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Vacation rentals in Port Byron

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Port Byron

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A cozy living room area features two armchairs and a spacious couch, all adorned with patterned covers. A wooden coffee table sits centrally on a soft rug, complemented by a stylish lamp on a side table. Natural light enters through the nearby window.
Guest suite in Le Claire
4.92 out of 5 average rating, 394 reviews

Paws & Relax Guest Suite #1

Please keep in mind, this is a second story suite. There is 1 flight of stairs. Paws & Relax Guest Suite is located a block and a half up from beautiful historic downtown LeClaire, next to the scenic Mississippi River. Plenty of shopping, restaurants, a distillery & brewery- all within walking distance! There is an outdoor patio with seating & table along with a porch for rainy days. Close enough to walk downtown, but just far enough to enjoy some peaceful rest. The perfect home away from home!

Top guest favorite
A hot tub is set on a deck overlooking the Mississippi River. The water bubbles gently, reflecting the serene landscape with trees lining the shore in the distance. The horizon features a slight view of buildings, enhancing the natural setting.
Home in Pleasant Valley
5 out of 5 average rating, 170 reviews

Mississippi River House

Now is a great time to stay in this completely furnished two-bedroom house directly overlooking the Mississippi River. The hot tub is amazing during the day and under the stars this time of year. Eagle watching in the winter is always entertaining while relaxing in the hot tub. This 1+ acre property is tucked away on a private dead end street, yet close to many great restaurants and shopping. If you're looking for a romantic getaway this house has everything you need for a wonderful time!

Guest favorite
A tranquil view of the Rock River is presented, featuring a wooden dock extending into the water. Lush trees line the shore, and the sky displays soft blue hues with wispy clouds. The calm water reflects the natural surroundings, creating a serene atmosphere.
Cabin in Moline
4.94 out of 5 average rating, 233 reviews

Riverfront Firepit, Kayaks, Huge Deck

Firepit ready for relaxing nights by the river. Kayaks included for warm days Wake up to sweeping Rock River views, sip coffee on the wrap-around deck, paddle out in the kayaks, and end your evening by the firepit as the sky glows at sunset. This eclectic riverfront bungalow blends vibrant décor with cozy comfort and seamless indoor-outdoor living. Perfect for girls’ weekends, fishing trips, romantic escapes, or peaceful fall getaways — just steps from the water and minutes to shops and dining

Guest favorite
The exterior of a two-story home is displayed, featuring a light-colored facade and a welcoming entrance with a sign labeled 'Rescue River Retreat.' A wooden fence surrounds the property, providing privacy, while a staircase leads to the upper level.
Home in Le Claire
4.9 out of 5 average rating, 125 reviews

Rescued River Retreat

A renovated 1890's two-story home overlooking the Mississippi. The upstairs has 2 large bedrooms: one with 2 full size beds, the other a queen size bed. Additionally, the living room has a sleeper sofa, so easily sleeps 8. The kitchen offers everything for cooking a family meal and the dining room has a large table. Enjoy the charming vintage bathroom while taking a soak in the claw foot tub. Whether you stay a weekend or more the laundry room has a wash sink, washer and dryer for you to use.

Top guest favorite
An outdoor deck area is furnished with a spacious sectional couch, a coffee table, and a dining table with chairs. A large blue umbrella provides shade, while decorative metal sculptures stand nearby. Lush greenery is visible in the background, enhancing the serene setting.
Home in Le Claire
4.96 out of 5 average rating, 435 reviews

Aire Leclaire 2-bedroom home

Your family will be close to everything when you stay at Aire Leclaire! Within walking distance from downtown and 2 blocks from American Pickers. This modern 2 bedroom, 1 bath home is a block away from the tugfest parade route. A barnyard turned farmhouse in the 1940’s, this home completely remodeled with the modern farm charm it has today. In town for a day or several, enjoy outdoor amenities, a lighted deck, outdoor couch, and table. Inside, a modern LED fireplace mixed with rustic beauty.

Top guest favorite
Cottage in Le Claire
4.97 out of 5 average rating, 534 reviews

Mississippi Overlook Cottage. Dogs welcome.

Settle into a fully renovated 1910 cottage perched on a steep hill above Buffalo Bill Cody’s original homestead. Enjoy a charming park right behind you and stunning river views in front. The cottage comfortably accommodates up to six guests. - The cottage is located on a steep hill. - You will hear trains, as LeClaire is a river and train town. 🚂🌊 - This is a wooded property, so expect sticks, leaves, and bugs. 🌿🐞 - There are many steps. 03/24/26. Cody Rd is under construction.

