items. A large window allows natural light and offers views of the surrounding area.

Apartment in Costa del Este

5 out of 5 average rating, 6 reviews

1bd/2Bthrm East Coast-Panama

What are you waiting for to get to know and enjoy Panama? Stay in our modern, furnished, and quiet apartment in Costa del Este, where you can enjoy a spectacular view, fast Wi-Fi, fully equipped kitchen, access to the pool on the top floor with a city view and an incredible sunset, gym, and more. Surrounded by cafes, parks, and everything you need to have the best experience in the city.

Top guest favorite

A spacious living area is highlighted by large windows that offer views of urban high-rises and the distant ocean. A soft, rounded sectional sofa and a plush armchair provide comfort, while a dark area rug anchors the space beneath a sleek coffee table.

Apartment in Costa del Este

5 out of 5 average rating, 20 reviews

Elegant Apt in Costa del Este. Premium Amenities

Enjoy a luxurious stay in our modern design apartment located in the exclusive Costa del Este area. It has a room with a private bathroom, a cozy living room, and a fully-equipped kitchen. Building facilities include a state-of-the-art gym, swimming pool, and co-working space ideal for remote work. Perfect for extended stays, combining comfort and convenience in the heart of Panama.

Guest favorite

A compact studio showcases a spacious bed with light bedding set against a soothing teal backdrop. A small dining table and a shelving unit are visible, enhancing the functional layout. Natural light enters through the window, highlighting a cozy and organized atmosphere.

Guesthouse in Panama City

4.89 out of 5 average rating, 227 reviews

Boho Studio-Private Terrace near the airport

Perfect for 1–2 guests, Wifi, quiet terrace, separate room, has A/C, and a small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is Close to 2 Shopping Centers, Metromall and Los Pueblos. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.

Guest favorite

A modern living area is showcased, featuring a light gray sofa positioned across from a flat-screen TV on a wooden console. Two abstract art pieces adorn the walls. Floor-to-ceiling windows offer views of the city skyline, enhancing natural light in the space.

Condo in Panamá

4.94 out of 5 average rating, 136 reviews

Beautiful Apartment 3 guests

Modern Superhost Apartment near Multiplaza- Pool, Gym & Free Parking Enjoy a stylish and comfortable stay in this modern, fully furnished apartment located in San Francisco, Panama City- just minutes from Multiplaza Mall, restaurants, pharmacies, and supermarkets.