Vacation rentals in San Antonio

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Top-rated vacation rentals in San Antonio

Guests agree: these stays are highly rated for location, cleanliness, and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.

Apartment in Los Canelos

4.71 out of 5 average rating, 45 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Superhost

Home in Santiago

4.81 out of 5 average rating, 21 reviews

Casa a minutos de Santiago, U Latina, HospChichoF.

Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Guest favorite

Home in Canto del Llano

4.92 out of 5 average rating, 12 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.

Apartment in Santiago

5 out of 5 average rating, 4 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A spacious living area is presented with a light-toned sofa adjacent to large windows, providing natural light. A metal shelving unit adorned with plants stands in the center, complemented by a simple round mirror on the wall. A wooden table and chair add functionality to the space.

Condo in Santiago

4.72 out of 5 average rating, 18 reviews

2A Apartment

Accessible apartment in downtown Santiago, located 300 meters from the Transportation Terminal and within walking distance of supermarkets and businesses. With a good layout, fresh and bright, and with all the basic amenities. The apartments provide a harmonious balance in the middle of the characteristic comings and goings of the center, perfect for stays of families, friends, professionals, couples.

The space features a kitchen nook with a wooden table and two patterned stools. Light grey curtains frame a window, while a door leads to an outdoor area. A modern refrigerator and a stovetop are visible in the kitchen area, complemented by a neutral wall color.

Tiny home in El Estero de San José

4.83 out of 5 average rating, 6 reviews

Furnished apartment Aguadulce

Mini house ideal for 1 or 2 people. It has a king size bed, private bathroom, closet, TV, wifi and ceiling fan. Integrated kitchen with breakfast bar, refrigerator, microwave, coffee maker and kitchen utensils. Located in a quiet and safe residential area, just 10 minutes from downtown Aguadulce. Perfect for those who need a comfortable and accessible place to rest during their time in the city.

A small dining area is featured with a round table and two folding chairs. Large windows offer views of lush greenery outside, while sheer white curtains partially filter natural light.

Apartment in Santiago

4.88 out of 5 average rating, 8 reviews

d'rosas apartments 3PB

Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from the city center, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

Guest favorite

The two-story colonial house is showcased with a white facade and wooden accents. Decorative balconies with railings are present at the front, along with several potted plants adding color. The street is lined with other buildings, under a clear blue sky dotted with clouds.

Cottage in Parita District

4.8 out of 5 average rating, 44 reviews

Colonial House in Parita

Discover the charm of Parita from a comfortable and spacious home, perfect for large groups. Located in the picturesque and peaceful town of Parita, in the Herrera Province, just 12 minutes from Chitré, this spacious home is the ideal place to immerse yourself in the history and culture of a historic colonial-era town.

Guest favorite

Apartment in Santiago

4.86 out of 5 average rating, 7 reviews

Accommodation in Santiago Centro

Enjoy easy access to everything from this perfectly located accommodation in downtown Santiago, 2 minutes from the cathedral church, park, and the central avenue. Fresh and comfortable on the ground floor of a property with a large terrace with access to the courtyard surrounded by nature.

A cozy living area features an orange couch paired with a circular coffee table. A large flat-screen TV is mounted on the wall, accompanied by decorative round mirrors. Sheer curtains allow natural light to enter, creating a bright environment.

Home in Santiago

4.5 out of 5 average rating, 4 reviews

Welcome Home Santiago

Welcome home in Santiago where you are find a place for enjoy with friends, family and your loved ones, it’s a house with two bedrooms, WiFi and cable tv, you will be like in home, our location is near to Santiago Mall

Guest favorite

A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.

Home in Santiago

4.86 out of 5 average rating, 21 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.