Top guest favorite
A spacious living area features large windows that allow for natural light, showcasing scenic views of the outdoors. Modern furniture, including a sectional sofa and accent chairs, is arranged around a central coffee table. A spiral staircase is visible, leading to an upper level.
Cabin in Princeton
4.96 out of 5 average rating, 158 reviews

Private & Modern. Near river and wildlife refuge!

Experience the outdoors in comfort from this modern cabin, situated next to the 2200 acre Princeton Wildlife Management Area, and the nearby Mississippi River. It is ranked as the most “Wish Listed” Iowa listing of 2025 on Airbnb. Are you into hiking, biking, fishing, hunting, boating, or other water, winter, and summer sports? This cabin can support it all! Sit back and relax on the large deck while enjoying a coffee & the local wildlife, flora, & fauna of the Mississippi Valley Region.

Top guest favorite
The entrance features a welcoming porch with a ceiling fan and decorative lights. A white picket fence includes a painted flower sign, while steps lead to a green door framed by large windows. Rocking chairs are placed on the porch, inviting relaxation.
Cottage in Le Claire
4.97 out of 5 average rating, 242 reviews

Grasshoppers Guest House Too, cozy, cute, cottage!

This cozy cottage is 1000 sq. feet of charm. You are in the heart of downtown, historical Le Claire. Your home away has everything you will need for your stay. The porch overlooks downtown, nestled in with views of the Mississippi River. Shops, dining, brewery & distillery all to enjoy. visitleclaire.com has monthly activities & festivities. Birthplace of Buffalo Bill Cody & home to Mike Wolfe on American Pickers. You may even see him unloading treasures at his shop Antique Archaeology!

Guest favorite
A historic Queen Anne Victorian home is showcased with vibrant blue siding and intricate architectural details. The front porch, adorned with hanging flower baskets, invites guests to relax. Lush greenery and a well-maintained lawn surround the property, complementing the charming façade.
Home in Le Claire
4.91 out of 5 average rating, 169 reviews

"The 504" - Historical Victorian Guest House

Prepare to walk back in time in this historical 1860 Queen Anne Victorian. Centrally located to restraunts, shops, wineries, a brewery & a dilstillary. River view w/private parking & fire pit. The property has a fun party room" w/TV, high top bar tables, sleeper sofa, kerug coffee maker, hot tea kettle, toaster oven, microwave & refridgerator. There is a comfortable living room with 2nd TV, 2 bedrooms w/queen beds & Victorian inspired bath w/clawfoot tub, shower & high tank toilet.

Top guest favorite
A serene view of the river at sunset, reflecting soft hues in the calm water. A gazebo is visible nearby, alongside a swing set on lush grass. A fire pit stands ready for gatherings, and boats are docked in the background.
Home in Le Claire
4.89 out of 5 average rating, 103 reviews

Rivers Paradise

This home has fabulous views of the mighty Mississippi, with plenty of space to allow you to absorb the beautiful atmosphere and relax comfortably. There is plenty of parking space , and it also has its own boat launch and dock . Lots of room for entertainment indoors and out . Grill and relax on the deck or have your morning coffee in the gazebo by the river . There are also 3 garage spaces . Three large bedrooms with king size beds, and three full baths. Bunk bed as well

Guest favorite
A modern kitchen with white cabinetry and stainless steel appliances is shown. A dining table with bright blue place settings is visible, while a cozy living room area featuring a dark sectional sofa and television is seen in the background.
Bungalow in Bettendorf
4.87 out of 5 average rating, 229 reviews

River Retreat

Welcome to our River Retreat. This house is situated at the end of a quiet dead end road right on the Mighty Mississippi River. Fully furnished with Wifi, washer/dryer and everything you need for a quiet and relaxing get away. Enjoy the river views from the deck and 3 season porch or relax in living room with a movie. Extra furnishings include a fire pit and charcoal grill. Book your stay today!!!

Top guest favorite
A simple white house is situated on a green slope, surrounded by trees and open fields. The structure features black shutters and a welcoming porch. A small outbuilding is visible nearby, with the expansive countryside stretching into the distance under a partly cloudy sky.
Cottage in Davenport
4.99 out of 5 average rating, 301 reviews

Iowa Farm Cottage

This small simple house is situated near Interstate 80, one mile from Davenport city limits, near John Deere Davenport Training Center and John Deere Davenport Works. The cottage is surrounded by cornfields in the heart of an Iowa farming community, yet not far town on a paved road (55 mph) . Enjoy wide open vistas in privacy. Easy drive to Mississippi River, shopping and restaurants.

Popular amenities for Port Byron vacation rentals